Clinical trials: Levonorgestrel
Clinical Trial ,Phase I
Drug-drug Interaction Study: Influence of Vilaprisan on Pharmacodynamics (PD) and Pharmacokinetics (PK) of a Combined Oral Contraceptive (COC)
This study will be performed as a multi-center, randomized, double-blind study in 60 healthy women (2 groups of 30 women) to investigate ovarian activity during simultaneous intake of a COC (containing the estrogen EE and the…
- Trial name
- NCT03210246
- Testing
- Vilaprisan (BAY 1002670), Microgynon
- Where
- 2 sites in Germany
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Bayer
Atypical Endometrial Hyperplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
Levonorgestrel-Releasing Intrauterine System With or Without Everolimus in Treating Patients With Atypical Hyperplasia or Stage IA Grade 1 Endometrial Cancer
This randomized phase II trial studies how well levonorgestrel-releasing intrauterine system works when given alone or with everolimus in treating patients with atypical hyperplasia (a pre-cancerous growth of the lining of the…
- Conditions
- Atypical Endometrial Hyperplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma
- Trial name
- LEVER (NCT02397083)
- Testing
- Everolimus, Laboratory Biomarker Analysis, Levonorgestrel-Releasing Intrauterine System
- Where
- 18 sites in United States
- Volunteers
- 102 people
- Sponsor
- M.D. Anderson Cancer Center
Menopausal and Other Perimenopausal Disorders
Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation Suppression
Hormonal treatment of perimenopausal women has frequently utilized oral contraceptive pills (OCPs). Because of their ability to suppress ovulation and establish cycle control, OCPs have become a popular option, and one that is…
- Trial name
- NCT01613131
- Testing
- Mirena, Estradiol
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Colorado, Denver
Contraception
Non-interventional Study of Long-term Intrauterine Contraceptives Acceptability and User Satisfaction
This is local prospective, non-interventional multi-center comparative study. Primary study objective is evaluation of the user satisfaction with Mirena or Copper IUD up to 1 year after insertion ( patient assessment…
- Trial name
- Mirabel (NCT01590537)
- Testing
- Levonorgestrel (Mirena, BAY86-5028), Copper IUD
- Where
- Russia
- Volunteers
- 2,348 people
- Sponsor
- Bayer
Lower Urinary Tract Symptoms
Genitourinary Symptoms With Levonorgestrel Releasing Intrauterine Systems
The main purpose of the study was to evaluate the efficacy of Levonorgestrel Releasing Intrauterine devices (LNR-IUD) on genitourinary symptoms in patients with abnormal uterine bleeding.
- Trial name
- NCT01730300
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Healthy
Cervical Device Contraception-2 (Nanopaz)
Measure blood progesterone by using cervical device contraception.
- Trial name
- NANOPAZ (NCT00689494)
- Testing
- Nanopaz contraception device
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Healthy Participants
A Study to Evaluate the Drug Interaction Between Povorcitinib and the Oral Contraceptive Levonorgestrel/Ethinyl Estradiol in Healthy Adult Females
The purpose of this study is to evaluate the drug interaction between povorcitinib and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females.
- Trial name
- NCT06380205
- Testing
- Povorcitinib, Levonorgestrel/Ethinyl estradiol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Healthy Women, Female Contraception
A Study to Evaluate the Efficacy and Safety of Subcutaneous Levonorgestrel Butanoate for Female Contraception
This is a multicenter, open-label, Phase 2b study to evaluate the efficacy and safety of 2 LB SQ injections administered at a 4-month (approximately 17 weeks) interval for female contraception.
- Trial name
- NCT07222228
- Testing
- Levonorgestrel butanoate
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Premier Research
Contraception
Cervical Lidocaine-Prilocaine Cream vs Glyceryl Trinitrate Cream in Nulliparous Women With LNG-IUD Insertion
the aim of the present study is to compare safety and efficacy of cervical Lidocaine-Prilocaine cream versus glyceryl trinitrate cream on pain perception during levonorgestrel- intrauterine device insertion among nulliparous…
- Trial name
- NCT04355598
- Testing
- Lidocaine-Prilocaine cream, glyceryl trinitrate cream
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Cairo University
Contraceptives, Postcoital
Cross-over Study to Prove Bioequivalence Between Two Oral Formulations of Levonorgestrel 1.5 mg
A single dose, two treatments (Postinor-2 and Opxion), two periods, two sequences, crossover, randomized, prospective design was chosen with a washout of 14 days between the two study periods.
- Trial name
- LEVEQ-3 (NCT01073904)
- Testing
- Levonorgestrel Emergency Pill (BAY86-5028), Postinor 2
- Where
- Mexico
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Oral Contraceptive
Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception
The purpose of this study is to evaluate the contraceptive efficacy and safety of an oral contraceptive containing a combination of LNG 100mcg/EE 20mcg compared to LNG 150mcg/EE 30 mcg.
- Trial name
- NCT02021097
- Testing
- Levonorgestrel 100 mcg and Ethinyl Estradiol 20 mcg, Levonorgestrel 150 mcg and Ethinyl Estradiol 30 mcg
- Where
- 21 sites in China
- Volunteers
- 1,008 people, healthy volunteers welcome
- Sponsor
- Regenex Pharmaceutical, China
Tuberculosis
A Study to Investigate the Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With GSK3036656 in Female Participants of Non-childbearing Potential Aged 18 to 65 Years of Age
The purpose of this study is to provide data showing if there are any effects of GSK3036656 on a combined oral contraceptive containing Ethinyl Estradiol (EE) and Levonorgestrel (LNG), which will help inform future studies on…
- Trial name
- NCT06354257
- Testing
- Microgynon, GSK3036656
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hepatitis C, Chronic
Drug-drug Interaction of BI 201335 and Microgynon
This study will investigate possible effect of multiple oral doses of BI 201335 on the steady state pharmacokinetics of ethinylestradiol and levonogestrel
- Trial name
- NCT01570244
- Testing
- levonorgestrel, Ethinylestradiol, BI 201335
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Pregnancy Related
A Study on the Feasibility and Acceptability of Pericoital Levonorgestrel 1.5mg
This study intends to build on the previous research and gather data in an actual use study / patient registry of pericoital LNG 1.5mg to understand women's acceptability of the product along with associated side effects, and…
- Trial name
- NCT04058873
- Testing
- Levonorgestrel 1.5mg
- Where
- Ghana
- Volunteers
- 1,980 people, healthy volunteers welcome
- Sponsor
- Camber Collective
Obesity, Overweight
A Study of Eloralintide (LY3841136) in Female Participants With Obesity or Overweight
The main purpose of this study is to evaluate how eloralintide (LY3841136) effects the way the body processes oral contraceptive in female participants with obesity or overweight.
- Trial name
- NCT07808060
- Testing
- Eloralintide, Combined oral contraceptive
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Adenomyosis, Chronic Pelvic Pain
Comparison of Estrogen-progestin Therapy in Continuous Regimen Versus Combination Estrogen-progestin Therapy in Continuous Regimen Plus Levonorgestrel-releasing Intrauterine System (LNG-IUS)
Adenomyosis is characterized by the appearance of endometrial cells in the muscular layer of the uterus. It affects about 15-20% of the female population.
- Trial name
- NCT02556411
- Testing
- LNG-IUS 13,5 mg Levonorgestrel, Levonorgestrel 0,10 mg+ ethinylestradiol 0,02 mg
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Healthy Participants
Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)
The main purpose of this study is to determine the effect of vimseltinib on pharmacokinetics of combined oral contraceptive (COC) (ethinyl estradiol/levonorgestrel) in healthy female participants.
- Trial name
- NCT07539090
- Testing
- Vimseltinib, Combined Oral Contraceptive (COC) (ethinyl estradiol [EE]/levonorgestrel [LNG])
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Deciphera Pharmaceuticals, LLC
Healthy Volunteer Study
Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Ethinyl Estradiol/Levonorgestrel (EE/LNG)
Drug-drug interaction study between Ethinyl Estradioll/Levonorgestrel and Bemnifosbuvir/Ruzasvir
- Trial name
- NCT07272889
- Testing
- Ethinyl Estradioll/Levonorgestrel (EE/LNG), Bemnifosbuvir/Ruzasvir (BEM/RZR), Bemnifosbuvir/Ruzasvir (BEM/RZR) + Ethinyl Estradioll/Levonorgestrel (EE/LNG)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Atea Pharmaceuticals, Inc.
Endometrioid Endometrial Adenocarcinoma
A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia
This study will explore the use of glucagon-like peptide 1 receptor agonist (GLP-1RA) used concurrently with levonorgestrel intrauterine device in patients with poor surgical candidacy for a hysterectomy or patients who are…
- Trial name
- NCT07107334
- Testing
- Glucagon-like peptide 1 receptor agonist
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Contraception
Comparative Safety and Efficacy of Vaginal Misoprostol Versus Lidocaine-prilocaine Cream in Levonorgestrel IUD Insertion
the aim of the present study is to compare the safety and Efficacy of vaginal misoprostol versus Lidocaine-prilocaine cream in reducing pain during levonorgestrel IUD Insertion in women delivered only by cesarean deliveries
- Trial name
- NCT04339348
- Testing
- vaginal misoprostol, Lidocaine-Prilocaine Topical cream
- Where
- Egypt
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cairo University