Clinical trials: Leukoplakic Lesions
Pachyonychia Congenita
International Pachyonychia Congenita Research Registry
International Pachyonychia Congenita Research Registry (IPCRR) is a patient registry for those suffering from Pachyonychia Congenita (PC).
- Trial name
- IPCRR (NCT02321423)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Pachyonychia Congenita Project
Erythroleukoplakia, Leukoplakia
Pembrolizumab in Treating Participants With Leukoplakia
This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.
- Conditions
- Erythroleukoplakia, Leukoplakia, Verrucous Oral Leukoplakia
- Trial name
- NCT03603223
- Testing
- Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Precancerous Condition
Aspirin Mouthwash in Treating Patients With Oral Leukoplakia
RATIONALE: Aspirin mouthwash may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of aspirin mouthwash in treating…
- Trial name
- NCT01238185
- Testing
- acetylsalicylic acid, gene expression analysis, protein expression analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Institute of Head and Neck Studies and Education, United Kingdom
Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
This is a prospective observational clinical study designed to evaluate the performance of artificial intelligence (AI) algorithms applied to upper aerodigestive tract (UADT) video-endoscopy.
- Conditions
- Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer, Upper Aero-digestive Tract (UADT) Neoplasm, Squamous Cell Carcinoma
- Trial name
- H&NANCE (NCT07596355)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 283 people
- Sponsor
- Istituto Italiano di Tecnologia
Lip and Oral Cavity Cancer, Oral Leukoplakia
Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia
This randomized phase II trial is studying how well Bowman-Birk inhibitor concentrate works in preventing cancer in patients with oral leukoplakia.
- Conditions
- Lip and Oral Cavity Cancer, Oral Leukoplakia, Oropharyngeal Cancer, Tongue Cancer
- Trial name
- NCT00330382
- Testing
- Bowman-Birk inhibitor concentrate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- National Cancer Institute (NCI)
Oral Leukoplakia
Candida Associated Cytokines in Oral Leukoplakia
This study aims to determine the correlation between candida and pro- inflammatory cytokines response in Oral Leukoplakia(OL) with antifungal therapy.
- Trial name
- NCT04712929
- Testing
- Fluconazole
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions
This study aims to identify the accuracy of DNA integrity index in differentiating between oral premalignant lesions and oral cancer.
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia
- Trial name
- NCT03682562
- Testing
- DNA Integrity Index
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Oral Leukoplakia
Rosiglitazone Maleate in Treating Patients With Oral Leukoplakia
This phase II trial is studying how well rosiglitazone works in preventing oral cancer in patients with oral leukoplakia. Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back.
- Trial name
- NCT00369174
- Testing
- rosiglitazone maleate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer
Fenretinide in Treating Patients With Leukoplakia of the Mouth
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of or treat early cancer. Fenretinide may be an effective drug in treating leukoplakia.
- Trial name
- NCT00004161
- Testing
- fenretinide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Oral Cancer, Oral Cavity Cancer
Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions
The primary goal of this study is to see if photodynamic therapy (PDT) is effective for treatment of lesions in the oral cavity which have high risk of becoming oral cancer.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Leukoplakia, Oral Lichen Planus
- Trial name
- NCT06876038
- Testing
- 5-Amino Levulinic Acid
- Where
- 2 sites in India
- Volunteers
- 65 people
- Sponsor
- University of Massachusetts, Boston
Oral Leukoplakia
Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia
The goal of this clinical trial is to learn if calcipotriol and photodynamic therapy are equally effective in treatment of leukoplakia or not.
- Trial name
- NCT07658508
- Testing
- Calcipotriol 0.005% gel, ALA mediated PDT
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Leukoplakia, Erythroplakia
Treatment of Oral Premalignant Lesions With 5-ALA PDT
Oral leukoplakia within the mouth is a visible white patch which can develop into cancer if not treated. There is no good treatment for these lesions, apart from surgery which is associated with significant side effects and…
- Trial name
- NCT00571974
- Testing
- PDL-585, ScleroPLUS laser, 5-Aminolevulinic Acid (Levulan KerastickTM), Fluorescence Diagnosis Imaging
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Arkansas
Oral Lichen Planus, Oral Leukoplakia
Intra and Extra Oral Inspection of Oral Mucosa
Dental health professionals have a responsibility to perform routine intra- and extraoral inspection on their patients for detecting abnormalities.
- Conditions
- Oral Lichen Planus, Oral Leukoplakia, Erythroplakia
- Trial name
- NCT04079491
- Testing
- questionnaire survey
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Dalarna County Council, Sweden
Mouth Neoplasms
Oral Cancer Screening for Early Detection of Premalignant Disorders (PMOD)
Cancer is a complex disease; its different causes and types have a strong impact on patient treatment and prognosis. To improve understanding of the disease, its causes and progression, the investigators will develop a simple…
- Trial name
- PMOD (NCT05296941)
- Testing
- Brush sampling
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Oral Cancer, Oral Lichen Planus
Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis
This study aims to develop an AI program that can classify oral findings into Normal/variation of normal or an oral disease by clinical photos analysis, aiding in lowering the percentages of false positive and false negative…
- Conditions
- Oral Cancer, Oral Lichen Planus, Fordyce Granule, Leukoplakia
- Trial name
- NCT06325514
- Testing
- Artificial intelligence based program
- Where
- Egypt
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Neoplasm
Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment
The purpose of this observational study is to evaluate the utility of the S100A7 immunohistochemistry signature-based assessment - STRATICYTE - in determining the risk of progression to cancer of clinically suspicious oral…
- Trial name
- NCT04622462
- Testing
- Standard of Care Histopathology, STRATICYTE Assessment
- Where
- 3 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Proteocyte Diagnostics Inc.
Oral Leukoplakia, Autofluorescence
Identification of Oral Lesions Through an Autofluorescence System
The aim of the study will be to evaluate the efficacy of a tissue autofluorescence detection system as an aid to clinical screening in identifying lesions of the oral mucosa.
- Conditions
- Oral Leukoplakia, Autofluorescence, Secondary Prevention, Keratosis
- Trial name
- NCT05942794
- Testing
- Screening examination
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Federico II University
Leukoplakia, Oral
This Study is to Evaluate the Safety and Pharmacokinetics of SBS-101 in Patients With Oral Premalignant Lesions
This study will be the first study investigating the safety, pharmacokinetics (PK), and efficacy of SBS-101 on oral pre-malignant lesions. As such, no clinical data has yet been generated using SBS-101 oral adhesive film.
- Trial name
- NCT03939364
- Testing
- SBS-101
- Where
- 5 sites in United States
- Sponsor
- Skyline Biosciences
Head and Neck Cancer
Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia
Patient at increased risk for developing a new head and neck squamous cell carcinoma are invited to take part in this study. The investigators of this trial will attempt to study the effectiveness of Celecoxib in preventing…
- Trial name
- NCT00052611
- Testing
- Celecoxib
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Oral Leukoplakia
A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia
You have been asked to participate in this research study because you have or may have oral leukoplakia. Oral leukoplakia is described as a white patch or plaque on the oral mucosa (mouth) that will not rub off and cannot be…
- Trial name
- NCT00176566
- Testing
- Lozenge Intake
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Medicine and Dentistry of New Jersey