Clinical trials: Live Birth
Embryo Growth Disorder, Humans
Impact of PH Values of the Embryo Culture Medium on Success of in Vitro Fertilization (IVF)
The objective of this study is to compare, through a multicentric randomized trial, the impact of two pH values in the embryo culture medium on the clinical results of In Vitro Fertilization (IVF) process and especially the…
- Conditions
- Embryo Growth Disorder, Humans, Pregnancy
- Trial name
- ACIDOFIV (NCT04456478)
- Testing
- pH at 7.38 ± 0.02, pH at 7.22 ± 0.02
- Where
- 3 sites in France
- Volunteers
- 429 people
- Sponsor
- University Hospital, Toulouse
Recurrent Pregnancy Loss
Prospective Recurrent Pregnancy Loss Registry
The purpose of this Registry is to prospectively collect data of Recurrent Pregnancy Loss (RPL) patients attending the specialized care centre at the BC Women's Hospital, in order to evaluate investigation practices, treatment…
- Trial name
- NCT05989178
- Testing
- Data Registry
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- University of British Columbia
Sterility
To Investigate the Cumulative Live Birth Rates Using GnRH Antagonist or Agonist Protocol for COS in ART Treatment
This is a Phase IV, prospective, randomized controlled study to investigate the cumulative live birth rates (CLBRs) of gonadotrophin-releasing hormone (GnRH) antagonist protocol (GnRH-ant group) compared with the standard GnRH…
- Trial name
- CLBR (NCT04026282)
- Testing
- GnRH-ant protocol, GnRH-a long protocol
- Where
- 4 sites in China
- Volunteers
- 888 people
- Sponsor
- Peking University Third Hospital
IVF, GnRH Antagonist
Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
Progestin can inhibit the pituitary LH surge during ovarian stimulation and various studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF.
- Conditions
- IVF, GnRH Antagonist, PPOS
- Trial name
- NCT04414761
- Testing
- Progesterone, GnRH Antagonist
- Where
- China
- Volunteers
- 784 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Polycystic Ovary Syndrome
CRD vs. Met in Patients With Obese PCOS Infertility
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease and a major cause of anovulatory infertility in reproductive-aged women.
- Trial name
- NCT06049186
- Testing
- CRD, Metformin
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Prematurity
Short-term Effects of Live Music in Preterm Infants
The purpose of this study is to determine the effects of pentatonic live music on physiological parameters in preterm infants.
- Trial name
- MTN05 (NCT01908244)
- Testing
- Music
- Where
- 2 sites in Germany
- Volunteers
- 21 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
IVF, Frozen Embryo Transfer
A Randomized Trial Comparing the Live Birth Rate of Immediate Versus Delayed FET Following a Freeze-all Strategy
This randomized trial we aim to compare the live birth rate of immediate versus delayed FET replacing a single blastocyst in the first FET of the first stimulated IVF cycle following.
- Trial name
- FET (NCT04371783)
- Testing
- Immediate FET, Delayed FET
- Where
- China
- Volunteers
- 828 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Pregnancy
Idealizing Pregnancy Outcome With Single Blastocyst Transfer in a FET Cycle
Single embryo transfer (SET) has been advocated as a means of reducing the risk of multiple pregnancies, but has meant a reduction in pregnancy risk per embryo transfer.
- Trial name
- NCT01987856
- Testing
- Blastocyst morphology
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Antalya IVF
Infertility
Impact of Sequential Double Embryo Transfer on Live Birth Rates: A Case-Control Study.
The main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART).
- Trial name
- SEQ-ET (NCT07499453)
- Where
- France
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Hopital Pierre Rouques - Les Bluets
Infertility, Female, Mitochondrial
Automitochondrial Transplantation Improves Live Birth in Elderly Patients With Low Prognosis After Repeated IVF Failure
The goal to this clinical trial is to study the effectiveness and safety of automitochondrial transplantation of urine derived stem cells(USCs) in in elderly patients with low prognosis after repeated IVF failure.
- Conditions
- Infertility, Female, Mitochondrial, Elderly, Assisted Reproductive Technique
- Trial name
- ACTILB (NCT06020742)
- Testing
- Autologous USC mitochondrial oocyte transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
In Vitro Fertilisation, Environmental Conditions
Influence of Environmental Conditions on In Vitro Fertilization (IVF) Attempts and Induced Pregnancies
The main purpose of the study is to assess the impact of environmental conditions on live-birth rates after intraconjugal IVF. The second purposes are to assess the impact on pregnancies (prematurity, preeclampsia); to assess the…
- Trial name
- MeteoFIV (NCT02236780)
- Where
- France
- Volunteers
- 24,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, Pregnancy Outcome, Live Birth
in Vitro Fertilization (IVF) Media Protein and Live Birth Rates
Human conception in vivo occurs in a complex milieu that includes proteins. It has been speculated that the addition of proteins more complex than human serum albumin to culture media may improve IVF outcomes.
- Conditions
- Infertility, Pregnancy Outcome, Live Birth, In Vitro Fertilization
- Trial name
- SSS (NCT00708383)
- Testing
- 10% SSS embryo culture medium protein supplementation, 0.5% HSA embryo culture medium protein supplementation
- Where
- 2 sites in United States
- Volunteers
- 538 people
- Sponsor
- Texas Health Resources
Endometrioma, Infertility
Ethanol Sclerotherapy Prior to ART
The goal of this randomized controlled trial is to assess the impact of ethanol sclerotherapy on ART cycle outcomes. The main questions it aims to answer are: 1.
- Conditions
- Endometrioma, Infertility, Sclerotherapy, ART
- Trial name
- START (NCT05962775)
- Testing
- Ethanol Sclerotherapy for Endometrioma
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Infertility
Cumulative Live Birth Rates in Dual Ovarian Stimulation Versus Two Antagonist Stimulations in Poor Ovarian Responders
To compare the difference in cumulative live birth rates between dual ovarian stimulation and two antagonist stimulations in poor ovarian responders.
- Trial name
- NCT06093984
- Testing
- duostim vs. two antagonist ovarian stimulations
- Volunteers
- 260 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Infertility
Evaluation of the Impact of Reduced Oxygen Concentration on Live Birth Rate
Clinical in vitro fertilization relies on successful embryo culture. The primary goal of embryo culture is to attempt to recapitulate the in vivo conditions as much as possible.
- Trial name
- NCT03147872
- Testing
- 2% Oxygen
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Pregnancy, Live Birth
Folic Acid and Zinc Supplementation Trial (FAZST)
The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to…
- Conditions
- Pregnancy, Live Birth, Spontaneous Abortion
- Trial name
- FAZST (NCT01857310)
- Testing
- 5 mg folic acid and 30 mg elemental zinc
- Where
- 4 sites in United States
- Volunteers
- 2,370 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Preterm Birth
Music Intervention for Preterm Birth
This study will test a music intervention (MI) versus a sham control (SC) arm which only includes a verbal intervention, to determine if the effects of the music intervention will reduce the biological impact of chronic stress…
- Trial name
- NCT05945264
- Testing
- Music Intervention (MI)
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Columbia University
Infertility, Pregnancy Rate, Live Birth
Live Births With Low Oxygen Blastocyst Culture
The potentially damaging effect of free O2 radicals to cultured embryos may be reduced by adding scavengers to the culture media or by reducing the incubator O2 levels.
- Conditions
- Infertility, Pregnancy Rate, Live Birth, In Vitro Fertilization
- Trial name
- Oxygen (NCT00708487)
- Testing
- Embryo incubator oxygen concentration
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Texas Health Resources
Repetition Failure
Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality.
Embryo quality was ranked as one of the most important predictors in determining the success of implantation, while clinically some patients may experience repeated IVF failure due to persistent poor embryo quality.Mitochondria…
- Trial name
- NCT03639506
- Testing
- autologous mitochondria transplantation, autologous mitochondria from bone marrow mesenchymal stem cells into oocyte as well as intracytoplasmic sperm injection (ICSI), intracytoplasmic sperm injection (ICSI)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infertility
Humidified Culture and Live Birth After ICSI
Humidity for human embryo culture has been raised as essential with advantageous effect on clinical pregnancy and ongoing pregnancy after ICSI compared with a dry incubator.
- Trial name
- NCT03823235
- Testing
- Human embryo culture
- Where
- 3 sites in Egypt
- Volunteers
- 1,837 people
- Sponsor
- Ibn Sina Hospital