Clinical trials: Liver Transplant Recipients
Pediatric Liver Transplanted Recipients
Health Advocate for Children After Liver Transplant
The HEAL-Tx is a 90-day intervention, in which a Health Advocate works with eligible families to identify and apply for community-based resources, alert healthcare providers to challenges the family is encountering, and guide…
- Trial name
- HEAL-Tx:RCT (NCT07279350)
- Testing
- Health advocate, Enhanced Control
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Francisco
Health Related Quality of Life
Health Related Quality of Life Assessment In Egyptian Recipients After Living Donor Liver Transplantation
Health Related Quality of Life Assessment In Egyptian Recipients After Living Donor Liver Transplantation
- Trial name
- NCT01784497
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Ain Shams University
Liver Transplantation
Efficacy of Low Dose, SubQ Interleukin-2 (IL-2) to Expand Endogenous Regulatory T-Cells in Liver Transplant Recipients
The purpose of this investigation is to study if very low dose IL-2, given to liver transplant patients by subcutaneous (under the skin) injections, over a 4 week period of time, will cause an increase in the number of Treg cells…
- Trial name
- NCT02739412
- Testing
- Interleukin-2
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hepatitis C Virus
Assessment of Biomarkers for Recurrent HCV Infection Post-liver Transplantation
The purpose of this study is to learn about how different immunosuppressant therapies impact on recurrent hepatitis C virus infection in the new liver after liver transplant.
- Trial name
- NCT00710801
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Liver Transplantation, Kidney Transplantation
A Study of Modigraf® (Tacrolimus Granules) to Evaluate the Pharmacokinetics and Long-term Safety and Efficacy in De Novo Pediatric Allograft Liver and Kidney Transplantation Recipients
The purpose of this study is to determine the pharmacokinetics of tacrolimus following oral administration of Modigraf, after the first oral dose and at steady state in pediatric participants undergoing de novo allograft liver or…
- Trial name
- NCT05152628
- Testing
- Tacrolimus granules
- Where
- 4 sites in China
- Volunteers
- 55 people
- Sponsor
- Astellas Pharma China, Inc.
Liver Transplantation
A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant Recipients
The aims of the study was to evaluate the safety and efficacy of early introduction one month post-transplantation of everolimus associated to EC-MPS with tacrolimus discontinuation in de novo liver transplant recipients and to…
- Trial name
- SIMCER (NCT01625377)
- Testing
- tacrolimus, everolimus, Basiliximab
- Where
- 14 sites in France
- Volunteers
- 188 people
- Sponsor
- Novartis Pharmaceuticals
Medication Adherence, Liver Transplantation
A Study of mDOT for Immunosuppressant Adherence in Solid Organ Transplant Recipients
In solid organ transplant recipients, poor adherence to immunosuppressant medications carries the risk of graft rejection (needing a new transplant), post-transplant complications, and increased healthcare costs.
- Conditions
- Medication Adherence, Liver Transplantation, Kidney Transplantation
- Trial name
- NCT04587024
- Testing
- mHealth intervention, standard of care
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Diabetes
Comparison of New-onset Diabetes After Transplantation Between Two Steroid Withdrawal Group With CellCept
With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality.
- Trial name
- NODAT (NCT02095418)
- Testing
- Mycophenolate mofetil, Corticosteroids, Corticosteroids, Mycophenolate mofetil
- Where
- 5 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Samsung Medical Center
Liver Transplant Disorder, Vitamin D Deficiency
Vitamin D Levels in Liver Transplantation Recipients Prospective Observational Study
Interest in vitamin D has seen an unprecedented revival sparked by the finding that vitamin D has pleiotropic effects with an intriguing link to the critically ill patients.
- Trial name
- D-LIVER-X (NCT03234218)
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Hepatocellular Carcinoma
Immunosuppression in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma
The purpose of this study is to determine the safety and efficacy of sirolimus-based immunosuppressive therapy in patients following orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC), with regard to HCC…
- Trial name
- NCT00355862
- Testing
- CNI, MMF, Steroids, Aza etc. (mTOR inhibitor free), Sirolimus
- Where
- Germany
- Volunteers
- 525 people
- Sponsor
- University of Regensburg
Intestine Transplantation, Kidney Transplantation
Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf®
Parts A \& B: Conversion of stable pediatric allograft recipients from Prograf® immunosuppression to Advagraf® immunosuppression to compare exposure and one year follow-up for safety and efficacy.
- Conditions
- Intestine Transplantation, Kidney Transplantation, Lung Transplantation, Liver Transplantation
- Trial name
- NCT01294020
- Testing
- Tacrolimus, Tacrolimus prolonged release
- Where
- 16 sites in Belgium, Czechia and 5 more
- Volunteers
- 81 people
- Sponsor
- Astellas Pharma Europe Ltd.
Liver Failure
TLI- and ATG-Enabled Minimization Protocol in Liver Transplantation
The unmet medical need in solid organ transplantation is to eliminate the lifelong requirement of powerful immune suppression drug combinations with their attendant side effects, and to prevent immune mediated rejection of the…
- Trial name
- TEMPO-LT (NCT07634562)
- Testing
- Anti-Thymocyte Globulin, ATG (Rabbit), Total lymphoid irradiation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Evidence of Liver Transplantation
Evaluate the Efficacy and Safety of the ADVAGRAF®
The primary objective of this study is to evaluate the efficacy of 6-month treatment with Advagraf® converted from 12-month treatment with tacrolimus in stable liver transplant recipients.
- Trial name
- STABLE (NCT04763096)
- Testing
- Advagraf
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Linical Korea
Liver Diseases, Reperfusion Injury
Effect Inhaled Nitric Oxide in Adult Liver Transplant
Liver transplantation remains the only cure for patients with end-stage liver disease. Despite continuous advances in medical care, ischemia-reperfusion injury (IRI) (tissue damage that occurs when blood supply is restored to an…
- Conditions
- Liver Diseases, Reperfusion Injury, Vasoplegia
- Trial name
- NCT07125443
- Testing
- Prospective iNO Administration ("After" Group), No Intervention Retrospective "Before" Group
- Volunteers
- 260 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hepatitis C Infection
Study of Hepatitis C Virus (HCV) Entry Inhibitor in Liver Transplant Recipients With HCV Infection
This study will test the safety and tolerability of HCV Entry Inhibitor ITX 5061 in Liver Transplant Recipients with Hepatitis C infection.
- Trial name
- NCT01560468
- Testing
- ITX 5061
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Schiano, Thomas D., MD
Kidney Transplant Recipients, Liver Transplant Recipients
Pharmacokinetic Studies of Tacrolimus in Transplant Patients
The study is designed to compare the steady-state pharmacokinetics of Prograf (Brand) and the two most disparate generic formulations (Generic Hi and Generic Lo) in a fully replicated, 3-way cross-over study in stable kidney…
- Trial name
- PK (NCT01889758)
- Testing
- Prograf, Tacrolimus
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Cincinnati
Recurrent Hepatitis C
Efficacy of Everolimus as Inhibitor of Fibrosis Progression in Liver Transplant Patients With Recurrence of Hepatitis C Viral Infection
This study will assess the efficacy of everolimus as an inhibitor of fibrosis progression in liver transplant patients who have a recurrence of hepatitis C viral infection in the transplant
- Trial name
- REVERT (NCT00582738)
- Testing
- CsA-TAC (standard Treatment), Everolimus
- Where
- Argentina
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
Liver Transplantation, Medication Adherence
Effect of Digital Follow-up Supported Patient Education on Immunosuppressive Medication Adherence and Quality of Life After Liver Transplantation
This randomized controlled study aimed to evaluate the effect of digital follow-up supported patient education on immunosuppressive medication adherence and quality of life in adult liver transplant recipients.
- Trial name
- NCT07728604
- Testing
- Digital Follow-up Supported Patient Education, Standard Care
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Cansu Yıldız
Liver Transplant; Complications
HEalth Advocate for Liver Transplantation: Improving Transition of Care for Adolescent Liver Transplant Recipients
The Health Advocate for Liver Transplant (HEAL-Tx) Transition of Care Pilot is a nonrandomized, open-label intervention pilot of a health advocate intervention aimed to assess feasibility and acceptability of integrating a Health…
- Trial name
- HEAL-Tx:ToC (NCT06386198)
- Testing
- Health Advocate
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Stem Cell Transplantation, Liver Diseases
Hepatic Artery Infusion of CD34+ Cells
The primary objective is to determine whether donor stem cells administered via hepatic artery infusion can produce liver cells in patients with severe hepatic dysfunction post stem cell transplantation (SCT) and the safety of…
- Trial name
- NCT00062543
- Testing
- Hepatic artery infusion of CD34+ cells, Cobe Spectra
- Sponsor
- M.D. Anderson Cancer Center