Clinical trials: Lipemia
Hypercholesterolemia, Familial, Hyperlipidemia
Carotid B-Mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrpib/Atorvastatin to Atorvastatin Alone.
The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To look at ultrasound images taken in the carotid arteries and to look at various lipids in the blood of people with heterozygous familial…
- Trial name
- RADIANCE 1 (NCT00136981)
- Testing
- torcetrapib/atorvastatin, atorvastatin
- Where
- 34 sites in United States, Canada and 6 more
- Volunteers
- 800 people
- Sponsor
- Pfizer
Dyslipoproteinemias, Hypercholesterolemia, Familial
Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry
This is a prospective German registry for patients with dyslipidemia with very high cardiovascular risk who principally meet the Gemeinsamer Bundesausschuss (G-BA) stipulations for Proprotein convertase subtilisin/kexin like type…
- Conditions
- Dyslipoproteinemias, Hypercholesterolemia, Familial, Familial Hypercholesterolemia - Homozygous, Familial Combined Hyperlipidemia
- Trial name
- PERI-DYS (NCT03110432)
- Testing
- PCSK9 Inhibitor [EPC], Standard lipid lowering therapy
- Where
- 3 sites in Germany
- Volunteers
- 1,695 people
- Sponsor
- GWT-TUD GmbH
Cardiovascular Diseases, Hyperlipidemias
Effect of n-3 Fatty Acid Supplementation in Hyperlipidemic Patients Taking Statins
Epidemiological and clinical evidence suggests that high-dose intake of long-chain n-3 fatty acids have a favorable role in altering blood TG and non-HDL cholesterol when combined with statins in hyperlipidemic patients.
- Conditions
- Cardiovascular Diseases, Hyperlipidemias, Dyslipidemias
- Trial name
- NCT03961763
- Testing
- EPA+DHA
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- University of Chester
Hypercholesterolemia
Efficacy of a One-a-Day L. Reuteri NCIMB 30242 Probiotic Supplement Capsule
Background: In recent years, probiotics have shown promise in treating a variety of diseases. Previously, the investigators have reported on the clinical efficacy of Lactobacillus reuteri NCIMB 30242 in improving the lipid…
- Trial name
- NCT01630668
- Testing
- One-a-Day L. reuteri NCIMB 30242 supplement capsule
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Micropharma Limited
Familial Hypercholesterolemia, Nutrition, Healthy
Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia.
The investigators will conduct a fully controlled dietary randomized crossover trial (RCT) including 10 adults with HeFH using lipid-lowering medication to investigate the impact of a diet low in red and processed meats and high…
- Conditions
- Familial Hypercholesterolemia, Nutrition, Healthy, Cholesterol, Elevated
- Trial name
- NCT06389825
- Testing
- Healthy diet
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Laval University
Obesity, Hypercholesterolemia
Improving the Management of Obesity in Primary Care Practice (The Power-UP Trial)
The purpose of the study is to compare three methods of achieving weight loss in primary care medical practice. The study will be conducted in six primary care practices.
- Conditions
- Obesity, Hypercholesterolemia, Metabolic Syndrome, Hypertension
- Trial name
- Power-UP (NCT00826774)
- Testing
- Usual Care, Brief Lifestyle Counseling, Enhanced Brief Lifestyle Counseling
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Overweight, Hypercholesterolemia
Supplementation of Alpha-linolenic Acid (ALA)-Rich Oil in Humans
The objective of this study is to investigate the accumulation of n-3 LC-PUFA (EPA, DPA and DHA) in human lipids by oral supplementation of ALA-rich linseed oil.
- Trial name
- ALA_KK (NCT01317290)
- Testing
- n-3 PUFA free olive oil, linseed oil
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Jena
Acute Kidney Injury, Arterial Hypertension
Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients
To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.
- Conditions
- Acute Kidney Injury, Arterial Hypertension, Obesity, Cardio Vascular Disease
- Trial name
- NCT02499185
- Testing
- Nephro Check Test, serum creatinine measurement
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Hypercholesterolemia, Cognitive Dysfunction
The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions
The study evaluates if the relationship between total serum cholesterol is dependent on the total serum homocysteine. Fasting blood samples will taken from participants and two batteries of cognitive scales will be used to asses…
- Conditions
- Hypercholesterolemia, Cognitive Dysfunction, Hyperhomocysteinemia
- Trial name
- NCT03631238
- Testing
- Blood sampling for total cholesterol and homocysteine and cognitive assessment by psychometric tests.
- Where
- Egypt
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bone Diseases, Cardiovascular Diseases
Postmenopausal Estrogen/Progestin Interventions (PEPI)
To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on…
- Conditions
- Bone Diseases, Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus
- Trial name
- NCT00000466
- Testing
- estrogens, conjugated, medroxyprogesterone, progesterone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypercholesterolemia
A Phase III Confirmatory Study of K-877 (Pemafibrate) in Patients With Hypercholesterolemia and Statin Intolerance
To investigate the efficacy and safety of K-877 Extended Release 0.2 mg/day or 0.4 mg/day for 12 weeks in patients with Statin Intolerant* Hypercholesterolemia,using placebo as a controll.
- Trial name
- NCT05923281
- Testing
- K-877 0.2 mg/day (once daily), K-877 0.4 mg/day (once daily)
- Where
- 22 sites in Japan
- Volunteers
- 71 people
- Sponsor
- Kowa Company, Ltd.
Heart Transplantation, Hypercholesterolemia
Fluvastatin After Heart Transplantation
Statin therapy is a treatment with a proven positive impact on survival after heart transplantation. However, it is unclear whether the beneficial effect of this class of drugs depends solely on their LDL-lowering properties or…
- Trial name
- NCT00421005
- Testing
- fluvastatin
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Bologna
HIV Infections, Lipodystrophy
Safety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood Lipids
The purpose of this study is to compare the safety and effectiveness of fenofibrate and pravastatin in treating HIV-positive patients who have abnormal levels of fat (lipids) in the blood.
- Trial name
- NCT00006412
- Testing
- Pravastatin sodium, Fenofibrate
- Where
- 58 sites in United States, Puerto Rico
- Volunteers
- 630 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity, Diabetes
Differential Metabolism of Dietary Fatty Acids
Differences in how diet fats are converted to energy could explain some of the reported differences in health effects among different classes of dietary fat (e.g. monounsaturated vs. saturated).
- Conditions
- Obesity, Diabetes, Hyperlipidemia
- Trial name
- NCT00059254
- Testing
- Oleic acid (OA), Palmitic Acid (PA)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Effect of Milk and Cheese on Fecal Fat Excretion and Blood Lipid
The aim is to study the effect of milk versus cheese on fecal fat excretion and blood lipids. To do this, a randomized crossover intervention study with 3 14-day periods (control diet, milk diet, cheese diet) will be conducted in…
- Trial name
- MOFF (NCT01317251)
- Testing
- Dietary intervention (without dairy products), Dietary intervention (high milk content), Dietary intervention (high cheese content)
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Coronary Artery Disease, Hyperlipidemia
Evaluation of Statin-induced Lipid-rich Plaque Progression by Optical Coherence Tomography (OCT) Combined With Intravascular Ultrasound (IVUS)
Many trials suggested that lipid lowering therapy could significantly reduce cardiovascular events. Enhancing stability of vulnerable plaque is probably the main reason by which statins reduce adverse coronary events.
- Trial name
- NCT01023607
- Testing
- Atorvastatin, Rosuvastatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Harbin Medical University
Obesity, Hyperlipidemias
Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)
This study aims to investigate the change in systemic exposure of simvastatin post LSG.
- Trial name
- NCT03571802
- Testing
- Simvastatin
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- National University Hospital, Singapore
Dyslipidemias
To Assess the Safety, Efficacy and Tolerability of CKD-519, Administered With HMG-CoA Reductase Inhibitors
A multicenter, double-blind, parallel-group, active-controlled, dose-ranging study to assess the safety and efficacy of the novel cholesteryl ester transfer protein (CETP) inhibitor CKD-519 in combination with atorvastatin or…
- Trial name
- NCT02977065
- Testing
- Atorvastatin 20mg, Atorvastatin 20 mg + CKD-519 50 mg, Atorvastatin 20 mg + CKD-519 100 mg
- Where
- Australia
- Volunteers
- 62 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Diabetes Mellitus, Dyslipidemia
Effect of a Decision Aid About Statin Use in Patients With Type 2 Diabetes Mellitus
Background- Statins are a safe and effective therapy to reduce cardiovascular risk in patients with type 2 diabetes; however some patients are not prescribed statins, others do not take it even after being prescribed, and others…
- Conditions
- Diabetes Mellitus, Dyslipidemia, Hypercholesterolemia, Cardiovascular Disease
- Trial name
- NCT00217061
- Testing
- Decision Aid Statin Choice
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Mayo Clinic
Hypercholesteremia
C-Control: Efficacy and Safety of Therapy With Rosuvastatin in Statin-Naive and in Statin-Switched Patients
The study explores efficacy and safety of the lipid-lowering therapy with CRESTOR in statin-naive patients and in patients with previously unsuccessful statin therapy.
- Trial name
- NCT00688454
- Volunteers
- 3,392 people
- Sponsor
- AstraZeneca
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