Clinical trials: Liver Function Failure
Fulminant Hepatic Failure
Maternal And Fetal Outcomes in Pregnant Women With Liver Disease
Liver disease complications during pregnancy can impact maternal and neonatal health, though not many studies are on view to investigate maternal and fetal outcomes in Pakistani pregnant women.
- Trial name
- NCT06594237
- Where
- Pakistan
- Volunteers
- 195 people
- Sponsor
- Muhammad Aamir Latif
Liver Transplantation, Tranexamic Acid
Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial
We propose a multi-center randomized trial to test the primary hypothesis that tranexamic acid is superior to placebo on blood loss in adult orthotopic liver transplantation within the initial 24 hours and that tranexamic acid is…
- Conditions
- Liver Transplantation, Tranexamic Acid, End-stage Liver Disease (ESLD)
- Trial name
- ESTA (NCT07157631)
- Testing
- tranexamic acid, 0.9 % saline
- Where
- China
- Volunteers
- 1,546 people
- Sponsor
- RenJi Hospital
Cirrhosis, Hepatic Encephalopathy
Factors Associated With End Stage Liver Disease
100 ambulatory cirrhotic patients attending a liver transplant clinic will undergo a comprehensive clinical evaluation for severity of liver disease, anemia, depression, and fatigue.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Fatigue, Depression
- Trial name
- NCT01846819
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Drug-Induced Liver Injury, Liver Failure
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries 2.
- Trial name
- NCT03000621
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Cirrhoses, Liver, Portal Hypertension Related to Cirrhosis
Appropriate Management of Hepatic EncePhalopaThy AmonG cirrhOtic patieNts Admitted to Internal Medicine
Patients with decompensated liver cirrhosis are mostly managed in Internal Medicine outpatient clinics and wards; among these patients, overt hepatic encephalopathy represents one of the most frequent causes of emergency hospital…
- Conditions
- Cirrhoses, Liver, Portal Hypertension Related to Cirrhosis, Liver Stiffness, Hepatic Encephalopathy
- Trial name
- HEPTAGON (NCT07727070)
- Where
- 41 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Fadoi Foundation, Italy
DPMAS Therapy in Liver Disease Patients
Precise Profiling of Liver Disease Patients With DPMAS Therapy, Treating Optimal Patients and Achieving Hard Endpoint (PADSTONE Study)
Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome occurring in patients with chronic liver disease. In China, hepatitis B virus (HBV) is the main cause of cirrhosis.
- Trial name
- PADSTONE (NCT05129904)
- Testing
- Double plasma molecular absorption system
- Where
- 56 sites in China
- Volunteers
- 1,300 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hepatic Encephalopathy
Minimal HePatic Encephalopathy Among CiRrhotics. A Cross SEctional, Clinico-EpidEmiological, Multi-Centre, Study in Patients of PakisTan
The Preempt study is likely to help determine the frequency of patients suffering from Minimal Hepatic Encephalopathy (MHE) and are cirrhotics. It will also enable us to know about the Quality of life of these patients.
- Trial name
- Preempt (NCT02613858)
- Where
- 6 sites in Pakistan
- Volunteers
- 550 people
- Sponsor
- Abbott
Portal Hypertension, Hepatic Encephalopathy
The Influence of Post-transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy
Through a multicenter randomized controlled trial of TIPS to prevent post-hepatitis B cirrhosis of esophagogastric varices, the incidence of hepatic encephalopathy, the rate of stent patency, the incidence of rebleeding and…
- Trial name
- NCT03825848
- Testing
- trans jugular intrahepatic portal systemic shunt
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Shanghai Zhongshan Hospital
Hepatic Insufficiency
Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure Hepatectomies
Extended hepatectomies of 4 or more segments are complicated by high rates of morbidity and mortality, mainly related to hepatic liver failure.
- Trial name
- SCINTIVOL (NCT02753517)
- Testing
- Hepatobiliary scintigraphy
- Where
- 12 sites in France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Lille
Acute Liver Failure, Acute on Chronic Liver Failure
Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver Failure (ACLF).
Blood will be collected after venepuncture from all patients for complete blood counts, Serum bilirubin (direct and indirect), aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl…
- Trial name
- NCT01946360
- Testing
- Methacetin Breath Test in ACLF and ALF patients
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Diseases
Liver Diseases: Extracellular Vesicles as Biomarkers
Worldwide, cirrhosis is responsible for 2 million deaths per year. Hepatocellular carcinoma (HCC) accounts for 800,000 of these deaths and is the 3rd leading cause of cancer related death.
- Trial name
- LIVER-TRACK (NCT07185360)
- Testing
- blood sampling for volunteers, blood sampling for diabetics patients with F3/F4 fibrosis, blood sampling for patients with liver disease
- Where
- France
- Volunteers
- 845 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Failure
Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative Recipients
To provide proof-of-concept data on the efficacy/safety of transplanting HCV positive donor grafts in HCV sero-negative liver recipients who are currently listed.
- Trial name
- NCT03650920
- Testing
- Liver Transplantation
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Loma Linda University
End Stage Liver Disease
Cardiopulmonary Exercise Testing in Cirrhotic Patients: a Pilot Study
Optimizing patient survival and organ utility is a constant struggle for the liver transplant community. Despite rigorous cardiovascular evaluation before liver transplantation cardiovascular events are one of the leading causes…
- Trial name
- NCT01658982
- Testing
- cardiopulmonary exercise testing
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic