Clinical trials: Live Birth Rate
Infertility
A Phase IV, Prospective, Observational, Open Label, Single Centre Cohort Trial to be Conducted in Norway During One Year to Assess the Cumulative Pregnancy Rate in a New Series of In-vitro Fertilization (IVF) Treatment Cycles Following Three or More Previous IVF Treatment Cycles Without Live Birth
The primary objective of this observational study is to assess the cumulative rate of ongoing pregnancy at 10 ±2 weeks after hCG administration in a new series of IVF-treatment cycles in a total of 176 subjects, who have…
- Trial name
- NCT01071148
- Where
- Norway
- Volunteers
- 166 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Sperm Motility and IUI Live Birth Rate
This prospective cohort study aims to establish a cut-off threshold for pre-washed total rapidly motile sperm count (TRMSC) based on WHO 2021 criteria to predict the live birth rate following intrauterine insemination (IUI).
- Trial name
- IUI (NCT06117995)
- Testing
- Assessment the pre-washed sperm motility before IUI
- Volunteers
- 536 people
- Sponsor
- Mỹ Đức Hospital
Poor Response to Ovulation Induction, Infertility, Female
Optimal Embryonic Stage for Transfer in Poor Responders
A Prospective cohort study including couples with poor responder females who undergoing ICSI
- Trial name
- NCT04485819
- Testing
- Cleavage stage transfer, Blast stage transfer
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ganin Fertility Center
Infertility, Preimplantation Genetic Screening
Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )
This is a single centre retrospective study in repeated implantation failure patients: < 39 years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred without implantation, absence of known causes of…
- Trial name
- NCT03001648
- Testing
- PGS (Preimplantation Genetic Screening) with trophectoderm biopsy
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundacion Dexeus
Infertility (IVF Patients), Infertility Treatment
Ketorolac Use and Fresh Embryo Transfer Outcomes
Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days…
- Conditions
- Infertility (IVF Patients), Infertility Treatment, Post-op Pain, Fresh Embryo Transfer
- Trial name
- NCT07185724
- Testing
- Ketorolac 30 mg IV
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jessica D. Kresowik
Embryo Growth Disorder, Humans
Impact of PH Values of the Embryo Culture Medium on Success of in Vitro Fertilization (IVF)
The objective of this study is to compare, through a multicentric randomized trial, the impact of two pH values in the embryo culture medium on the clinical results of In Vitro Fertilization (IVF) process and especially the…
- Conditions
- Embryo Growth Disorder, Humans, Pregnancy
- Trial name
- ACIDOFIV (NCT04456478)
- Testing
- pH at 7.38 ± 0.02, pH at 7.22 ± 0.02
- Where
- 3 sites in France
- Volunteers
- 429 people
- Sponsor
- University Hospital, Toulouse
Sterility
To Investigate the Cumulative Live Birth Rates Using GnRH Antagonist or Agonist Protocol for COS in ART Treatment
This is a Phase IV, prospective, randomized controlled study to investigate the cumulative live birth rates (CLBRs) of gonadotrophin-releasing hormone (GnRH) antagonist protocol (GnRH-ant group) compared with the standard GnRH…
- Trial name
- CLBR (NCT04026282)
- Testing
- GnRH-ant protocol, GnRH-a long protocol
- Where
- 4 sites in China
- Volunteers
- 888 people
- Sponsor
- Peking University Third Hospital
IVF, GnRH Antagonist
Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
Progestin can inhibit the pituitary LH surge during ovarian stimulation and various studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF.
- Conditions
- IVF, GnRH Antagonist, PPOS
- Trial name
- NCT04414761
- Testing
- Progesterone, GnRH Antagonist
- Where
- China
- Volunteers
- 784 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Polycystic Ovary Syndrome
CRD vs. Met in Patients With Obese PCOS Infertility
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease and a major cause of anovulatory infertility in reproductive-aged women.
- Trial name
- NCT06049186
- Testing
- CRD, Metformin
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
IVF, Frozen Embryo Transfer
A Randomized Trial Comparing the Live Birth Rate of Immediate Versus Delayed FET Following a Freeze-all Strategy
This randomized trial we aim to compare the live birth rate of immediate versus delayed FET replacing a single blastocyst in the first FET of the first stimulated IVF cycle following.
- Trial name
- FET (NCT04371783)
- Testing
- Immediate FET, Delayed FET
- Where
- China
- Volunteers
- 828 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility
Impact of Sequential Double Embryo Transfer on Live Birth Rates: A Case-Control Study.
The main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART).
- Trial name
- SEQ-ET (NCT07499453)
- Where
- France
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Hopital Pierre Rouques - Les Bluets
In Vitro Fertilisation, Environmental Conditions
Influence of Environmental Conditions on In Vitro Fertilization (IVF) Attempts and Induced Pregnancies
The main purpose of the study is to assess the impact of environmental conditions on live-birth rates after intraconjugal IVF. The second purposes are to assess the impact on pregnancies (prematurity, preeclampsia); to assess the…
- Trial name
- MeteoFIV (NCT02236780)
- Where
- France
- Volunteers
- 24,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, Pregnancy Outcome, Live Birth
in Vitro Fertilization (IVF) Media Protein and Live Birth Rates
Human conception in vivo occurs in a complex milieu that includes proteins. It has been speculated that the addition of proteins more complex than human serum albumin to culture media may improve IVF outcomes.
- Conditions
- Infertility, Pregnancy Outcome, Live Birth, In Vitro Fertilization
- Trial name
- SSS (NCT00708383)
- Testing
- 10% SSS embryo culture medium protein supplementation, 0.5% HSA embryo culture medium protein supplementation
- Where
- 2 sites in United States
- Volunteers
- 538 people
- Sponsor
- Texas Health Resources
Endometrioma, Infertility
Ethanol Sclerotherapy Prior to ART
The goal of this randomized controlled trial is to assess the impact of ethanol sclerotherapy on ART cycle outcomes. The main questions it aims to answer are: 1.
- Conditions
- Endometrioma, Infertility, Sclerotherapy, ART
- Trial name
- START (NCT05962775)
- Testing
- Ethanol Sclerotherapy for Endometrioma
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Infertility
Cumulative Live Birth Rates in Dual Ovarian Stimulation Versus Two Antagonist Stimulations in Poor Ovarian Responders
To compare the difference in cumulative live birth rates between dual ovarian stimulation and two antagonist stimulations in poor ovarian responders.
- Trial name
- NCT06093984
- Testing
- duostim vs. two antagonist ovarian stimulations
- Volunteers
- 260 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Infertility
Evaluation of the Impact of Reduced Oxygen Concentration on Live Birth Rate
Clinical in vitro fertilization relies on successful embryo culture. The primary goal of embryo culture is to attempt to recapitulate the in vivo conditions as much as possible.
- Trial name
- NCT03147872
- Testing
- 2% Oxygen
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility, Pregnancy Rate, Live Birth
Live Births With Low Oxygen Blastocyst Culture
The potentially damaging effect of free O2 radicals to cultured embryos may be reduced by adding scavengers to the culture media or by reducing the incubator O2 levels.
- Conditions
- Infertility, Pregnancy Rate, Live Birth, In Vitro Fertilization
- Trial name
- Oxygen (NCT00708487)
- Testing
- Embryo incubator oxygen concentration
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Texas Health Resources
Repetition Failure
Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality.
Embryo quality was ranked as one of the most important predictors in determining the success of implantation, while clinically some patients may experience repeated IVF failure due to persistent poor embryo quality.Mitochondria…
- Trial name
- NCT03639506
- Testing
- autologous mitochondria transplantation, autologous mitochondria from bone marrow mesenchymal stem cells into oocyte as well as intracytoplasmic sperm injection (ICSI), intracytoplasmic sperm injection (ICSI)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infertility
Humidified Culture and Live Birth After ICSI
Humidity for human embryo culture has been raised as essential with advantageous effect on clinical pregnancy and ongoing pregnancy after ICSI compared with a dry incubator.
- Trial name
- NCT03823235
- Testing
- Human embryo culture
- Where
- 3 sites in Egypt
- Volunteers
- 1,837 people
- Sponsor
- Ibn Sina Hospital
COVID-19, Frozen Embryo Transfer
The Impact of Past Coronavirus Disease 19 (COVID-19) Infection on the Live Birth Rates of Frozen Embryo Transfer Cycles
This is a prospective observational study. In this study, we aim to investigate the effect of a recent past Covid-19 infection on the live birth rate in the frozen embryo transfer cycles
- Trial name
- NCT05739019
- Testing
- frozen embryo transfer
- Where
- China
- Volunteers
- 820 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute