Clinical trials: Liver Cirrhoses
Portal Hypertension Related to Cirrhosis, Variceal Bleeding
Clinical Outcomes in Patients Presenting With Acute Variceal Bleeding
The goal of this observational study is to learn about the outcomes of patients presenting with acute variceal bleeding and treated by endoscopic intervention.
- Conditions
- Portal Hypertension Related to Cirrhosis, Variceal Bleeding, Cirrhoses, Liver
- Trial name
- BLEED-OUTcomes (NCT07870850)
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Hepatitis C, Hepatitis B
Safety and Effectiveness of PRI-724 for Hepatitis C or B Virus Derived Liver Cirrhosis
To investigate the safety and efficacy of PRI-724 against HCV or HBV liver cirrhosis.
- Conditions
- Hepatitis C, Hepatitis B, Liver Cirrhoses
- Trial name
- NCT03620474
- Testing
- PRI-724
- Where
- 3 sites in Japan
- Volunteers
- 27 people
- Sponsor
- Kiminori Kimura, MD
Antibiotic Resistant Infection, Liver Cirrhoses
Antibiotic-resistant Bacterial Infection of Hepatic Patients
the investigators want to identify the microbial profile, antibiotic resistant bacteria in hepatic patients with infections in Liver ICU, and explore risk factors and outcomes in those patients with antibiotic resistant bacteria.
- Trial name
- NCT03855709
- Testing
- microbiological culture and sensetivity
- Volunteers
- 200 people
- Sponsor
- Assiut University
Liver Cirrhoses
Concordance Between Echocardiographic Assessment Performed in the Initial Phase of Decompensated Cirrhosis With Edema and Ascites by an Expert Intensive Care Physician and a Non-expert Gastroenterologist
The investigators hypothesize that trans-thoracic ultrasound performed by non-specialist gastroenterologists with a standard training by intensive care doctors will give equivalent results to those achieved by experts for a…
- Trial name
- EchoCirrho (NCT03650660)
- Testing
- Trans-thoracic ultrasound
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Liver Cirrhoses
Efficacy and Safety of Early TIPS (Transjugular Intrahepatic Portosystemic Shunts) in the Management of Cirrhosis With Recurrent Ascites.
All consecutive patients with cirrhosis of liver who satisfy the criteria will be included and will be evaluated clinically along with all routine investigations and standard medical therapy will be continued among these…
- Trial name
- NCT04013074
- Testing
- Transjugular Intrahepatic Portosystemic Shunt, Standard Medical Treatment
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Spontaneous Bacterial Peritonitis, Cirrhoses, Liver
Comparative Study of Secondary Prophylaxis for SBP
The goal of this clinical trial is to learn if norfloxacin, nitazoxanide, and colistin work as secondary prophylactic agents for spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites.
- Conditions
- Spontaneous Bacterial Peritonitis, Cirrhoses, Liver, Ascites
- Trial name
- 3C-SPS (NCT06827756)
- Testing
- Norfloxacin 400 MG, Nitazoxanide 500 MG, Colistin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Non-alcoholic Steatohepatitis, Liver Diseases
Assessing Kids for Liver Inflammation and Fibrosis Using Non-invasive MRI
This is a prospective observational study which will recruit up to 100 paediatric participants over a period of 30 months to determine whether MRI is as accurate at detecting, distinguishing, and monitoring liver disease as…
- Conditions
- Non-alcoholic Steatohepatitis, Liver Diseases, Liver Fibroses, Autoimmune Hepatitis
- Trial name
- Kids4LIFe (NCT03198104)
- Testing
- MRI
- Where
- Poland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Perspectum
Liver Cirrhoses
Umbilical Cord Mesenchymal Stem Cell for Liver Cirrhosis Patient Caused by Hepatitis B
The study aims to evaluate the effect of allogeneic mesenchymal stem cell therapy on patients who suffered from liver cirrhosis caused by Hepatitis B.
- Trial name
- NCT04357600
- Testing
- Allogeneic Umbilical Cord Mesenchymal Stem Cell
- Where
- Indonesia
- Volunteers
- 12 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Cirrhoses, Liver
Allopurinol and Pathogenesis of Cirrhosis
Hepatic decompensation is a common healthcare issue . This study was conducted to investigate how allopurinol can interfere with the pathological mechanisms of HD.
- Trial name
- NCT07033533
- Testing
- Allopurinol Tablet
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Tanta University
End Stage Liver Disease, Sarcopenia
Exercise Intervention in Liver Transplant Patients
The purpose of this study is to learn more about the effects of exercise on functional status and outcomes on patients with end-stage liver disease on the liver transplant waiting list and who have undergone liver transplantation.
- Conditions
- End Stage Liver Disease, Sarcopenia, Liver Cirrhoses
- Trial name
- NCT02367092
- Testing
- Exercise Program
- Where
- 3 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of California, San Francisco
Liver Cirrhoses
The Spectrum and Profile of COVID-19 Infection and Its Impact on Liver.
To address the existing deficiencies in the knowledge regarding liver involvement and spectrum of clinical presentation and the impact of COVID-19 infection in patients of liver disease was planned.
- Trial name
- NCT04345640
- Testing
- no intervention
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhoses
Statins for Prevention of Disease Progression and Hospitalization in Liver Cirrhosis
In a randomized, doubleblind and placebo-controlled trial we assess both clinical and cellular effects of atorvastatin in patients with liver cirrhosis.
- Trial name
- STATLiver (NCT04072601)
- Testing
- Atorvastatin 10mg
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Hepatocellular Carcinoma, Liver Cirrhoses
Pravastatin Intervention to Delay Hepatocellular Carcinoma Recurrence
Hepatocellular Carcinoma (HCC) is a major health concern in the United States, particularly among people with liver cirrhosis. Out of every 100 patients with liver cancer, only 18 will survive 5 years or more.
- Trial name
- NCT03219372
- Testing
- Pravastatin Pill
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Cedars-Sinai Medical Center
Liver Cirrhoses
Propofol for Sedation of Postoperative Electively Ventilated Liver Transplant Recipients.
All consenting, adult patients aged 18 years and above who will require elective ventilation after liver transplant recipient surgery will be enrolled for the study.
- Trial name
- NCT03837145
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Diagnostic Techniques, Ophthalmological, Liver Transplantation
Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters
This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics.
- Conditions
- Diagnostic Techniques, Ophthalmological, Liver Transplantation, Liver Cirrhoses
- Trial name
- NCT06756009
- Testing
- Ophthalmic examination, General Condition Examination
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Cirrhoses, Liver
Nursing Needs of Patients With Cirrhosis
The primary objective of this study is to examine the quality of life, disease-related knowledge, and perceived nursing needs of adult patients diagnosed with liver cirrhosis who attend the outpatient clinic at Landspítali…
- Trial name
- NCT07273331
- Testing
- blood sample, blood samples for analysis of cirrhosis
- Where
- 2 sites in Iceland
- Volunteers
- 150 people
- Sponsor
- Landspitali University Hospital
Cirrhoses, Liver, Hepatic Encephalopathy (HE)
Study on Proteomic and Microbiome Changes in Patients With Hepatic Encephalopathy (HE)
The objective of this observational study is to compare the differences in proteomics and gut microbiome between the liver cirrhosis group without hepatic encephalopathy and the hepatic encephalopathy group through proteomics and…
- Trial name
- NCT07150195
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cirrhoses, Liver, Oesophageal Varices
Beta-blockers for Oesophageal Varices
To determine if carvedilol reduces the rate of variceal haemorrhage in patients with cirrhosis and small oesophageal varices
- Trial name
- BOPPP (NCT03776955)
- Testing
- Carvedilol
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- King's College Hospital NHS Trust
Liver Cirrhoses
"To Study the Impact of Balloon-occluded Retrograde Transvenous Obliteration (BRTO)/Plug Assisted Retrograde Transvenous Obliteration (PARTO) Mediated Portal Flow Modulation in Reduction of Ammonia and Improvement in Organ Volume and Functionality in Patients of Cirrhosis With LR Shunt
The informed consent will be obtained from the participants in the study. The study will be conducted on indoor patients, Department of Hepatology ILBS, New Delhi.
- Trial name
- NCT04089878
- Testing
- Plug assisted retrograde transvenous obliteration/Balloon-occluded retrograde transvenous obliteration, Standard Medical Treatment
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Gastric Varices Bleeding, Liver Cirrhoses
Interventional Devascularization Plus HVPG-Guided Carvedilol Therapy vs TIPS
Gastric varices (GV) are present in around 20% of patients with cirrhosis. Bleeding from GV accounts for 10-20% of all variceal bleeding.
- Trial name
- NCT04198259
- Testing
- interventional devascularization, TIPS
- Volunteers
- 212 people
- Sponsor
- Air Force Military Medical University, China