Clinical trials: Liver Regeneration
Liver Regeneration
Platelets in Liver Regeneration
The most relevant factor predicting morbidity and mortality after liver resections is the ability of the remnant liver to regenerate.
- Trial name
- NCT02113059
- Where
- 2 sites in Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Liver Cancer
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
The study will monitor carbon monoxide production in patients undergoing liver resection. Carbon monoxide will be checked from arterial blood gas obtained routinely as a part of the postoperative care as well as from the exhaled…
- Trial name
- NCT04195438
- Testing
- CO Testing Pre/Post Hepatic Resection, ABG Testing Pre/Post Hepatic Resection, CT Evaluations
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Maryland, Baltimore
Liver Resection
Energy Expenditure and Regeneration Following Liver Resection Resection
This observational study will measure resting energy expenditure in patients who have undergone liver resection and compare methods of measuring resting energy expenditure.
- Trial name
- EAGLE (NCT02031094)
- Testing
- Observational study: Sense Wear armband and indirect calorimetry used to measure resting energy expenditure
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Edinburgh
Liver Resection, Cancer
Regeneration of Liver: Portal Vein Embolization Versus Radiofrequency Assisted Ligation for Liver Hypertrophy (REBIRTH)
The aim of this study is to compare two different techniques (portal vein embolization and radiofrequency assisted liver partition with portal vein ligation) for increasing liver volume prior to major liver resection.
- Trial name
- REBIRTH (NCT02216773)
- Testing
- Radiofrequency assisted liver partition with portal vein ligation (RALPP), Portal vein embolization (PVE)
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Imperial College London
Mediators of Post Hepatectomy Liver Regeneration
Study of Mediators of Post Hepatectomy Liver Regeneration
Prospective non-randomized trial to study expression of mediators of post hepatectomy liver regeneration (PHLR) and compare with a non-hepatectomy group: a pilot study Background : Experimental studies using post hepatectomy…
- Trial name
- NCT02077062
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Govind Ballabh Pant Hospital
Liver Cancer Adult, Liver Regeneration
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection or ablation(2) to assess the…
- Trial name
- NCT06681818
- Testing
- carbon monoxide measurement via smokerlyzer
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Englewood Hospital and Medical Center
Liver Regeneration, Reversible Portal Vein Embolization
Reversible Portal Vein Embolization Before Major Hepatectomy
The aim of this study is to prospectively evaluate the tolerance and efficiency of a new technique of preoperative selective portal vein embolization (PVE) in patients requiring major hepatic resection.
- Trial name
- EMBORES (NCT02945059)
- Testing
- Selective reversible portal vein embolization
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Failure After Operative Procedure
A Machine Learning Architecture to Predict Post-Hepatectomy Liver Failure Using Liver Regeneration Biomarkers and Time-Phased Data
Post-hepatectomy liver failure (PHLF) is the leading cause of morbidity and mortality following major hepatectomy. Existing prediction models fail to capture the dynamic liver regeneration and perioperative changes, limiting…
- Trial name
- PHLF predictio (NCT05779098)
- Where
- China
- Volunteers
- 1,071 people
- Sponsor
- Shen Feng
Liver Cancer, Surgery
HepaT1ca: Quantifying Liver Health in Surgical Candidates for Liver Malignancies
This observational clinical cohort study aims to evaluate the clinical utility of LiverMultiScan in quantifying liver health prior to liver resection or TACE.
- Conditions
- Liver Cancer, Surgery, Liver Regeneration, Colorectal Cancer Metastatic
- Trial name
- Hepatica (NCT03213314)
- Testing
- Multiparameter magnetic resonance imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 149 people
- Sponsor
- University of Edinburgh
Hepatectomy
Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties. No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepatic surgery.
- Trial name
- NCT00219856
- Testing
- Propofol, Penthotal, Desflurane
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Liver Regeneration, Ursodeoxycholic Acid
Effect of Ursodeoxycholic Acid Supplementation on Liver Regeneration on Right Lobe Donor Hepatectomy
The goal of this open label randomized trial is to understand the role of oral ursodeoxycholic acid(UDCA) supplementation in the liver regeneration (in terms of liver function and anatomical growth) following right lobe donor…
- Conditions
- Liver Regeneration, Ursodeoxycholic Acid, Partial Liver Resection
- Trial name
- NCT06091787
- Testing
- Ursodeoxycholic acid, Standard Medical Treatment
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Carcinoma, Hepatocellular
Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or Portal Vein Occlusion in Treating Patients With Liver Cancer
This randomized phase II trial compares how well associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) or portal vein occlusion (PVO) works in treating patients with liver cancer.
- Trial name
- ALPPS (NCT01722175)
- Testing
- ALPPS surgery, PVO surgery
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine