Clinical trials: Linezolid
Other Infectious Diseases
Comparative Study To Determine The Efficacy, Safety, And Tolerability Of Ceftolozane-Tazobactam
The goal of this clinical research study is to learn if the study drug ceftolozane-tazobactam is more effective in controlling febrile neutropenia (fever and low white blood cell counts) than using approved antibiotics in…
- Trial name
- NCT03485950
- Testing
- Cefepime, Ceftolozane, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Community Acquired Pneumonia
Study to Compare Lefamulin to Moxifloxacin (With or Without Linezolid) for the Treatment of Adults With Pneumonia
This study evaluates the safety and efficacy of lefamulin, a pleuromutilin, for the treatment of adults with moderate to severe community-acquired bacterial pneumonia.
- Trial name
- LEAP (NCT02559310)
- Testing
- lefamulin, Moxifloxacin, Linezolid
- Where
- 99 sites in United States, Argentina and 16 more
- Volunteers
- 551 people
- Sponsor
- Nabriva Therapeutics AG
Cytopenias, Erythropenia (Diagnosis)
Vitamin B6 on Relieving Linezolid-associated Cytopenias
Linezolid is the first approved synthetic oxazolidinone that is active against multidrug-resistant Gram-positive pathogens. Because of its significant efficacy, linezolid is widely used in clinical treatment.
- Trial name
- NCT01295801
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Tuberculosis
Safety, Tolerability, Pharmacokinetics And Measurement Of Whole Blood Activity (WBA) Of PNU-100480 After Multiple Oral Doses In Healthy Adult Volunteers
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of multiple doses of PNU-100480 given for 14 or 28 days.
- Trial name
- NCT00990990
- Testing
- PNU-100480, Linezolid
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Sequella, Inc.
Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
Linezolid Plus Standard of Care
The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.
- Trial name
- LIPS (NCT06958835)
- Testing
- Linezolid 600 mg
- Where
- 12 sites in Switzerland
- Volunteers
- 606 people
- Sponsor
- University Hospital, Basel, Switzerland
Methicillin-resistant Staphylococcus Aureus, Pneumonia, Ventilator-Associated
Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia
As previous studies showed that the synergy between linezolid and carbapenem in vitro and in vivo (animal studies), our study is aim to investigate the activity of linezolid, alone and in combination with carbapenem against…
- Trial name
- NCT01356472
- Testing
- Imipenem/cilastatin
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Drug Susceptible Pulmonary Tuberculosis
Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary Tuberculosis
The purpose of this study is to evaluate if TBD09 in combination with other active agents in adults with drug sensitive pulmonary tuberculosis has potential to be safe and effective.
- Trial name
- NCT07525427
- Testing
- Bedaquiline, pretomanid and TBD09, Bedaquiline, pretomanid and linezolid
- Where
- 13 sites in South Africa
- Volunteers
- 150 people
- Sponsor
- Gates Medical Research Institute
Tuberculous Meningitis
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC)…
- Trial name
- NCT05383742
- Testing
- Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD)
- Where
- 18 sites in Brazil, India and 10 more
- Volunteers
- 330 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, Meningeal
Adjunctive Linezolid for the Treatment of Tuberculous Meningitis
This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at Masaka Regional Referral Hospital…
- Trial name
- ALTER (NCT04021121)
- Testing
- LZD, High dose RIF, Standard dose RIF
- Where
- Uganda
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Bacterial Infections, Skin Structures and Soft Tissue Infections
Omadacycline Versus Linezolid for the Treatment of ABSSSI (EudraCT #2013-003644-23)
The purpose of this study is to evaluate the safety and efficacy of omadacycline as compared to linezolid in the treatment of adults with acute bacterial skin and skin structure infections.
- Trial name
- NCT02378480
- Testing
- Omadacycline, Linezolid
- Where
- 78 sites in United States, Bulgaria and 12 more
- Volunteers
- 655 people
- Sponsor
- Paratek Pharmaceuticals Inc
Septic Shock
Plasma and Lung Tissue Concentrations of Linezolid in Septic Shock Patients
The study measures the plasma and bronchoalveolar lavage fluid concentrations of linezolid in septic shock patients comparing with non-septic shock patients to confirm the impact of septic shock on PK/PD of linezolid.
- Trial name
- NCT03308227
- Volunteers
- 46 people
- Sponsor
- Southeast University, China
Non-tuberculous Mycobacterial Infections
Linezolid for Treatment of Nontuberculous Mycobacterial Diseases
A prospective open study to determine the efficacy and tolerability of oral linezolid 600mg./day for the treatment of 40 patients with nontuberculous mycobacterial diseases will be conducted at Siriraj Hospital, Mahidol…
- Trial name
- NCT03220074
- Testing
- Oral Tablet
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Skin Structures and Soft Tissue Infections
Phase 3 Study - Safety and Efficacy of PTK 0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI)
A Phase III trial to demonstrate the safety and efficacy of PTK 0796 in the treatment of complicated skin and skin structure infections (cSSSI).
- Trial name
- NCT00876850
- Testing
- PTK 0796, Linezolid
- Sponsor
- Paratek Pharmaceuticals Inc
Neurosurgery
Study of Antibiotics in Cerebrospinal Fluid Following Intravenous Injection
Three different antibiotics are used to prevent infection in case of neurosurgery - this study examines to which extent the antibiotics penetrate from the blood to the cerebrospinal fluid (surrounding the brain).
- Trial name
- NCT00925093
- Testing
- Vancomycin, Teicoplanin, Linezolid
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Gram-Positive Bacterial Infections
Post Marketing Surveillance Study on Linezolid
The purpose of this study is to determine if Linezolid is safe for adult Filipino patients diagnosed with gram positive infections.
- Trial name
- A5951090 (NCT01564758)
- Testing
- Linezolid
- Volunteers
- 99 people
- Sponsor
- Pfizer
Tuberculosis Meningitis, HIV-1-infection
Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM
LASER-TBM is a parallel group, randomized, multi-arm phase IIa trial evaluating the safety of increased dose rifampicin (RIF) plus linezolid (LZD), with or without aspirin (ASA), for the treatment of HIV-infected adults with…
- Trial name
- LASER-TBM (NCT03927313)
- Testing
- Linezolid, High dose rifampicin, Aspirin
- Where
- 4 sites in South Africa
- Volunteers
- 52 people
- Sponsor
- University of Cape Town
Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant
Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis
To evaluate the efficacy, safety and tolerability of various doses and durations of linezolid plus bedaquiline and pretomanid after 26 weeks of treatment in participants with either pulmonary XDR-TB, pre-XDR-TB, or treatment…
- Conditions
- Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant, Tuberculosis, MDR, Tuberculosis
- Trial name
- ZeNix (NCT03086486)
- Testing
- Pretomanid, Linezolid, Bedaquiline
- Where
- 11 sites in Georgia, Moldova and 2 more
- Volunteers
- 181 people
- Sponsor
- Global Alliance for TB Drug Development
Methicillin-Resistant Staphylococcus AureuS
Population Pharmacokinetics of Linezolid
Linezolid is the first of a new class of antibacterial drugs, the oxazolidinones. It has a specific inhibitory activity against Gram positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- NCT01200654
- Testing
- Linezolid
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Linezolid, Antioxidant
Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients
Study the effect of acetylcysteine on decreasing the incidence of LIT in critically ill patients. Study the impact of acetylcysteine on the time to onset of LIT and the time to recovery of platelets.
- Conditions
- Linezolid, Antioxidant, Thrombocytopenia, Critical Illness
- Trial name
- NCT05944458
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Helwan University
Renal Failure, Impaired Renal Function
Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6)
Renal failure patients were treated with linezolid (LZD) for proven or suspected infections by multiresistant Gram-positive cocci.
- Trial name
- LZDPPT6 (NCT02087566)
- Testing
- 600 mg linezolid
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Damanhour University