Clinical trials: Lipemia
Hypercholesterolemia
Genome-wide Analysis of Lipid-lowering Efficacy and Drug Level of Simvastatin and Rosuvastatin
This study will perform a genome-wide association study (GWAS) of the lipid responses to rosuvastatin and simvastatin and plasma concentrations of these two statins in a homogeneous group of Han Chinese patients.
- Trial name
- NCT04921657
- Testing
- Rosuvastatin 10mg
- Where
- Hong Kong
- Volunteers
- 362 people
- Sponsor
- Chinese University of Hong Kong
Hypercholesteremia
Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin Therapy
The primary objective of the study is to compare the efficacy of rosuvastatin 10 mg with atorvastatin 10 mg by assessment of the percentage of subjects who reach EAS LDL-C target goals after 12 weeks of therapy.
- Trial name
- NCT00239330
- Testing
- Rosuvastatin, Atorvastatin
- Where
- 26 sites in Belgium
- Volunteers
- 824 people
- Sponsor
- AstraZeneca
Symptomatic Carotid Stenosis, Hypercholesterolemia
The Multicenter Atorvastatin Plaque Stabilization (MAPS) Study
The impact on cardiovascular events achieved by statin therapy seems to be mostly attributable to the cholesterol-lowering effect with a highly debated contribution of the lipid-independent pleiotropic effects.
- Conditions
- Symptomatic Carotid Stenosis, Hypercholesterolemia, Indication for Carotid Endarterectomy
- Trial name
- MAPS (NCT01053065)
- Testing
- Atorvastatin - Cholestyramine - Sitosterol
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
Severe Hypertriglyceridemia During Pregnancy
Safety Study of Fenofibrate During Pregnancy
The purpose of this study is to evaluate the safety of fenofibrate in severe hypertriglyceridemia pregnant women.
- Trial name
- NCT05883865
- Testing
- Fenofibrate
- Where
- China
- Volunteers
- 250 people
- Sponsor
- First People's Hospital of Hangzhou
Hypercholesterolemia
Kefir Cholesterol Lowering Pilot Study
High cholesterol (a type of fat in humans blood) may be one factor that can lead to heart disease. If people have higher cholesterol, it is possible that kefir (a food similar to yogurt) may help to control blood cholesterol…
- Trial name
- NCT04247139
- Testing
- Kefir
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypercholesterolemia
A Study to Investigate the Safety, Tolerability, Immunogenicity, and Pharmacodynamics of VXX-401 Administered IM in Adult Participants
This first-in-human (FIH) study of VXX-401, an anti-PCSK9 peptide-based immunotherapeutic candidate, is designed to assess the safety, tolerability, immunogenicity, and pharmacodynamics (PD) of VXX-401 and to determine an optimal…
- Trial name
- NCT05762276
- Testing
- VXX-401
- Where
- 5 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vaxxinity, Inc.
Hypercholesterolemia
To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)
To evaluate the efficacy and safety of ezetimibe/simvastatin and niacin in patients with high cholesterol.
- Trial name
- NCT00271817
- Testing
- Comparator: ezetimibe/simvastatin + niacin (ER), Comparator: niacin (ER) tablet, Comparator: ezetimibe (+) simvastatin
- Volunteers
- 1,220 people
- Sponsor
- Organon and Co
Hypercholesterolemia
Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR)
The purpose of this study is to compare the efficacy and safety of rosuvastatin with simvastatin and atorvastatin in reducing levels of low density lipoprotein cholesterol in subjects with hypercholesterolaemia
- Trial name
- SOLAR (NCT00654173)
- Testing
- Rosuvastatin, Simvastatin, Atorvastatin
- Volunteers
- 4,444 people
- Sponsor
- AstraZeneca
Acute Pancreatitis
Plasma Exchange vs Conservative Management in Non-severe Acute Hypertriglyceridemic Pancreatitis
To compare effectiveness in reducing triglycerides between daily plasma exchange and glucose+insulin infusion in patients with non-severe acute hypertriglyceridemic pancreatitis with mildly elevated triglycerides
- Trial name
- NCT02622854
- Testing
- plasma exchange, conservative treatment
- Where
- Slovenia
- Volunteers
- 22 people
- Sponsor
- University Medical Centre Ljubljana
Hypertriglyceridemia
Efficacy and Safety Study of DHA-O in Adults With Hypertriglyceridemia
The purpose of this study is to investigate the efficacy and safety of DHA-O to lower elevated triglyceride levels in healthy adults with hypertriglyceridemia.
- Trial name
- DHA-O (NCT01737099)
- Testing
- DHA-O, Fish oil
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Cardiovascular, Metabolic Disease
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
This is a single-arm, open-label, multicenter, ascending dose Phase 1 trial that will enroll participants 18 to 75 years of age with dyslipidemias that are refractory to available treatments.
- Conditions
- Cardiovascular, Metabolic Disease, Dyslipidemias, Lipid Disorder
- Trial name
- NCT07491172
- Testing
- CTX310
- Where
- 17 sites in United States, Australia and 2 more
- Volunteers
- 90 people
- Sponsor
- CRISPR Therapeutics AG
Hyperlipidemia
Biosynthesis of PGD2 in Vivo
The investigator would like to see if aspirin could block niacin-induced flushing by analyzing blood and urine after taking aspirin. Phase I: Subjects were assigned to either placebo or aspirin groups.
- Trial name
- NCT01275300
- Testing
- Aspirin, Niacin
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Thyroid Associated Ophthalmopathy, Hypercholesterolemia
Effects of Atorvastatin in Graves' Orbitopathy (GO)
Graves' orbitopathy (GO) is the most common extra-thyroidal manifestation of Graves' disease (GD), being observed in ~25% of patients.
- Trial name
- STAGO (NCT03110848)
- Testing
- Atorvastatin, Methylprednisolone
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University of Pisa
Hypertension, Hyperlipidemia
Efficacy and Safety of Irbesartan and Atorvastatin in Hypertension and Hyperlipidemia
The purpose of this study is to evaluate efficacy and safety of coadministered Irbesartan and Atorvastatin in patients with hypertension and hyperlipidemia.
- Trial name
- NCT01442987
- Testing
- Irbesartan/Atorvastatin A, Irbesartan, Atorvastatin A
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Obesity, Hyperlipidemia
A Study on Efficacy and Safety of Topiramate in Treatment of Obese Subjects With Dyslipidemia
The purpose of this study is to compare the efficacy and safety of daily topiramate versus placebo for the treatment of obese subjects with dyslipidemia.
- Conditions
- Obesity, Hyperlipidemia, Hypertriglyceridemia
- Trial name
- NCT00231621
- Testing
- topiramate
- Volunteers
- 179 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy Volunteers; High Cholesterol
A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation II
In this study, the study drug 'NNC0385-0434' will be tested in 3 different tablet formulations. These formulations are being tested for the treatment of hypercholesterolemia (high cholesterol).
- Trial name
- NCT05333107
- Testing
- NNC0385-0434 G, NNC0385-0434 F, NNC0385-0434 B
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Hypertension, Diabetes
Medication Adherence With Polyglot Meducation
The investigators propose a 6 month pre-post, pilot,feasibility study with up to 25 individuals among veterans with cardiovascular disease risk factors including Hypertension (HT), Diabetes Mellitis (DM) and Hyperlipidemia (HL)…
- Conditions
- Hypertension, Diabetes, Hypercholesterolemia
- Trial name
- NCT01744392
- Testing
- education intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Durham VA Medical Center
Hypercholesterolemia, Dyslipidemias
A Study on Efficacy and Safety of HST101 in Chinese Patients with Hypercholesterolemia
This randomized study is to assess LDL-C reductions at Week 12 with monthly (Q4W [≤31 days]) dosing of HST101 (lerodalcibep) 300 mg administered subcutaneously (SC) compared to placebo in patients with atherosclerotic…
- Conditions
- Hypercholesterolemia, Dyslipidemias, Primary Hypercholesterolemia, Heterozygous Familial Hypercholesterolemia
- Trial name
- NCT06568471
- Testing
- Lerodalcibep
- Where
- 18 sites in China
- Volunteers
- 210 people
- Sponsor
- Hasten Biopharmaceutical Co., Ltd.
Hypercholesterolemia
Vascular and Metabolic Effects of Vytorin vs Simvastatin
The investigators hypothesize that vytorin will improve insulin resistance compared with simvastatin
- Trial name
- NCT01666067
- Testing
- vytorin, simvastatin
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Gachon University Gil Medical Center
Chronic Condition
Digital Solution for Salutogenic Brain Health (DiSaB): A Pilot Protocol for Clinical Implementation
The goal of this clinical trial is to develop and learn if a digitally delivered brain health intervention (DiSaB) can help improve cognitive, physical and psychosocial health in middle-aged adults with chronic conditions at-risk…
- Trial name
- DiSaB (NCT06582316)
- Testing
- Brain Health Training Programme
- Where
- Singapore
- Volunteers
- 160 people
- Sponsor
- National University of Singapore
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