Clinical trials: Liver Transplant; Complications
Pulmonary Complication, Post Operative Complication
Lung Ultrasound Score as Post Operative Predictive Value of Pulmonary Complications in Living Liver Transplant Recipient
The aim of this study is to determine if lung ultrasound score has a strong predictive value for post operative pulmonary complications in living liver transplant recipient
- Trial name
- NCT06498895
- Testing
- lung ultrasound
- Volunteers
- 25 people
- Sponsor
- Ain Shams University
Liver Transplant; Complications, Ischemic Cholangiopathy
Seladelpar in Adult Liver Transplant Recipients With Ischemic Cholangiopathy (SELIC).
A prospective, open-label, single-arm, investigator-initiated study (SELIC) to evaluate the efficacy and safety of seladelpar in adult liver transplant recipients with Ischemic cholangiopathy (IC).
- Trial name
- SELIC (NCT07305363)
- Testing
- Seladelpar
- Volunteers
- 10 people
- Sponsor
- University of California, San Diego
Hepatopulmonary Syndrome, Liver Cirrhosis
Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study
Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations.
- Trial name
- HPS (NCT03092401)
- Volunteers
- 142 people
- Sponsor
- Hospices Civils de Lyon
Liver Transplant; Complications
Hepatitis B Virus Reactivation: a Cautionary Event After Liver Transplantation for Patients With Hepatocellular Carcinoma
Highly active hepatitis B virus (HBV) is known to be associated with poor outcomes in patients with hepatocellular carcinoma (HCC).
- Trial name
- NCT06114251
- Testing
- Diagnosis of postoperative recurrence of liver cancer
- Volunteers
- 920 people
- Sponsor
- Zhejiang University
Acute Kidney Injury, Acute Renal Injury
Renal and Cardiac Risk Factors of AKI After Liver Transplantation
Background: Liver transplantation (LT) is an extensive operation with various factors contributing to the development of acute kidney injury in the perioperative period.
- Conditions
- Acute Kidney Injury, Acute Renal Injury, Liver Transplant; Complications
- Trial name
- NCT05666232
- Testing
- renal resistive index and myocardial performance index
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the…
- Conditions
- Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant
- Trial name
- ALLELE (NCT03394365)
- Testing
- tabelecleucel
- Where
- 71 sites in United States, Australia and 7 more
- Volunteers
- 115 people
- Sponsor
- Pierre Fabre Medicament
Cirrhosis, Liver
To Assess the Efficacy of Midodrine in Prevention of Cirrhosis Related Complications in Children Awaiting Liver Transplantation.
Children with cirrhosis awaiting transplantation are more proned to develop various complications. The pathogenesis of cirrhotic complications (ascites, hyponatremia, acute kidney injury) includes release of vasodilatory…
- Trial name
- NCT05287100
- Testing
- Midodrine Oral Tablet, Standard Medical Treatment
- Where
- India
- Volunteers
- 35 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Transplant; Complications, Quality of Life
Starzl Network Patient Reported Outcomes
This study uses a smartphone application/web interface (RealTime Clinic; RTC) to collect patient and parent reports of a pediatric liver transplant recipient's quality of life (QOL), and examines the extent to which QOL…
- Conditions
- Liver Transplant; Complications, Quality of Life, Child Behavior, Adolescent Behavior
- Trial name
- SPaRO (NCT05241847)
- Testing
- PeLTQL delivery via electronic means
- Where
- 7 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Pediatric Liver Transplantation, Developmental Delay
Intraoperative Cerebral and Renal Tissue Oxygen Saturation and Pediatric Living Donor Liver Transplantation Prognosis.
This rSO2 study is a prospective clinical study. The purpose of the rSO2 study is to investigate whether there is a correlation between the intraoperative cerebral and renal tissue oxygen saturation and the incidence of…
- Conditions
- Pediatric Liver Transplantation, Developmental Delay, Postoperative Complications, Socioemotional Delay
- Trial name
- rSO2-LDLT (NCT04518332)
- Where
- China
- Volunteers
- 123 people
- Sponsor
- RenJi Hospital
Ischemia Reperfusion Injury
Tacrolimus During the Implantation and the Effect on Ischemia-reperfusion Injury in Liver Transplantation
The evaluation of the efficacy of an intraportal infusion with Tacrolimus, at the time of liver graft implantation, compared to a control group without immunosuppressive intraportal infusion (Placebo: Saline solution 0.9%) with…
- Trial name
- TAC-Infusion (NCT00609388)
- Testing
- Tacrolimus, Saline solution 0.9% (250mL)
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Liver Transplant; Complications, Cardiovascular Complication
Cardiovascular Outcomes in Orthotopic Liver Transplanted Patients (COLT Study)
All patients with orthotopic liver transplantation who are evaluated and followed at each participating centers will be recorded in this study. Within this register a characterization of patients and therapy will be done.
- Conditions
- Liver Transplant; Complications, Cardiovascular Complication, Cardiovascular; Attack, Cardiovascular Stroke
- Trial name
- COLT (NCT05895669)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli
Liver Transplantation, Ultrasonography, Doppler, Transcranial
Transcranial Doppler During Liver Transplantation
This is a prospective study that would investigate the transcranial doppler (TCD) changes during the living donor liver transplantation and the association between the TCD changes and the post-transplant neurological…
- Conditions
- Liver Transplantation, Ultrasonography, Doppler, Transcranial, Complication, Postoperative, Neurologic Deficits
- Trial name
- NCT05144451
- Testing
- Transcranial Doppler
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Liver Transplant; Complications
Perioperative Hemostasis Management in Liver Transplantation
Liver transplantation (LT) is a surgery with risk of bleeding. Several risk factors have been identified: complex dissection, portal hypertension, history of ascites fluid infections, history of surgical procedures, pre-existing…
- Trial name
- HEMOTRANSPLANT (NCT06257407)
- Where
- 16 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
Liver Transplant; Complications, Pain, Postoperative
Effects of Comedy Therapy on Pain and Comfort Levels in Liver Transplant Recipients
This study was conducted to investigate the effects of watching excerpts from classical Turkish comedy films on pain and comfort levels in liver transplant recipients during the postoperative period.
- Conditions
- Liver Transplant; Complications, Pain, Postoperative, Care Acceptor, Health
- Trial name
- NCT06816628
- Testing
- comedy therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Renal Failure Chronic, Hepatitis C
Multi-center Study to Transplant Hepatitis-C Infected Kidneys
Open label multi center study for the donation of HCV positive kidneys to HCV negative recipients with interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- MYTHIC (NCT03781726)
- Testing
- glecaprevir/pibrentasvir treatment
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Raymond Chung
Heart Failure, Respiratory Failure
Donor Simvastatin Treatment in Organ Transplantation
The aim of the study is to investigate the effects of donor simvastatin treatment on ischemia-reperfusion injury after heart transplantation.
- Conditions
- Heart Failure, Respiratory Failure, Liver Failure, Kidney Failure
- Trial name
- SIMVA (NCT01160978)
- Testing
- Simvastatin 80mg, Control Rx
- Where
- Finland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
End Stage Liver DIsease, Obesity
Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
This study is being conducted to assess the safety of Direct Peritoneal Resuscitation (DPR) in high-risk liver transplant patients.
- Conditions
- End Stage Liver DIsease, Obesity, Acute Kidney Injury
- Trial name
- NCT05195125
- Testing
- Direct Peritoneal Resuscitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Cervical Cancer, Hpv
Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls?
The purpose of the study is to understand if children with liver and kidney transplants develop the antibodies from the Gardasil vaccine.
- Conditions
- Cervical Cancer, Hpv, Warts
- Trial name
- NCT01101750
- Testing
- Quadrivalent HPV for types 6, 11, 16 and 18
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Medstar Health Research Institute
Cirrhosis, End Stage Liver Disease
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies).
- Conditions
- Cirrhosis, End Stage Liver Disease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- MHALT (NCT03534141)
- Testing
- Esophageal cooling/warming device, Mild hypothermia, Normothermia
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco