Clinical trials: Liver Disease; Alcohol-Related
Hepatitis C, Liver Diseases
Improving Hepatitis C Treatment in Injection Drug Users
The overall goal of the research project is to improve the outcome of medical care for injection drug users (IDUs) with Hepatitis C viral (HCV) infection.
- Conditions
- Hepatitis C, Liver Diseases, Drug Abuse, Alcoholism
- Trial name
- NCT00148031
- Testing
- Pegylated Interferon and Ribavirin, Psychosocial, On-site (MMT Clinic) HCV evaluation and treatment
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- State University of New York - Upstate Medical University
Alcoholic Hepatitis, Alcoholic Cirrhosis
Validation of the Procedure of Early Liver Transplantation in Alcoholic Hepatitis Resisting to Medical Treatment
The purpose of this study is to validate a strategy of identification of patients for early liver transplantation in severe alcoholic hepatitis. In this setting, short-term survival is very low (approx.
- Trial name
- QuickTrans (NCT01756794)
- Testing
- Liver transplantation
- Where
- 32 sites in Belgium, France
- Volunteers
- 284 people
- Sponsor
- University Hospital, Lille
Alcoholic Hepatitis
Short-term Survival in Patients With Severe Alcoholic Hepatitis Treated With Steroid Versus Pentoxifylline
Alcoholic hepatitis represents one of the more serious forms of alcoholic liver disease. Critically ill patients with alcoholic hepatitis have high morbidity and mortality rate.
- Trial name
- NCT01455337
- Testing
- pentoxifylline, Prednisolone
- Volunteers
- 126 people
- Sponsor
- Inje University
Liver Transplant Recipient, Alcohol Use Disorders (AUD)
Intervention for Alcohol Use Disorder Recovery After Liver Transplantation
The goal of this clinical trial is to learn if it is feasible and acceptable to use a recovery coach and an online sober active community to help with alcohol use disorder after liver transplant.
- Trial name
- ILTARP (NCT07214259)
- Testing
- Online Sober Active Community, Recovery coach
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Leigh Anne Dageforde
Alcoholic Hepatitis
Pentoxyphilline Versus Fecal Microbiota Therapy in Severe Alcoholic Hepatitis
Treatment for severe alcoholic hepatitis patients not eligible for steroid therapy is a dilemma. Pentoxyfilline has been shown to have no improvement in outcomes as per current studies and liver transplantation is with great risk…
- Trial name
- NCT02458079
- Testing
- Pentoxiphylline, Stool microbiota transplantation
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcoholic Hepatitis
Liver Transplantation in Alcoholic Hepatitis
Patients with alcoholic hepatitis non-responsive to steroids have a poor prognosis. Recently a French-Belgian prospective study has obtained good results (acceptable survival with a low rate of alcohol recidivism).
- Trial name
- SETH-HA (NCT01768715)
- Where
- 17 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Sociedad Española de Trasplante Hepático
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
NAFLD, Alcoholic Hepatitis
EUS Guided Liver Biopsy - Will it Give Better Yield, More Tissue With Less Complication?
Liver biopsy would be done by Endoscopic Ultrasound using Acquire needle.
- Trial name
- NCT04235855
- Testing
- Endoscopic USG guided Liver biopsy, Percutaneous Liver Biopsy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Alcoholic Hepatitis
Randomized Controlled Trial of Mycophenolate Mofetil Versus Steroid Therapy in Alcoholic Hepatitis
Patients with acute alcoholic hepatitis will be identified based on national institute on alcohol abuse and alcoholism (NIAAA) will be identified, MELD score will be calculated, patents with MELD score between 20-35 will be…
- Trial name
- NCT06789315
- Testing
- Mycophenolate Mofetil, Prednisone
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Alcoholic Liver Disease, Alcohol Dependence
Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease
To explore the effectiveness and biobehavioural basis of baclofen in improving treatment outcomes for alcohol dependence in people with or without alcoholic cirrhosis in a double-blind randomised placebo-controlled trial.
- Trial name
- BacALD (NCT01711125)
- Testing
- Baclofen 30mg/day, Baclofen 75mg/day
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- South West Sydney Local Health District
Alcohol Dependence
Treatment of Patients Suffering of Alcohol Dependence and Impaired Liver Function With Selincro® As-needed Use
The purpose of this study is to explore the treatment effects of Selincro in alcohol dependent patients with liver impairment.
- Trial name
- NCT02197598
- Testing
- nalmefene
- Where
- 3 sites in Germany
- Volunteers
- 45 people
- Sponsor
- H. Lundbeck A/S
Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Alcohol-Related Liver Disease
A Large Language Model-based Chatbot for Alcohol Reduction in Patients With Metabolic Alcohol-Related Liver Disease
The goal of this pilot randomized controlled trial is to evaluate the trial feasibility and acceptability of LLM-based chatbot for reducing alcohol use among patients with metabolic alcohol-related liver disease.
- Trial name
- NCT07450144
- Testing
- LLM-based chatbot, Telephone counseling, Alcohol Brief Intervention
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Hepatitis, Alcoholic
Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis
Hypothesis: Oral administration of hyperimmune bovine colostrum enriched with anti-LPS antibodies will reduce endotoxemia, and improve pathophysiological and clinical parameters related to severe alcoholic hepatitis (SAH).
- Trial name
- TREAT (NCT01968382)
- Testing
- IMM 124-E (Hyperimmune Bovine Colostrum)
- Where
- 3 sites in United States
- Volunteers
- 57 people
- Sponsor
- Virginia Commonwealth University
Liver Diseases, Liver Transplant; Complications
Prognostic Factors After Liver Transplantation
The study retrospectively reviewed the medical records of patients who received adult liver transplantation in Changhua Christian hospital from 2002 to 2019.
- Trial name
- NCT05018741
- Testing
- liver transplantation
- Volunteers
- 600 people
- Sponsor
- Changhua Christian Hospital
Alcoholic Hepatitis
Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
Inflammatory responses in response to alcohol have been identified as contributing to the development of alcoholic hepatitis. The inflammatory response including that to LippoPolySaccharide is known to lead to progression of…
- Trial name
- NCT04088370
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Alcoholic Liver Disease
Quantitative MRI for Non-invasive Assessment of Severity of Alcoholic Liver Disease (ALD)
The current goal in the treatment of Alcoholic Liver Disease (ALD) is to manage ALD-associated complications as there are no disease-specific therapies.
- Trial name
- NCT03113929
- Testing
- MRI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Alcoholic Liver Disease, Liver Cirrhosis, Alcoholic
Profermin®: Prevention of Progression in Alcoholic Liver Disease by Modulating Dysbiotic Microbiota
Investigators wishes to influence the gut microbiota in patients with alcoholic liver disease in a randomized controlled clinical trial.
- Conditions
- Alcoholic Liver Disease, Liver Cirrhosis, Alcoholic, Probiotics, Liver Fibrosis
- Trial name
- SYN-ALD (NCT03863730)
- Testing
- Profermin Plus, FSMP, probiotics, Fresubin, dietary supplement
- Where
- 2 sites in Denmark
- Volunteers
- 56 people
- Sponsor
- Odense University Hospital
Hepatitis C, Alcohol Abuse
Web-based Intervention to Reduce Alcohol Use in Veterans With Hepatitis C
Many people who are infected with Hepatitis C misuse alcohol, which is even more dangerous for them than it is for a non-infected person.
- Trial name
- NCT01707030
- Testing
- Web-Based Brief Alcohol Intervention, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 138 people
- Sponsor
- VA Office of Research and Development
Alcoholic Cirrhosis
SAMe Trial for Patients With Alcoholic Cirrhosis
The proposed of this randomized, double blinded, placebo-controlled study is to assess the effect of SAMe compared to placebo in patients with alcoholic cirrhosis Child Class A and B.
- Trial name
- NCT04250259
- Testing
- SAMe 400 mg tablet
- Where
- 2 sites in United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alcoholic Hepatitis
Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis.
Alcoholic hepatitis (AH) is the most severe form of acute alcohol-related liver disease. Maddrey's discriminant function (mDF) >32 defines the severe form of AH, which is associated with a high mortality.
- Trial name
- AH2023 (NCT05883891)
- Testing
- prothrombin time
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS