Clinical trials: Live Birth Rate
Fertility, In Vitro Fertilization
A Study Comparing a Shorter Exposure of Oocyte to Spermatozoa Versus a Standard Incubation on the Live Birth Rate of In-vitro Fertilization Treatment
In vitro fertilization (IVF) treatment is now commonly used to treat infertile couples. During IVF treatment, oocytes and sperm are routinely incubated overnight and this may lead to suboptimal culture conditions because of…
- Trial name
- NCT02534857
- Testing
- a shorter exposure of oocyte to spermatozoa
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
DNA Methylation
Preimplantation DNA Methylation Test (PIMT) in ART
The purpose of this clinical trial is to determine the safety and effect of methylation level of DNA methylation in embryos on the outcome of assisted reproductive technology (ART) during blastocyst embryo screening.
- Trial name
- NCT03642574
- Testing
- CNV
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Chen Zi-Jiang
Unexplained Infertility
Uterine Flushing With Human Chorionic Gonadotrophin and Unexplained Infertility
A prospective randomized study included 210 women with Unexplained infertility subjected to combined ovarian stimulation and Intrauterine insemination (IUI). Two equal groups.
- Trial name
- NCT03461601
- Testing
- HCG Uterine flushing, IUI, Vaginal flushing with 10 ml normal saline
- Volunteers
- 210 people
- Sponsor
- Ahmed Walid Anwar Murad
IVF, Frozen Embryo Transfer (FET)
Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET
The multi-step thawing protocol with a reduction of non-permeable cryoprotectant concentrations to reduce osmotic shock caused by the rapid influx of water.
- Conditions
- IVF, Frozen Embryo Transfer (FET), Embryo Thawing Protocol
- Trial name
- ONESTEP (NCT07088640)
- Testing
- Single-step warming protocol by thawing solution only, Standard warming protocol
- Where
- Vietnam
- Volunteers
- 816 people
- Sponsor
- Mỹ Đức Hospital
Duration of Estrogen Administration
The Impact of Estrogen Administration Duration in Hormonally Prepared Frozen Embryo Transfer Cycles
This prospective controlled study aimed to investigate the effect of the duration of estrogen (E2) administration prior to progesterone (P) initiation on live birth rates (LBR) in frozen embryo transfer (FET) cycles.
- Trial name
- NCT05825885
- Testing
- E2
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Akdeniz University
Covid-19 Vaccination
The Effect of Covid-19 Vaccination in Patients Undergoing IVF
Since emerging in the last months of 2019, over 127 000 000 individuals have suffered severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and the documented death toll from coronavirus disease 2019 (COVID-19)…
- Trial name
- Covid-19 (NCT05063942)
- Volunteers
- 712 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Infertility
Maternal and Fetal Compatibility in Assisted Reproductive Technology (ART)-Oocyte Donor Influences Live Birth Rate
Has the maternal KIR haplotype an impact in pregnancy, miscarriage and live birth rates per embryo transfer in donor oocytes -ART by paternal and oocyte donor HLA-C?
- Trial name
- NCT02718105
- Testing
- KIR HLAC determinations
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
IVF, Infertility
Comparing KIDScore™ D5 and iDAScore®. The KiDA Study
A pilot study to gather information on clinical pregnancy rates for preparation of the planning of a larger randomized controlled trial comparing two decision support tools: the deep learning tool iDAScore® and the current…
- Trial name
- NCT04956848
- Testing
- iDAScore®
- Where
- 2 sites in Sweden
- Volunteers
- 165 people
- Sponsor
- Vitrolife
IVF, Frozen Embryo Transfer
Lipiodol Prior to FET (LIFE)
Lipiodol® flushing is an effective fertility treatment for women with unexplained infertility. It is speculated that the treatment effect could work through a direct effect of Lipiodol® on the endometrium.
- Conditions
- IVF, Frozen Embryo Transfer, Hysterosalpingography
- Trial name
- LIFE (NCT06563908)
- Testing
- Lipiodol® uterine treatment prior to IVF/ICSI
- Volunteers
- 784 people
- Sponsor
- Mỹ Đức Hospital
In Vitro Fertilization
Acupuncture and Chinese Herbal Medicine to Improve Live Birth Rate of in Vitro Fertilization (IVFAct)
The most successful treatment for infertility is in vitro fertilization (IVF), but less than 10% of infertile couples undergo IVF because of the high cost and relatively low success rate.
- Trial name
- IVFAct (NCT04407871)
- Testing
- Acupuncture and Chinese Herbal Medicine
- Where
- 12 sites in China
- Volunteers
- 2,728 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Infertility, Female
The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
This randomized controlled trial aims to determine whether Erzhi Tiangui Formula can optimize the reproductive outcomes of elderly patients with expected poor ovarian response, and to provide a new approach to traditional Chinese…
- Trial name
- NCT05698550
- Testing
- Erzhi Tiangui Granule
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility
The Correlation Between Luteal Serum Progesterone and Live Birth Rate
The study design is an observational cohort study. Level of serum P4 will be collected on day OR+4 as well as on the day of embryo transfer (ET) either day OR+3 or OR+5.
- Trial name
- NCT05323513
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Peter Humaidan
Infertility, Female
MEDAM (Menopur Retrospective Data prograM)
French, non-interventional, retrospective, multicentric analysis of patients who have undergone a controlled ovarian stimulation (COS) for in-vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI).
- Trial name
- MEDAM (NCT04876300)
- Testing
- No intervention
- Where
- 10 sites in France
- Volunteers
- 11,488 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
Cumulative Live Birth After Double Stimulation Protocol Versus Antagonist Protocol for Poor Ovarian Responders
To compare the difference in cumulative live birth rates within one year between double stimulations protocol and two-cycle antagonist protocol in poor ovarian responders.
- Trial name
- NCT05765968
- Testing
- Double Stimulation Protocol, Antagonist Stimulation Protocol
- Where
- China
- Volunteers
- 1,198 people, healthy volunteers welcome
- Sponsor
- Shandong University
Infertility, Female, IVF
Effect of Intrauterine Administration of Autologous PBMC Modulated With IFNt on IVF Outcome
The goal of this clinical trial is to test the effect of modulated specialised immune cells isolated from the patients' own blood when administered to the uterus before embryo transfer on the IVF outcome (implantation, pregnancy…
- Trial name
- NCT05775198
- Testing
- PBMC immunomodulated with IFNt
- Where
- Bulgaria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nadezhda Women's Health Hospital
Diminished Ovarian Reserve (DOR), Infertility (IVF Patients)
RCT Study on the Effect of ETN on Live Birth Rate in DOR Patients Undergoing IVF-ET
The goal of this clinical trial is to examine the effect of ETN on live birth rate in patients with diminished ovarian reserve (DOR) undergoing in vitro fertilizitaion-embryo transfer (IVF-ET).
- Trial name
- ETN-LBR-DOR (NCT07769684)
- Testing
- electro-thumbtack needle (ETN) / thumbtack needle (TN)
- Where
- 4 sites in China
- Volunteers
- 406 people
- Sponsor
- Huazhong University of Science and Technology
Infertility
What Embryoselection for What Chance of Success ? EmbryoSelect Study
The aim of the research is to evaluate the results of the first in vitro fertilization (IVF) attempt according to the type of embryo culture.
- Trial name
- EmbryoSelect (NCT04484181)
- Testing
- Embryo culture in time lapse technology (TLT), Embryo culture in conventional incubator
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Bordeaux
Fertility Preservation, Cancer Remission
Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.
- Conditions
- Fertility Preservation, Cancer Remission, Reproductive Outcomes, Reproductive Health
- Trial name
- FERT-ISSUES (NCT07312058)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Infertility
Microfluidic Chip Method Versus Density-gradient Centrifugation Method in IVF
Infertile patients attending IVF treatment at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF.
- Trial name
- NCT06005311
- Testing
- Microfluidic chip, Density-gradient centrifugation
- Where
- China
- Volunteers
- 1,136 people
- Sponsor
- Professor Ernest Hung-Yu Ng
Pregnancy, Ovarian
Clinical and Live Birth Rates After Following Long Antagonist Protocol Versus Classical Antagonist Protocol
A randomized prospective study of the evaluation of the clinical IVF results after following Long Antagonist protocol for controlled ovarian stimulation versus following classical antagonist protocol
- Trial name
- NCT03684421
- Testing
- Pregnancy Rate
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assisting Nature