Clinical trials: Levothyroxine
Subclinical Hypothyroidism
Mechanistic Study of Subclinical Hypothyroidism In the Elderly
Subclinical hypothyroidism, defined as an elevated TSH in the setting of normal thyroid hormone levels, is a common diagnosis in the elderly.
- Trial name
- NCT02399475
- Testing
- Levothyroxine, Liothyronine, Thyrotropin-Releasing Hormone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Pennsylvania
Malignant Neoplasm of Thyroid Stage I, Malignant Neoplasm of Thyroid Stage II
Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer
Differentiated thyroid cancer is the most common neoplasm of endocrine system. After surgery and radioiodine treatment, thyroid stimulating hormone (TSH) suppression is the main goal which is achieved with levothyroxine…
- Trial name
- NCT01341886
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 51 people
- Sponsor
- Mashhad University of Medical Sciences
Differentiated Thyroid Cancer, Thyroid Cancer
Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy
This study will be a multicentre prospective cohort study on TH-substitution after thyroid hormone withdrawal preceding radioiodine treatment.
- Conditions
- Differentiated Thyroid Cancer, Thyroid Cancer, Levothyroxine, Liothyronine
- Trial name
- THRIVE (NCT06647602)
- Testing
- Euthyrox (levothyroxine), Cytomel (liothyronine)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Hypothyroidism, Biomarkers
Identification of Non-responders to Levothyroxine Therapy
The purpose of this study is to assess differential effects of T4 and T3 on cell and tissue level
- Conditions
- Hypothyroidism, Biomarkers, Endocrine System Diseases
- Trial name
- NCT03627611
- Testing
- Levothyroxin, Liothyronine
- Where
- Norway
- Volunteers
- 69 people
- Sponsor
- Oslo University Hospital
Thyroid Nodule
Levothyroxine Treatment in Thyroid Benign Nodular Goiter
We will study the effect of taking eltroxin at different time, i.e. fasting or postprandial periods. We will also study the effect of levothyroxin treatment in Chinese people
- Trial name
- NCT00552253
- Testing
- Levothyroxin treatment
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Attention Deficit With Hyperactivity Disorder
Thyroid Profile in Attention Deficit With Hyperactivity Disorder (ADHD)
Rationale: The observational data of University Children's Hospitals of Nice, suggest that about a quarter of children and adolescents with ADHD may present with an abnormal thyroid profile.
- Trial name
- THYRADHD (NCT05080491)
- Testing
- immuno analysis and neuropsychological tests
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Fondation Lenval
Hypothyroidism
Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers
GSK markets a drug called levothyroxine or T4 that is used to treat patients with hypothyroidism. Till date, the active drug substance or active pharmaceutical ingredient (API) for levothyroxine tablets marketed in India has been…
- Trial name
- NCT01536678
- Testing
- Levothyroxine
- Where
- India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Congenital Hypothyroidism
Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH)
This is a multi-center, prospective, parallel-group, open-label, randomized clinical study in one hundred and twenty-six (126) neonates and infants diagnosed with CH.
- Trial name
- NCT05228184
- Testing
- Tirosint®-SOL, Levothyroxine Sodium
- Where
- 10 sites in United States
- Volunteers
- 34 people
- Sponsor
- IBSA Institut Biochimique SA
Morbid Obesity
Levothyroxine (L-T4) Absorption After Bariatric Surgery
Intestinal absorption of levothyroxine (LT4) tablets depends on its dissolution in gastric acid secretion, which is reduced after bariatric interventions.
- Trial name
- RYS (NCT01189344)
- Testing
- Levothyroxine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Congenital Hypothyroidism
Comparison of Levothyroxine Formulations in the Treatment of Congenital Hypothyroidism
Observational, retrospective, prospective, pharmacological, single-centre, non-profit study. The aim is to evaluate, in newborns diagnosed with Congenital Hypothyroidism, the medium- and long-term efficacy and safety of the new…
- Trial name
- NCT06724224
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Intraventricular Hemorrhage of Prematurity
Thyroxine Treatment in Premature Infants With Intraventricular Hemorrhage
Brain bleed in premature infants damages the brain and survivors suffer from cerebral palsy (weakness in the extremities), cognitive deficits, and neurobehavioral disorders.
- Trial name
- IVHT4 (NCT03390530)
- Testing
- Thyroxine
- Where
- United States
- Sponsor
- Albert Einstein College of Medicine
Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2
Levothyroxine for Non-Alcoholic Fatty Liver Disease (NAFLD)
Background: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disorders characterized by lipid accumulation in hepatocytes. Evidence shows that thyroid hormone might be beneficial for this condition.
- Trial name
- NCT03281083
- Testing
- Levothyroxine Sodium
- Volunteers
- 29 people
- Sponsor
- Duke-NUS Graduate Medical School
Graves' Disease
Early Levothyroxine Post Radioactive Iodine
The study will try to answer the question of whether early treatment with levothyroxine at 4 weeks after radioactive iodine for Graves'disease will prevent overt hypothyroidism (low thyroid hormone levels).
- Trial name
- NCT01950260
- Testing
- Levothyroxine
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Mayo Clinic
Febrile Convulsion, Neuroendocrine Stress Response
Neuroendocrine Response in Pediatric Febrile Seizures
Febrile seizures are the most common seizure type in early childhood and usually occur during febrile illnesses. Although most febrile seizures are benign, the biological stress response during seizures is not fully understood.
- Conditions
- Febrile Convulsion, Neuroendocrine Stress Response, Fever
- Trial name
- NCT07463222
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Aydin Adnan Menderes University
Recurrent Pregnancy Loss, Not Pregnant, Recurrent Implantation Failure
Treatment With Prednisone of Women With RPL or RIF Positive to Antithyroid Antibodies and Embryotoxicity Test
In Reproductive Medicine there is a unresolved question, whether thyroid autoimmunity may promote infertility, embryo demise and miscarriage.
- Trial name
- NCT06641440
- Testing
- Prednisone
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Centre for Endocrinology and Reproductive Medicine, Italy
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism
Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism
The goal of this randomized controlled trial is to compare letrozole alone versus letrozole plus levothyroxine for ovulation induction in infertile women with both PCOS and subclinical hypothyroidism.
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Subclinical Hypothyroidism, Female Infertility
- Trial name
- NCT06041204
- Testing
- Letrozole 2.5mg, Levothyroxine 25 Mcg (0.025 Mg) Oral Tablet
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy
Patient Compliance
Effect of Levocarnitine Supplementation for the Management of Fatigue in Levothyroxine-Treated Hypothyroid Patients
It has been observed that despite administration of apparently adequate thyroid hormone replacement in hypothyroid patients, many of them experience persistent fatigue and fatigue-related symptoms.
- Trial name
- NCT03372772
- Testing
- Levocarnitine
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Healthy
Bioequivalence Study of Levothyroxine Sodium Tablets 100 mcg
The objective of this study is to establish the bioequivalence of two levothyroxine formulations through the estimation of T4 levels in serum samples after baseline correction, according to Food and Drugs Administration (FDA)…
- Trial name
- NCT04573907
- Testing
- Drug Levothyroxine 100 mcg, Drug Eutirox 100 mcg
- Where
- Argentina
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tecnoquimicas
Schizophrenia, Avolition
A Clinical Trial of Adjunctive Thyroxine for Avolition in Schizophrenia
The goal of this clinical trial is to investigate whether adjunctive thyroxine treatment can ameliorate motivation deficits in adults with schizophrenia experiencing predominant avolition (core negative symptom).
- Trial name
- NCT07011953
- Testing
- Antipsychotics plus Levothyroxine Sodium
- Volunteers
- 90 people
- Sponsor
- Peking University
Congenital Hypothyroidism, Hypothyroidism
Generic vs. Name-Brand Levothyroxine
This study compares two different brands of thyroxine (thyroid hormone). Currently, pharmacists may be substituting generic formulations of thyroid hormone without your doctor knowing about this.
- Trial name
- NCT00403390
- Testing
- Brand Name Levothyroxine (Synthroid), Generic formulation of Levothyroxine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital