Clinical trials: Liver Transplant Surgery
Acute Liver Failure, Fulminant Hepatic Failure
Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF)
This phase 2 study is developed to evaluate the effect of ELAD on overall survival (OS) in subjects with acute liver failure (ALF) compared to matched historical controls.
- Conditions
- Acute Liver Failure, Fulminant Hepatic Failure, Primary Graft Non-Function, Surgically-Induced Liver Failure
- Trial name
- NCT01875874
- Testing
- ELAD
- Where
- 18 sites in United States
- Volunteers
- 8 people
- Sponsor
- Vital Therapies, Inc.
Hepatic Complication
Sirolimus, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients At High Risk for Cholangiocarcinoma Recurrence After Liver Transplant or Surgery
This pilot phase I trial studies the side effects and best way to give sirolimus, gemcitabine hydrochloride, and cisplatin in treating patients at high risk for cholangiocarcinoma recurrence after liver transplant or surgery.
- Trial name
- NCT01888302
- Testing
- Cisplatin, Gemcitabine Hydrochloride, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Portal Vein Thrombosis, Liver Transplant; Complications
Living Donor Liver Transplantation to Patients With Portal Vein Thrombosis
Data of demographic, clinical, laboratory and imaging studies of living donor liver transplantation (LDLT) recipients from two transplant centers were collected.
- Trial name
- NCT05132192
- Testing
- living donor liver transplantation, Thrombectomy or interposition graft
- Volunteers
- 335 people
- Sponsor
- Elvan Onur Kirimker
Liver Transplant; Complications, Pain, Postoperative
Effects of Comedy Therapy on Pain and Comfort Levels in Liver Transplant Recipients
This study was conducted to investigate the effects of watching excerpts from classical Turkish comedy films on pain and comfort levels in liver transplant recipients during the postoperative period.
- Conditions
- Liver Transplant; Complications, Pain, Postoperative, Care Acceptor, Health
- Trial name
- NCT06816628
- Testing
- comedy therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Stereotactic Body Radiation Therapy in Liver Cancer That Cannot be Removed by Surgery or Transplant
RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue in patients with liver cancer.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT01194206
- Testing
- stereotactic body radiation therapy
- Sponsor
- Case Comprehensive Cancer Center
Liver Transplant; Complications, Immunosuppression
Effect of Cognitive Therapy on Immunosuppressive Treatment Compliance and Motivation
The study aims to analyze the effects of Mindfulness-Based Cognitive Therapy (MBCT) on the motivation levels and compliance with immunosuppressive therapy of post-liver transplant recipients.
- Conditions
- Liver Transplant; Complications, Immunosuppression, Compliance, Treatment
- Trial name
- NCT06879106
- Testing
- Intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Bitlis Eren University
Liver Transplant Surgery
Home-based EXercise and motivAtional Program Before and After Liver Transplantation
Liver disease is the 3rd commonest cause of death in adults of working age and liver transplantation (LT) remains the only cure for liver failure.
- Trial name
- EXALT (NCT07063940)
- Testing
- Home-based exercise and theory-based motivation support programme, Patient exercise advice leaflet before and after LT.
- Where
- 3 sites in United Kingdom
- Volunteers
- 269 people
- Sponsor
- University of Birmingham
Acquired Bleeding Disorder, Bleeding During/Following Surgery
Safety and Efficacy of Activated Recombinant Human Factor VII in Patients Undergoing Orthotopic Liver Transplantation
This trial is conducted in Europe, North America and Oceania. The aim of this trial is to evaluate the haemostatic efficacy of activated recombinant human factor VII in subjects undergoing orthotopic liver transplantation surgery.
- Trial name
- NCT01563458
- Testing
- activated recombinant human factor VII
- Where
- 18 sites in Australia, Canada and 5 more
- Volunteers
- 208 people
- Sponsor
- Novo Nordisk A/S
Hepatocellular Carcinoma
Changing Trends in HCC Procedures
In France, as in most countries, the incidence of primary liver cancer has increased significantly since the 1980s. In the United States, a study estimating cancer incidence and mortality rates in the coming years predicts that…
- Trial name
- NCT04163627
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Blood Loss, Postoperative, Liver Transplant
Individualized Multimodal Hemostasis Evaluation Pyramid (IMHOTEP)
This study evaluates the hemostatic changes defined as hemostasis reserve capacity (HRC) in the first perioperative 48 hours of bloodless liver transplanted patients.
- Conditions
- Blood Loss, Postoperative, Liver Transplant, Hemostatic Disorder
- Trial name
- NCT03555383
- Testing
- Coagulation factor levels
- Where
- Hungary
- Volunteers
- 59 people
- Sponsor
- Semmelweis University
Liver Transplantation
Evaluation of Liver Disease With Elastography Measurements in Patients Undergoing Liver Transplant Surgery
The purpose of the study is to compare ultrasound measurements of the liver obtained prior to surgery on the skin to measurements obtained during surgery directly on the diseased liver.
- Trial name
- SupersonicOR (NCT01890460)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute