Clinical trials: Liver Circulation
Metastatic Colorectal Cancer
PERfusion CT in the FOXFIRE Trial to Study Blood Flow to Liver Metastases
The PERFORM study is a pilot study investigating the feasibility and usefulness of performing a novel CT (Computed Tomography)scanning technique called Perfusion CT(CTP) as an addition to normal CT scanning in patients recruited…
- Trial name
- PERFORM (NCT01410760)
- Testing
- Perfusion CT scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Hepatocellular Carcinoma
Prospective Cohort Study of Changes in Circulatory MicroRNA of Resected Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the 4th most common cause of cancer death globally but only 20% are diagnosed in its early stages where curative treatment can be carried out.
- Trial name
- PROSECT (NCT05148572)
- Where
- 6 sites in Singapore
- Volunteers
- 101 people
- Sponsor
- National Cancer Centre, Singapore
Smoking, Cigarette, Maternal Exposure
Effects of Maternal Smoking on Fetal Liver Circulation
According to the hypothesis of this study presented, the effects of smoking on the fetus can be determined by the liver circulation and hepatic metabolism.
- Conditions
- Smoking, Cigarette, Maternal Exposure, Ultrasound, Fetal; Circulation
- Trial name
- NCT04721782
- Testing
- smoking
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Hepatocellular Carcinoma
Risk Factors for the Leakage of Anticancer Drugs to Systemic Circulation by Transcatheter Arterial Chemoembolization
Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Transcatheter arterial chemoembolization (TACE) is the traditional method for the palliative management of patients with HCC.
- Trial name
- NCT00630240
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Fontan Circulation
IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease
This is a single center, open-label, prospective, investigation to quantify the effects liver congestion and fibrosis has on hepatic drug metabolism and transport in children, adolescents, and young adults with Fontan circulation.
- Trial name
- IMPROVE-FALD (NCT06324396)
- Testing
- Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg), Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Mercy Hospital Kansas City
Liver Transplantation
Post-Static Cold Storage Hypothermic Oxygenated Perfusion in Bergamo Liver Transplant Program
In light of the widespread organ shortage, dynamic preservation by means of Machine Perfusion (MP) has been proposed as a strategy to increase the pool of suitable grafts for liver transplantation.
- Trial name
- NCT03098043
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Papa Giovanni XXIII Hospital
Ascites
Comparison of Crystalloid and Colloid I.V Fluid Therapy in Prevention of Paracentesis Induced Circulatory Dysfunction (PICD) and Renal Dysfunction in Patients With Decompensated Liver Cirrhosis in Egypt: a Randomized Piolet Study
2.2 Aim(s) of the Research (50 words max): To Compare between crystalloid and colloid I.V fluid therapy in the prevention of paracentesis induced circulatory dysfunction (PICD) and renal dysfunction in patients with decompensated…
- Trial name
- NCT05220891
- Testing
- Paracentesis
- Volunteers
- 60 people
- Sponsor
- Shady Ashraf Kassem
Portal Blood Pressure, Liver Surgery
Optimization of Hepatic Hemodynamics During Liver Surgery
The purpose of this study is to determine if vasopressin and nitroglycerin in combination will affect hepatic hemodynamics, in the setting of liver surgery.
- Conditions
- Portal Blood Pressure, Liver Surgery, Hepatic Hemodynamics
- Trial name
- NCT02993640
- Testing
- vasopressin + nitro
- Volunteers
- 13 people
- Sponsor
- Sahlgrenska University Hospital
Benign Liver Tumor, Malignant Tumor Liver
Liver Resection Modeling
Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific…
- Conditions
- Benign Liver Tumor, Malignant Tumor Liver, Cirrhosis
- Trial name
- LRM (NCT04023136)
- Testing
- partial hepatectomy by laparotomy on healthy or pathologic parenchyma.
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Portal Vein, Hepatic Veins
Ultrasound Measurements of Hepatic Vasculatures and Hepatic Doppler Assessment of Healthy Children
Flow dynamics in the liver is altered in different hepatobiliary and cardiac pathologies, causing changes in hepatic vasculatures sizes and flow pattern changes which can be assessed by ultrasound (USG) study.
- Conditions
- Portal Vein, Hepatic Veins, Hepatic Artery, Liver Circulation
- Trial name
- NCT04619966
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hong Kong Children's Hospital
Cirrhosis, Liver, Refractory Ascites
Effects of Treatment of Ascites by the ALFApump System on Renal and Circulatory Function
This is a single centre, prospective, uncontrolled study to include 12 consecutive patients with cirrhosis of the liver and recurrent or refractory ascites.
- Trial name
- NCT01438970
- Testing
- ALFApump system
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Sequana Medical N.V.
Liver Cirrhosis, Ascites
Intestinal Decontamination With Rifaximin. The Inflammatory and Circulatory State in Patients With Cirrhosis
This investigational trial will be assessing the effect of rifaximin on pathophysiology and haemodynamics in the patient with liver cirrhosis, and addressing the effect of rifaximin on several organs on marker level.
- Trial name
- NCT01769040
- Testing
- Rifaximin
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Chronic Liver Disease
Non-invasive Evaluation of Portal Pressure by MRI
The objective of this research is to study the correlation between the portosystemic pressure gradient and azygos blood flow measured by MRI.
- Trial name
- ENIP (NCT02530567)
- Testing
- Intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Tense Ascites in Cirrhosis
Albumin 4 gr/L vs 8 gr/L in the Prevention of Post-Paracentesis Circulatory Dysfunction
The purpose of this study is to determine whether the infusion of albumin 4 gr per liter of ascites removed is as effective as the infusion of albumin 8 gr per liter of ascites removed in the prevention of post-paracentesis…
- Trial name
- NCT00428506
- Testing
- albumin 4 gr/L ascites removed, albumin 8 gr/L ascites removed
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Turin, Italy
Liver Transplant
Early Signals of the Transition From Immune Quiescence to Activation in the Liver Allograft Microenvironment and in the Circulation
This is a prospective multi-center, longitudinal study to determine efficacy of 50 percent Immunosuppression (IS) reduction. One hundred fully eligible participants will reduce IS by 50 percent in two steps.
- Trial name
- iSYNAPSE (NCT07549503)
- Testing
- Immunosuppression Reduction
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Portal Hypertension
The Role of Somatostatin in the Hemodynamics of the Hepatic Circulation in Patients Undergoing Liver Resection
The purpose of the present clinical trial is to study the effect of somatostatin in the regulation of velocity and blood flow of the hepatic circulation in patients undergoing liver resection.
- Trial name
- NCT04010669
- Testing
- Somatostatin
- Volunteers
- 40 people
- Sponsor
- Laikο General Hospital, Athens
Liver Transplant
A Study to Assess the Role of Fenofibrate in Preventing Ischemic Cholangiopathy After Liver Transplantation
The purpose of this study is to evaluate the safety and effectiveness of a once-daily medication, fenofibrate (Lofibra), to prevent ischemic cholangiography (IC) in persons who were transplanted with livers donated after…
- Trial name
- FICsDCD (NCT05514119)
- Testing
- Fenofibrate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Acute Kidney Injury, Liver Failure
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
Comparing the effects of MAP 60, 75 and 90 mmHg, respectively, on renal blood flow, glomerular filtration rate and renal oxygen demand in patients with terminal liver failure directly after liver transplantation.
- Trial name
- NCT02455115
- Testing
- Alternating mean arterial pressure, Norepinephrine, Chromium ethylenediaminetetraacetic acid
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Sahlgrenska University Hospital
Acute on Chronic Liver Failure
Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.
All consecutive patients admitted in ILBS from MAY 2015 to DECEMBER 2016.ACLF (Acute on chronic Liver Failure). ACLF will be randomize into Group 1: MVP (Modest Volume Paracentesis) OF Less than 5 liters with IV albumin at a dose…
- Trial name
- NCT02467348
- Testing
- Albumin, Ascitic fluid
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Obesity, Obesity (Body Mass Index >30 kg/m2)
ENLIGHT Trial: ESG With Fundal Mucosal Ablation
The ENLIGHT Trial is a single-center, randomized controlled trial evaluating whether adding fundal mucosal ablation (FMA) to endoscopic sleeve gastroplasty (ESG) improves weight loss and metabolic outcomes in adults with obesity.
- Trial name
- NCT07792226
- Testing
- Endoscopic Sleeve Gastroplasty (ESG), Fundal Mucosal Ablation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- West Virginia University