Clinical trials: Ligament Tear Knee, open to volunteers
Anterior Cruciate Ligament Tear
Therapeutic Benefits of a Motor Imaging Protocol Following Anterior Cruciate Ligament Reconstruction Surgery
The purpose of this study is to compare changes in lower limb symmetry during functional and strength tests, before and after the motor imagery program, in patients who received the 3-week motor imagery program starting 3 months…
- Trial name
- IMAGERIEMOTR (NCT07210489)
- Testing
- Reconstructive surgery after anterior cruciate ligament rupture, sessions from a physical therapist
- Where
- France
- Volunteers
- 70 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
ACL Tear, ACL-injury
Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?
The goal of this prospective, cross-sectional study is to test the strength of the soleus muscle in participants who have a ACL tear confirmed by MRI.
- Conditions
- ACL Tear, ACL-injury, ACL - Anterior Cruciate Ligament Rupture
- Trial name
- ACL (NCT06235736)
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Vibration on Patellofemoral Joint Pain After ACLR
Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Patellofemoral Pain
- Trial name
- NCT05501210
- Testing
- WBV, PEMF
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Rupture
Follow-up of Anterior Cruciate Ligament Reconstruction
Rupture of Anterior Cruciate Ligament (ACL) is a common pathology, but is subject to variability of associated lesions, surgical management and rehabilitation.
- Trial name
- NCT04781920
- Testing
- datas collection
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
ACL Injury, ACL Augmentation
Augmentation of Partial Anterior Cruciate Ligament Tear: Early Results
Clinical evaluation for the patients with partial ACL tear who had ACL augmentation
- Trial name
- Augmentation (NCT05391672)
- Testing
- we will do ACL augmentation surgery to the patients who have partial ACL tear
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Knee Injury, ACL Injury
Reducing Disparities in Knee Arthroscopy for Adolescents
Hundreds of thousands of youth athletes require surgery for knee injuries annually. The incidence of operative knee injuries has skyrocketed, but surgery can be delayed due to late recognition and barriers, such as insurance…
- Conditions
- Knee Injury, ACL Injury, Meniscus Tear, Hispanic or Latino
- Trial name
- RED KARD (NCT07580625)
- Testing
- Educational program and patient navigator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Anterior Cruciate Ligament Rupture
Obtain Safety and Effectiveness of CT-ACL001, a Regenerative Ligament Using Biological Tissue, in ACLR
A randomized, multicenter study comparing the safety and efficacy of CT-ACL001, a regenerative ligament, with standard treatment in anterior cruciate ligament reconstruction
- Trial name
- NCT07129694
- Testing
- Anterior cruciate ligament reconstruction
- Where
- 6 sites in Japan
- Volunteers
- 64 people
- Sponsor
- CoreTissue BioEngineering Inc.
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Clinical and Biological Outcomes of BioBrace-Augmented ACL Reconstruction
This prospective, single-center, single-arm observational cohort study aims to evaluate the clinical, radiological, and arthroscopic outcomes and safety of primary anterior cruciate ligament (ACL) reconstruction augmented with…
- Trial name
- NCT07906860
- Testing
- BioBrace® Reinforced BioInductive Implant
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Anterior Cruciate Ligament Rupture
Return to Play After ACL Reconstruction With Bone Marrow Aspirate, DBM, and an Internal Brace
The Investigators are studying the effect of an ACL reconstruction on return to play by capturing outcome measures and biomechanics information.
- Trial name
- NCT06294314
- Testing
- Fertilized ACL
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Marshall University
Bone Diseases, Infectious, Musculoskeletal Diseases
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health.
- Conditions
- Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis
- Trial name
- MVMS_MRI (NCT04536103)
- Testing
- MRI
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Xiaojuan Li
Rupture of Anterior Cruciate Ligament
Biomechanical Analysis of Dynamic Tasks and Muscular Strength Following Anterior Cruciate Ligament Reconstruction
Background Anterior cruciate ligament (ACL) injuries are one of the most common sporting injuries of the knee. ACL reconstruction (ACLR) has become one of the most common surgical procedures in an attempt to increase joint…
- Trial name
- NCT02771548
- Testing
- Anterior Cruciate Ligament Reconstruction
- Where
- Ireland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Dr Neil Welch ASCC
Anterior Cruciate Ligament Rupture, Ligament Knee Injury
Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction
Abstract Introduction: Autologous hamstring tendons are the most commonly used grafts in ACL reconstruction worldwide. There are several ways to prepare the graft using these tendons.
- Trial name
- NCT06505525
- Testing
- Extra-articular reconstruction with the Anterolateral Ligament
- Where
- 2 sites in Brazil
- Volunteers
- 146 people
- Sponsor
- Federal University of São Paulo
Anterior Cruciate Ligament Rupture
Assessing the Efficacy of a Preoperative Navigation System in Anterior Cruciate Ligament Reconstruction
The ACL surgery robot features a preoperative navigation system that enhances the precision of bone tunnel placement. As the first dual-bundle reconstruction surgical robot developed in China, it integrates advanced technology to…
- Trial name
- NCT06858930
- Testing
- ACL footprint localization after preoperative navigation executed by robotic arm, ACL footprint localization after preoperative navigation executed by rmanual execution
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
ACL Injury, Meniscus Tear
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of…
- Conditions
- ACL Injury, Meniscus Tear, Post-traumatic Osteoarthritis
- Trial name
- MOCHA (NCT04572256)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Austin V Stone
Anterior Cruciate Ligament Injuries
How to Best Treat Anterior Cruciate Ligament Injuries
The project is a pragmatic registry-based RCT aiming to investigate ACL injury treatment. Study results will help fill knowledge gaps, facilitate shared decision making and strengthen patient treatment.
- Trial name
- NCT04770233
- Testing
- Early ACL reconstruction, Active rehabilitation
- Where
- 2 sites in Norway
- Volunteers
- 328 people
- Sponsor
- University Hospital, Akershus
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Biologic Augmentation With Mesenchymal Stem Cells in Patients Undergoing Anterior Cruciate Ligament Reconstruction
This study will evaluate the efficacy of biologic augmentation of ACL reconstruction with bone marrow derived mesenchymal stem cells as measured by magnetic resonance imaging to detect graft healing and integration.
- Trial name
- BMAC (NCT04650568)
- Testing
- Autologous Bone Marrow Derived Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
ACL Tears
BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures
This research study will evaluate mid-term clinical safety and performance outcomes of the BioBrace® Reinforced Implant when used to augment a tissue graft during anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT06948591
- Testing
- Anterior cruciate ligament reconstruction with BioBrace® augmentation, Arthroscopic anterior cruciate ligament reconstruction
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- CONMED Corporation
Anterior Cruciate Ligament Rupture
Are Clinical Outcomes Unchanged by ALL Fixation at 0° or 30° of Knee Flexion in Combined ACL-ALL Reconstruction? Despite Numerous Technical Descriptions of Anterolateral Procedures, There is Limited Knowledge Regarding the Effect of Knee Flexion Angle During Graft Fixation.
This study evaluates whether the knee flexion angle used during fixation of the anterolateral ligament (ALL) affects clinical outcomes in patients undergoing combined anterior cruciate ligament (ACL) and ALL reconstruction.
- Trial name
- ACL ALL (NCT07451743)
- Testing
- anterolateral ligament reconstruction
- Volunteers
- 100 people
- Sponsor
- ASL Lecce
Osteoarthritis, Knee, Post-traumatic Osteoarthritis
Preventing Injured Knees From osteoArthritis: Severity Outcomes
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction.
- Conditions
- Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
- Trial name
- PIKASO (NCT06096259)
- Testing
- Metformin
- Where
- 9 sites in United States
- Volunteers
- 512 people
- Sponsor
- Brigham and Women's Hospital
ACL - Anterior Cruciate Ligament Rupture
SharkScrew ACL RCT
This prospective, randomized controlled trial will compare three tibial interference screw types used for graft fixation during primary anterior cruciate ligament (ACL) reconstruction: a polyetheretherketone (PEEK) screw, a…
- Trial name
- NCT07830953
- Testing
- ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Austrian Workers Compensation Board Styria