Clinical trials: Liver Function Failure
End Stage Liver DIsease, Liver Transplantation
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.
- Trial name
- NCT04107883
- Testing
- fresh frozen plasma, blood sample
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Liver Cirrhosis, Hemophilia
Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease
The goal of this observational study is to learn about the changes in coagulation factor VIII and IX levels in patients undergoing liver transplantation to help guide future management of coagulation factor replacement in…
- Conditions
- Liver Cirrhosis, Hemophilia, Hemophilia A, Hemophilia B
- Trial name
- NCT06014320
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
End Stage Liver Disease
A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease
The goal of this pilot randomized trial is to assess the feasibility and preliminary efficacy of an advanced care planning (ACP) video decision support tool for improving patients' knowledge regarding their goals of care options…
- Trial name
- NCT03557086
- Testing
- Advance Care Planning Video Decision Support Tool, Verbal Narrative
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Chronic Liver Disease and Cirrhosis
Impact of Home-Based Aerobic and Resistance Training in Chronic Liver Disease: a Randomized Control Trial
The goal of this clinical trial is to evaluate whether home-based exercise interventions, including aerobic exercise (AE) and a combination of aerobic and resistance exercise (ARE), can improve physical and health-related…
- Trial name
- NCT06892366
- Testing
- Home-Based Aerobic Exercise Program, Home-Based Aerobic and Resistance Exercise (ARE) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Hacettepe University
Alcoholic Liver Disease
Cognitive Function of Alcoholic Compensated Liver Cirrhosis
Differences in cognitive function between patients with viral and alcoholic compensated liver cirrhosis
- Trial name
- NCT04557774
- Testing
- Cognitive function test
- Where
- South Korea
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Hepatic Failure
Ex Vivo Perfusion of Gene-Edited Porcine Livers in Patients With Severe Hepatic Failure
The goal of this clinical trial is to evaluate whether extracorporeal perfusion using a gene-edited pig liver can significantly improve liver function and serve as a bridge-to-transplant therapy in patients with severe hepatic…
- Trial name
- NCT07519005
- Testing
- Ex vivo perfusion of six-gene-edited porcine liver, Multi-drug immunosuppressive therapy
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Xijing Hospital
End Stage Liver Disease
Impact of MELD Score for 1000 Consecutive Liver Transplantations
The goal of this observational study was to evaluate the impact of the adoption of the MELD system to prioritize patients on the waiting list for OLT on survival for 1000 consecutive liver transplantations.
- Trial name
- NCT02548130
- Testing
- MELD score
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cirrhosis, Liver, Hepatic Encephalopathy
Role of Sarcopenia and Nutritional/Physical Therapy Intervention in Post-TIPS Hepatic Encephalopathy
The placement of TIPS (transjugular intrahepatic portosystemic shunt) is the most effective strategy to treat complications of portal hypertension.
- Conditions
- Cirrhosis, Liver, Hepatic Encephalopathy, Sarcopenia
- Trial name
- NCT05346029
- Testing
- Lifestyle intervention
- Where
- 3 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Anna Baiges
Liver Failure
Registry Study for Optimal Management of Liver Failure in the Chinese Population
Liver failure is the most severe form of liver damage caused by viral, alcoholic, drug-related and ischemia-reperfusion factors, often combined with extrahepatic organ damage, resulting in a high mortality rate.
- Trial name
- RESOLVE-C (NCT05740696)
- Testing
- ALF, SALF, ACLF
- Where
- 14 sites in China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hepatic Encephalopathy
Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patients
The aim of this study is to compare the efficacy and safety of colistin versus lactulose for secondary prophylaxis of overt hepatic encephalopathy in patients with liver cirrhosis.
- Trial name
- NCT05279586
- Testing
- lactulose, colistin
- Volunteers
- 316 people
- Sponsor
- Madonna Magdy Fahmy
Cirrhoses, Liver, Hepatic Encephalopathy (HE)
Study on Proteomic and Microbiome Changes in Patients With Hepatic Encephalopathy (HE)
The objective of this observational study is to compare the differences in proteomics and gut microbiome between the liver cirrhosis group without hepatic encephalopathy and the hepatic encephalopathy group through proteomics and…
- Trial name
- NCT07150195
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Indocyanine Green, Postoperative Complications
One Way to Diagnose Hepatic Insufficiency the First Postoperative Day After Resection: Prospective Cohort Study
Introduction: Hepatic insufficiency is a complication that puts the life of the patient undergoing resective surgery at risk. Thus, the diagnosis should be made early.
- Conditions
- Indocyanine Green, Postoperative Complications, Acute Liver Failure
- Trial name
- IGHI (NCT04570800)
- Volunteers
- 44 people
- Sponsor
- Castilla-La Mancha Health Service
Liver Cancer, Liver Failure
Quantitative MRI and Outcomes of Liver Resection
The present observational study aims to assess the benefit of this quantitative multiparametric magnetic resonance imaging (MRI) in clinical practice, to quantify future liver remnant performance, and to accurately predict the…
- Conditions
- Liver Cancer, Liver Failure, Bile Leak, Liver Metastases
- Trial name
- NCT06181318
- Testing
- Multiparametric MRI scan of the liver
- Volunteers
- 33 people
- Sponsor
- University Hospital Heidelberg
Hepatitis B, Acute-On-Chronic Liver Failure
Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF
This study is to investigate the clinical efficacy of three types of nucleotide/nucleoside analogues in treatment of HBV-related acute-on-chronic liver failure.
- Trial name
- HBV (NCT03920618)
- Testing
- Entecavir, Tenofovir Disoproxil Fumarate, Tenofovir Alafenamide
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Liver Failure, Liver Transplant; Complications
Telemedicine Based Remote Home Monitoring After Liver Transplantation
A significant opportunity exists to involve patients and their caregivers in more effective perioperative care and transition to home for transplant patients.
- Trial name
- TelehealthOLT (NCT03878329)
- Testing
- remote home monitoring
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Worsening Chronic Heart Failure, Diabetic Nephropathy
A Study to Learn How Finerenone (BAY94-8862) Moves Into, Through and Out of the Body, How it Affects the Body, and How Safe it is in Adult Participants With Different Degrees of Reduced Liver Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should, as well as to treat patients who have diabetic…
- Trial name
- NCT04881994
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayer
Hepatic Encephalopathy
S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE
The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.
- Trial name
- endtxninHE (NCT01446523)
- Testing
- Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Govind Ballabh Pant Hospital
Liver Failure, End Stage Liver Disease
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Rationale: Recent publications report good results of controlled donation after circulatory death (DCD) Maastricht category III liver transplantation when strict donor-recipient matching is applied and ischemia times are kept to…
- Conditions
- Liver Failure, End Stage Liver Disease, Biliary Tract Diseases
- Trial name
- DHOPE-DCD (NCT02584283)
- Testing
- Dual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid
- Where
- 6 sites in Belgium, Netherlands and 1 more
- Volunteers
- 157 people
- Sponsor
- Robert J. Porte
Acute Liver Failure, Mitochondrial Diseases
Longitudinal Study of Mitochondrial Hepatopathies
The specific aims of this study are (1) to determine the clinical phenotypes and natural history of hepatic RC and FAO disorders, (2) to determine the correlation between genotype and phenotype, (3) to determine if circulating…
- Conditions
- Acute Liver Failure, Mitochondrial Diseases, End Stage Liver Disease, Respiratory Chain Deficiencies, Mitochondrial
- Trial name
- MITOHEP (NCT01148550)
- Where
- 16 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Arbor Research Collaborative for Health
Septic Shock and Acute Kidney Injury
Early Versus Late CRRT in ACLF Patients With Septic Shock and AKI
Consecutive patients with ACLF (Acute on Chronic Liver Failure) and septic shock with AKI (Acute Kidney Injury) who give written informed consent will be included in this prospective trial at ILBS.
- Trial name
- NCT03343340
- Testing
- Early CRRT, Late CRRT, Standard Medical Therapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India