Clinical trials: Liver Inflammation
Alcoholic Hepatitis
Efficacy of Plasma Exchange Therapy vs Standard Medical Therapy in Severe Alcoholic Hepatitis With High Discriminant Function
Alcoholic hepatitis, the most florid form of alcoholic liver disease, has a very high short-term mortality of up to 50% and no specific therapies are available other than steroids.
- Trial name
- NCT06355726
- Testing
- Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis B Disease
Safety and Efficacy of SmithKline Beecham (GlaxoSmithKline [GSK]) Biologicals' Candidate Adjuvanted Vaccines (287615)
This study was done to evaluate the effect of various adjuvants in combination with HBsAg as a model antigen on the induction of immune responses, mainly cytotoxic T lymphocytes (CTL) in healthy volunteers.
- Trial name
- NCT00508833
- Testing
- 287615 containing HBsAg with adjuvants
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hepatitis B Virus Infection
Inhibition of HBV Replication and Biological Reversal of Cirrhosis (F3-F4) and HCC by Flavonoids
SB Flavonoids for Advanced Liver Disease ManagementSB Flavonoids represents a multi-target therapeutic composition engineered for the comprehensive management of Hepatitis (Acute and Chronic), Advanced Cirrhosis (F3)-(F4), and…
- Trial name
- Flavonoids (NCT07084948)
- Testing
- Flavonoid, Tenofovir
- Where
- 2 sites in United States, Vietnam
- Volunteers
- 134 people
- Sponsor
- Trieu, Nguyen Thi, M.D.
Hepatitis B
The Investigation of Peginterferon Alfa-2a on Optimal in Chronic Hepatitis B Patients Who Have a High Risk of HCC
The CHB subjects who are cirrhosis, will be randomized to two groups. The subjects who go into group A will be treated by nucleotide analogue (NA) combination with peginterferon alfa-2a,180μg/week for 48 weeks.
- Trial name
- NCT03084250
- Testing
- Peginterferon Alfa-2A, Adefovir, entecavir,tenofovir, either of them
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Nanhui Nanhua Hospital
Hepatitis B， Chronic
The Study of Two Different Chinese Traditional Medicine Treatment on Chronic Hepatitis B
Although the incidence of Hepatitis B has been decreased a lot recently years, there are still quite a few chronic hepatitis B patients in China.
- Trial name
- NCT03018821
- Testing
- Standard - Yinchengao Decoction plus Ganlu Detoxification Pill, Entecavir or Tenofovir, Standard - Ge Xia Zhu Yu Decoction
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xi'an Traditional Medicine Hospital
Hepatitis C, Chronic, HIV Infection
ADHEPTA Study: Adherence Questionnaire in Hepatitis C
Main objective: To study and validate a questionnaire measuring treatment adherence in patients with Hepatitis C virus (HCV) infection.
- Trial name
- ADHEPTA (NCT00998621)
- Testing
- Adherence questionnaire
- Where
- Spain
- Volunteers
- 1,120 people
- Sponsor
- Fundacion IMIM
Chronic Hepatitis C
Phase II Study of Immunization With a Hepatitis C Virus (HCV) Antigen Peptide Vaccine
The objectives are 1. to determine the immunological profile (CD4+, CD8+ cells, DTH) induced by immunization with HCV antigen peptide vaccine with polyarginine. 2.
- Trial name
- NCT00602784
- Testing
- IC41
- Volunteers
- 66 people
- Sponsor
- Valneva Austria GmbH
Hepatocellular Carcinoma, Hepatitis B Virus
Effects of Antiviral Therapy on Patients With HBV-related HCC
Based on the follow-up data of patients who underwent hepatectomy for HBV-related HCC at the First Affiliated Hospital of Xi'an Jiaotong University.
- Conditions
- Hepatocellular Carcinoma, Hepatitis B Virus, Survival
- Trial name
- NCT05406089
- Testing
- Medication history
- Volunteers
- 494 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Ascites, Blunt Abdominal Trauma
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican Community
The role of teleradiology has far reaching implications for the health of remote and underserved populations. The ability to coordinate radiographic evaluation and diagnosis from a distance has the potential to raise the standard…
- Conditions
- Ascites, Blunt Abdominal Trauma, Cholelithiasis, Cholecystitis
- Trial name
- NCT00591968
- Testing
- SonoSite Titan portable ultrasound coupled with email telediagnosis
- Where
- Dominican Republic
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Hepatitis C
Occult HCV Infection After DAAD Treatment in Haemodialysis Patients
This research aims to evaluate the prevalence and predictors of Occult HCV among hemodialysis (HD) patients who achieved 24 weeks sustained virological response (SVR) after treatment with direct-acting antiviral agents (DAA) by…
- Trial name
- NCT04719338
- Testing
- presence of HCV RNA in peripheral blood mononuclear cells (PBMCs) .
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Hepatitis C Virus (HCV)
Sofosbuvir/Velpatasvir/Voxilaprevir Salvage Therapy in Hepatitis C Patients Who Relapsed After DAA Treatment
This multicenter study evaluates the effectiveness and safety of a 12-week regimen of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C who relapsed after prior direct-acting antiviral therapy.
- Trial name
- NCT07565948
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Chronic Hepatitis C, People Who Inject Drugs
Treatment of HCV-Infected Recent Injection Drug Users in U.S. Liver Clinics
Direct antiviral therapy (standard of care) administered to chronic hepatitis C-infected patients, in two hepatology clinics, who had used intravenous drugs in the past 6 months of signing informed consent (IC).
- Trial name
- NCT05895448
- Testing
- velpatasvir and sofosbuvir once daily for 12 weeks (brand or branded generic) .
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Center For Hepatitis C, Atlanta, GA
Hepatitis C, Hepatitis B
Systematic Screening for Viral Hepatitis B and C at the PASS Consultation of the Montpellier University Hospital
A high number of people are infected by viral hepatitises B and C without knowing it, especially vulnerable population such as the ones who come in consultation in continuous health care access center (Permanence d'accès aux…
- Conditions
- Hepatitis C, Hepatitis B, Addiction
- Trial name
- dHEPass (NCT04959643)
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Contraception
Acceptability of Depo-subQ in Uniject
This is an observational study to assess the experience of current depot medroxyprogesterone acetate (DMPA) intramuscular (IM) clients and providers when they try Depo-subQ in Uniject and offer recommendations for the…
- Trial name
- NCT01667276
- Where
- 2 sites in Senegal, Uganda
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- FHI 360
Chronic Hepatitis C
Subcutaneous Continuous Infusion of Interferon Alfa-2b and Ribavirin in Hepatitis C Genotype 1 Nonresponders
For chronic hepatitis C patients unresponsive to previous (PEG-)IFN/RBV combination therapy we propose continuous subcutaneous administration of high-dose IFN-a2b (Intron A®) for 48 weeks in combination with 15 mg/kg/day RBV…
- Trial name
- SCIN-C (NCT00624325)
- Testing
- interferon alfa-2b
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Foundation for Liver Research
Hepatitis C
Trial of Hepatitis C Self-Testing in the Hands of Untrained Lay Users
This is a controlled study intended to evaluate the usability, label comprehension and performance of the INSTI® HCV Self Test in the hands of untrained lay users using fingerstick blood, with instructions for use specifically…
- Trial name
- NCT06369116
- Testing
- INSTI HCV Self Test
- Where
- South Africa
- Volunteers
- 1,415 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories
HCV, Hepatitis C Infection
Coadministration of ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) With Ribavirin (RBV) in Adults With Genotype 4 (GT4) Hepatitis C Virus (HCV) in Egypt
This study evaluates the efficacy and safety of ABT-450/r/ABT-267 with RBV in treatment-naive and treatment-experienced HCV GT4 subjects without or with compensated cirrhosis.
- Conditions
- HCV, Hepatitis C Infection, Genotype 4
- Trial name
- NCT02247401
- Testing
- 2 DAA, RBV
- Volunteers
- 160 people
- Sponsor
- AbbVie
Hepatitis C
A Study of the Use of Hepatitis C Positive Donors for Hepatitis C Negative Lung Transplant Recipients With Post-transplant Treatment With Mavyret
Patients who are Hepatitis C Negative (HCV negative) and are on the waiting list for a lung transplant at NYULH who consent to participate in this study will receive a lung transplant from a deceased donor that is HCV positive.
- Trial name
- NCT03523871
- Testing
- Mavyret
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Chronic Hepatitis C
Taribavirin Phase 2 Dose Finding Study for the Treatment of Hepatitis C Virus (HCV)
The objective of the study is to select an optimal dose of taribavirin by comparing the efficacy and safety of 3 taribavirin dose levels, 20, 25, and 30 mg/kg/day, versus ribavirin 800 to 1400 mg/day based on body weight, both…
- Trial name
- NCT00446134
- Testing
- Taribavirin, Ribavirin
- Where
- United States
- Volunteers
- 278 people
- Sponsor
- Bausch Health Americas, Inc.
Hepatitis C, Chronic
Directly Observed Therapy for HCV in Chennai, India
The primary objective of this pilot trial is to evaluate the feasibility of 12 weeks vs. 24 weeks of field-based directly observed therapy (DOT) for HCV therapy in a resource-limited setting.
- Trial name
- C-DOT (NCT02541409)
- Testing
- Sofosbuvir, Pegylated Interferon alfa-2a, Ribavirin
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
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