Clinical trials: Limb Fracture
Bone Fracture
Enhancement of Bone Regeneration and Healing in the Extremities by the Use of Autologous BonoFill-II
The purpose of this clinical study is to evaluate the safety and the efficacy of BonoFill-II as an autologous bone-regenerating graft in the reconstruction of deficient bone in two clinical indications: 1.
- Trial name
- NCT03024008
- Testing
- BonoFill-II
- Where
- 6 sites in Israel
- Volunteers
- 40 people
- Sponsor
- BonusBio Group Ltd
Trauma Injury
SFDI in High Energy Lower Extremity Fracture
This is a non-randomized prospective study of 20 patients with high energy lower extremity fractures evaluating feasibility and acceptability of SFDI, a real-time optical imaging technology.
- Trial name
- NCT05635617
- Testing
- Lower Extremity Surgery
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Lower Extremity Fracture
Diffusion Length of Local Anesthetics in the Subparaneural Space and Duration of Analgesia
Ultrasound-guided popliteal sciatic nerve block is a widely practiced technique to provide anesthesia or analgesia for below-knee surgeries.
- Trial name
- NCT05437835
- Testing
- Ropivacaine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- General Hospital of Ningxia Medical University
Hip Injuries, Hip Dislocation
Does Limb Pre-Conditioning Reduce Pain After Hip Arthroscopy
The purpose of this study is to determine if the utilization of Ischemic Pre-Conditioning 24-hours prior to hip arthroscopy decreases patient's post-operative pain and opioid consumption.
- Conditions
- Hip Injuries, Hip Dislocation, Hip Fractures
- Trial name
- NCT04925791
- Testing
- standardized pre-conditioning treatment, Partial occlusion
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Fracture Lower Leg, Diabetes
Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients
The goal of this clinical trial is to learn if taking an antibiotic pill for 7 days after surgery reduces the risk of wound infection in adults with poorly controlled diabetes who have surgery to fix a broken bone in the leg…
- Conditions
- Fracture Lower Leg, Diabetes, Fracture Fixation, Internal
- Trial name
- NCT07561541
- Testing
- Cefadroxil 500 mg Capsules, Clindamycin, Bactrim DS
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Limb Fracture
Impact of Continuous Regional Analgesia in Severe Trauma Patients
Regional analgesia, based on its physiological effects and efficacy, is used for optimal perioperative pain relief. However, for acute pain in multiple trauma patients in a critical condition, it has not been prospectively…
- Trial name
- ALRréa (NCT04546503)
- Testing
- Continuous Regional analgesia, Control Group
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Orthopedic Surgery of Lower Extremity
Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
A nerve block catheter is a small tube placed next to a nerve through a needle, and the needle is then removed. Numbing medicine is dripped through the tube to reduce pain sensation from the nerve.
- Trial name
- NCT01167907
- Testing
- 0.2% ropivacaine, saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Necrosis of Femoral Head, Knee Osteoarthritis
MRI Maker of Perioperative Neurocognitive Disorder
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Lower Limb
- Trial name
- MRIPND (NCT03773627)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Local Anesthesia Adjuvants, Upper Extremity Fracture
Effect of Dexmedetomidine As Adjuvant to Ropivacaine for Brachial Plexus Block
Brachial plexus block is used for upper limb surgery. Local anesthesia alone for brachial plexus block provides good operative conditions, but have short duration of postoperative analgesia.
- Conditions
- Local Anesthesia Adjuvants, Upper Extremity Fracture, Brachial Plexus Block
- Trial name
- NCT05767827
- Testing
- ropivacaine, lidocaine with adrenaline, Dexmedetomidine, ropivacaine, lidocaine with adrenaline
- Where
- Nepal
- Volunteers
- 40 people
- Sponsor
- Nepal Medical College and Teaching Hospital
Muscle Degeneration
Postoperatively Treated Patients With Lower Limb Fracture With or Without an Anti-gravity Treadmill
The presented study is designed to prove efficacy of the anti-gravity treadmill (alter G®) compared to a standard rehabilitation protocol in patients with tibial plateau or ankle fractures with six weeks of partial weight bearing.
- Trial name
- NCT02790229
- Testing
- anti-gravity treadmill (alter G®), standardized physiotherapy
- Where
- 2 sites in Germany
- Volunteers
- 73 people
- Sponsor
- University of Leipzig
Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified
A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements
This study is a prospective, randomized, double-blind clinical trial evaluating whether intraoperative intravenous lidocaine infusion (IVLI) reduces opioid requirements and improves postoperative pain control in children…
- Conditions
- Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified, Fracture Elbow, Fracture Fixation
- Trial name
- NCT07552766
- Testing
- Lidocaine Infusion, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Nemours Children's Clinic
Femur Fracture
Study Comparing Ultrasound-guided FICNB Block to Systemic Analgesia in Treatment of Pediatric Femur Fracture
The goal of this prospective observational study is to compare pain control strategies in children with femur fractures. Researchers will compare ultrasound-guided fascia iliaca compartment nerve block to IV pain control alone.
- Trial name
- PLEXUS (NCT05947292)
- Testing
- Ultrasound-Guided Fascia Iliaca Compartment Nerve Block
- Where
- 10 sites in United States, Australia
- Volunteers
- 114 people
- Sponsor
- Zachary Binder
Fracture of Proximal End of Humerus, Fracture of Distal End of Radius
Feasibility of the PERformance Guided Fracture Rehablitation Method-protocol
Introduction: The scientific support for prescribed rehabilitation programs for upper extremity fractures is scarce, early mobilization has previously been shown to benefit the speed of recovery at the activity and participation…
- Conditions
- Fracture of Proximal End of Humerus, Fracture of Distal End of Radius, Upper Extremity Fracture, Upper Limb Fracture
- Trial name
- PERFoRM (NCT05390463)
- Testing
- PERformance guided Fracture Rehablitation Method (PERFoRM) protocol.
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Zuyderland Medisch Centrum
Radius Fractures
Comparison 1 Plane-1 Injection and 2 Plane-2 Injection Ultrasound-guided Supraclavicular Brachial Plexus Block
Ultrasound-guided supraclavicular brachial plexus block (US-SCBPB) has been a generalized regional anesthesia in upper extremity surgery.
- Trial name
- US-SCBPB (NCT02505633)
- Testing
- Stimuplex insulated needle, lidocaine mixed with epinephrine
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Lower Limb Fractures
Predictive Factors for Failure of Internal Fixations of Lower Limb Fractures
Background: A predictive factor is a measure that predicts treatment response. Decisions on internal fixations of lower limb fractures should regard predictive factors to personalize (e.g. age) treatment.
- Trial name
- NCT03091114
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- University of Witten/Herdecke
Lower Limb Fracture
Prognostic Value of Preoperative Frailty Assessment in Geriatric Lower Limb Orthopedic Surgery
This retrospective study evaluates the effectiveness of frailty assessment tools-specifically the Risk Analysis Index (RAI) and the 5-Item Modified Frailty Index (5-mFI)-in predicting postoperative outcomes for elderly patients…
- Trial name
- NCT07422025
- Testing
- Preoperative Frailty Scoring
- Where
- Egypt
- Volunteers
- 149 people
- Sponsor
- Benha University
Orthopedic Surgery
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients
Postoperative delirium (POD) is one of the most frequent complications after surgery in elderly patients, affecting between 20 and 40% of patients older than 60 after major surgery.
- Trial name
- DELIRLESS (NCT04335968)
- Testing
- Melatonin 4 mg
- Where
- France
- Volunteers
- 357 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lower Extremity Fracture
Feasibility and Efficacy of the Use of Telephysiotherapy in Anantapur
Injuries remain the most frequent cause of mortality in children and young people. Studies with: telephysiotherapy programmes have published results of effectiveness, validity, non-inferiority and important advantages, providing…
- Trial name
- Telefisio (NCT04946695)
- Testing
- Telefisio India
- Volunteers
- 30 people
- Sponsor
- University of Malaga
Tranexamic Acid, Trauma
Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery
This study was done to evaluate the efficacy of Tranexamic Acid (TXA) in reducing blood transfusion requirement in patients of lower limb trauma undergoing surgery.
- Conditions
- Tranexamic Acid, Trauma, Lower Extremity Fracture
- Trial name
- NCT04986813
- Testing
- Tranexamic acid injection, Normal Saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Jaspreet Singh
Osteoarthritis, Spinal Diseases
The Effect of AposTherapy on the Level of Pain, Function and Quality of Life in Patients With Neuro-muscular and Neurological Disorders
The purpose of the study is to examine the effect of a new biomechanical device and treatment methodology (AposTherapy) on gait patterns, pain, function and quality of life of patients with musculoskeletal and neurological…
- Conditions
- Osteoarthritis, Spinal Diseases, Ligament Rupture, Lower Extremity Fracture
- Trial name
- NCT01266382
- Testing
- AposTherapy
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center