Clinical trials: Liver Regeneration
Liver Cirrhosis
Liver Regeneration Therapy by Intrahepatic Arterial Administration of Autologous Adipose Tissue Derived Stromal Cells
Mesenchymal stem cells have capability to differentiate into hepatocyte and will be useful for liver regeneration. Adipose tissue is relatively enriched with mesenchymal stem cell compared to bone marrow tissue.
- Trial name
- NCT01062750
- Testing
- adipose tissue derived stromal cells dosage
- Where
- Japan
- Volunteers
- 4 people
- Sponsor
- Kanazawa University
Liver Cancer Adult, Liver Regeneration
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection or ablation(2) to assess the…
- Trial name
- NCT06681818
- Testing
- carbon monoxide measurement via smokerlyzer
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Englewood Hospital and Medical Center
Living Donor Liver Transplantation
The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study
Rationale: Living donor liver transplantation (LDLT) offers a promising solution to the organ shortage. During living liver donation, a substantial portion of the donor's liver is resected.
- Trial name
- LRLDLT (NCT07329296)
- Testing
- Living liver donation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Liver Cirrhosis
Liver Regeneration Therapy Using Autologous Adipose Tissue Derived Stromal Cells
Mesenchymal stem cells have the capability to differentiate into hepatocytes and will be useful for liver regeneration. Adipose tissue is relatively enriched with mesenchymal stem cells compared to bone marrow tissue.
- Trial name
- NCT00913289
- Testing
- adipose tissue derived stromal cells
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Kanazawa University
Liver Diseases, Hepatectomy
Liver Regeneration After Liver Resection
The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy.
- Trial name
- NCT01220986
- Testing
- Liver biopsy
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Liver Cirrhosis
Evaluation of Liver Regeneration With Autologous Peripheral Stem Cells
For patient with liver cirrhosis who need to right or extended right hepatectomy, we will treat with autologous peripheral stem cells transplantation to facilitate liver regeneration.
- Trial name
- NCT01108380
- Testing
- Plasma pheresis, Right portal vein embolization
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Malignant Liver Disease, Major Liver Resection
Administration of Rifaximin to Improve Liver Regeneration and Outcome Following Major Liver Resection
Surgery is in almost all cases the only potentially curative treatment option for patients with primary or secondary malignancies of the liver.
- Trial name
- ARROW (NCT02555293)
- Testing
- XIFAXAN® (Rifaximin)
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- RWTH Aachen University
Liver Failure After Operative Procedure
A Machine Learning Architecture to Predict Post-Hepatectomy Liver Failure Using Liver Regeneration Biomarkers and Time-Phased Data
Post-hepatectomy liver failure (PHLF) is the leading cause of morbidity and mortality following major hepatectomy. Existing prediction models fail to capture the dynamic liver regeneration and perioperative changes, limiting…
- Trial name
- PHLF predictio (NCT05779098)
- Where
- China
- Volunteers
- 1,071 people
- Sponsor
- Shen Feng
Liver Neoplasms, Liver Regeneration
Registry of Major Liver Resections Including ALPPS and Other Liver Resections in Two Stages
Recently a new method of induce similar hypertrophy in the liver as is observed after hepatectomy has been described and was given the eponym "ALLPS".
- Trial name
- ALPPSREG (NCT01924741)
- Testing
- ALPPS
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Liver Transplant Rejection
Cell Infusion Intraportal Autologous Bone Marrow Mononuclear as Enhancer of Liver Regeneration
This is a randomized controlled trial in which the safety and feasibility of cell therapy medicinal product shall be measured by comparing the variables of the response after treatment compared to baseline prior to…
- Trial name
- NCT01745731
- Testing
- Cell infusion intraportal mononuclear bone marrow autologous and portal embolization of the affected segments.
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Hepatorenal Syndrome, Liver Regeneration
Plasma and Hemodynamic Markers During Hepatectomy
Introduction Liver resection is considered the only curative treatment option for mCRC patients without extrahepatic disease and is accepted practice.
- Trial name
- NCT01700231
- Testing
- Liver resection
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Rotator Cuff Tear
Polydeoxyribonucleotide (PDRN) for Cuff Regeneration
This study is to evaluate the effect of polydeoxyribonucleotide (PDRN) for healing and fatty degeneration of rotator cuff. The investigators will enroll 130 patients with rotator cuff tear who will undergo arthroscopic rotator…
- Trial name
- NCT03916198
- Testing
- Polydeoxyribonucleotides, Normal saline
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Chuncheon Sacred Heart Hospital