Clinical trials: Levonorgestrel
Endometrial Hyperplasia
Treatment of Endometrial Hyperplasia With an Intrauterine Device (IUD)
The purpose of this research is to determine the effectiveness of the intrauterine device (IUD) called Mirena when compared to the Provera tablets used in treating this condition.
- Trial name
- NCT00123175
- Testing
- Intrauterine Device
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Relapsing Multiple Sclerosis (RMS)
Effects of Cladribine Tablets on the PK of Microgynon®
The purpose of this study was to investigate the potential effects of cladribine on the pharmacokinetics (PK) of monophasic oral contraceptive microgynon® by assessment of its constituents, ethinyl estradiol (EE) and…
- Trial name
- NCT03745144
- Testing
- Cladribine, Microgynon®
- Where
- 7 sites in Germany, Poland
- Volunteers
- 28 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Abnormal Uterine Bleeding
Evaluation of the Effects of Levonorgestrel-releasing Intrauterine Device and Dydrogestreone on Quality of Life and Sexual Life in Patients With Abnormal Uterine Bleeding.
This study was retrospectively collected from patients who were diagnosed with abnormal uterine bleeding and received oral dydrogesterone therapy for at least six months or who were administered an intrauterine device containing…
- Trial name
- NCT05474703
- Testing
- SF-36 Scores
- Where
- Turkey (Türkiye)
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Emergency Contraception
Emergency Contraception Actual Use Study
This is a non-comparative case series study to assess the ability of females 11-16 years of age, inclusive, who are requesting emergency contraception (EC) to use the study product, DR-104 (Plan B® 1.5), appropriately and safely…
- Trial name
- NCT00777556
- Testing
- DR-104
- Where
- 5 sites in United States
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Duramed Research
Tuberculosis
A Study to Investigate the Repeat-dose Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With Ganfeborole in Female Participants of Non-childbearing Potential
This study is designed to assess the pharmacokinetics (PK), safety, and tolerability of Ganfeborole and Microgynon, an oral contraceptive containing ethinylestradiol (EE) and levonorgestrel (LNG), when Microgynon is administered…
- Trial name
- NCT07784894
- Testing
- Ganfeborole, Microgynon
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Contraception
Immediate Postplacental IUD Insertion
The study will be a randomized clinical trial. Women with less than 10 prenatal visits and/or 2 or more no show visits who desire an Intrauterine Device (IUD) will be considered for enrollment.
- Trial name
- NCT02169869
- Testing
- Mirena, Paragard
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Oregon Health and Science University
Contraception
Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing IUD
Does the addition of cervical lidocaine injections and valium to the current practice result in decreased reported pain with tenaculum placement, IUD insertion, and post procedural discomfort? The current practice is ibuprofen…
- Trial name
- NCT02799641
- Testing
- Diazepam, Lidocaine
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Contraception
LCS16 vs. COC User Satisfaction and Tolerability Study
To evaluate user satisfaction in young nulliparous and parous women (18-29 years of age [inclusive]), using LCS16 compared to a COC over a period of 12 months.
- Trial name
- NCT03074045
- Testing
- Levonorgestrel (Kyleena, BAY86-5028), Ethinyl estradiol and drospirenone (Yarina, BAY86-5131)
- Where
- 9 sites in Russia
- Volunteers
- 145 people
- Sponsor
- Bayer
Healthy
This Study Tests in Healthy Korean Women Which Effects BI 409306 and a Birth-control Pill Have on Each Other
The primary objective of this trial is to investigate the effect of multiple doses of ethinylestradiol / levonorgestrel (Microgynon®) on single dose pharmacokinetics of BI 409306 and the effect of single dose of BI 409306 on…
- Trial name
- NCT03193307
- Testing
- Microgynon® 30, BI 409306
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Endometrial Hyperplasia Without Atypia
Vaginal Micronized Progesterone Versus Levonorgestrel for Treatment of Non-atypical Endometrial Hyperplasia
The purpose of this study is to compare the efficacy of the vaginal micronized progesterone and Levonorgestrel-releasing Intrauterine System for treatment of non-atypical endometrial hyperplasia in premenopausal women.
- Trial name
- NCT03992937
- Testing
- Vaginal Micronized Progesterone, Levonorgestrel-Intrauterine System
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Kocaeli University
Healthy
A Study in Healthy Women to Test Whether BI 425809 Influences the Amount of a Contraceptive in the Blood
The main objective of this trial is to investigate the possible effect of multiple oral doses of BI 425809 on the steady state pharmacokinetics of ethinylestradiol (EE) and levonogestrel (LNG) (administered as the combined oral…
- Trial name
- NCT05613777
- Testing
- Microgynon®, Iclepertin
- Where
- Germany
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Vaginal Bleeding
Does Skyla Insertion Timing Impact Bleeding?
Women presenting for contraception will be offered the IUS Skyla and study participation. Daily bleeding will be collected for a total of 90 days and correlated with insertion timing and baseline endometrial thickness.
- Trial name
- NCT03074903
- Testing
- Intrauterine system
- Where
- 3 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Contraception
Kenya Sino-implant (II) PK Study
A cross-sectional study to compare pharmacokinetics of Sino-implant (II) during four years of used and Jadelle during five years of use by Kenyan women.
- Trial name
- NCT01930994
- Where
- Kenya
- Volunteers
- healthy volunteers welcome
- Sponsor
- FHI 360
Contraception
Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start
This is a prospective clinical research study to test the effectiveness of the Levonorgestrel (LNG) 52 mg Intrauterine Device (IUD) for emergency contraception (EC) and same-day start use that will enroll people receiving care at…
- Trial name
- NCT05444582
- Testing
- Levonorgestrel 52 MG Intrauterine System
- Where
- 8 sites in United States
- Volunteers
- 1,404 people
- Sponsor
- University of Utah
Contraception
Levonorgestrel-piroxicam Versus Ulipristal Acetate for Emergency Contraception
The goal of this clinical trial is to compare the failure rate of the levonorgestrel (LNG)-piroxicam combination regimen versus ulipristal acetate (UPA) as emergency contraception (EC).
- Trial name
- NCT06727734
- Testing
- Levonorgestrel, Piroxicam, Ulipristal Acetate
- Where
- Hong Kong
- Volunteers
- 980 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Endometrial Hyperplasia
A Study Comparing Mirena and Systemic Progestin for Endometrial Hyperplasia
Randomized controlled multi-center study with three arms including 200 patients with low risk endometrial hyperplasia. After confirmed diagnosis the patients will receive one of the following treatments: 1.
- Trial name
- Mirena (NCT01074892)
- Testing
- Provera (medroxyprogesterone/progestin), Provera (medroxyprogesterone), Mirena (levonorgestrel)
- Where
- Norway
- Volunteers
- 170 people
- Sponsor
- University Hospital of North Norway
Contraception, Female Contraception
Relative Risks for Non-fatal Venous Thromboembolism, Ischemic Stroke and Myocardial Infarction in Users of ORTHO EVRA(Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared to Levonorgestrel-containing Oral Contraceptives.
This study uses the PharMetrics and MarketScan US health care insurance claims database to estimate relative risks for non-fatal venous thromboembolism (including cerebral venous sinus thrombosis), ischemic stroke, and acute…
- Conditions
- Contraception, Female Contraception, Fertility Control
- Trial name
- NCT00511784
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Venous Thromboembolism
RIVET - Retrospective Cohort Study on the Risk of Venous Thromboembolism
The risk of venous thromboembolism (VTE) associated with the use of chlormadinone acetate (CMA) compared to the gold-standard progestin levonorgestrel (LNG) as component of combined oral contraceptives (COC) is currently unknown.
- Trial name
- RIVET-RCS (NCT02828904)
- Where
- Germany
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Contraception
Effects of St. John's Wort on the Oral Contraceptive Hormone Levonorgestrel
This study will determine the effects of St. John's wort, a common herbal remedy, on metabolism of the female contraceptive hormone levonorgestrel.
- Trial name
- NCT00131885
- Testing
- St. John's Wort, Levonorgestrel
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Utah
Contraception
Mirena Post-marketing Surveillance in Japan
This study is a regulatory post-marketing surveillance in Japan, and it is a local prospective and observational study of women who are inserted Mirena for intrauterine contraception.
- Trial name
- NCT01414140
- Testing
- Levonorgestrel IUS (Mirena, BAY86-5028)
- Where
- Japan
- Volunteers
- 567 people
- Sponsor
- Bayer