Clinical trials: Liver Inflammation
Chronic Hepatitis B
Comparison Between Lamivudine and Entecavir Treatment in Spontaneous Severe Acute Exacerbation
This is a prospective, observational, open-label, 2-arm, parallel, multi-center study. Patients with HBV-associated severe acute exacerbation for whom the treatment with NRTI (such as lamivudine and entecavir) is medically…
- Trial name
- NUC115132 (NCT01627223)
- Testing
- Lamivudine, Entecavir
- Where
- 8 sites in Taiwan
- Volunteers
- 17 people
- Sponsor
- Taichung Veterans General Hospital
Thrombocytopenia
Managed Access Programs for ETB115, Eltrombopag
The purpose of this registration is to list Managed Access Programs (MAPs) related to ETB115, Eltrombopag
- Trial name
- NCT04837703
- Testing
- Eltrombopag
- Sponsor
- Novartis Pharmaceuticals
Hepatitis B, HBV
A Study Evaluating GS-9620 in Treatment Naive Subjects With Chronic Hepatitis B
Dose cohorts may be dosed with one of up to 4 possible total weekly doses (0.3 mg, 1 mg, 2 mg, 4 mg). Dose escalation or repetition will be governed by pre-specified safety and activity rules.
- Trial name
- NCT01590641
- Testing
- Single Ascending Dose (SAD) Cohorts GS-9620, Multiple Ascending Dose (MAD) Cohorts
- Where
- 23 sites in United States, Australia and 3 more
- Volunteers
- 49 people
- Sponsor
- Gilead Sciences
Hepatitis C Infection
Safety and Efficacy of Daclatasvir (BMS-790052) Plus Standard of Care (Pegylated-interferon Alpha-2b and Ribavirin) in Japanese Patients
The purpose of this study is to identify at least 1 dose of daclatasvir that is safe, well tolerated, and efficacious when combined with peginterferon-alfa and ribavirin for the treatment of hepatitis C virus genotype 1 in…
- Trial name
- NCT01016912
- Testing
- BMS-790052, Peginterferon alfa-2b, Ribavirin
- Where
- 6 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Bristol-Myers Squibb
Hepatitis C
Reviewing DAA Efficacy Managing Patient Treatment In Online Neighbourhoods
REDEMPTION (Reviewing DAA Efficacy Managing Patient Treatment In Online Neighbourhoods) is observing and collating the treatment course, safety profile, and outcomes of patients around the world who are choosing to self import…
- Trial name
- REDEMPTION (NCT02657694)
- Testing
- Sofosbuvir+Ledipasvir, Sofosbuvir+Daclatasvir, Sofosbuvir+Velpatasvir
- Where
- Australia
- Volunteers
- 10,000 people
- Sponsor
- FixHepC
Chronic Hepatitis C
Effectiveness of Paritaprevir/Ritonavir, Ombitasvir, + Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C in Romania
This study seeks to provide evidence of the effectiveness and obtain patient reported outcome (PRO) data for the interferon-free regimen of paritaprevir (PTV)/ritonavir (r) + ombitasvir (OBV), + dasabuvir (DSV), +/- ribavirin…
- Trial name
- NCT02807402
- Volunteers
- 522 people
- Sponsor
- AbbVie
Hepatitis C, Chronic
A Study of TMC435350 Administered With or Without Standard of Care Therapy in Participants With Genotype 1 Hepatitis C Virus Infection
The purpose of this study is to investigate how efficient TMC435350 will work against the Hepatitis C virus genotype 1 (genotypes refer to the genetic constitution of the virus) and what the concentrations of TMC435350 in the…
- Trial name
- NCT00561353
- Testing
- TMC435, Peginterferon (PegIFNα-2a), Ribavirin
- Where
- 24 sites in Belgium, France and 4 more
- Volunteers
- 121 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Influenza Human
Field Trial of Maternal Influenza Immunization in Asia
This project is designed to assess the efficacy of immunizing women during pregnancy with influenza vaccine on the health of these women during their pregnancy and for 6 months post-partum as well as on the health of their…
- Trial name
- Mothers'Gift (NCT01034254)
- Testing
- influenza vaccine
- Where
- Nepal
- Volunteers
- 3,693 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Primary Biliary Cirrhosis, Liver Inflammation
sCD163 in PBC Patients - Assessment of Disease Severity and Prognosis
Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, characterised by destruction of the small intrahepatic bile ducts.
- Trial name
- NCT02924701
- Testing
- Blood samples, fibroscan and questionaires
- Where
- Denmark
- Volunteers
- 168 people
- Sponsor
- University of Aarhus
Hepatitis C, Deglutition Disorders
Bioequivalence Study of Crushed Elbasvir/Grazoprevir Compared to the Whole Tablet
Elbasvir/grazoprevir (Zepatier®) is a once-daily tablet for the treatment of chronic hepatitis C virus (HCV) GT1a, 1b or 4 infection containing the NS5A inhibitor elbasvir (ELB) 50 mg and the NS3/4A protease inhibitor grazoprevir…
- Trial name
- CRUSADE-2 (NCT03817619)
- Testing
- Zepatier whole tablet, Zepatier crushed tablet
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hepatitis C
Drug Interaction Study of an OCP (Norethindrone (ND) Acetate and Ethinyl Estradiol (EE))With a Combination of Daclatasvir (DCV) Asunaprevir (ASV) and BMS-791325
The purpose of this study is to assess the effect of DCV/ASV/BMS-791325 fixed dose combination (FDC) + 75mg BMS-791325 on the Pharmacokinetics (PK) of the oral contraceptive agent.
- Trial name
- NCT02103569
- Testing
- FDC of Daclatasvir, Asunaprevir and BMS-791325, FDC of Norethindrone and Ethinyl Estradiol, BMS-791325
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Chronic Hepatitis C
Safety and Tolerability of Boceprevir in Combination With Peginterferon Alfa-2b Plus Ribavirin for the Treatment of Vietnamese Subjects With Chronic Hepatitis C Genotype 1 (P08599)
This study is designed to assess the safety and tolerability of boceprevir dosed 800 mg three times daily (TID) orally (PO) in combination with Peginterferon alfa-2b (PEG2b) 1.5 mcg/kg once a week (QW) administered subcutaneously…
- Trial name
- NCT01641666
- Testing
- Boceprevir, Peginterferon Alfa-2b 1.5 mcg/kg/week, Ribavirin
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Hepatitis B
Trial of Telbivudine Combination Therapy vs. Continued Adefovir Monotherapy
The purpose of this study is to find out if taking a combination of telbivudine and adefovir or tenofovir and telbivudine can lower the amount of Hepatitis B virus in patients that have been taking adefovir alone for at least 5…
- Trial name
- NCT00409019
- Testing
- Telbivudine, Adefovir, Tenofovir
- Sponsor
- Novartis Pharmaceuticals
Hepatitis C
Generation of Anti-HCV Antibodies From Bone Marrow: Defining the Repertoire of Immune Response to HCV Quasispecies
To generate a library of genes that reflect the entirety of antibody responses to hepatitis C virus (HCV) made during the 20-year course of HCV infection in a single patient (WH) whose viral quasispecies has been extensively…
- Trial name
- NCT00004851
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Autoimmune Hepatitis
Quantitative Magnetic Resonance Imaging to Aid Clinical Decision Making in Autoimmune Hepatitis.
This will be a prospective, observational, cross-sectional study designed to assess how a quantitative Magnetic Resonance Imaging (MRI) scan will aid in a physicians' clinical decision making process in patients with suspected or…
- Trial name
- NCT03979053
- Testing
- Multiparametric MRI Scan
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Perspectum
Chronic Hepatitis C Infection
Sofosbuvir Containing Regimens for the Treatment of Chronic HCV GT2 Infected Patients
The purpose of this study is to assess the safety, tolerability, and efficacy of Sofosbuvir containing regimens in treatment-naive or treatment-experienced patients with HCV genotypes 2 infection.
- Trial name
- NCT02482077
- Testing
- SOF+RBV, SOF+DCV, LDV/SOF
- Where
- 2 sites in China
- Volunteers
- 112 people
- Sponsor
- Humanity and Health Research Centre
Hepatitis C, Chronic
HELPS Study - A Study of Peginterferon Alfa-2a (Pegasys) in Patients With Chronic Hepatitis C (CHC) and End-Stage Renal Disease (ESRD)
This study evaluated the safety and efficacy of peginterferon alfa-2a monotherapy in participants with Chronic Hepatitis C (CHC) who have End-Stage Renal Disease (ESRD) and were undergoing hemodialysis.
- Trial name
- NCT02806505
- Testing
- Peginterferon alfa-2a
- Where
- 22 sites in Austria, Brazil and 6 more
- Volunteers
- 81 people
- Sponsor
- Hoffmann-La Roche
Hepatitis B Virus Related Hepatocellular Carcinoma
The SIMPLY-B Study
This study will be conducted in three parts: Part A: A prospective open label pilot intervention study, comparing the proportion of people with hepatitis B who are managed by their GP in primary care settings before, 12 months…
- Trial name
- NCT05614466
- Testing
- The Simply B Study
- Volunteers
- 100 people
- Sponsor
- Nadine Barnes
Hepatitis C, Chronic
PegIntron Injection Surveillance Plan (Study P04123)
Surveillance will be conducted at digestive departments of internal medicine in university or general hospitals where participants with chronic hepatitis C are generally treated.
- Trial name
- NCT00723931
- Testing
- Peginterferon alfa-2b (SCH 54031)
- Volunteers
- 1,267 people
- Sponsor
- Merck Sharp & Dohme LLC
Hepatitis C
Advanced Care Coordination and Enhanced Linkage and Retention Among Transitional Re-Entrants
The overarching goal of this study is to develop a peer-based care coordination intervention for individuals with Hepatitis C Virus (HCV) who were recently released from correctional settings to promote linkage to and retention…
- Trial name
- ACCELERATE (NCT04701437)
- Testing
- Peer mentor, Standard of care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Montefiore Medical Center
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