Clinical trials: Limping, open to volunteers
Peripheral Arterial Disease
Local or Systemic Effects: Mechanisms Related to Arm Crank Exercise - Comparison Between Individuals With and Without PAD
INTRODUCTION: Exercise with an arm ergometer (EB) overcomes the main barrier to physical exercise in patients with Peripheral Artery Disease (PAD), leg pain during walking.
- Trial name
- NCT06828172
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Symptomatic Lumbar Spinal Stenosis
Home-based Cycling for People With Lumbar Spinal Stenosis
The main objective of the study is to compare the efficacy on back-specific activity limitations at 4 months after-randomisation of home-based cycling using connected ergometric bicycles associated with usual care to usual care.
- Trial name
- FLEXCAL (NCT04075539)
- Testing
- Home-based cycling program, usual care
- Where
- France
- Volunteers
- 302 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hip Osteoarthritis, Muscle Weakness
The Role of Surgical Approach on Residual Limping After Total Hip Arthroplasty
Residual limping after total hip arthroplasty is empirically associated with the use of lateral approach but has been reported in litterature even with the use of posterior approach.
- Conditions
- Hip Osteoarthritis, Muscle Weakness, Muscle Atrophy, Muscle Injury
- Trial name
- HSS (NCT05216666)
- Testing
- Lateral approach, Posterior approach
- Where
- Sweden
- Volunteers
- 580 people
- Sponsor
- Sahlgrenska University Hospital
Intermittent Claudication
MetfOrmin BenefIts Lower Extremities With Intermittent Claudication
Peripheral arterial disease (PAD) affects over 20% of aged adults and is very common among Veterans due significant tobacco use.
- Trial name
- MOBILE IC (NCT05132439)
- Testing
- Metformin ER
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Peripheral Artery Disease, Claudication, Intermittent
Passive Calf Stretching Therapy in Peripheral Artery Disease
The goal of this clinical trial is to assess the effects of passive calf muscle stretching in patients diagnosed with peripheral artery disease (PAD). The main question it aims to answer are: 1.
- Trial name
- NCT06041880
- Testing
- Passive calf muscle stretching device
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Penn State University
Peripheral Vascular Disease
Observing the Role of Inflammation in Peripheral Artery Disease and Its Impact on Heart and Mobility Health: PANACEA-O.
This registry aims to collect detailed information about people in Canada who have Peripheral Artery Disease (PAD) and are receiving care in heart clinics while still able to walk and live in the community.
- Trial name
- PANACEA-O (NCT07500610)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Cardiology Research UBC
Peripheral Arterial Disease, Cardiovascular Health
Heat Therapy and Peripheral Artery Disease
The purpose of the study is to assess the efficacy of a novel 8 week heat therapy intervention in intermittent claudication compared to usual care controls.
- Conditions
- Peripheral Arterial Disease, Cardiovascular Health, Vascular Function, Intermittent Claudication
- Trial name
- NCT06827691
- Testing
- Heat Therapy Intervention
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Manchester Metropolitan University
Sarcopenia, Body Composition
CT Body Composition as Predictor of Exercise Therapy Outcome in Peripheral Arterial Disease
Supervised exercise therapy (SET) is the recommended first treatment for patients with leg artery disease (peripheral arterial disease, PAD) causing pain when walking.
- Conditions
- Sarcopenia, Body Composition, Sarcopenic Obesity, Peripheral Arterial Disease
- Trial name
- COMPOSE-PAD (NCT07433309)
- Testing
- SET physiotherapy, CT scan
- Volunteers
- 128 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Peripheral Arterial Disease, Atherosclerotic Lesion
Study of the R3 Vascular Drug-Eluting Bioresorbable Scaffold in Treating Below the Knee Arterial Disease
This first-in-human clinical feasibility study will evaluate the safety and performance of the R3 Vascular MAGNITUDE® Bioresorbable Drug-Eluting Scaffold and Delivery System in patients undergoing treatment for peripheral…
- Conditions
- Peripheral Arterial Disease, Atherosclerotic Lesion, Lower Extremity Ischemia, Lower Extremity Claudication
- Trial name
- RESOLV I (NCT04912323)
- Testing
- Percutaneous Implantation of the MAGNITUDE® Bioresorbable Arterial Scaffold
- Where
- 7 sites in Austria, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- R3 Vascular Inc.
Arthroplasty Complications, Muscle Weakness
Achilles Tendon for the Treatment of Gluteus Medius Insufficiency
Residual limping after total hip arthroplasty is a serious complication that lacks effective treatment. The purpose of this study is to evaluate a surgical treatment for residual limping and compare its results with non-surgical…
- Conditions
- Arthroplasty Complications, Muscle Weakness, Muscle Atrophy, Muscle Tear
- Trial name
- HLS (NCT05206838)
- Testing
- Surgical reconstruction of gluteus medius with Achilles tendon allograft
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Sahlgrenska University Hospital
Claudication, Peripheral Artery Disease
The Effects of Diet and Exercise Interventions in Peripheral Artery Disease
This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the DASH dietary program combined with a home-based exercise program, quantified by a step activity monitor, to…
- Trial name
- NCT03845036
- Testing
- DASH Diet plus Home-Based Exercise, Home-Based Exercise
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Peripheral Arterial Disease, Aging
Fisetin to Reduce Senescence and Mobility Impairment in PAD
The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutaneous and inter muscular…
- Conditions
- Peripheral Arterial Disease, Aging, Peripheral Vascular Diseases, Walking, Difficulty
- Trial name
- FIRST (NCT06399809)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Northwestern University
Peripheral Arterial Disease, Intermittent Claudication
Personalised Multicomponent Exercise Programme in Peripheral Arterial Disease
Peripheral arterial disease (PAD) is characterised as an atherosclerotic disease, most common in the lower limbs (aortoiliac, femoropopliteal, and infrapopliteal arterial segments), which causes a decrease in blood flow to the…
- Trial name
- NCT06410521
- Testing
- Exercise, Usual care
- Where
- 3 sites in Portugal
- Volunteers
- 40 people
- Sponsor
- University of Trás-os-Montes and Alto Douro
Peripheral Arterial Disease (PAD)
Recreational Team Handball Programme for Patients With Peripheral Arterial Disease
This randomized controlled trial (RCT) aims to evaluate the physical and physiological demands, the feasibility and the health, physical fitness and disease-specific outcomes of a progressive recreational team handball-based…
- Trial name
- NCT07582588
- Testing
- Recreational team handball programme
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- University Institute of Maia
Peripheral Arterial Disease
Evaluation of the Effectiveness of Hybrid Cardiac Rehabilitation in Peripheral Artery Disease
Peripheral artery disease (PAD) is a common atherosclerotic condition characterized by reduced blood flow to the lower extremities, leading to intermittent claudication, decreased walking capacity, and impaired quality of life.
- Trial name
- NCT07550959
- Testing
- Hybrid Cardiac Rehabilitation, Supervised Exercise Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Biruni University
Peripheral Artery Disease, Exercise
Response to Exercise and Nitric Oxide in PAD
RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise "responders" have…
- Conditions
- Peripheral Artery Disease, Exercise, Intermittent Claudication, Nitric Oxide
- Trial name
- RESIST (NCT06657976)
- Testing
- Supervised Treadmill Exercise, Attention Control, Nitrate-Rich Beetroot Juice + supervised exercise therapy
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Claudication, Intermittent
Exercise Training Study of Patients With Claudicatio Intermittens
The aim of the study is to evaluate whether walking capacity in patients with intermittent claudication is improved more by home-based 5+ exercise training than by current recommendations of daily walking.
- Trial name
- NCT06448390
- Testing
- Physical training
- Where
- 14 sites in Norway, Sweden
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Intermittent Claudication
Home-based Exercice Therapy for Patients With Intermittent Claudication Using a New Smartphone Application
The main characteristic of PAD is to limit physical activity by the appearance of claudication of the lower limbs which limits the walking distance, or the maximum distance traveled by the patient before the pain forces to stop.
- Trial name
- APAISE (NCT05457738)
- Testing
- E-REVA® app, No E-REVA® app
- Where
- France
- Volunteers
- 52 people
- Sponsor
- CHU de Reims
Peripheral Arterial Disease, Aortoiliac Occlusive Disease
Predictors of Major Adverse Limb Events After Endovascular Iliac Stenting: a Real-world Cohort Study
Peripheral arterial disease involving the iliac arteries is a common manifestation of systemic atherosclerosis and a major cause of lifestyle-limiting claudication and chronic limb-threatening ischemia.
- Conditions
- Peripheral Arterial Disease, Aortoiliac Occlusive Disease, Chronic Limb-Threatening Ischemia, Intermittent Claudication
- Trial name
- PREMISE-ILIAC (NCT07672249)
- Testing
- Iliac stenting
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Superficial Femoral Artery Stenosis, Claudication
Contribution of Optical Coherence Tomography in the Endovascular Treatment of Femoral Occlusions
This is a common care study. A study for evaluating the quality of balloon inflation and stent application will be performed in 2D angiography alone in the control group and then by 2D and OCT angiography for the experimental…
- Conditions
- Superficial Femoral Artery Stenosis, Claudication, Ischemic Leg
- Trial name
- TOCAF (NCT04434586)
- Testing
- femoropopliteal revascularization for TASC C or TASC D lesion
- Where
- France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Lille