Clinical trials: Limb Fracture
Upper Limb Fracture
Biobased Polyester Versus Synthetic Fiberglass Casts for Treating Stable Upper Limb Fractures in Children
From Feb 2022 to Nov 2022, we undertook a single-center prospective randomized trial involving 100 children with cast-immobilized stable upper limb fractures.
- Trial name
- NCT06102603
- Testing
- the biobased polyester cast, the synthetic fiberglass cast
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Pain, Postoperative, Fractures, Closed
Cognitive Behavioural Therapy to Reduce Persistent Post-Surgical Pain After Fracture
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Fractures, Closed, Fractures, Open
- Trial name
- SPOC_CBT (NCT03196258)
- Testing
- Cognitive behavioural therapy
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Bone Fractures
Diagnostic Performance of the Ultra Low-Dose (ULD) Scanner vs. Diagnostic Performance With Standard X-rays in the Emergency Department Compared With Performance of the Standard Classical-dose Scanner for Trauma of the Dorsolumbar Spine, Pelvis and Extremities
The conventional standard-dose scanner leads to a significantly greater X-ray exposure than the standard X-ray. Recently, technological innovations like the ULD ("Ultra Low Dose") scanner have been developed to reduce the dose of…
- Trial name
- ULD-Traumato (NCT04074733)
- Testing
- Patient undergoes a ULD scan, Patient undergoes a standard X-ray, Patient undergoes a classic-dose scan
- Where
- 5 sites in France
- Volunteers
- 554 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Postsurgical Pain
CSF Single-cell Sequencing and Proteomics of Chronic Postsurgical Pain in Patients With Lower Limb Fractures
The purpose of this study is to assess the proteomics and transcriptomic differences between pain-free control subjects and patients with chronic postoperative pain through single-cell sequencing technology.
- Trial name
- NCT06126289
- Volunteers
- 20 people
- Sponsor
- Xuzhou Central Hospital
Wound Healing
Efficacy of Early Postoperative ON101 Application for Lower-extremity Fracture Incisions: a Prospective Evaluator-blinded Controlled Study of Scar Quality and Digital-clinical Concordance
Background: Postoperative scars after lower-extremity fracture fixation endure high tension, where excessive scarring can restrict periarticular mobility.
- Trial name
- ON101 Efficacy (NCT07854470)
- Testing
- ON101
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- LIN Kai-Cheng
Lower Extremity Fractures
Feasibility of Structured Resistance Training After Lower Extremity Fracture
Adults recovering from surgically managed diaphyseal femur or tibia fractures often experience persistent weakness, pain, and functional limitations despite successful fracture healing.
- Trial name
- NCT07629180
- Testing
- Structured Supervised Resistance Training and Coaching Program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Venous Thromboembolism
Prevention of Venous Thromboembolism in Subjects Undergoing Hip Fracture Surgery or Surgery in the Lower Extremities
The study objective is to evaluate the efficacy and safety of oral YM150 for prevention of venous thromboembolism in subjects undergoing hip fracture surgery or surgery in the lower extremities.
- Trial name
- NCT00937911
- Testing
- YM150
- Where
- 8 sites in Japan
- Volunteers
- 101 people
- Sponsor
- Astellas Pharma Inc
Plantar Fasciitis, Flatfoot
Foot and Ankle Range of Motion (Stretching) Apparatus
Range of motion at ankle joint and subtalar joint will be assessed before and after utilization of ARM device. The changes in range of motion will be recorded and compared to literature.
- Conditions
- Plantar Fasciitis, Flatfoot, Calcaneus Fractures
- Trial name
- NCT00527748
- Testing
- Non-Measuring Ankle Exerciser
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Missouri-Columbia
Open Fracture
Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage
The purpose of this study is to characterize the bacteria in the wound "bioburden" at the time of definitive wound coverage/closure of severe tibia fractures in both the military and civilian populations.
- Trial name
- Bioburden (NCT01496014)
- Where
- 40 sites in United States
- Volunteers
- 646 people
- Sponsor
- Major Extremity Trauma Research Consortium
Ankle Fractures, Ankle Fracture - Lateral Malleolus
Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture Surgery
This study aims to 1) characterize skeletal muscle pH during/after tourniquet use and 2) investigate any relationship between intraoperative tourniquet use and postoperative functional measures and patient-reported outcomes.
- Conditions
- Ankle Fractures, Ankle Fracture - Lateral Malleolus, Ankle Fracture, Bimalleolar, Ankle Fracture, Trimalleolar
- Trial name
- NCT05445960
- Testing
- Tourniquet
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Oregon Health and Science University
Fracture
Adequacy of Pain Management for Upper Extremity Fracture After Discharge From a Pediatric Emergency Depart
Pain is a common cause for children seeking care in the Emergency Department (ED). Children with orthopedic injuries often require pain control when seeking emergency care.
- Trial name
- NCT01514097
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Deformity, Defect, Congenital
Observational Study on JuniOrtho Plating System for Deformities and Fractures Treatment in Lower Limb
Orthofix Srl put the JPS on the European market (2019) by the mean of a pre-market clinical evaluation made under the Medical Device Directive (MDD) requirements that were based on the analysis of the scientific literature of…
- Conditions
- Deformity, Defect, Congenital, Trauma
- Trial name
- JPS (NCT05245617)
- Testing
- JuniOrtho™ Plating System™
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Orthofix s.r.l.
Myocardial Injury
Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3.
- Trial name
- Sipwlefsmdfs (NCT06808841)
- Testing
- Sufentanil injection
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Stress Fracture
US vs MRI for Stress Injuries
The primary purpose of this study is to determine whether or not there is a correlation between MRI and ultrasound for the diagnosis of lower limb stress injuries.
- Trial name
- NCT05876897
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ryan Kruse
Lower Extremity Fractures
Insole Sensor to Determine Optimal Limb Loading
The purpose of this study is to use a novel load monitoring technology to correlate limb loading to OTA type 42IIIB and IIIC tibial fracture outcomes.
- Trial name
- NCT02170493
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Utah
Distal Limbs Bones Fractures
Assessment of Distal Limbs Fractures With Cone-Beam CT Newtom 5G
ConeBeam scanner (CBCT) is a widely technique used for dental and maxillofacial imaging. Patients can be set up in a sitting or a laying position in the, Newtom 5G CBCT allowing for an analysis of the distal appendicular…
- Trial name
- FRADICOBE (NCT01796600)
- Testing
- The patients will have a conventional scanner, a reference examination, and a cone-beam scanner Newtom 5G just after the conventional scanner
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Fracture Dislocation of Ankle Joint, Fracture Leg
Single Shot Exparel vs Catheters in Lower Extremity Trauma
This study will compare the use of single-shot Exparel, a long-acting local anesthestic, with the use of catheters that deliver a continuous flow of the short-acting local anesthetic ropivacaine.
- Conditions
- Fracture Dislocation of Ankle Joint, Fracture Leg, Fracture Femur, Fracture Lower Leg
- Trial name
- NCT07221019
- Testing
- Bupivacaine, Exparel + Bupivacaine
- Where
- United States
- Sponsor
- George Washington University
Musculoskeletal Injury
Use of a Self-Directed Exercise Program (SDEP) Following Selected Lower Extremity Fractures
The purpose of this study is to compare the effectiveness and value of clinic-based physical therapy (PT) and a home-based, self-directed exercise program (SDEP).
- Trial name
- NCT04612478
- Testing
- Self-Directed Exercise Program, Clinic-Based Physical
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Wake Forest University Health Sciences
Joint Dislocation, Limb Fracture
Target-controlled Infusion With Propofol in the Emergency Department : a Prospective Study on 45 Adult Patients
Procedural sedation is an emergency medicine technique that provides a brief, deep sedation in order to perform very painful emergency emergent procedures such as displaced fracture or dislocated joints reduction.
- Trial name
- SIVOC (NCT03783494)
- Testing
- Target control infusion with propofol
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Femoral Fractures, Tibial Fractures
Intra-op Monitoring With NIRS and NICOM, and Surgical Outcome in Elderly Patients With Fractures of Lower Limbs
In Taiwan, about 75.92% of the elderlies above 65 years old suffered from chronic diseases or major diseases, especially in circulatory system. Thus, dramatic hemodynamic change is often observed in surgeries in this population.
- Trial name
- NCT02280512
- Testing
- elderly with fractures
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital