Clinical trials: Liver Transplant Recipients
High Blood Pressure, Liver Transplant
Mechanism of Hypertension Treatments in Liver Transplant Recipients (BLOCK LTR-HTN)
Liver transplantation is a high risk, high-cost intervention that extends life in over 8,000 patients in the US each year. Of those that receive transplants, 1 in 3 will have a complication related to their heart after…
- Conditions
- High Blood Pressure, Liver Transplant, Renal Function Abnormal
- Trial name
- NCT05275907
- Testing
- Amlodipine Besylate, Chlorthalidone
- Where
- United States
- Sponsor
- Northwestern University
Hepatitis C Virus
Assessment of Biomarkers for Recurrent HCV Infection Post-liver Transplantation
The purpose of this study is to learn about how different immunosuppressant therapies impact on recurrent hepatitis C virus infection in the new liver after liver transplant.
- Trial name
- NCT00710801
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Post Liver Transplant Infection
Effect of Preoperative Vitamin D Supplementation in Liver Transplant Recipients With Vitamin D Deficiency on Post Transplant Outcomes
Liver transplantation (LT) remains the ultimate option to cure intractable end stage liver disease. Vitamin D deficiency is very common in these subsets of patients.
- Trial name
- NCT06736093
- Testing
- Vitamin D3
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Neurotoxicity, Liver Transplant; Complications
Envarsus Neurotoxicity Burden in Liver Transplant Patients
This study will compare neurologic side effects associated with two immunosuppressant medications used in liver transplant patients.
- Trial name
- NCT03823768
- Testing
- Envarsus, Tacrolimus Immediate release
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Cytomegalovirus Infection
Quantiferon - Cytomegalovirus (CMV) and the Prediction of CMV Infection In High Risk Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00817908
- Where
- Canada
- Volunteers
- 131 people
- Sponsor
- University of Alberta
Liver Transplantation, Kidney Transplantation
A Study to Evaluate the Safety and Efficacy of a Modigraf® Based Immunosuppression Regimen in De Novo Pediatric Allograft Liver and Kidney Transplantation Recipients
The purpose of this study is to observe the safety and efficacy of Modigraf in de novo pediatric allograft liver and kidney transplantation recipients.
- Trial name
- NCT05153915
- Testing
- Tacrolimus granules
- Where
- 7 sites in China
- Volunteers
- 56 people
- Sponsor
- Astellas Pharma China, Inc.
Liver Transplantation
RESCUE Study - Everolimus in Liver Transplantation Recipients With Renal Insufficiency
The purpose of the study is to assess the effect of everolimus initiation together with reduction or discontinuation of calcineurin inhibitor (CNI) on renal function in maintenance liver transplant recipients with CNI-related…
- Trial name
- NCT00267189
- Testing
- Everolimus, Calcineurin inhibitors (CNI), Mycophenolate acid (MPA)/ Azathioprine (AZA)
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 145 people
- Sponsor
- Novartis Pharmaceuticals
Condition Requiring Rapid Transfusion During Liver Transplantation Surgery
Effect of Rapid Transfusion With Fluid Management System (FMS) on Plasma Potassium in Liver Transplantation Recipients
Rapid infusion of red blood cells is known to result in hyperkalemia in the body. However, potassium concentration in the blood mixture (usually made of RBC, FFP and normal saline) in the reservoir of rapid infusion system and…
- Trial name
- NCT01331889
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Artificial Intelligence (AI), Hepatocellular Carcinoma (HCC)
Use of Machine-learning Algorithms, Biomarkers and Measures of Quality of Life to Personalize Medical Management of Liver and Heart Transplant Recipients
This is an observational, low risk tissue based, non-pharmacological, retrospective-prospective study for adults heart and liver transplant patients, related to IRCCS Azienda Ospedaliero-Universitaria di Bologna (IRCCS AOUBO).
- Conditions
- Artificial Intelligence (AI), Hepatocellular Carcinoma (HCC), Heart Transplantation, Liver Transplantation
- Trial name
- DARE (NCT06774768)
- Where
- 2 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Transplant; Complications, COVID19
COVID-19 in Liver Transplant Recipients
Prospective observational study aimed at analyzing the incidence, clinical characteristics and outcomes of COVID-19 in LT in Spain.
- Conditions
- Liver Transplant; Complications, COVID19, Respiratory Failure
- Trial name
- COVID19-SETH (NCT04361591)
- Testing
- Observational only
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplant Recipients, Liver Transplantation
Discovery and Validation of Proteogenomic Biomarker Panels in Liver Transplant Recipients
The main focus of this study is to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had a liver transplant.
- Trial name
- PROGENI-LI (NCT01672164)
- Where
- 6 sites in United States
- Volunteers
- 202 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplant; Complications
HEalth Advocate for Liver Transplantation: Improving Transition of Care for Adolescent Liver Transplant Recipients
The Health Advocate for Liver Transplant (HEAL-Tx) Transition of Care Pilot is a nonrandomized, open-label intervention pilot of a health advocate intervention aimed to assess feasibility and acceptability of integrating a Health…
- Trial name
- HEAL-Tx:ToC (NCT06386198)
- Testing
- Health Advocate
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Liver Transplantation, Biomarkers
Molecular Assessment and Profiling of Liver Transplant Recipients
The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation.
- Trial name
- MAPLE (NCT04793360)
- Testing
- LiverCare
- Where
- 26 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- CareDx
HBV, Liver Transplant Disorder
Tenofovir Alafenamide for HBV Prophylaxis in HBV(-) Liver Transplant Recipients With HBcAb+ Donors
Liver transplantation is currently the only effective way to treat end-stage liver disease.The shortage of donor liver is still the major problem. Incidence of HBcAb+ varies between different regions.
- Trial name
- NCT04703465
- Testing
- Tenofovir Alafenamide 25 MG
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Awaiting Organ Transplant, Infection in Solid Organ Transplant Recipients
Cell Mediated Immunity With Risk of Cytomegalovirus (CMV) in Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common infection with 60-90% of all adults worldwide having evidence of having the infection at sometime in their life.
- Trial name
- ViracorCMI (NCT01558037)
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Michael Ison
Liver Transplantation
Propofol Versus Dexmedetomidine for Prevention of Sevoflurane Agitation in Recipients of Living Donor Liver Transplantation
The use of propofol or dexmedetomedine for prevention of sevofurane emergence agitation in LDLT recipients
- Trial name
- Agitation (NCT02544906)
- Testing
- Propofol, dexmedetomedine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- AlRefaey Kandeel
Liver Transplantation
Effect of Rapamycin on Tolerance-related Biomarkers on Stable Liver Transplant Recipients
In contrast to calcineurin inhibitors, sirolimus is known to exert remarkable tolerance-promoting properties in multiple animal transplant models.
- Trial name
- NCT01034345
- Testing
- Sirolimus, Calcineurin inhibitor
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplantation
Data Collection Study From Donors and Recipients to Optimize Donor-recipient Matching in Liver Transplantation
A major limitation of liver transplantation is organ shortage. To avoid exposing patients to death on the waiting list, organs are used that would have been discarded few years ago.
- Trial name
- OPTIMATCH-LT (NCT03371264)
- Volunteers
- 9,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Massive Ascites
Impact Of Timing Of Drainage Of Massive Ascites On Operative And Post-Operative Course In Living-Donor Liver Transplant Recipients. A Prospective Randomized Controlled Trial.
Massive ascites is usually controlled over several weeks pre-operatively in liver transplant recipients with the risk of encephalopathy and peritonitis.
- Trial name
- AscitesLDLT (NCT02867293)
- Testing
- ultrasound guided ascitic fluid drainage, operative drainage of ascites through small skin incision after induction of anesthesia, ultrasound
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Medication Adherence, Liver Transplant
A Pilot Study of mDOT for Immunosuppressant Adherence in Adult Liver Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppressant medication adherence among adult liver transplant recipients.
- Trial name
- NCT03515330
- Testing
- mHealth Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University