Clinical trials: Levothyroxine
Congenital Hypothyroidism, Hypothyroidism
Generic vs. Name-Brand Levothyroxine
This study compares two different brands of thyroxine (thyroid hormone). Currently, pharmacists may be substituting generic formulations of thyroid hormone without your doctor knowing about this.
- Trial name
- NCT00403390
- Testing
- Brand Name Levothyroxine (Synthroid), Generic formulation of Levothyroxine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hypothyroidism
Timing of Thyroxine Dose In Ramadan
A Randomized trial comparing two different timing of taking thyroxine in patients with Hypothyroidism during fasting the month of Ramadan.
- Trial name
- NCT05421468
- Testing
- L-Thyroxine time B (5-15 minutes Before dawn)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 250 people
- Sponsor
- King Abdullah International Medical Research Center
Diabetes, Healthy
A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects.
This trial is conducted in Europe. The aim of this trial is to investigate the influence of oral semaglutide on the pharmacokinetics (the exposure of the trial drug in the body) of levothyroxine and the influence of…
- Trial name
- NCT02920385
- Testing
- Semaglutide, SNAC, Levothyroxine
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Subclinical Hypothyroidism
Thyroid Hormone Replacement for Subclinical Hypothyroidism
Subclinical hypothyroidism (SCH) is a common condition among older men and women. Although by definition SCH comprises biochemically mild thyroid hormone deficiency without overt symptoms, it is a possible contributor to multiple…
- Trial name
- TRUST (NCT01660126)
- Testing
- Levothyroxine
- Where
- United Kingdom
- Volunteers
- 737 people
- Sponsor
- NHS Greater Glasgow and Clyde
Down Syndrome, Subclinical Hypothyroidism
Treatment Trial of Subclinical Hypothyroidism in Down Syndrome
The purpose of this research study is to learn about the effects of treating subclinical hypothyroidism (SCH) with thyroid hormone replacement in children and adolescents with Down syndrome (DS).
- Trial name
- NCT01832753
- Testing
- Levothyroxine
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Philadelphia
Hypothyroidism Primary
The Effect of Dietary Supplements for Pregnant Women on Levothyroxine Absorption
Hypothyroidism is a common disease that is successfully treated with the replacement of thyroid hormones in the form of levothyroxine.
- Trial name
- NCT04988802
- Testing
- Prenatal Nutrients Solgar
- Where
- Croatia
- Volunteers
- 37 people
- Sponsor
- University Hospital Dubrava
Healthy
Fasting Study of Levothyroxine Sodium Tablets 300 μg to Synthroid® Tablets 300 μg
The objective of this study was to investigate the bioequivalence of Mylan's levothyroxine sodium 300 μg tablets to Abbott's Synthroid® 300 μg tablets following a single 600 μg (2 x 300 μg) dose administered in healthy volunteers…
- Trial name
- NCT00647855
- Testing
- Levothyroxine Sodium Tablets 300 μg, Synthroid® Tablets 300 μg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Healthy
A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers
The study investigated the bioequivalence between the new and the approved formulation for levothyroxine.
- Trial name
- NCT03979274
- Testing
- Reference Eutirox®, Test Eutirox®
- Where
- Mexico
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Hypothyroidism;Postablative
Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump Inhibitors
This is an open-label therapeutic efficacy study of Tirosint (levothyroxine sodium) capsules in thyroidectomized patients taking proton pump inhibitors and levothyroxine, evaluating changes in serum levels of Thyroid Stimulating…
- Trial name
- NCT03094416
- Testing
- levothyroxine sodium capsule, Proton pump inhibitor (PPI), Levothyroxine Sodium (LT4) Tablets
- Where
- 9 sites in United States
- Volunteers
- 66 people
- Sponsor
- IBSA Institut Biochimique SA
Attention Deficit With Hyperactivity Disorder
Thyroid Profile in Attention Deficit With Hyperactivity Disorder (ADHD)
Rationale: The observational data of University Children's Hospitals of Nice, suggest that about a quarter of children and adolescents with ADHD may present with an abnormal thyroid profile.
- Trial name
- THYRADHD (NCT05080491)
- Testing
- immuno analysis and neuropsychological tests
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Fondation Lenval
L-thyroxine
Impact of Increasing Levothyroxine Dose in Ramadan for UAE Patients With Hypothyroidism
The study aims to compare the mean change in Thyroid Stimulating Hormone (TSH) levels among patients with hypothyroidism treated with an increased dose of L-thyroxine (treatment group) versus standard/regular dose of L-thyroxine…
- Trial name
- NCT06135948
- Testing
- Extra dose of L-thyroxine, 25 mcg during Ramadan
- Where
- United Arab Emirates
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Emirates Health Services (EHS)
Graves' Disease
Early Levothyroxine Post Radioactive Iodine
The study will try to answer the question of whether early treatment with levothyroxine at 4 weeks after radioactive iodine for Graves'disease will prevent overt hypothyroidism (low thyroid hormone levels).
- Trial name
- NCT01950260
- Testing
- Levothyroxine
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Mayo Clinic
Febrile Convulsion, Neuroendocrine Stress Response
Neuroendocrine Response in Pediatric Febrile Seizures
Febrile seizures are the most common seizure type in early childhood and usually occur during febrile illnesses. Although most febrile seizures are benign, the biological stress response during seizures is not fully understood.
- Conditions
- Febrile Convulsion, Neuroendocrine Stress Response, Fever
- Trial name
- NCT07463222
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Aydin Adnan Menderes University
Pharmacokinetics
Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 100 μg/ 75 μg Tablets
The purpose of this study is to measure the area under the curve (AUC0-48h; extent of systemic availability) and the maxi-mum concentrations (Cmax) of total serum levothyroxine (TT4, bound and free fraction) after a single…
- Trial name
- NCT01465646
- Testing
- levothyroxine
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Hypothyroidism
Monitoring and Evaluation of the Levothyroxin Replacement Therapy in Pregnant Women With Hypothyroidism
The aim of the study was to evaluate the clinical control program in patients with hypothyroidism during pregnancy (suggested in resent guidelines). Is it possible by monitoring the patients every 4.
- Trial name
- NCT02094079
- Testing
- biomedical outcomes
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Birte Nygaard
Hypothyroidism
Variations in the DIO2 and MCT10 Genes and Effect of Triiodothyronine Treatment
Hypothesis: Variations in the deiodinase 2 gene and monocarboxylate transporter 10 gene is associated with improvement in quality of life after initiation of combination therapy with L-Thyroxine and Liothyronine in patients with…
- Trial name
- NCT03926585
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Birte Nygaard