Clinical trials: Limb Salvage
Stroke
Effects of Device-assisted Practice of ADL on Arm/Hand Recovery in Individuals With Moderate to Severe Stroke
A large number of post-stroke survivors cannot functionally use their paretic upper extremity (UE). This study therefore investigates effects of device-assisted practice of activities of daily living (ADL) in a close-to-normal…
- Trial name
- NCT04077073
- Testing
- ReIn-Hand, Robot
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Northwestern University
Spinal Cord Injury, Tetraplegia/Tetraparesis
MEP Up-conditioning to Target Corticospinal Plasticity
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist…
- Trial name
- uMEP2 (NCT06989905)
- Testing
- Up-conditioning of the wrist extensor motor evoked potential
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Stroke, Hemiparesis
Translating Intensive Arm Rehabilitation in Stroke to a Telerehabilitation Format
Loss of arm use and strength are common problems after stroke that greatly affects independence in activities of daily living. Arm rehabilitation using robot-assisted repetitive task training has shown to improve motor recovery.
- Trial name
- TeleBATRAC (NCT02665052)
- Testing
- Home-Based BATRAC plus TTT, Lab-based BATRAC plus TTT, Delayed Entry Usual Care
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Stroke, Cerebrovascular Disorders
Dose Optimization for Stroke Evaluation
This study is about rehabilitation of arm function after a stroke. The investigators are testing the dosage of therapy that is needed for meaningful recovery of arm and hand function.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Ischemia, Infarction
- Trial name
- DOSE (NCT01749358)
- Testing
- Accelerated Skill Acquisition Program (ASAP), Active Monitoring
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Southern California
CVA (Cerebrovascular Accident), Stroke
Application of a Reimbursable Form of Constraint-Induced Movement Therapy for Upper Extremity
CI therapy is a family of techniques that has systematically applied intensive treatment daily over consecutive days, supervised motor training using a technique called shaping, behavioral strategies to improve the use of the…
- Conditions
- CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
- Trial name
- NCT05311384
- Testing
- Keys Constraint-induced Movement Therapy protocol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Stroke, Rehabilitation
The Kinesio-taping for the Prevention of Painful Shoulder and for the Functional Recovery of Upper Limb After Stroke
This RCT aims to investigate the effectiveness of the early use of Kinesio-taping (KT) together with standard physiotherapy treatment, in the prevention of the shoulder pain of the hemiplegic upper limb following a cerebral…
- Trial name
- NCT05156164
- Testing
- Kinesio Tape Group, Control Group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Stroke, Hemiparesis
Personalized Robotic Telerehabilitation for Upper Limb Functional Recovery After Stroke in a Home-Based Setting
Stroke is a leading cause of long-term disability worldwide, with upper-limb impairment representing a major determinant of functional limitation and reduced independence.
- Conditions
- Stroke, Hemiparesis, Upper Extremity Paresis, Motor Impairment
- Trial name
- ROBOHOME (NCT07590349)
- Testing
- Robotic-Assisted Telerehabilitation Virtual Reality-Based Telerehabilitation, Virtual reality-based rehabilitation platform without robotic assistance
- Volunteers
- 70 people
- Sponsor
- University of Campania Luigi Vanvitelli
Neglect, Hemispatial, Stroke, Cardiovascular
Implementation of IVS3 for Upper Limb Motor Recovery
This study measures participant satisfaction and upper extremity function in outpatients with chronic stroke when exposed to the IVS3 device.
- Conditions
- Neglect, Hemispatial, Stroke, Cardiovascular, Mirror Movement, Motor Activity
- Trial name
- NCT06483230
- Testing
- Intensive Visual Stimulation Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Stroke
FES VS Constrained Induced MT Recovery and Spasticity in Upper Limb Hemiparetic Ischemic Patients
To determines the effects of Functional Electrical Stimulation versus Constrained Induced Movement Therapy for motor recovery and spasticity in Upper Limb Hemiparetic Chronic Ischemic Stroke Patients
- Trial name
- NCT05854121
- Testing
- Functional Electrical Stimulation, Constrained Induced Movement Therapy
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Superior University
Ischemic Stroke
Effectiveness of Theta Burst Stimulation For Upper and Lower Extremity Recovery in Stroke
This single-center, single-blind, randomized, sham-controlled clinical trial will include 60 patients aged >45 years who are within 3 months of a first-ever middle cerebral artery ischemic stroke.
- Trial name
- NCT07834333
- Testing
- Continuous Theta Burst Stimulation (cTBS), Intermittent Theta Burst Stimulation (iTBS)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Stroke
Impact of a New Technology to Functional Recovery Upper Limb in Post Stroke Patients.
54 inpatients participants were randomly divided into two groups (experimental and conventional). Individual of experimental group were treated according to an established protocol for ARMEO Spring (30 minutes/session with "Armeo…
- Trial name
- NCT02721212
- Testing
- Armeo Spring, Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Habilita S.p.A.
Stroke, Cerebrovascular Accident
Robot-assisted Rehabilitation of the Upper Limb in Acute and Subacute Post-stroke Patients
The goal of this study is to determine if robot aided rehabilitation therapy can be equivalent to or more effective than conventional rehabilitation therapy at promoting functional recovery of the paretic upper limb in acute and…
- Conditions
- Stroke, Cerebrovascular Accident, Upper Extremity Paresis
- Trial name
- NCT01102309
- Testing
- Robot therapy (NeReBot), Conventional therapy
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Eremo Hospital, Arco
Peripheral Arterial Disease
Autologous Bone Marrow Mononuclear Cell Implantation for Moderate to Severe Peripheral Arterial Disease
The purpose of this study is to evaluate the efficacy of dual intramuscular and intra-arterial autologous bone marrow mononuclear cell implantation for the treatment of patients with moderate to severe peripheral arterial disease…
- Trial name
- NCT00919516
- Testing
- Bone marrow mononuclear cell implantation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- The Vascular and Vein Center, Columbus, OH
Repetitive Transcranial Magnetic Stimulation, Stroke
Comparative Effectiveness of Ipsilesional High-frequency rTMS, Contralesional Continuous Burst Theta rTMS, and Sham rTMS, Each Combined With Physiotherapy, in Subacute Ischemic Stroke Upper Limb Recovery : Clinical, Neurophysiological and Radiological
To compare the efficacy of lesional high-frequency rTMS, contralesional cTBS, and sham stimulation in improving motor and cognitive recovery in post-stroke patients undergoing physiotherapy.
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Stroke, Functional MRI
- Trial name
- NCT06799312
- Testing
- Ipsilesional high frequency rTMS combined with physiotherapy, Contralesional Continuous Burst Theta rTMS (cTBS) + Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Assiut University
Limb Salvage
Reconstruction of Extensive Upper Extremity Long Bone Defects With a Microvascular Fibula Flap
This study assesses the long-term functional outcomes of upper extremity long bone defects treated with the free fibula bone transfer.
- Trial name
- NCT02372838
- Testing
- Microvascular fibula bone transfer
- Volunteers
- 13 people
- Sponsor
- Helsinki University Central Hospital
Stroke/Brain Attack, Upper Extremity Paresis
Tendon Vibrations Effect on Upper Limb Motor Recovery After Recent Stroke
Stroke is the leading cause of severe acquired disabilities in adults. It can affect sensory and motor functions which are closely entangled. Among them, upper limb function is often strongly impaired.
- Trial name
- VIBRAMOT (NCT04504214)
- Testing
- Upper limb repeated multi-site tendon vibrations
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Borelli UMR 9010
Stroke
Changes in Brain Activity Associated With Upper Limb Motor Recovery
This study is to investigate changes in brain activities in acute stroke patients , and to correlate findings with clinical outcome measures.
- Trial name
- NCT02325427
- Testing
- tDCS
- Where
- Singapore
- Volunteers
- 8 people
- Sponsor
- National University Hospital, Singapore
Wrist Injuries, Hand and Upper Limb Trauma
Virtual Reality Therapy for Wrist and Hand Injury Recovery
The goal of this randomized clinical trial is to find out whether an early neuro-functional rehabilitation program using virtual reality and action observation can improve recovery after a traumatic injury of the wrist or hand…
- Conditions
- Wrist Injuries, Hand and Upper Limb Trauma, Muskuloskeletan Pain
- Trial name
- AOT+VR (NCT07408622)
- Testing
- Virtual reality
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Malaga
Hemiplegia, Lower Extremity Dysfunction
Lower Extremity Pressure Splints in HP
Hemiplegia (weakness or paralysis on one side of the body) often impacts the lower extremities, making it challenging for patients to walk or move their legs effectively.
- Conditions
- Hemiplegia, Lower Extremity Dysfunction, Stroke Rehabilitation
- Trial name
- NCT06965894
- Testing
- Johnston Pressure Splint, Rehabilitation Program
- Where
- Lebanon
- Volunteers
- 30 people
- Sponsor
- Istinye University
Cardiovascular Diseases
Effects of Lower Limb Resistance Band Exercises in Phase 1 Cardiac Rehabilitation
This study will be randomized controlled trial with non-probability purposive sampling. Study conducted among post CABG patients. Sample size will be 56, 28 in each group.
- Trial name
- NCT06319651
- Testing
- Lower Limb Resistance Band Exercises, Routine Phase 1 cardiac rehabilitation
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Riphah International University