Clinical trials: Liver Fibrosis
Liver Cirrhosis
Hepatic Sugar Metabolism Measured by PET/CT in Patients and Healthy Subjects
The investigators wish to determine the lumped constant (LC), which is a correction factor necessary for converting measurements of hepatic FDG metabolism (measured by PET) to those of regular glucose in patients with cirrhosis…
- Trial name
- NCT01369979
- Testing
- Liver vein catheter
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Primary Biliary Cirrhosis
Fenofibrate in Combination With Ursodeoxycholic Acid (UDCA) in Primary Biliary Cirrhosis
The purpose of this study is to determine if the combination of ursodeoxycholic acid (UDCA) and fenofibrate is more effective than UDCA alone in the treatment of primary biliary cirrhosis.
- Trial name
- NCT01141296
- Testing
- fenofibrate
- Where
- 2 sites in United States
- Sponsor
- University of Miami
Liver Fibrosis, Steatohepatitis
Liver Fibrosis in HIV-Infected Patients With Elevated Liver Enzymes on Antiretroviral Therapy
This study will provide a basis for research on the impact of liver injury caused by antiretroviral therapy in HIV-infected patients.
- Conditions
- Liver Fibrosis, Steatohepatitis, Elevated Transaminases
- Trial name
- NCT00326482
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cirrhosis
Evaluating Ultrasound, Elastometry, Minilaparoscopy and Histology for the Diagnosis of Compensated Liver Cirrhosis.
Prospective study to evaluate the dignostic value of b-mode ultrasound, elastometry and mini-laparoscopic guided liver biopsy for the diagnosis of compensated liver cirrhosis.
- Trial name
- NCT01807013
- Testing
- ultrasound, liver elastometry, minilaparoscopy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Erlangen
Liver Cirrhosis, Portal Hypertension
Rifaximin and Propranolol Combination Therapy Versus Propranolol Monotherapy in Cirrhotic Patients
To reduce portal pressure, the only recommended medication is nonselective beta blocker(NSBB). However, NSBB has some limitation to apply clinically because of poor response rate and compliance.
- Trial name
- RECOVER (NCT01897051)
- Testing
- Rifaximin + propranolol
- Where
- 2 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Yonsei University
Chronic Liver Disease (CLD), Liver Fibrosis
Correlation Of EUS-SWQ And Liver Fibrosis Pathology In Chronic Liver Disease
The goal of this clinical study is to learn whether the Olympus EU-ME3 endoscopic ultrasound shear wave quantification (EUS-SWQ) function can accurately diagnose and grade liver fibrosis in patients with chronic liver disease.
- Trial name
- EUS-SWQ-202601 (NCT07588854)
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Adhesions
Adhesions After Open Versus Laparoscopic Resection of Colorectal Malignancies Detected During Liver Resection
Rationale: Adhesion formation is a frequent complication after abdominal surgery. Adhesion formation might be reduced by laparoscopic surgery, however sound evidence is lacking.
- Trial name
- ALIVE (NCT01720966)
- Testing
- Liver resection
- Where
- 6 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Primary Biliary Cirrhosis
Use of Fenofibrate for Primary Biliary Cirrhosis
This is a pilot study to evaluate the safety and efficacy of fenofibrate on patients with primary biliary cirrhosis who have an incomplete response to ursodeoxycholic acid.
- Trial name
- NCT00575042
- Testing
- Fenofibrate IDD-P (Insoluble Drug Delivery-Micro Particle)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Thrombocytopenia Related to Chronic Liver Disease, Anticoagulation Treatment
Safety of Anticoagulation Therapy in Cirrhotic Patients With PVT and Severe Thrombocytopenia
Severe thrombocytopenia (platelet count ≤ 50 × 10^9/L) can significantly increase the risk of bleeding. Safety of Anticoagulation (AC) therapy in cirrhotic patients with portal vein thrombosis (PVT) and severe thrombocytopenia is…
- Conditions
- Thrombocytopenia Related to Chronic Liver Disease, Anticoagulation Treatment, Safety, Portal Vein Thrombosis
- Trial name
- AC in PVT (NCT07885969)
- Testing
- Anticoagulation Therapy
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Qilu Hospital of Shandong University
Liver Cirrhosis
Natural Course and Prognosis of Hospitalized Patients With Cirrhosis
The aim of this prospective study is to evaluate the natural course and prognosis of hospitalized patients with liver cirrhosis.
- Trial name
- NCT05185154
- Where
- 4 sites in South Korea
- Volunteers
- 336 people
- Sponsor
- Kangbuk Samsung Hospital
Primary Biliary Cholangitis (PBC)
Using Digital Health Technology to Monitor Patients With Primary Biliary Cholangitis (PBC)
The purpose of this study is to explore the use of digital health technology for measuring symptoms and daily health in people with primary biliary cholangitis (PBC).
- Trial name
- NCT07631442
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Liver Cirrhosis, Biliary
Physical Therapy for Liver Cirrhosis
Patients with liver cirrhosis have severe physical deconditioning. Aim: To compare between the effect of neuromuscular electric stimulation(NMES) and exercises (EX)on treatment of patients with liver cirrhosis.
- Trial name
- NCT04629456
- Testing
- neuromuscular electric stimulation, Exercises
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Liver Cancer, Liver Cirrhosis
Diagnosis of Nodules ≤2 cm Based on US and CEUS Compared With Current Clinical Procedure
Due to different etiologies, diagnosis and treatment of HCC in China is different from that in Western countries.US is an important screening method for HCC in patients with liver cirrhosis.
- Trial name
- NCT05360420
- Testing
- Immediate CEUS
- Where
- China
- Volunteers
- 6,730 people
- Sponsor
- Tianjin Third Central Hospital
Primary Biliary Cholangitis
A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment
This study will collect information from participants with Primary Biliary Cholangitis (PBC) as they use the drug elafibranor in real world setting.
- Trial name
- ELFINITY (NCT06447168)
- Where
- 72 sites in United States, Australia and 9 more
- Volunteers
- 424 people
- Sponsor
- Ipsen
Alcoholic Cirrhosis
EUS Based Prevalence of Chronic Pancreatitis in Alcoholic Cirrhosis
Alcohol is the common precipitating factor for both cirrhosis of liver as well as alcohol related chronic pancreatitis. However, in real life clinical setting, clinicians do not frequently see many cases of symptomatic…
- Trial name
- NCT04245189
- Testing
- Endoscopic ultrasound for detection of Chronic pancreatitis
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Hepatic Encephalopathy, Cirrhosis
Albumin Infusion Effects in Mortality in Patients With Cirrhosis and Hepatic Encephalopathy
To assess whether albumin administration after an episode of hepatic encephalopathy (≥ grade II) improves survival at 90 days (mortality endpoint treated as a composite endpoint death and/ or liver transplantation).
- Trial name
- BETA (NCT02401490)
- Testing
- Human albumin
- Where
- 7 sites in Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hepatitis, Chronic
Telaprevir With Peginterferon Alfa & Ribavirin in Ex-People Who INject Drugs Infected by Genotype 1 Chronic Hepatitis C
The purpose of this study is to collect information on the efficacy, safety and tolerability of telaprevir (in combination with other medications), in patients who have a history of intravenous drug use with genotype 1 chronic…
- Trial name
- INTEGRATE (NCT01980290)
- Where
- 18 sites in Belgium, France and 4 more
- Volunteers
- 50 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
PBC, Primary Biliary Cholangitis
Swiss Primary Biliary Cholangitis Cohort Study
Research project in which biological material is sampled and health-related medical data is collected. In addition, already existing health-related medical data are used for further research. Coded data are used.
- Trial name
- NCT03146910
- Where
- 13 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- Fondazione Epatocentro Ticino
Decompensated Cirrhosis, Portal Hypertension
TIPS With 8- OR 10-mm Covered Stent for Preventing Variceal Rebleeding
The purpose of this study is to determine whether transjugular intrahepatic portosystemic shunt (TIPS) with 10-mm covered stent is associated with lower shunt dysfunction in comparing TIPS with 8-mm covered stent in cirrhotic…
- Conditions
- Decompensated Cirrhosis, Portal Hypertension, Bleeding Varices
- Trial name
- T8/10SVB (NCT01410591)
- Testing
- 8-mm covered stent group, 10-mm covered stent group
- Where
- China
- Volunteers
- 127 people
- Sponsor
- Air Force Military Medical University, China
Inflammation, Fibrosis
Effect of Vitamin E on Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
No proven treatment exists for nonalcoholic fatty liver disease (NAFLD) in children and adolescents. We aim to determine the efficacy of lifestyle intervention with or without antioxidant therapy in pediatric NAFLD.
- Conditions
- Inflammation, Fibrosis, Insulin Resistance
- Trial name
- VITENAFLD (NCT00655018)
- Testing
- Vitamin treatment (alpha tocopherol plus ascorbic acid)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Bambino Gesù Hospital and Research Institute