Clinical trials: Limited Stage Small-Cell Lung Cancer
Lung Cancer
Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as etoposide, carboplatin and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by…
- Trial name
- NCT00632853
- Testing
- Standard Radiation Dose Therapy, cisplatin, etoposide
- Where
- 934 sites in United States, Israel and 2 more
- Volunteers
- 731 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Small-cell Lung Cancer
Simultaneous Integrated Boost vs. Routine IMRT in Limited-stage Small-cell Lung Cancer
Thoracic radiotherapy concurrent with chemotherapy stands for the standard regime for limited staged small cell lung cancer. Involved node radiation（INF） replaced elective node irradiation（ENI） as the more popular since several…
- Trial name
- NCT04500145
- Testing
- SIB-IMRT, routine IMRT
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Non Small Cell Lung Cancer
Neoadjuvant Afatinib in Early Stage Non Small Cell Lung Cancer.
This is a multicenter, randomized, 1:1, non-comparative phase II trial. Patients with early stage NSCLC will be randomized between ARM A: neoadjuvant afatinib followed by surgery and ARM B: immediate surgery with curative intent.
- Trial name
- REMNANT (NCT02470065)
- Testing
- Afatinib, Immediate surgery
- Volunteers
- 38 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Non-small Cell Lung Cancer, Primary Neoplasm
Synapse 3D With Intravascular Indocyanine Green
With the advent of CT screening for lung cancer, an increasing number of NSCLCs are being detected at very early stages, and the demand for pulmonary segmentectomy is rising rapidly.
- Trial name
- NCT03953144
- Testing
- Synapse 3D Lung Modelling, IC-Green (ICG)
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Lung Cancer (NSCLC), Early Stage Lung Non-Small Cell Carcinoma
Interventional Ablation for Early-stage Lung Cancer
What is this study about? This clinical trial aims to compare two treatments for high-risk lung nodules or early-stage lung cancer: interventional ablation (a minimally invasive procedure that destroys tumors with heat or cold)…
- Trial name
- NCT07005999
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Non Small Cell Lung Cancer
NSCLC Heterogeneity in Early Stage Patients and Prediction of Relapse Using a Personalized "Liquid Biopsy"
The purpose of his study is to investigate the intra tumor heterogeneity of the primary tumor and the involved lymph nodes from patients with resectable NSCLC, to detect primary tumor genetic alternations using "liquid biopsy"…
- Trial name
- NCT03771404
- Testing
- blood sampling
- Where
- 6 sites in Greece
- Volunteers
- 50 people
- Sponsor
- Hellenic Oncology Research Group
Small Cell Lung Cancer, SCLC
MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer
This study has 2 cohorts: MOZART-ES cohort (for extensive-stage SCLC) and MOZART-LS cohort (for limited-stage SCLC). MOZART-ES cohort: Study treatment will consist of a platinum drug (carboplatin or cisplatin per investigator's…
- Conditions
- Small Cell Lung Cancer, SCLC, Extensive Stage Small Cell Lung Cancer, Limited Stage Small-Cell Lung Cancer
- Trial name
- MOZART (NCT05903092)
- Testing
- Durvalumab, Monalizumab, Carboplatin or Cisplatin
- Where
- 4 sites in United States
- Volunteers
- 84 people
- Sponsor
- Hirva Mamdani
Small Cell Lung Cancer
Clinical Randomized Study of Concurrent Chemo-radiotherapy vs Radiotherapy Alone to Local-advanced Small Cell Lung Cancer (SCLC)
This trial aims to evaluate the efficacy and safety between radiotherapy alone and concurrent chemo-radiotherapy after 3-4 cycles of chemotherapy in LS-SCLC.
- Trial name
- SCLC (NCT01745445)
- Testing
- concurrent chemo-radiotherapy arm
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Myelosuppression
Trilaciclib Prevents Myelosuppression With Chemoradiotherapy
To evaluate the protective effect of Trilaciclib on myelosuppression in patients with limited-stage small cell lung cancer associated with concurrent chemoradiotherapy and discuss the effect of gut microbiota changes on…
- Trial name
- NCT06490081
- Testing
- Trilaciclib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Early Lung Cancer
Serplulimab Combined With Cryoablation for Early-Stage Non-Small Cell Lung Cancer
The goal of this clinical trial is to learn if serplulimab combined with cryoablation can effectively treat early-stage non-small cell lung cancer (NSCLC) in adults who are not eligible for or decline surgery or radiotherapy.
- Trial name
- NCT07064876
- Testing
- Serplulimab, CT-guided Cryoablation
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xi Junjie
Lung Cancer
The Lived Experiences of Persons With Early Stage Non-small Cell Lung Cancer and Their Significant Other(s) Following Surgery: a Rapid Ethnographic Approach
To understand the lived experiences, thoughts and habits about exercise and PA of persons with early stage non-small cell lung cancer and their significant other(s) following surgery.
- Trial name
- LEILA (NCT06536140)
- Testing
- Home observations and interview
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- Hasselt University
Early Stage Non-Small Cell Lung Cancer
Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer
The first phase of this study was an open label, randomized pilot study. Enrollment for this phase is now complete. The second phase is a single arm phase 1 safety study.
- Trial name
- NCT03546829
- Testing
- Vancomycin, Precision hypofractionated radiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lung Non-Small Cell Carcinoma
Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial
This phase III trial compares the effect of atezolizumab (or atezolizumab and recombinant human hyaluronidase) to standard observation for preventing cancer return after surgery (recurrence) in patients who have undergone a…
- Trial name
- NCT07388524
- Testing
- Atezolizumab, Atezolizumab and Recombinant Human Hyaluronidase, Biospecimen Collection
- Where
- 110 sites in United States
- Volunteers
- 336 people
- Sponsor
- National Cancer Institute (NCI)
Small Cell Lung Cancer Limited Stage
A Clinical Study of TQB2450 Combined With Anlotinib in Limited-Stage Small Cell Lung Cancer Patients
This study is a randomized, double-blind, placebo-controlled phase III clinical study to evaluate the efficacy and safety of TQB2450 in combination with anlotinib as maintenance therapy in patients with limited-stage small cell…
- Trial name
- NCT06469879
- Testing
- TQB2450+Anlotinib
- Where
- 16 sites in China
- Volunteers
- 358 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Small Cell Lung Cancer
Chemotherapy and Radiotherapy to Treat Patients With Limited Stage of Small Cell Lung Cancer (SCLC)
This is a multicenter, phase II, open-label trial to evaluate the efficacy of pemetrexed + carboplatin combined with thoracic radiotherapy in patients with Limited Stage of small cell lung cancer
- Trial name
- NCT00494026
- Testing
- pemetrexed, carboplatin, radiotherapy
- Where
- 12 sites in Italy, Poland and 2 more
- Volunteers
- 4 people
- Sponsor
- Eli Lilly and Company
Lung Cancer
S0004: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Limited-stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00006487
- Testing
- cisplatin, etoposide, tirapazamine
- Where
- 87 sites in United States
- Volunteers
- 30 people
- Sponsor
- SWOG Cancer Research Network
Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer
Stereotactic Radiosurgery Followed by Wedge Resection in Treating Patients With Early Stage Peripheral Non-small Cell Lung Cancer
This pilot clinical trial studies the side effects and how well stereotactic radiosurgery followed by wedge resection works in treating patients with early stage non-small cell lung cancer that is located in the outer, or…
- Conditions
- Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
- Trial name
- NCT02250378
- Testing
- stereotactic radiosurgery, therapeutic conventional surgery, laboratory biomarker analysis
- Where
- United States
- Sponsor
- University of Southern California
Non-small Cell Lung Cancer
Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations
Beamion LUNG-3 study evaluates whether zongertinib, an oral HER2-targeted treatment, can improve outcomes compared with standard adjuvant treatment in adults with completely resected Stage II-IIIB non-small cell lung cancer…
- Trial name
- NCT07195695
- Testing
- Zongertinib, Pembrolizumab, Atezolizumab
- Where
- 202 sites in United States, Argentina and 26 more
- Volunteers
- 400 people
- Sponsor
- Boehringer Ingelheim
Small Cell Lung Cancer
A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy
This is a randomized, double-blind, phase III clinical study to compare the efficacy and safety of AK112 to placebo as consolidation treatment for patients with limited stage small cell lung cancer who have not progressed…
- Trial name
- AK112-311 (NCT07010263)
- Testing
- AK112
- Where
- 53 sites in China
- Volunteers
- 560 people
- Sponsor
- Akeso
Lung Neoplasm, Small Cell Carcinoma
Hypofractionated Radiotherapy for Small Cell Lung Cancer
Current treatments for limited stage small cell lung cancer have poor cure rates. The addition of chest radiation to chemotherapy improves cure rates, but these cancers still come back in the chest 30-50% of the time.
- Trial name
- NCT00469222
- Testing
- hypofractionated external beam
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- AHS Cancer Control Alberta