Clinical trials: Levonorgestrel
Abnormal Uterine Bleeding, Cesarean Section Complications
Oral Contraceptive Pills Versus Levonorgestrel-Releasing Intrauterine System for Niche-Related Abnormal Uterine Bleeding
The purpose of the study is to compare the clinical efficacy and niche morphological changes following treatment with combined oral contraceptive pills (OCPs) versus a levonorgestrel-releasing intrauterine system (LNG-IUS) in…
- Conditions
- Abnormal Uterine Bleeding, Cesarean Section Complications, Uterine Scar
- Trial name
- NCT07229209
- Testing
- transvaginal ultrasonography, monophasic combined oral contraceptive pill, 52 mg levonorgestrel-releasing intrauterine system
- Where
- Egypt
- Volunteers
- 166 people
- Sponsor
- Benha University
Contraception
EC PK in Women With Normal and Obese BMI
A well-designed pharmacokinetics (PK) study may identify the physiologic basis for observed differences in levonorgestrel emergency contraception (LNG-EC) and ulipristal acetate emergency contraception (UPA-EC) failure rates in…
- Trial name
- NCT02689804
- Testing
- LNG-EC, UPA-EC
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Columbia University
Contraception
Safety and Efficacy of CDB-2914 in Comparison to Levonorgestrel for Emergency Contraception
The purpose of this study is to assess the safety and efficacy of CDB-2914 in comparison to levonorgestrel for preventing pregnancy up to 5 days after unprotected sexual intercourse.
- Trial name
- NCT00551616
- Testing
- CDB-2914, Levonorgestrel
- Where
- 33 sites in United States, Ireland and 1 more
- Volunteers
- 2,221 people
- Sponsor
- HRA Pharma
Contraception, Contraception, Postcoital
Cross -Over Study to Prove Bioequivalence Between Two Oral Formulations of Levonorgestrel
A single dose, two treatments (Postday and Opxion), two periods, two sequences, crossover, randomized, prospective design was chosen with a washout of 21 days between the two study periods.
- Trial name
- LEVEQ-2 (NCT01096498)
- Testing
- Levonorgestrel Emergency Pill (BAY86-5028/Opxion), Levonorgestrel (Postday)
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Atypical Endometrial Hyperplasia, Stage I Uterine Corpus Cancer AJCC v7
Levonorgestrel-Releasing Intrauterine System in Treating Patients With Complex Atypical Hyperplasia or Grade I Endometrial Cancer
This phase II trial studies how well levonorgestrel-releasing intrauterine system works in treating patients with complex atypical hyperplasia or grade I endometrial cancer.
- Conditions
- Atypical Endometrial Hyperplasia, Stage I Uterine Corpus Cancer AJCC v7, Stage IA Uterine Corpus Cancer AJCC v7, Stage IB Uterine Corpus Cancer AJCC v7
- Trial name
- NCT00788671
- Testing
- Laboratory Biomarker Analysis, Levonorgestrel-Releasing Intrauterine System, Quality-of-Life Assessment
- Where
- 7 sites in United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Postmenopause
Effects of Wellnara on Climacteric Symptoms
Aim of this NIS is to obtain further information on efficacy, tolerability, and acceptance of Wellnara in a large user population under the conditions of routine medical practice.
- Trial name
- NCT00913926
- Testing
- E2/LNG oral (Wellnara, BAY86-5029)
- Where
- Germany
- Volunteers
- 749 people
- Sponsor
- Bayer
Healthy Participants
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
This study will measure the effects of multiple doses of AZD6234, AZD9550 and a combination of AZD9550 and AZD6234 given as injection(s) on pharmacokinetics (PK) of combined oral contraceptive (CoC) ethinyl estradiol…
- Trial name
- NCT07013643
- Testing
- AZD6234, Ethinyl estradiol/Levonorgestrel (EE/LEVO), Acetaminophen (APAP)
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Adenomyosis
Adenomyosis and Pregnancy: Levonorgestrel vs. GnRH for Blastocyst Transfer
Adenomyosis is a condition where endometrial tissue grows into the uterine muscle, causing symptoms like pelvic pain, heavy bleeding, and infertility.
- Trial name
- NCT06581679
- Testing
- Triptorelin, levonorgestrel-releasing intrauterine system, frozen embryo transfer
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Zagazig University
Contraception
Pharmacodynamics and Pharmacokinetics Study of Existing DMPA Contraceptive Methods
This is a randomized, multi-center, parallel-group Phase I study to evaluate the pharmacodynamics (PD) of Medroxyprogesterone Acetate (MPA) after a single subcutaneous (SC) injection of 150 mg/mL or 300 mg/2 mL Depo-Provera CI in…
- Trial name
- NCT02456584
- Testing
- DMPA 150, DMPA 300, DMPA 104
- Where
- 2 sites in United States, Dominican Republic
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- FHI 360
Complex Atypical Hyperplasia, Endometrial Cancer
Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients
Purpose: This is an open label, single-arm, single-center study of the addition of metformin to standard levonorgestrel-releasing intrauterine device (LR-IUD) treatment of 30 evaluable non-surgical patients with either complex…
- Trial name
- NCT02035787
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Contraception Desired, Obesity
Levonorgestrel-releasing Intrauterine Device on Obese Women: Effects on Hemostatic and Arterial Function
Obesity is a disorder associated with metabolic dysfunction and changes in cardiovascular risk markers; the use of oral contraceptives (OCs) may exert a further negative effect on these alterations in patients with PCOS.
- Trial name
- NCT01320917
- Testing
- Levonorgestrel releasing device, Cu-IUD insertion
- Where
- Brazil
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Female Participants, Postmenopause
A Study to Assess the Bioavailability and Adhesion of Estradiol/Levonorgestrel TDS in Healthy Post-Menopausal Female Participants
The purpose of this study is to compare the bioequivalence and adhesion performance of a test estradiol/levonorgestrel transdermal delivery system (TDS) with the reference product, Climara Pro® (estradiol/levonorgestrel…
- Trial name
- NCT07851649
- Testing
- Test Estradiol/Levonorgestrel Transdermal Delivery System, Climara Pro® (Estradiol/Levonorgestrel Transdermal System)
- Where
- India
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Contraception
GA Levonorgestrel Intrauterine Contraceptive System (LCS) Phase III Study China
The purpose of this study is to assess the efficacy, safety, bleeding pattern of low dose LNG (12 mg/ 24 hrs), delivered locally by a new intrauterine contraceptive system suitable for use by women 18 to 40 years of age.
- Trial name
- NCT00884260
- Testing
- Levonorgestrel IUS (LCS, BAY86-5028)
- Where
- 25 sites in Australia, China and 1 more
- Volunteers
- 918 people, healthy volunteers welcome
- Sponsor
- Bayer
Adenomyosis, IVF
Ambispective Study to Assess the Effect of Pretreatment With a Levonorgestrel-Releasing Intrauterine System Versus Oral Progestin
The study participants' relevant medical records will be collected and reviewed for the retrospective subjects and after obtaining informed consent for the prospective subjects.
- Trial name
- NCT05152667
- Testing
- levonorgestrel-releasing intrauterine device (LNG-IUS)
- Where
- Egypt
- Volunteers
- 354 people
- Sponsor
- Wael Elbanna Clinic
to Study the Estimate Difficulty of Insertion Mirena IUD With Use of Prostaglandins
Prostaglandins Use Before Mirena IUD Insertion in Prev CS Women During Lactational Amenorrhea
This is a prospective randomized controlled study to determine the effect of prostaglandin intake before Mirena IUD insertion It was conducted at the Department of Obstetrics \& Gynecology, Kasr El-Ainy Teaching Hospital, Faculty…
- Trial name
- NCT04646161
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cairo University
Levonorgestrel, Intrauterine Systems
Development of a Shared Decision Tool to Facilitate Uptake of the Levonorgestrel-releasing Intrauterine System for the Primary Prevention of Endometrial Cancer
To develop an educational tool to help patients and healthcare professionals make informed decisions about endometrial cancer and available prevention options for it (such as the use of a levonorgestrel-releasing intrauterine…
- Conditions
- Levonorgestrel, Intrauterine Systems, Prevention, Endometrial Cancer
- Trial name
- NCT07382583
- Testing
- Survey using a questionnaire
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- M.D. Anderson Cancer Center
Epithelial Ovarian Cancer
Mirena® IUD's Effect on Fallopian Tube Fimbriae and Ovarian Cortical Inclusion Cyst Cell Proliferation
Combination-type oral contraceptives (COCs) have been shown to significantly reduce the risk of invasive epithelial ovarian cancer (IEOC); this protective effect may be achieved to a large extent through COCs ability to reduce…
- Trial name
- NCT02477202
- Testing
- Mirena® intra-uterine device (IUD)
- Where
- 6 sites in United States
- Volunteers
- 7 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Contraception
Effects on Bone Mineral Density (BMD) of the Combined Oral Contraceptive NOMAC-E2 Compared to a COC Containing LNG/EE (292005)(P05765)(COMPLETED)
The primary purpose of this study is to evaluate the effects of the NOMAC-E2 combined oral contraceptive (COC) on bone mineral density (BMD).
- Trial name
- NCT00511342
- Testing
- NOMAC-E2, LNG-EE
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Ovarian Carcinoma
Levonorgestrel in Preventing Ovarian Cancer in Patients at High Risk for Ovarian Cancer
This randomized phase II trial is studying how well levonorgestrel works in preventing ovarian cancer in patients at high risk for ovarian cancer. Chemoprevention is the use of certain drugs to keep cancer from forming.
- Trial name
- NCT00445887
- Testing
- Laboratory Biomarker Analysis, Levonorgestrel
- Where
- 66 sites in United States
- Volunteers
- 60 people
- Sponsor
- Gynecologic Oncology Group
Idiopathic Menorrhagia
MiCo - Mirena or Conventional Medical Treatment for Menorrhagia
The aim of this prospective, non-interventional post-marketing surveillance study is to obtain data on safety and efficacy of Mirena in treatment of heavy menstrual bleeding (Menorrhagia) under daily-life treatment conditions.For…
- Trial name
- NCT01085487
- Testing
- Levonorgestrel (Mirena, BAY86-5028), Hormonal treatment, Antifibrinolytic treatment
- Where
- 14 sites in Albania, Bosnia and Herzegovina and 12 more
- Volunteers
- 1,211 people
- Sponsor
- Bayer