Clinical trials: Limping
Peripheral Arterial Disease
Intermittent Mechanical Compression For Peripheral Arterial Disease
The study tests the use of a portable mechanical compression device (FM220, Flowmedic, USA) for the treatment of claudication and peripheral arterial disease.
- Trial name
- FM-S1 (NCT00855673)
- Testing
- Intermittent Mechanical Compression, Control
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Getafe
Intermittent Claudication, Peripheral Vascular Diseases
Does Neuromuscular Electrical Stimulation Improve the Absolute Walking Distance in Patients With Intermittent Claudication Compared to Best Available Treatment?
Intermittent claudication (IC) is caused by a blockage in the artery of the leg, causing muscle pain. Although some evidence of the efficacy of neuromuscular electrical stimulation (NMES) in the management of patients with IC…
- Trial name
- NESIC (NCT03446027)
- Testing
- NMES
- Where
- 11 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Peripheral Artery Disease
Isometric Handgrip Training on Blood Pressure of Peripheral Artery Disease Patients
The aim of this study is to analyze the effects of isometric handgrip training (IHT) on blood pressure of hypertensive patients with peripheral arterial disease.
- Trial name
- NCT02742220
- Testing
- Isometric Handgrip Training Group, Control Group
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- University of Pernambuco
Peripheral Arterial Disease, Intermittent Claudication
A New Heat Therapy Device for Home-based Leg Heating in Patients With Lower-extremity Peripheral Artery Disease
The goal of the proposed pilot study is to evaluate the feasibility of a new leg heat therapy system treatment for patients with lower extremity PAD.
- Trial name
- NCT05335161
- Testing
- Home-based leg heat therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Purdue University
Vascular Diseases, Peripheral Artery Disease
RECCORD (Recording Courses of Vascular Diseases) Registry
The RECording COurses of vasculaR Diseases registry (RECCORD registry) is an observational, prospective, multicentre, all-comers registry platform.
- Conditions
- Vascular Diseases, Peripheral Artery Disease, Claudication, Critical Limb Ischemia
- Trial name
- RECCORD (NCT03448029)
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Deutsche Gesellschaft für Angiologie, Gesellschaft für Gefäßmedizin e.V.
Stable Coronary Artery Disease, Acute Coronary Syndromes
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.
- Conditions
- Stable Coronary Artery Disease, Acute Coronary Syndromes, Critical Limb Ischemia, Intermittent Claudication
- Trial name
- NCT07588295
- Testing
- Optical Coherence Tomography assessment
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Maria Cecilia Hospital
Peripheral Arterial Disease
Safety and Efficacy Study of Bosentan for Intermittent Claudication in Peripheral Arterial Disease
A prospective study, proof-of concept, randomized, controlled, parallel groups, simple blind was performed in 30 male patients (50-60 years old) with Intermittent Claudication (Rutherford category 1-2) recently diagnosed and…
- Trial name
- CLAU (NCT01738542)
- Testing
- Bosentan, Antiaggregant therapy, Statins
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Getafe
Spinal Stenosis Lumbar, Low Back Pain
Validation of a Treadmill Walking Test to Discriminate Neurogenic Claudication From Vascular Claudication
The first aim of this study was to elaborate and validate a treadmill walking test that would help discriminate between neurogenic claudication from vascular claudication.
- Conditions
- Spinal Stenosis Lumbar, Low Back Pain, Peripheral Artery Disease, Claudication
- Trial name
- NCT04058171
- Testing
- Treadmill walking test
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Université du Québec à Trois-Rivières
Peripheral Arterial Disease, Cardiovascular Health
Heat Therapy and Peripheral Artery Disease
The purpose of the study is to assess the efficacy of a novel 8 week heat therapy intervention in intermittent claudication compared to usual care controls.
- Conditions
- Peripheral Arterial Disease, Cardiovascular Health, Vascular Function, Intermittent Claudication
- Trial name
- NCT06827691
- Testing
- Heat Therapy Intervention
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Manchester Metropolitan University
Claudication
Neurostimulation in Intermittent Claudication
Intermittent claudication is a condition where a patient suffers with cramp-like pain experienced in the muscles of the legs (often the calf muscles) brought on by walking and relieved by stopping walking and resting.
- Trial name
- NCT06176898
- Testing
- Neurostimulating device
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Diabetes Mellitus, Type 2, Intermittent Claudication
Exercise Training for Patients With Poor Leg Circulation
The purposes of this pilot project are to (a) determine changes in calf muscle blood flow and energy supply resulting from calf muscle exercise, and (b) to determine changes in these variables resulting from exercise training…
- Trial name
- NCT00118560
- Testing
- Physical exercise, Physical walking
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Peripheral Artery Disease
Structured Home-based Exercise Versus Walking Advice in Claudication Patients: a Randomized-controlled Trial
A recent position paper calls for effective home-based exercise program for patients with peripheral artery disease (PAD) and claudication to be implemented in real-world care.
- Trial name
- NCT04751890
- Testing
- Structured home-based exercise, Walking advice
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- University Hospital of Ferrara
Peripheral Arterial Disease, Atherosclerosis
Sonodynamic Therapy on Patients With Femoropopliteal PAD and Claudication
The purpose of this trial is to evaluate the safety and efficacy of sonodynamic therapy (SDT) in reducing atherosclerotic plaques inflammation and increasing peak walking time (PWT) among peripheral artery disease (PAD) patients…
- Conditions
- Peripheral Arterial Disease, Atherosclerosis, Cardiovascular Diseases
- Trial name
- NCT03318484
- Testing
- Optimal Medical Care, Sonodynamic therapy
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Atherosclerosis, Intermittent Claudication
Whole-Body MRA at 3T - A Comparison Between Two Different Scan Protocols
To compare to different approaches in whole-body magnetic resonance angiography of patients suffering peripheral arterial disease.
- Trial name
- NCT00834548
- Testing
- Whole body magnetic resonance angiography (WB-MRA)
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Copenhagen University Hospital at Herlev
Peripheral Arterial Disease
Effect of Evolocumab in Functional Status and LDL Oxidation of Patients With Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerotic cardiovascular disease (ASCVD) and is associated with increase cardiovascular risk.
- Trial name
- Evol-PAD (NCT04306081)
- Testing
- Evolocumab 140 mg/mL Subcutaneous Injection 1 milliliter (mL) pre-filled injector Pen x 3 for a monthly dose of 420 mg for 6 months.
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Leonardo Clavijo
Peripheral Vascular Diseases, Intermittent Claudication
Safety and Efficacy of Propionyl-L-Carnitine in the Treatment of Peripheral Arterial Disease (Intermittent Claudication)
Patients with peripheral artery disease have decreased blood flow to exercising muscle causing pain. This decreased blood flow to the muscle affects the level of acylcarnitines which in turn decreases the level of carnitine.
- Trial name
- NCT00399919
- Testing
- Propionyl-L-Carnitine, PLC
- Where
- 9 sites in United States
- Volunteers
- 69 people
- Sponsor
- Sigma-Tau Research, Inc.
Degenerative Lumbar Spinal Stenosis, Neurologic Intermittent Claudication
Clinical and Radiological Outcomes Following Insertion of a Novel Removable Percutaneous Interspinous Process Spacer: an Initial Experience.
Purpose To evaluate clinical and radiologic outcome of a series of patients treated with a removable percutaneous interspinous process spacer (IPS) (LobsterProject® Techlamed®) for symptomatic degenerative lumbar spinal stenosis…
- Trial name
- LOBSTER (NCT05203666)
- Testing
- percutaneous removable interspinous process
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Intermittent Claudication
The Effects of Fish Oil Supplements During Supervised Exercise Therapy in Patients With Intermittent Claudication
Intermittent claudication (IC) is caused by peripheral arterial disease and has a high morbidity and mortality. Etiologic factors are similar to those of cardiovascular disease.
- Trial name
- FISHTIC (NCT02152930)
- Testing
- Omega-3 fatty acids
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Medical Center Alkmaar
Peripheral Arterial Disease, Intermittent Claudication
Arm-crank Exercise Training on Cardiovascular Function of Patients With Peripheral Artery Disease
The aim of the study is to analyze the effect of 12 weeks of arm crank exercise (ACE) training on cardiovascular function in PAD patients, and compare it with treadmill exercise (TE), the actual recommendation for this patients.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Hypertension
- Trial name
- NCT03837639
- Testing
- Arm ergometer, Treadmill ergometer, Control group
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Hospital Israelita Albert Einstein
Diabetic Angiopathies, Intermittent Claudication
Trial Comparing Different Medical Devices for Infragenual Dilatation
This study is a comparison of different medical devices for infragenual dilatation.
- Trial name
- NCT00134277
- Testing
- Infragenual dilatation, Infragenual dilatation with stenting, Infragenual dilatation with cutting balloon
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- University Hospital, Ghent