Clinical trials: Liver Cirrhosis, completed
Anorexia Nervosa
Liver Biomarkers in Anorexia Nervosa
The main goal of the Liver Biomarkers in Anorexia Nervosa (LIBAN) study is to determine the prevalence of liver fibrosis in patient with Anorexia Nervosa.
- Trial name
- LIBAN (NCT05861375)
- Testing
- Fibroscan
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Nantes University Hospital
Cirrhosis, Fatty Liver
A Pathophysiological Study of the Postprandial Human Liver (PLS)
Fatty liver disease is a globally widespread disease. The identification of valid biomarkers and targets for potential treatments requires in-depth knowledge about the pathophysiology of the postprandial liver.
- Trial name
- PLS (NCT03849235)
- Testing
- Standardised meal, Glucagon bolus
- Where
- Denmark
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Hepatitis C, Cirrhosis
Study to Evaluate the Safety and Efficacy of Daclatasvir/Sofosbuvir/Ribavirin for 16 Versus 24 Weeks for HCV Genotype 3 Cirrhotics
This is a randomized, open label, single center safety and efficacy study. At least 40 cirrhotic subjects with HCV genotype 3 will receive standard of care treatment of sofosbuvir and ribavirin (SOF/RBV) as well as 60 mg daily of…
- Trial name
- NCT02304159
- Testing
- daclatasvir, Sofosbuvir, Sovaldi, Ribavirin
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Tarek I. Hassanein, M.D., FACP, FAG, AGAF
Hepatitis C
A Study of Daclatasvir and Sofosbuvir With Ribavirin in Subjects With Cirrhosis and Genotype 3 Hepatitis C Infection
The purpose of this study is to determine whether 24 weeks of Daclatasvir and Sofosbuvir with Ribavirin is safe and effective in the treatment of genotype 3 hepatitis C infected patients with liver cirrhosis.
- Trial name
- NCT02673489
- Testing
- DCV, SOF, RBV
- Where
- 19 sites in United States, Canada
- Volunteers
- 106 people
- Sponsor
- Bristol-Myers Squibb
Liver Cirrhosis, Hepatocellular Carcinoma
Safety Study of Liver Natural Killer Cell Therapy for Hepatoma Liver Transplantation
The objective of this study is to evaluate feasibility and safety of the adoptive transfer of activated natural killer (NK) cells extracted from cadaveric donor liver graft perfusate for liver transplant recipients with…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, Evidence of Liver Transplantation
- Trial name
- MIAMINK (NCT01147380)
- Testing
- Liver NK cell inoculation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seigo Nishida
Cirrhosis, Periodontitis
Oral Gut Liver Axis in Cirrhosis
This will be a prospective study of cirrhotics and healthy controls comparing their oral microbiota, endotoxemia and systemic inflammation at baseline and at 30 days after clinically indicated systematic oral cleansing and…
- Conditions
- Cirrhosis, Periodontitis, Gingivitis
- Trial name
- NCT03030820
- Testing
- Dental Cleaning
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Liver Fibroses
The EUS ShearWave Elastography Liver Fibrosis Study
The study objective is to demonstrate the clinical performance of ShearWave Elastography (SWE) in Endoscopic Ultrasound (EUS) when compared to FibroScan for evaluation of liver fibrosis.
- Trial name
- NCT04115046
- Testing
- ShearWave Elastography (SWE) in Endoscopic Ultrasound (EUS), FibroScan, ALOKA ARIETTA 850 -
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Olympus Corporation of the Americas
Cirrhosis, Hepatic Fibrosis
Prevalence of Pain in Hospitalized Cirrhotic Patients
According to the WHO, pain is an "unpleasant sensory and emotional experience, linked to existing or potential tissue damage, or described in terms suggestive of such damage".
- Conditions
- Cirrhosis, Hepatic Fibrosis, Pain, Acute, Pain, Chronic
- Trial name
- LIVERPAIN (NCT06062108)
- Testing
- Pain evaluation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Cryptogenic Cirrhosis, Cryptogenic Chronic Hepatitis
Bartonella in Liver Transplant Patients
Approximately 20 volunteers who have received a liver transplant and have been diagnosed with cryptogenic cirrhosis will be included in this study. Blood, skin and urine samples will be analyzed for Bartonella spp..
- Trial name
- NCT02595710
- Testing
- skin punch biopsy collection, Blood collection, Urine sample collection
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Liver Fibrosis
Development of Non-Invasive MRI Applications for Liver Fibrosis and Inflammation
Chronic liver disease is a major healthcare problem in Hong Kong and worldwide. The diagnosis of liver fibrosis and inflammation in patients with chronic liver disease has important prognostic and therapeutic implications.
- Trial name
- NCT05168982
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cramps, Muscle Cramp
The RELAX Trial: Nonpharmaceutical Intervention for Nocturnal Muscle Cramps
The purpose of the study is to learn about reducing the symptoms and severity of nighttime lower body muscle cramps in patients with and without cirrhosis.
- Trial name
- RELAX (NCT05457322)
- Testing
- Behavioral intervention one, Behavioral intervention two
- Where
- 6 sites in United States
- Volunteers
- 99 people
- Sponsor
- University of Michigan
Portal Hypertension, Cirrhosis
Esophageal Capsule Endoscopy in Children
The portal hypertension (PHT) is the main complication in patients presenting with cirrhosis. It can be the direct cause of bleeding by rupture of the esophageal or gastric varices and can also contribute to the development of…
- Trial name
- PREVOCAP (NCT01551966)
- Testing
- Wireless esophageal capsule endoscopy ( PillCam Eso2)
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Liver Cirrhosis, Portal Hypertension
Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal Hypertension
The purpose of this study is to determine whether sapropterin (an oral analogue of tetrahydrobiopterin) could have a role in the treatment of portal hypertension secondary to liver cirrhosis.
- Trial name
- NCT01456286
- Testing
- sapropterin
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cirrhosis
Correlation of Hepatitis C, Alcoholic Liver Disease, and Renal Failure With Hyperfibrinolysis in Liver Failure
1. Further characterize the incidence of hyperfibrinolysis in cirrhotics 2. Correlate hyperfibrinolysis with 1. hepatitis C 2. alcoholic liver disease 3. the subset of a\&b with renal failure with and without dialysis 3.
- Trial name
- NCT02737345
- Testing
- Rotem
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Scott Allen
Chronic Hepatitis C, Decompensated Cirrhosis
A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With Ribavirin in Adults With Genotype 1 and Ombitasvir/Paritaprevir/Ritonavir With Ribavirin in Adults With Genotype 4 Chronic Hepatitis C Virus Infection and Decompensated Cirrhosis
The primary objectives of this study are to assess the safety and the SVR12 rate of ombitasvir/paritaprevir/ritonavir and dasabuvir with RBV in GT1-infected participants with decompensated cirrhosis.
- Conditions
- Chronic Hepatitis C, Decompensated Cirrhosis, Hepatitis C Virus
- Trial name
- TURQUOISE-CPB (NCT02219477)
- Testing
- ombitasvir/paritaprevir/ritonavir, dasabuvir, ribavirin
- Volunteers
- 36 people
- Sponsor
- AbbVie
Hepatic Encephalopathy, Cirrhosis
Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy Outcome
Investigating the impact of hepatic encephalopathy on default mode networks within the brain to provide more clues with understanding the physiology of consciousness and predicting the reversibility of comatose states.
- Conditions
- Hepatic Encephalopathy, Cirrhosis, Nonalcoholic Steatohepatitis, Hepatitis C
- Trial name
- NCT02083367
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- OSF Healthcare System
Cirrhosis, Asthma
A Pilot Study of Mirabegron and Montelukast in Cirrhotic Patients
This study was a prospective, interventional, pilot clinical study conducted over 3 months on cirrhotic patients with overactive bladder and asthma, evaluating the real-world applicability of selected PBPK-guided dosing regimens.
- Trial name
- NCT07533565
- Testing
- Mirabegron 100 mg, Mirabegron 50mg, mirabegron 25 mg
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Alcoholic Liver Cirrhosis
REVIVE(Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient)
If the participant voluntarily agrees to participate in the clinical trial before registration, the investigator conducts a screening test to evaluate the participant's suitability.
- Trial name
- NCT01875081
- Testing
- Livercellgram
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Pharmicell Co., Ltd.
Liver Cirrhosis, Portal Vein
Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis
The prevalence of portal vein thrombosis (PVT) in patients with liver cirrhosis is 5-20%. Current evidence regarding the effect of portal vein thrombosis on the prognosis of cirrhotic patients remains under debate.
- Conditions
- Liver Cirrhosis, Portal Vein, Venous Thrombosis, Varicose Veins
- Trial name
- NCT02335580
- Testing
- Somatostatin and its analogs, Endoscopic sclerotherapy, endoscopic variceal ligation, endoscopic tissue glue injection
- Where
- China
- Volunteers
- 475 people
- Sponsor
- General Hospital of Shenyang Military Region
Hepatitis C Virus
A Randomized, Open-Label Study to Evaluate the Safety and Efficacy of Ombitasvir/ABT-450/Ritonavir Co-administered With Ribavirin (RBV) in Adults With Genotype 4 Chronic Hepatitis C Virus (HCV) Infection and Cirrhosis (AGATE-1)
The purpose of this study in HCV genotype 4-infected participants with compensated cirrhosis is to assess the safety and to compare the percentage of participants achieving a 12-week sustained virologic response (SVR12), [HCV…
- Trial name
- AGATE-1 (NCT02265237)
- Testing
- ombitasvir/paritaprevir/ritonavir, ribavirin
- Volunteers
- 184 people
- Sponsor
- AbbVie
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