Clinical trials: Liver Surgery
ColoRectal Cancer, Liver Metastasis Colon Cancer
COLLISION Trial - Colorectal Liver Metastases: Surgery vs Thermal Ablation
The primary objective is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable colorectal liver metastases (≤3cm) and no extrahepatic disease.
- Conditions
- ColoRectal Cancer, Liver Metastasis Colon Cancer, Liver Metastases, Surgery
- Trial name
- COLLISION (NCT03088150)
- Testing
- Thermal ablation, Surgical resection
- Where
- Netherlands
- Volunteers
- 618 people
- Sponsor
- Amsterdam UMC, location VUmc
Liver Transplant Surgery, Liver Transplantation
Open Label Trial of Deceased Donor Livers Transplanted After DHOPE With eXVIVO LIVER Perfusion
The purpose of this clinical study is to confirm the safety and effectiveness of dual hypothermic oxygenated perfusion (DHOPE) using the Liver Assist to preserve deceased donor livers for transplantation.
- Trial name
- NCT06916325
- Testing
- dual hypothermic oxygenated perfusion (DHOPE)
- Volunteers
- 215 people
- Sponsor
- XVIVO Perfusion
Colorectal Neoplasms
Effect of TroVax in Patients Having Colorectal Cancer With Liver Metastases Removed
This study will test the safety and efficacy of TroVax in patients undergoing surgical resection of colorectal cancer with liver metastases.
- Trial name
- NCT00259844
- Testing
- TroVax
- Volunteers
- 20 people
- Sponsor
- Cancer Research UK
Liver Retraction During Bariatric Surgery
Organ Retractor Device Study
This study aims to assess the safety and efficacy of an organ retraction device. The study is low risk as it is only being used in patients already undergoing primary robotic bariatric surgery.
- Trial name
- NCT06754514
- Testing
- liver retraction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Boehringer Labs LLC
Metastasis, Quality of Life
Health Related Quality of Life After Surgery and Oncological Treatment of Colorectal Liver Metastases
The purpose of this trial is to study health related quality of life (HQoL)after resection of colorectal liver metastases combined with perioperative chemotherapy.
- Trial name
- HQOL (NCT01587976)
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Liver Cirrhosis, Acute on Chronic Liver Failure
To Compare Relaxed Rotational Thromboelastometry Cut-offs With Standard Cut-offs for Guiding Blood Product Use Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure Patients
Hypothesis Relaxed ROTEM cutoff guided blood product transfusion will result in less blood products use without increasing bleeding complications for invasive procedures in cirrhosis or acute on chronic liver failure (ACLF)…
- Trial name
- NCT05672589
- Testing
- Relaxed Rotational Thromboelastometry, Standard Coagulation Tests
- Where
- India
- Volunteers
- 1,050 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Diseases, Liver Cancer
Accuracy of the LiverVision® Semi-automated Liver Volumetry Software
The LiverVision® software was designed to provide three-dimensional (3D) visualisation of the liver using Computed Tomography (CT) scans. It provides semi-automated volumetry measurements, vascular structure and territory tools.
- Trial name
- LiverVision (NCT03766633)
- Testing
- Liver volumetry of the graft on CT
- Where
- 3 sites in Germany, Turkey (Türkiye) and 1 more
- Volunteers
- 108 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Obesity, Morbid
Preoperative Ultrasound as a Predictor for Difficulty in Bariatric Surgery
the left lobe of the liver in obese patient usually fatty and enlarged and may cause difficulty during bariatric surgery. the aim of this study is to test the impact of routine preoperative ultrasound to evaluate the size of left…
- Trial name
- NCT03486691
- Testing
- Routine measurement of left lobe, control group
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Minia University
Hepatocellular Carcinoma, Hepatoma
Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery
It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI). Sevoflurane may increase the risk for postoperative AKI because of production of compound-A.
- Conditions
- Hepatocellular Carcinoma, Hepatoma, Cholangiocarcinoma, Gallbladder Neoplasms
- Trial name
- NCT02174575
- Testing
- Sevoflurane, Desflurane
- Where
- Japan
- Sponsor
- Tokyo Medical and Dental University
Morbid Obesity, Obstructive Sleep Apnea Syndrome
LAGB as a Treatment for Morbid Obesity in Adolescents
Laparoscopic adjustable gastric banding (LAGB) has been used worldwide to help selected morbidly obese adults to lose weight. The FDA has approved LAGB only for patients 18 years or older.
- Conditions
- Morbid Obesity, Obstructive Sleep Apnea Syndrome, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01045499
- Testing
- Laparoscopic adjustable gastric banding (Allergan Lap Band)
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Jeffrey L Zitsman, MD
Hydatid Cyst
Radical Versus Conservative Surgical Treatment of Liver Hydatid Cysts
The management of liver hydatid cysts (LHC) is controversial. Surgery remains the basic treatment, and can be divided into radical and conservative approaches.
- Trial name
- NCT04988958
- Testing
- hydatid cyst resection
- Volunteers
- 914 people
- Sponsor
- Université de Sousse
NAFLD, NASH - Nonalcoholic Steatohepatitis
The Franciscus Obesity NASH Study
The purpose of this study is to evaluate Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) changes in terms of steatosis and elasticity in patients with morbid obesity 1, 3 and 5 years after…
- Conditions
- NAFLD, NASH - Nonalcoholic Steatohepatitis, Obesity, Morbid
- Trial name
- FONS (NCT05499949)
- Testing
- NASH screening, Cardiac dysfunction screening, Liver biopsy
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Franciscus Gasthuis
Liver Transplantation
Application of in Vivo Splitting Technique in Adult Liver Transplantation
The feasibility of split liver transplantation (SLT) remains controversial. This study aimed to evaluate the outcomes of SLT in adult recipients and to identify specific areas of improvements.
- Trial name
- NCT06925828
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Morbid Obesity
Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function
Gastric bypass surgery is the gold standard in bariatric surgery and is a successful method to reduce weight in morbidly obese subjects.
- Trial name
- OLIVIER (NCT02206256)
- Testing
- Omega-3 fatty acid capsules, Low calorie diet
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Medical Center Alkmaar
Echinococcosis, Hepatic
Presentation of Protoscolexes and Acephalocysts in the Fibrous Capsule Area of the Liver With Echinococcosis
The objective of the study is to determine the presence of germinal elements of echinococcosis in the liver parenchyma next to and in the thickness of the fibrous capsule of hydatid cysts.
- Trial name
- PAFCLE (NCT06316154)
- Testing
- Echinococcectomy
- Where
- Uzbekistan
- Volunteers
- 100 people
- Sponsor
- Republican Specialized Scientific and Practical Medical Center of Surgery Named After V. Vakhidov
Surgery, Hepatocellular Carcinoma
Transient Elastography in Hepatectomy for Hepatocellular Carcinoma
The purpose of this study is to determine whether liver transient elastography performed before the surgical procedure is able to predict liver failure in patients undergoing hepatectomy for hepatocellular carcinoma.
- Trial name
- NCT01441453
- Testing
- FibroScan (Transient Elastography measurement)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hepatocellular Carcinoma, Portal Vein Thrombosis
Neo-TACE-HAIC for PVTT-HCC
Hepatocellular carcinoma (HCC) patients is a common disease in the East Asia. During the disease course, 20%-50% patients suffered portal vein tumor thrombus (PVTT), which is characterized with poor outcome and low response for…
- Trial name
- NeoconceptC (NCT04181931)
- Testing
- neo-TACE-HAIC+Surgery, Surgery alone
- Where
- 2 sites in China
- Volunteers
- 320 people
- Sponsor
- Sun Yat-sen University
Liver Cancer, Hepatoma
Radiolabeled Glass Beads Used for Treating Patients With Primary Liver Cancer When Surgery is Not an Option
Fewer than 15% of hepatoma patients are suitable candidates for surgical removal of their cancer. The purpose of this protocol is to provide supervised access at Oregon Health and Science University to Y-90 treatment to provide…
- Trial name
- Y-90HDE (NCT00740753)
- Testing
- Yttrium 90 (TheraSphere)
- Volunteers
- 339 people
- Sponsor
- OHSU Knight Cancer Institute
Postoperative Bile Leak, Focal Liver Lesions
Prevention of Bile Leakage After Liver Resection in Children
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery.
- Trial name
- NCT07867522
- Testing
- prophylactic extrahepatic biliary drainage during liver resection
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology