Clinical trials: Lichen Planus, Oral
Oral Lichen Planus
Impact of PDT and Topical Corticosteroids on Taste Perception and Salivary Oxidative Stress Markers in Patients With OLP
Oral lichen planus (OLP) is a long-term inflammatory disease affecting the lining of the mouth. It may cause pain, burning sensations, discomfort, and changes in the appearance of the oral mucosa.
- Trial name
- NCT07536737
- Testing
- 5-Amino Levulinic Acid, Clobetasol Propionate 0.05% Cream
- Where
- Poland
- Volunteers
- 65 people
- Sponsor
- Medical University of Bialystok
Lichen Planus, Oral
Evaluation of Desmoglein-3 Autoantibodies in the Tissues of Oral Lichen Planus and Correlation with Disease Severity
1. evaluate the level of Dsg3 autoantibodies in tissue biopsy of Atrophic/Bullous Erosive (A/BE) OLP (Primary Objective). 2. correlate the severity of the disease with the level of tissue Dsg3 autoantibodies (Secondary Objective).
- Trial name
- NCT06652477
- Testing
- ELISA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Lichen Planopilaris, Frontal Fibrosing Alopecia
Oral Low-Dose Naltrexone for Lichen Planopilaris and Frontal Fibrosing Alopecia
Oral naltrexone was initially FDA approved to treat opioid use disorder and alcohol dependence at doses from 50-100mg/day. At lower doses of 1-5mg/day, naltrexone has been used off-label with success in treatment of several…
- Trial name
- NCT04409041
- Testing
- Low-Dose Naltrexone
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Oral Lichen Planus
Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus
60 individuals were subdivided into 2 groups, 30 patients with oral lichen planus, 30 control individuals. Expression of miRNA-138 and cyclin D1 were evaluated in oral mucosa utilizing Quantitative real-time polymerase chain…
- Trial name
- NCT02834520
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Management of Pain in Oral Lichen Planus
Treating Oral Lichen Planus (OLP) is a big challenge for clinicians. Despite numerous existing remedies, to date no effective cure has been found, which is mainly attributed to the lack of understanding of the pathogenesis of the…
- Trial name
- NCT03572959
- Testing
- 0.1 % topical triamcinolone acetonide, SIROIaser
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sherine Adel Nasry
Oral Lichen Planus
Efficacy of Topical Glucosamine Versus Corticosteroid in Oral Lichen Planus
Glucosamine (GlcN) is an N-deacetyl amino sugar derived from the complete hydrolysis of chitosan. It is classified as a nutraceutical and it is used mainly orally for the therapy of osteoarthritis since GlcN has immunoregulatory…
- Trial name
- NCT07114016
- Testing
- Glucosamine Hydrochloride, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Future University in Egypt
Oral Lichen Planus
Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus
Lichen planus is an inflammatory disorder of unknown aetiology affecting the stratified squamous epithelia, with an estimated global prevalence of 0.22 to 0.5 %.
- Trial name
- NCT06260904
- Testing
- Prednisolone, Apremilast, Methotrexate
- Where
- India
- Volunteers
- 64 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Erosive and Atrophic Oral Lichen Planus
Cedar Honey in Oral Lichen Planus
The study aimed to evaluate the effect of cedar honey in treatment of erosive and atrophic oral lichen planus ( a common oral problem).
- Trial name
- NCT01974414
- Testing
- orally administered cedar honey
- Where
- Iran
- Volunteers
- 36 people
- Sponsor
- Mashhad University of Medical Sciences
Oral Lichen Planus
Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus.
The investigators want to study the effect of clobetasol in symptomatic oral lichen planus. The investigators will include 90 patients and randomly allocate them in three groups.
- Trial name
- NCT04364555
- Testing
- Clobetasol Propionate
- Where
- 2 sites in Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Malmö University
Oral Lichen Planus
Dexamethasone to Treat Oral Lichen Planus
This study will evaluate the effectiveness of dexamethasone 0.01% solution in treating pain associated with oral lichen planus, a chronic disease that causes painful ulcers inside the mouth.
- Trial name
- NCT00111072
- Testing
- dexamethasone 0.01% solution
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Lichen Planus, Oral
Study on Treatment for Patients With Symptomatic Oral Lichen Planus
The primary objective of this study was to compare the therapeutic efficacy of Tacrolimus gel versus an anti-inflammatory mouthwash in an oral solution for the management of patients suffering from symptomatic OLP.
- Trial name
- NCT04718311
- Testing
- Oral lichen clinical Healing evaluation
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Catania
Oral Lichen Planus
A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus
A phase 2 randomized, placebo-controlled, double-blind trial of a two week course of curcuminoids in oral lichen planus will be conducted.
- Trial name
- NCT00525421
- Testing
- Curcuminoids
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nita Chainani Wu
Desquamative Gingivitis
Propolis Extract, Nanovitamin C and Nanovitamin E on Desquamative Gingivitis
Objective: To evaluate the effectiveness of a gel containing nanovitamin C, nanovitamin E and propolis extract compared to a placebo in the treatment of desquamative gingivitis (GD) in patients with mucocutaneous diseases with…
- Trial name
- NCT05124366
- Testing
- dental prophylaxis + oral hygiene instructions
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Universidad Complutense de Madrid
Oral Lichen Planus
Tacrolimus Ointment in Oral Lichen Planus
The purpose of this study is to compare the effectiveness of topical tacrolimus, triamcinolone and placebo in alleviating signs and symptoms of oral lichen planus (OLP).
- Trial name
- NCT01544842
- Testing
- 0.1 % tacrolimus ointment, 0.1 % triamcinolone paste, Orabase paste
- Where
- 2 sites in Finland
- Volunteers
- 28 people
- Sponsor
- University of Oulu
Oral Lichen Planus, Periodontal Diseases
Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus
The purpose of this clinical trial is to understand whether the combination of periodontal initial treatment under local anesthesia and glucocorticoids can improve the effectiveness of treatment for erosive oral lichen planus.
- Trial name
- NCT06498180
- Testing
- Periodontal initial treatment under local anesthesia, Glucocorticoid Therapy, oral hygiene instruction
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Oral Premalignant Lesions as Leukoplakia and Lichen Planus, Oral Cancer
Dipeptidyl Peptidase-4 Link With Oral Cancer and Premalignant Lesions
Aim: The current study targets linking serum and salivary dipeptidyl peptidase-4 with oral squamous cell carcinoma and comparing it with potentially malignant lesions and control to validate dipeptidyl peptidase-4 as a diagnostic…
- Trial name
- NCT06087042
- Testing
- serum and unstimulated salivary samples
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Lichen Planus
Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus
The study included forty individuals divided into 3 groups. 10 control subjects, 15 oral lichen planus (OLP) patients who were treated with topical corticosteroids and 15 oral lichen planus (OLP) patients who were treated with…
- Trial name
- NCT02329600
- Testing
- green tea tablets (Green tea extract 5:1) 200 mg, Triamcinolone Acetonide
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Evaluation of Mucoadhesive Tacrolimus Patch on Caspase-3 Inducing Apoptosis in Oral Lichen Planus
tacrolimus has been widely used as an immunosuppressant. the objective of this study was to evaluate the clinical efficacy of tacrolimus 0.1 % in muco adhesive patch compared to tacrolimus or corticosteroids in paste forms for…
- Trial name
- NCT05139667
- Testing
- Corticosteroid Topical
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Oral Lichen Planus
Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus
Oral lichen planus (OLP) is a chronic disease characterized by periods of remission and relapse. Therapeutic objectives for OLP should be to quickly reduce disease symptoms by targeting pathophysiological pathways, and to provide…
- Trial name
- NCT02443311
- Testing
- Pimecrolimus 1% cream, Betamethasone 17-valerate 0.1% cream
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
Lichen Planus, Oral
Treatmant of Oral Lichen Planus With Lycopene
the purpose of this study was to evaluate that if lycopene, a potent antioxidant can be used in the treatment of oral lichen planus.
- Trial name
- NCT00656214
- Testing
- Lycopene
- Where
- India
- Volunteers
- 30 people
- Sponsor
- College of Dental Sciences, India