Clinical trials: Lipids Metabolism
Hyperglycaemia (Diabetic), Hyperlipidemias
The Effect of Omega-3 FA on Glucose and Lipid Homeostasis Disorders in Obese/Diabetic Patients
A double-blind and placebo-controlled study is conducted in the current human study. The purpose of this study is to investigate the effects of n-3 PUFA intervention on glucose and lipid homeostasis in Chinese diabetic/obese…
- Trial name
- NCT03708887
- Testing
- Low dose omega-3 fatty acid supplementation, High dose omega-3 fatty acid supplementation, Control drug
- Where
- China
- Volunteers
- 415 people
- Sponsor
- Zhejiang University
Diabete Mellitus, Lipid Profile
Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers
This Phase I randomized clinical trial aims to investigate the short-term effects of three commonly prescribed statins (atorvastatin, rosuvastatin, and simvastatin) at different dose levels on blood glucose homeostasis in healthy…
- Trial name
- [Statins] (NCT07378293)
- Testing
- Simvastatin (10mg, 20mg, 40mg), Rosuvastatin (5mg, 20mg, 40mg), Atorvastatin (10mg, 20mg, 40mg)
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaheed Benazir Bhutto University Sheringal Dir Upper
Cardiovascular Diseases, Hypertension
Developing a Learning COmmunity to Increase eNgagemeNt and Enrollment in Cardiovascular Clinical Trials (CONNECT)
The CONNECT: "Developing a learning COmmunity to increase eNgagemeNt and Enrollment in cardiovascular Clinical Trials" is comprehensive, participant-centered learning platform designed to increase diversity in cardiovascular…
- Conditions
- Cardiovascular Diseases, Hypertension, Diabetes Type 2, Stroke
- Trial name
- CONNECT (NCT06347484)
- Testing
- EHR-informed Recruitment Method of Contact, Educational Text-Messages and Connection to Cardiovascular Research Opportunities
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
End Stage Renal Disease
Effect of Omega-3 Fatty Acids on Oxidative Stress and Dyslipidemia in Pediatric Patients Undergoing Hemodialysis
The purpose of the study is to evaluate the effect of omega-3 fatty acids supplementation on pediatric patients undergoing hemodialysis via the measurement of the following before and after omega-3 administration:oxidative stress…
- Trial name
- NCT02581449
- Testing
- omega-3, empty soft gelatin capsules
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Hypertriglyceridemias
Effects of Monascus Garlic Fermented Extract on Serum Triglyceride Level
The purpose of the study is to determine the effect of monascus garlic fermented extract on serum lipid concentrations in subjects with moderately elevated serum triglyceride.
- Trial name
- NCT00938249
- Testing
- Monascus Garlic Fermented Extract
- Where
- Japan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Hyperlipidemia, Medication Nonadherence
AdLip: Human Coach-supported Digital/AI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medication
Investigators hypothesize that the use of a human coach-supported digital/AI personal health assistant (app) will improve adherence to cholesterol-lowering medications (statins with or without ezetimibe) among patients with…
- Trial name
- AdLip (NCT06614049)
- Testing
- Human Coach-supported Digital/AI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medications
- Where
- 2 sites in Singapore
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Hypercholesterolemia
LDL-cholesterol Lowering Effect of a New Dietary Supplement
The aim of this study was to assess the lipid-lowering activity and safety of a dietary supplement containing monacolin K, L-arginine, coenzyme Q10 and ascorbic acid (vitamin C).
- Trial name
- NCT03425630
- Testing
- Argicolina, Normolip
- Volunteers
- 20 people
- Sponsor
- Ispharm srl
HIV Infections, Lipid Metabolism
Pravastatin for Hyperlipidaemia in HIV.
This study is a randomised, placebo-controlled study of the effect of treatment with the HMG-CoA reductase inhibitor, pravastatin, in HIV-infected, protease inhibitor treated patients with high serum cholesterol.
- Conditions
- HIV Infections, Lipid Metabolism, Glucose Metabolism, Metabolic Abnormality
- Trial name
- NCT00227500
- Testing
- Pravastatin
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Kirby Institute
Gaucher Disease Type 1
A Second-generation AI Based Therapeutic Regimen in Patients With Gaucher Disease Treated With Enzyme Replacement Therapy.
An open-labeled, prospective, single-center proof-of-concept study. Patients with Gaucher Disease aged 18-75 who received intravenous Enzyme Replacement Therapy once every two weeks were enrolled.
- Trial name
- NCT06050967
- Testing
- Enzyme replacement therapy for Gaucher disease in combination with altus care application
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Hypertriglyceridemia, Overweight or Obesity
Intermittent Fasting in Hypertriglyceridemic Overweight or Obese Subjects
some studies have shown similar effects of intermittent fasting and continuous caloric restriction on body weight and plasma lipid profile, but there is still a wide controversy.
- Trial name
- NCT04143971
- Testing
- intermittent fasting diet, low calorie diet
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University
Cardiovascular Risk Factor, Lipemia
Postprandial Monocyte Maturation and Vascular Dysfunction Following High-Fat Meals - Study 1
The purpose of this research study is to examine the effect of high-fat meals on the health of blood vessels. In addition, the study will examine how exercise/fitness/physical activity impacts blood vessels after consumption of a…
- Trial name
- NCT03958734
- Testing
- High-fat meal
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Hyperlipidemia, Atherosclerotic Cardiovascular Disease (ASCVD)
PCSK9 Inhibitors in Hyperlipidemia and Atherosclerosis
PCSK9 inhibitors, including evolocumab and alirocumab, are lipid-lowering therapies used in patients with hyperlipidemia and atherosclerotic cardiovascular disease.
- Trial name
- NCT07856264
- Volunteers
- 100 people
- Sponsor
- Fundación Santa Fe de Bogota
Obesity & Overweight
Effects of Exercise on Lipids and Endothelial Function in Youth
This study is for individuals who have a BMI that is at or above the 95th percentile and are participating in the Cincinnati Children's Hospital Healthworks! Structured weight loss program.
- Trial name
- NCT07409064
- Testing
- Exercise Program
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiometabolic Conditions, Hypertension (HTN)
To Test the Effectiveness and Implementation Approach of a 3-month PILI Pasifika Program Lifestyle Program With Components of Social Determinants of Health Activities in Real-world Settings (Clinical and Non-clinical Settings) Across 3 Years
In this study, the investigators are conducting a Type 3 hybrid effectiveness-implementation trial to evaluate the implementation of the Community Health Workers (CHW)-delivered PILI Pasifika Program (PPP) across 3 regions, the…
- Conditions
- Cardiometabolic Conditions, Hypertension (HTN), Dyslipidemia, Pre-diabetes
- Trial name
- NCT07387393
- Testing
- PILI (Partnership for Improving Lifestyle Intervention) Pasifika Program
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Hawaii
Gaucher Disease, Type 3
Efficacy and Safety Study of Velaglucerase Alfa in Children and Adolescents With Type 3 Gaucher Disease
Gaucher disease is a rare lysosomal storage disorder caused by the deficiency of the enzyme glucocerebrosidase (GCB). Gaucher disease has been classified into 3 clinical subtypes based on the presence or absence of neurological…
- Trial name
- NCT01685216
- Testing
- velaglucerase alfa
- Where
- 5 sites in Egypt, India and 1 more
- Volunteers
- 7 people
- Sponsor
- Shire
Obesity, Cardiovascular Risk Factor
Dietary Sources of Lysophospholipids
This study aims to test the hypothesis that dietary intake of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) acutely alters plasma lysophosphatidic acid (LPA) levels and autotaxin activity in normal weight and obese…
- Conditions
- Obesity, Cardiovascular Risk Factor, Hyperlipidemia
- Trial name
- NCT02952638
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Susan Smyth
Obesity
Comparison Of Uninclined And Inclined Treadmill Training In Obese Adults.
The goal of this clinical trial is to compare the effects of inclined and uninclined treadmill training on total body fat, lipid profile and quality of life in obese adults.
- Trial name
- NCT05854732
- Testing
- Inclined Treadmill Training, Uninclined Treadmill Training
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Hypercholesterolemia
A Study to Evaluate the Effects of Extended Release (ER) Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites in Subjects With High Cholesterol (0524A-075)(COMPLETED)
The purpose of this study is to evaluate the potential effects of ER niacin/laropiprant, ER niacin, laropiprant, and placebo over the course of seven days on urinary levels of a metabolite of thromboxane A2 (TxA2), as a marker of…
- Trial name
- NCT00769132
- Testing
- Comparator: niacin + laropiprant, Comparator: niacin, Comparator: laropiprant
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hypercholesterolemia, Medication Adherence
Effectiveness of a Combined Strategy to Improve Therapeutic Compliance and Degree of Control Among Patients With Hypercholesterolaemia
Background In subjects with hypercholesterolaemia, cholesterol values remain above guideline levels. One of the limiting factors to the achievement of goals in such patients is therapeutic non-adherence.
- Conditions
- Hypercholesterolemia, Medication Adherence, Primary Health Care
- Trial name
- EFESCOM (NCT02314663)
- Testing
- "COMBINED STRATEGY"
- Volunteers
- 358 people
- Sponsor
- Gerencia de Atención Primaria, Albacete
Chronic Myeloid Leukemia
Impact of Tyrosine Kinase Inhibitors on Glucose Level and Lipid Metabolism in Chronic Myeloid Leukemia Patients
to known the impact of drugs that used in CML pt as TKIs on glucose and lipid metabolism
- Trial name
- NCT07413263
- Testing
- Tyrosine kinase Inhibitors (Imatinib & Nilotinib)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University