Clinical trials: Levonorgestrel
Contraceptive Usage
'Levonorgestrel IUD Insertion After D&E Procedure
This study is a randomized controlled trial of insertion of the levonorgestrel-releasing intrauterine device (LNG-IUD) immediately following dilation \& evacuation (D\&E) compared to delayed insertion 3-6 weeks post-D\&E.
- Trial name
- ILIAD (NCT00475228)
- Testing
- Levonorgestrel IUD
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity
Effects of Obesity on Pharmacokinetics of the Levonorgestrel Emergency Contraceptive Pill
The purpose of this study is to determine the effects of obesity on the pharmacokinetics of the levonorgestrel (LNG) only emergency contraceptive (EC) regimen and on markers of ovulation Primary hypothesis: 1) Obese users of…
- Trial name
- NCT02104609
- Testing
- Levonorgestrel 1.5mg by mouth once
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Endometrial Cancer
A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for the Prevention of Endometrial Cancer in Patients Aged 40-50 With BMI Greater Than 35
Endometrial (uterine) cancer affects over 40,000 women each year in the United States. At this time there are no medications to prevent endometrial cancer. Women who are heavy are at increased risk of this cancer.
- Trial name
- NCT00161226
- Testing
- Levonorgestrel intrauterine system
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Contraception
A Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible Contraception
The primary objective of this study is to assess the efficacy of a levonorgestrel-releasing intrauterine system (LNG20) in nulliparous and parous females of child-bearing potential who request long-term, reversible contraception…
- Trial name
- NCT00995150
- Testing
- LNG20, Mirena
- Where
- 25 sites in United States
- Volunteers
- 1,910 people, healthy volunteers welcome
- Sponsor
- Medicines360
Bioequivalence
Bioavailability of Levonorgestrel and Ethinyl Estradiol Tablets 15.0 mg/0.03 mg With Regards to Reference Product
This Pivotal study will investigate the bioavailability in women of 2 tablet formulations containing Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg. The Pivotal study will be performed at a single site with 30 subjects.
- Trial name
- NCT04230070
- Testing
- Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg Test Drug, Levonorgestrel 15.0 mg and Ethinyl estradiol 0.03 mg Reference Product
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Andromaco S.A.
Endometrial Bleeding, Periodontal Disease
Norplant and Irregular Bleeding/Spotting
Irregular or prolonged menstrual bleeding and/or spotting are common side effects in patients using progestin-only hormonal contraception such as levonorgestrel implants (Norplant).
- Trial name
- NCT00064766
- Testing
- doxycycline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Women in Need of Long Acting Reversibel Cntraception With the Intrauterine Levonorgestrel Releasing System, Mirena
Pretreatment With Mifepristone Prior to Mirena Insertion
Hypothesis: Pretreatment with mifeprsitone prior to Mirena placement will induce amenorrhea and reduce bleeding irrregularities during the initial months of Mirena use.
- Trial name
- MiMi (NCT01931657)
- Testing
- Mifepristone prior to Mirena
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Medicated Intrauterine Devices, Contraception
Mirena Efficiency and Tolerability During the First Year of Use
In this trial the efficacy and safety of Mirena was investigated during the first year of use
- Trial name
- NCT00696202
- Testing
- Mirena (BAY86-5028)
- Where
- France
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Bayer
Contraception
Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg
The proposed research study is a Phase IIb, multi-center, single-blind, randomized study of UPA 30 mg, LNG 1.5 mg and LNG 3.0 mg to evaluate EC effectiveness in women with weight ≥ 80 kg who present within 72 hours of unprotected…
- Trial name
- NCT03537768
- Testing
- Ulipristal Acetate, Levonorgestrel
- Where
- 18 sites in United States
- Volunteers
- 532 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer
Contraception
A Trial of Efficacy, Safety and Tolerability of LVDS (Levonorgestrel Vaginal Delivery System) During 13 Cycles
Multicentre, single arm phase III trial to assess the pearl index of LVDS. The trial lasts 13 cycles.The assessments include (but are not limited to) recording demographic data, pregnancy tests, gynaecological examinations…
- Trial name
- NCT06019533
- Testing
- LVDS
- Where
- Spain
- Volunteers
- 1,039 people, healthy volunteers welcome
- Sponsor
- Chemo Research
Estrogen Therapy
An Observational Study to Learn How Mirena and Other Progestogen Treatments Are Used for Endometrial Protection in Women 40+ With a Uterus in the United States Receiving Estrogen Therapy, and Their Respective Health Outcomes
This is an observational study in which researchers will use claims data already collected from women in the United States who received their usual care.
- Trial name
- SHIELD-ET (NCT07795606)
- Testing
- Estrogen therapy, Mirena levonorgestrel-releasing intrauterine system, Other progestogen therapy
- Where
- 2 sites in United States
- Volunteers
- 456,000 people
- Sponsor
- Bayer
Menorrhagia, Dysmenorrhea
Prospective, Non-interventional, Multi-center Safety Study of Mirena for Heavy Menstrual Bleeding and Dysmenorrhea
The primary objective in this study is collecting post-marketing information on the safety. Thus, it includes information under the routine clinical practice on adverse events (AEs) and adverse drug reactions (ADRs) including…
- Trial name
- J-MIRAI (NCT02475356)
- Testing
- Levonorgestrel IUS (Mirena, BAY86-5028)
- Where
- Japan
- Volunteers
- 601 people
- Sponsor
- Bayer
Contraception
Safety and Contraceptive Efficacy of an Intravaginal Ring With LNG (Levonorgestrel) Over One Year in Healthy Women
Purpose of the study is to investigate safety and contraceptive efficacy of an LNG-containing intravaginal ring.
- Trial name
- NCT02403401
- Testing
- Levonorgestrel (BAY98-7196)
- Where
- 100 sites in United States, Japan
- Volunteers
- 1,471 people
- Sponsor
- Bayer
Endometrial Cancer, Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)
Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome
RATIONALE: The use of intrauterine levonorgestrel may prevent atypical endometrial hyperplasia and endometrial cancer in women with hereditary non-polyposis colorectal cancer or Lynch syndrome.
- Trial name
- NCT00566644
- Testing
- levonorgestrel-releasing intrauterine system, questionnaire administration, observation
- Where
- 20 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- St George's, University of London
Atypical Endometrial Hyperplasia
LVN- IUS Versus Oral Megesterol Acetate in Treatment of Atypical Endometrial Hyperplasia
This randomized controlled trial is aimed to compare the efficacy between Megestrol acetate (MA) and the levonorgestrel intrauterine system (LNG-IUD) regarding the ability and duration to produce complete regression for cases…
- Trial name
- NCT04385667
- Testing
- levonorgestrel intrauterine system (LNG-IUD), Oral Megesterol 160 mg daily
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Zagazig University
Endometrial Hyperplasia, Fertility Issues
A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore
The investigators' objective is to determine the regression rate, side effects and acceptability of Mirena compared to megace in the treatment of atypical endometrial hyperplasia among women desiring fertility.
- Conditions
- Endometrial Hyperplasia, Fertility Issues, Disease Regression, Treatment Side Effects
- Trial name
- NCT05492487
- Testing
- Mirena, Megace
- Where
- 3 sites in Singapore
- Volunteers
- 60 people
- Sponsor
- KK Women's and Children's Hospital
Endometriosis
IUD and Norethindrone Acetate for Treatment of Endometriosis
Endometriosis is the most common reproductive disease afflicting young women, often leading to debilitating chronic pelvic pain and impaired quality of life.
- Trial name
- NCT04948489
- Testing
- norethindrone acetate (NETA)
- Where
- United States
- Sponsor
- Boston Children's Hospital
Migraine, Migraine;Menstrual
Oral Contraceptive Pill Compared With Vitamin E in Women With Migraine
Open-label randomized controlled trial to study the efficacy of continuous daily use of ethinylestradiol/levonorgestrel (30/150 µg/day) compared with vitamin E (400 IU/day) in the treatment of women with menstrually-related and…
- Trial name
- WHATT (NCT04007874)
- Testing
- Ethinylestradiol/levonorgestrel, Vitamin E
- Where
- Netherlands
- Volunteers
- 360 people
- Sponsor
- Leiden University Medical Center
Emergency Contraception
Efficacy Trial of CDB 2914 for Emergency Contraception
Objective: To compare the efficacy, safety and tolerance of a 50 mg dose of a new antiprogestin, CDB-2914 with a 0.75 mg bid dose of levonorgestrel as emergency contraception Design: Multicenter, randomized, double blind Phase II…
- Trial name
- NCT00271583
- Testing
- CDB-2914, levonorgestrel
- Where
- 6 sites in United States
- Volunteers
- 1,672 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Adenomyosis
LNG-IUS for Treatment of Dysmenorrhea
Adenomyosis is a disease entity diagnosed when endometrial glands and stroma deep in the myometrium are associated with surrounding myometrial hypertrophy.
- Trial name
- LNGIUSAD (NCT01601366)
- Testing
- LNG-IUS, Combined oral contraceptives
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Omar Mamdouh Shaaban