Clinical trials: Liver Resection, open to volunteers
Hepatocellular Carcinoma (HCC), Metastasis
Surgery Plus Systemic Therapy for Liver Cancer With Extrahepatic Metastases
This study will evaluate whether resection of the primary liver tumor, in addition to standard first-line systemic therapy, improves survival in patients with hepatocellular carcinoma that has spread outside the liver but still…
- Trial name
- NCT07537959
- Testing
- Primary Tumor Resection, Protocol-Allowed First-Line Immune-Based Systemic Therapy
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Tongji Hospital
Carcinoma, Hepatocellular, Metabolic Syndrome
Liver Resection and Simultaneous Sleeve Gastrectomy for MS-HCC (LIRESS)
Hepatocellular carcinoma (HCC) related to metabolic syndrome (MS) as unique risk factor is gradually overpassing the more common viral and alcohol etiology, becoming a global health issue.
- Trial name
- LIRESS (NCT06060847)
- Testing
- Liver resection and simultaneous sleeve gastrectomy for HCC induced by metabolic syndrome, Liver resection for HCC induced by metabolic syndrome
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale V. Fazzi
Postoperative Pain After Laparoscopic Liver Resection
Intraoperative Continuous Lidocaine Infusion in Laparoscopic Liver Surgery
The goal of this clinical trial is to learn about effect of intraoperative continuous lidocaine infusion on postoperative pain, gut function and insulin resistance in patients undergoing laparoscopic liver surgery in adults.
- Trial name
- ICLIL (NCT07012889)
- Testing
- lidocaine infusion
- Volunteers
- 94 people
- Sponsor
- Medical University of Warsaw
Hepatocellular Carcinoma
The Impact on Survival of Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Hepatocellular Carcinoma And Portal Vein Tumor Thrombosis (PVTT) Who Underwent Hepatectomy : A Random, Controlled, Stage III Clinical Trial.
To compare the impact on survival of neo-adjuvant TAI for patients with HCC and PVTT who underwent hepatectomy.
- Trial name
- NCT03368651
- Testing
- TAI
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Sun Yat-sen University
Hepatocellular Carcinoma
To Compare the Efficacy of Microwave Ablation and Laparoscopic Hepatectomy for Hepatocellular Carcinoma
The study was a prospective multicenter cohort control study, which was divided into 1:1 groups to compare the clinical efficacy of percutaneous microwave ablation and laparoscopic hepatocellular carcinoma resection (tumor…
- Trial name
- NCT04365751
- Testing
- Percutaneous microwave ablation, Laparoscopic hepatectomy
- Where
- China
- Volunteers
- 1,134 people
- Sponsor
- Chinese PLA General Hospital
Colorectal Cancer, Colorectal Liver Metastases
Adjuvant FOLFIRI Based-chemotherapy After Resection of CLM Responding to Preoperative FOLFIRI
Eligible patients are patients with contraindication to preoperative oxaliplatin based-chemotherapy who underwent resection of no more than 10 colorectal liver metastases after preoperative FOLFIRI based chemotherapy with or…
- Trial name
- IRIMAD (NCT06501482)
- Testing
- Postoperative reintroduction of FOLFIRI based chemotherapy
- Where
- France
- Volunteers
- 254 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatic Cancer, Hepatocellular Carcinoma
Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy
How to accurately and safely evaluate regional liver function before hepatectomy remains an important unsolved problem in the surgical management of hepatocellular carcinoma (HCC).
- Conditions
- Hepatic Cancer, Hepatocellular Carcinoma, Intrahepatic Cholangiocellular Carcinoma, Metastatic Hepatocellular Carcinoma
- Trial name
- NCT07704203
- Testing
- Three-Dimensional Magnetic Resonance Elastography
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Liver Steatoses, Liver Metastasis Colon Cancer
Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis
Non-alcoholic fatty liver disease is becoming increasingly common in Canada and throughout the world. Fatty liver can increase the risks of perioperative complications for those who need liver surgery.
- Conditions
- Liver Steatoses, Liver Metastasis Colon Cancer, NAFLD
- Trial name
- NCT05884723
- Testing
- Ketogenic Diet
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Anton Skaro
Liver Transplant Surgery, Colorectal Cancer Metastatic
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM).
- Conditions
- Liver Transplant Surgery, Colorectal Cancer Metastatic, Colon Cancer Liver Metastases
- Trial name
- CLEAR (NCT06698146)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Gallbladder Diseases, Cholelithiasis
Impact of Pringle Maneuver on Postoperative Gallbladder Diseases After Hepatectomy
The liver is an organ with a rich blood supply. During liver surgery (hepatectomy), surgeons often temporarily clamp the blood vessels supplying the liver to maintain a clear surgical field and reduce bleeding.
- Trial name
- NCT07452848
- Testing
- Pringle maneuver
- Where
- 8 sites in China
- Volunteers
- 2,000 people
- Sponsor
- West China Hospital
Hepatocellular Carcinoma, Hepatocellular Cancer
Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC
This is a single arm phase II study of adjuvant intra-dermal NA DC vaccine combined with intravenous nivolumab in patients with resectable HCC (group A) or CRLM (group B) planned for curative surgery (with/without local ablation).
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Cancer, Colorectal Cancer, Colorectal Carcinoma
- Trial name
- NCT04912765
- Testing
- Neoantigen Dendritic Cell Vaccine, Nivolumab
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- National Cancer Centre, Singapore
Liver Dysfunction, Liver Metastasis Colon Cancer
Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy.
- Conditions
- Liver Dysfunction, Liver Metastasis Colon Cancer, Liver Regeneration
- Trial name
- NCT06126419
- Testing
- High-Dose Insulin Therapy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hepatectomy, Intertransverse Process Block
Intertransverse Process Block for Quality of Recovery Post-Open Hepatectomy
The study aims to assess the analgesic efficacy of the ITPB at the retro-SCTL space in patients undergoing major open hepatectomy surgery.
- Conditions
- Hepatectomy, Intertransverse Process Block, Quality of Recovery (QoR-15)
- Trial name
- ITPB QoR (NCT06957041)
- Testing
- Intertransverse process block
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
HCC - Hepatocellular Carcinoma
Defining the Ablative Dose for Y-90 TARE
This study is being done to help doctors improve how they treat liver tumors that cannot be removed by surgery or treated with standard ablation techniques.
- Trial name
- MARGIN (NCT07586046)
- Testing
- Yttrium-90 Radiation Segmentectomy (Y90 RS) using glass microspheres
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Liver Tumours, Liver Cancer (Primary and Metastatic)
Italian Group of Regenerative and Occlusive Worldwide-used Techniques of Hepatic Hypertrophy
The goal of this national mutlticenter observational study is to learn and describe trends over time in the use of techniques for inducing hepatic hypertrophy in Italy.
- Conditions
- Liver Tumours, Liver Cancer (Primary and Metastatic), Liver Resection, Liver Hypertrophy
- Trial name
- I-GROWtoh (NCT07445412)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Cancer, Liver Metastases
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
The DRAGON registry aims to collect data on combined portal and hepatic vein embolization (PVE/HVE) for liver tumors, a technique expected to enhance liver regeneration compared to standard PVE.
- Trial name
- NCT07717437
- Where
- 31 sites in United States, Australia and 11 more
- Volunteers
- 350 people
- Sponsor
- Maastricht University Medical Center
HCC - Hepatocellular Carcinoma
The DoHAICs Study Expansion Phase
We explored the efficacy and safety of the first-line treatment of unresectable hepatocellular carcinoma with donafenib combined with hepatic artery infusion chemotherapy (HAIC) and sintilimab .
- Trial name
- NCT07584018
- Testing
- Donafenib, sintilimab, HAIC
- Volunteers
- 90 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Liver Cancer, Surgery
Pre- Vs Postoperative Thromboprophylaxis for Liver Resection
Thromboprophylaxis for liver surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in liver surgery patients, there is no international consensus when…
- Conditions
- Liver Cancer, Surgery, Thrombosis, Deep Vein, Embolism, Pulmonary
- Trial name
- PREPOSTEROUS (NCT04731558)
- Testing
- enoxaparin or tinzaparin or dalteparin, No intervention
- Where
- 7 sites in Finland, Norway
- Volunteers
- 1,012 people
- Sponsor
- Helsinki University Central Hospital
Unresectable Hepatocellular Carcinom
Conversion Therapy Using TACE/HAIC With Anti-Angiogenic and Immunotherapy for Initially Unresectable Hepatocellular Carcinoma Achieving Complete Response or Resectability, Followed by Surgery or Continued Systemic Treatment: A Prospective Cohort Study
This is a prospective cohort study designed to evaluate the effectiveness and safety of two post-conversion treatment strategies for patients with initially unresectable hepatocellular carcinoma (uHCC).
- Trial name
- THAI-CONVERT (NCT07206511)
- Volunteers
- 278 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Cancer Adult, Liver Regeneration
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO…
- Trial name
- NCT06681818
- Testing
- carbon monoxide measurement via smokerlyzer
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Englewood Hospital and Medical Center