Clinical trials: Lichen Sclerosus
Lichen Sclerosus Et Atrophicus, Lichen Planus
Laser Therapy in Women With Lichenoid Disorders
Primary aim of the trial is to compare improvement of lichen symptoms according to a composite VAS scale (burning, itching and pain) between women with vulvovaginal laser therapy vs. sham laser therapy at three months.
- Trial name
- Liser (NCT04697563)
- Testing
- Laser
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Vulvar Disease, Lichen Sclerosus
Vulvar Mucosal Specialty Clinic Chart Review
This study aims to develop a clinical database of patients presenting with vulvar complaints in order to comprehensively assess the presentation and current trends in management of vulvar disease.
- Conditions
- Vulvar Disease, Lichen Sclerosus, Lichen Planus, Vulvodynia
- Trial name
- NCT02881229
- Where
- United States
- Volunteers
- 719 people
- Sponsor
- Northwestern University
Vulvar Lichen Sclerosus, Vulvar Atrophy
Efficacy of Collagendep in Reducing Vulvar Dryness in Patients With Lichen Sclerosus Treated With Fat Grafting
This randomized, interventional study evaluates the efficacy of Collagendep Pink Beauty, an oral nutritional supplement, in reducing vulvar dryness in women with Genital Lichen Sclerosus (VLS) who are undergoing fat grafting…
- Trial name
- Collagendep (NCT07450625)
- Testing
- Autologous Fat Grafting (Lipofilling), Collagendep Pink Beauty
- Volunteers
- 40 people
- Sponsor
- San Gallicano Dermatological Institute IRCCS
Quality of Life
Low-Level Laser Therapy: an Efficient Supplement to Treatments of Vulvar Lichen Sclerosus to Improve Quality of Life
Objectives: The aim of this study was to investigate whether Low Level Laser therapy (LLLT) can improve the quality of life in women with Lichen Sclerosus (LS) and insufficient topical treatment.
- Trial name
- NCT05060224
- Testing
- EasyLaser: Low Level Laser therapy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kolding Sygehus
Vulvar Lichen Sclerosus
Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy.
Vulvar lichen sclerosus (VLS) is a chronic inflammatory skin condition that affects the vulvar area, often causing itching, burning, and pain, and may lead to scarring and narrowing of the vaginal opening.
- Trial name
- VULIS-3T (NCT07240389)
- Testing
- Platelet-Rich Plasma (PRP) Treatment, Clobetasol Propionate 0.05% Cream (Dermovate), Pimecrolimus Cream (Elidel)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Milosz Pietrus
Lichen Sclerosus, Lichen Planus
Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis
The objective of the study was to determine sensitivity, specificity and diagnostic accuracy of "Three Rings Vulvoscopy" for detection of vulvar dermatosis using histopathology as the reference standard.
- Conditions
- Lichen Sclerosus, Lichen Planus, Lichen Simplex Chronicus, Vulvodynia
- Trial name
- DATRIV (NCT02732145)
- Testing
- "Three Rings Vulvoscopy" (TRIV), Histopathology
- Where
- Croatia
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Ginekološka Poliklinika Dr. Vesna Harni
Vulva Lichen Sclerosus
Carbon Dioxide（CO2）Fractional Laser Plus Photodynamic Therapy in Female Patients With Vulvar Lichen Sclerosus
The objective of this study is to evaluate the safety and efficacy of CO2 fractional laser combined with photodynamic therapy in female patients with vulvar lichen sclerosus.
- Trial name
- NCT05228483
- Testing
- CO2 fractional laser, 5-aminolevulinic acid (5-ALA) with red light illumination, Mometasone furoate (MMF) 0.1% ointment
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Xijing Hospital
Herpes Genitalis, Genital Wart
Safety and Efficacy of Laser Therapy in Gynaecology
The aim of this study is to retrospectively evaluate the effectiveness and safety of Er:YAG laser for treatment of different gynecological indication, e.g.
- Conditions
- Herpes Genitalis, Genital Wart, Lichen Sclerosus, Cervical Intraepithelial Neoplasia
- Trial name
- NCT04073082
- Where
- Slovenia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Juna d.o.o.
Vulvar Lichen Sclerosus
Clobetasol Propionate Versus Fractionated Carbon Dioxide Laser for the Treatment of Lichen Sclerosus
This study is being done to compare the effects, good and bad, of fractionated CO2 laser treatment and clobetasol propionate .05% ointment on vulvar lichen sclerosus.
- Trial name
- CuRLS (NCT02573883)
- Testing
- Fractionated Carbon Dioxide Laser, Clobetasol Propionate 0.05% ointment
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Medstar Health Research Institute
Lichen Sclerosus
Male Lichen Sclerosus - Risk Factors, Treatment, and Impact on Quality of Life
This observational study aims to evaluate routine treatment outcomes in men with lichen sclerosus (LS), including a long-term follow-up to assess disease progression and histopathological changes.
- Trial name
- NCT06984263
- Testing
- Circumcision
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Vulvar Lichen Sclerosus
Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus
This is a randomized placebo-controlled trial design to determine whether combining FxCO2-laser with the traditional therapy of clobetasol propionate 0.05% ointment (combined treatment) as compared to FxCO2-laser and placebo…
- Trial name
- VULVIE (NCT04951206)
- Testing
- Fractionated CO2-laser, Clobetasol Propionate 0.05% Ointment
- Where
- 10 sites in United States
- Volunteers
- 212 people
- Sponsor
- Medstar Health Research Institute
Normal Vulval Skin, Lichen Sclerosus
Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease
Can vibrational spectroscopy be used to accurately assess vulval skin conditions? Vulval skin disorders are common and the diagnosis of these conditions can be difficult.
- Conditions
- Normal Vulval Skin, Lichen Sclerosus, High Grade Dysplasia - Usual Type ('VIN 2-3'), High Grade Dysplasia - Differentiated Type ('VIN 2-3')
- Trial name
- Vulval VS (NCT02223975)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Vulvar Lichen Sclerosus
To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.
The present study is a Clinical trial that compares clobetasol ointment versus Fractional CO2 laser for vulvar lichen sclerosus (VLE) treatment confirmed by histology, with no previous treatment.
- Trial name
- LASER (NCT07240519)
- Testing
- Fractional microablative CO2 Laser
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Vulvar Lichen Sclerosus
The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients
This explorative investigation will assess the adhesion and tolerability of the Rivelin® plain patch when applied directly on lesions in subjects with Vulvar Lichen Sclerosus (VLS).
- Trial name
- NCT03686800
- Testing
- Rivelin® plain patches
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Dermtreat
Lichen Sclerosus of Vulva
Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03045172
- Testing
- Platelet Rich Plasma
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Center for Vulvovaginal Disorders
Lichen Sclerosus Lesion
Identification of Genetic Variants Associated With Lichen Sclerosus
Lichen Sclerosus (LS) is a common genital skin condition that severely impacts on daily living. LS occurs worldwide but may be more common in the white population.
- Trial name
- GENITALS (NCT07720830)
- Testing
- No Interventions
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gudula Kirtschig
Lichen Sclerosus of External Female Genital Organs
Lichen Sclerosus - Treatment With Triamcinolone Acetonide: Injections (Syringe and Needle) x Micro Injections (MMP Technique)
This research is about a genital disease known as Lichem Sclerosus and Atrophic. It mainly affects women over 18 years of age. The treatment will involve injections of a medicine that contains cortisone, using two different…
- Trial name
- NCT06079645
- Testing
- Infiltration of triamcinolone acetonide (2mg/ml) through syringes and needles, Infiltration of triamcinolone acetonide (40 mg/ml) with needles
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Clinica Dermatologica Arbache ltda
Lichen Sclerosus, Lichen Sclerosus et Atrophicus
Vulvar Scarring Grading Scale for Lichen Sclerosus
The study aims to validate a vulvar scarring grading scale for lichen sclerosus (LS).
- Trial name
- NCT02880904
- Testing
- Photography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Vulvar Lichen Sclerosus
A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen Sclerosus
The purposes of this study are to determine the safety and feasibility of autologous platelet-rich plasma for the treatment of vulvar lichen sclerosus, and to determine the efficacy of autologous platelet-rich plasma for the…
- Trial name
- NCT04967170
- Testing
- Autologous Platelet-Rich Plasma (PRP)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jennifer R. Arthurs
Lichen Sclerosus
MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus
Lichen sclerosus (LS) is a skin condition of the external genitals (vulva) of women. LS causes vulvar itching, pain, and burning.
- Trial name
- NCT03665584
- Testing
- FxCO2 Laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Center for Vulvovaginal Disorders