Clinical trials: Liver Transplant Recipients
Liver Transplant; Complications, Pain, Postoperative
Effects of Comedy Therapy on Pain and Comfort Levels in Liver Transplant Recipients
This study was conducted to investigate the effects of watching excerpts from classical Turkish comedy films on pain and comfort levels in liver transplant recipients during the postoperative period.
- Conditions
- Liver Transplant; Complications, Pain, Postoperative, Care Acceptor, Health
- Trial name
- NCT06816628
- Testing
- comedy therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Orthotopic Liver Transplant
Everolimus Post Orthotopic Liver Transplant
The purpose of this study is to evaluate the efficacy of an everolimus conversion (EVR) protocol as compared to the standard tacrolimus (TAC) based protocol in liver transplant recipients, as determined by renal function…
- Trial name
- NCT01998789
- Testing
- Everolimus, Standard Tacrolimus
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Tomoaki Kato
Liver Transplantation
Study to Evaluate Pharmacokinetic and Bioavailability of Envarsus® vs. Advagraf® in Liver Transplant Recipients
Single centre, open-label, randomized, controlled, cross over study to evaluate the pharmacokinetic and bioavailability of Envarsus® in comparison to Advagraf® in de novo liver transplant recipients
- Trial name
- NCT03241043
- Testing
- Treatment 2 weeks Envarsus followed by 2 weeks Advagraf, Treatment 2 weeks Advagraf followed by 2 weeks Envarsus
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Osteoporosis
A Study to Evaluate Efficacy and Safety of Denosumab for Prevention and Treatment of Osteoporosis in 1st Time Liver Transplant Recipients.
Organ transplant recipients are known to suffer from bone loss and subsequent fractures after the transplant operation with the most rapid bone loss occurring within the first 3-12 months.
- Trial name
- NCT04231682
- Testing
- Denosumab Injection
- Sponsor
- Albert Einstein Healthcare Network
Liver Transplant; Complications, Quality of Life
Starzl Network Patient Reported Outcomes
This study uses a smartphone application/web interface (RealTime Clinic; RTC) to collect patient and parent reports of a pediatric liver transplant recipient's quality of life (QOL), and examines the extent to which QOL…
- Conditions
- Liver Transplant; Complications, Quality of Life, Child Behavior, Adolescent Behavior
- Trial name
- SPaRO (NCT05241847)
- Testing
- PeLTQL delivery via electronic means
- Where
- 7 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Liver Transplantation
A Study of TCD601 in the Induction of Tolerance in de Novo Liver Transplantation
The purpose of this study is to evaluate if treatment with a siplizumab-based regimen can induce allogeneic tolerance in liver transplant recipients.
- Trial name
- NCT06019507
- Testing
- TCD601, Cyclophosphamide, TAC
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- ITB-Med LLC
Prophylaxis Against Liver Transplant Rejection
Bioavailability and Practicability of Envarsus Versus Advagraf in Liver Transplant Recipients
Trial participants are randomised within 14 days after liver transplantation surgery in a 1:1 ratio to two alternative treatment arms containing either Envarsus® (test arm) or Advagraf® (comparator arm) as first-line calcineurin…
- Trial name
- NCT04720326
- Testing
- Tacrolimus Pill, Tacrolimus capsule
- Where
- 15 sites in Germany
- Volunteers
- 268 people
- Sponsor
- Edward Geissler
Physical Activity After Organ Transplantation
High-intensity Training Safely Improves Exercise Capacity in Heart, Lung, Kidney, and Liver Transplant Recipients: a Comparative Study
The investigators will investigate whether high-intensity exercise training can safely improve physical performance in long-term stable heart, kidney, lung, and liver transplant recipients.
- Trial name
- NCT03329586
- Testing
- High-intensity training
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Nonadherence, Tacrolimus
Improving Medication-taking After Liver Transplant
The specific aim is to pilot-test our developed intervention manual's ability to improve patients' adherence to medications and medical outcomes (rejection rate, liver enzyme levels) in participating centers.
- Conditions
- Nonadherence, Tacrolimus, Pediatric Liver Transplant Recipients
- Trial name
- I-AM (NCT01960322)
- Testing
- Telemetric
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type 1 Diabetes Mellitus
MRI Imaging of Labeled Human Islets Transplanted Into the Liver
The purpose of the study is to determine whether human islets labeled by iron contrast agents could be imaged using magnetic resonance after transplantation into the liver of Type 1 diabetic recipients.
- Trial name
- NCT01050166
- Testing
- Transplantation of labeled islets
- Where
- Czechia
- Volunteers
- 8 people
- Sponsor
- Frantisek Saudek
Liver Transplant Disorder
Incentive Spirometer in Liver Transplant Recipients
This study evaluated the effect of adjunctive incentive spirometer on arterial blood gases (ABGs) and early postoperative recovery in liver transplant recipients.
- Trial name
- LT (NCT07318766)
- Testing
- Incentive Spirometry
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Liver Transplantation, Infection
Italian National Study on the Critically Ill Liver Transplant Patient With an Infection
Despite major advances, infections remain one of the major causes of morbidity and mortality in patients undergoing orthotopic liver transplantation (OLT).
- Conditions
- Liver Transplantation, Infection, Sepsis, Intensive Care Unit
- Trial name
- INFE-OLT (NCT03363646)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Kidney Transplant, Hepatitis C
Utilization of Hepatitis C Positive Kidneys in Negative Recipients
To evaluate the safety and feasibility of transplanting kidneys from Hepatitis C virus (HCV) infected donors into recipients without HCV infection
- Conditions
- Kidney Transplant, Hepatitis C, HCV
- Trial name
- NCT03801707
- Testing
- Sofosbuvir / Velpatasvir Oral Tablet [Epclusa], Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet [MAVYRET]
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Ohio State University
Liver Transplant; Complications, Diabetes Mellitus
Semaglutide vs Sitagliptin
The effect of once daily dosing of oral Semaglutide versus once daily dosing Sitagliptin on glycemic control, body weight, and safety and tolerability will be compared in Liver Transplant Recipients with poorly-controlled…
- Conditions
- Liver Transplant; Complications, Diabetes Mellitus, NASH - Nonalcoholic Steatohepatitis, NAFLD
- Trial name
- NCT05195944
- Testing
- Semaglutide Treatment, Sitagliptin 100mg
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- University Health Network, Toronto
Candidiasis
Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants
The purpose of this study is to compare the safety and effectiveness of 2 treatments to prevent invasive fungal infections (IFI), which are infections caused by yeasts and molds that are common in patients with weak immune…
- Trial name
- NCT00001107
- Testing
- Fluconazole, AmBisome
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients
Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors
This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors.
- Conditions
- Living Donor Liver Transplantation Recipients, Deceased Donor Liver Transplantation Recipients, Living Liver Donor
- Trial name
- NCT07301853
- Testing
- liver transplantation, Living Donor Hepatectomy
- Where
- China
- Volunteers
- 9,999 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lymphopenia
Persistent Lymphopenia in Liver Transplantation and Its Molecular Insights for Hepatocellular Carcinoma
A total of 145 Liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) were retrospectively enrolled at Kaohsiung Chang Gung Memorial Hospital between 2006 and 2019.
- Trial name
- NCT06368349
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Chang Gung Memorial Hospital
Lung Transplant Infection, Heart Transplant Infection
Transplantation Using Hepatitis C Positive Donors, A Safety Trial
The success of transplantation is significantly hindered by the lack of sufficient number of available donors. Many potential donor organs cannot be utilized in clinical transplantation because donors have chronic viral…
- Conditions
- Lung Transplant Infection, Heart Transplant Infection, Kidney Transplant Infection, Kidney Pancreas Infection
- Trial name
- NCT04017338
- Testing
- Glecaprevir 300 MG / Pibrentasvir 120 MG Oral Tablet, Ezetimibe 10Mg Oral Tablet, Ex Vivo Lung Perfusion
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Jordan Feld
Diabetes Mellitus, Type 2, Glucose, High Blood
The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients
It is believed that important brain centers send signals through the vagus nerve to the liver to suppress the amount of glucose (sugar) that gets produced.
- Conditions
- Diabetes Mellitus, Type 2, Glucose, High Blood, Glucose Metabolism Disorders
- Trial name
- NCT03685773
- Testing
- Diazoxide, Nicotinic acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Liver Transplant; Complications, Perioperative/Postoperative Complications
Impact of Age and BMI on Liver Transplant Outcomes
Prospectively enrolled retrospective chart review and Liver Transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to Living Donor Liver Transplants.
- Trial name
- NCT04853641
- Testing
- Cadaveric, Living Donor
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Pittsburgh