Clinical trials: Liver Transplants
ICU-acquired Weakness
The Early Rehabilitation Program in Post-LT Pts
The purpose of this study is to determine whether an early rehabilitation program for immediate liver transplant patients is safe and effective in preventing critical care illness and intensive care unit acquired weakness.
- Trial name
- NCT03529656
- Testing
- Early rehabilitation program for liver transplantation
- Volunteers
- 236 people
- Sponsor
- Asan Medical Center
Colorectal Cancer, Liver Metastases
Liver Transplantation for Non-resectable Colorectal Liver Metastases: Translational Research
The patients with non-resectable colorectal liver metastases (CRLM) have always being considered a particular subgroup of CRLM in which the therapeutic approach, is focused on strategies that allow a potential surgery like…
- Conditions
- Colorectal Cancer, Liver Metastases, Genetic Change
- Trial name
- NCT05398380
- Testing
- Liver transplantation
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Hospital Vall d'Hebron
Sarcopenia, Sarcopenia in Liver Cirrhosis
Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients
Patients will be informed by obtaining consent when they meet the inclusion criteria. Written consent will be obtained when the patient arrives in the operating room.
- Conditions
- Sarcopenia, Sarcopenia in Liver Cirrhosis, Liver Transplantation
- Trial name
- NCT06909942
- Testing
- Psoas Muscle Index, Handgrip Dynamometer, SARC-F Score
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Inonu University
Liver Diseases, Liver Cirrhosis
Better Diagnostic Tools for Children and Adolescents With Acute Liver Failure and Chronic Liver Insufficiency
The aim of this study is to validate and develop a new diagnostic and prognostic approach for assessment of liver function in children and adolescents with acute liver failure and chronic liver insufficiency.
- Conditions
- Liver Diseases, Liver Cirrhosis, Pediatric Disorder
- Trial name
- DAKL (NCT03509194)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Failure, End Stage Liver Disease
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Rationale: Recent publications report good results of controlled donation after circulatory death (DCD) Maastricht category III liver transplantation when strict donor-recipient matching is applied and ischemia times are kept to…
- Conditions
- Liver Failure, End Stage Liver Disease, Biliary Tract Diseases
- Trial name
- DHOPE-DCD (NCT02584283)
- Testing
- Dual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid
- Where
- 6 sites in Belgium, Netherlands and 1 more
- Volunteers
- 157 people
- Sponsor
- Robert J. Porte
Liver Cancer, Dropout, Patient
A Worldwide Score for Hepatocellular Cancer and Liver Transplantation
The present study has been developed with multiple aims: 1) to refine available models for liver transplantation which would be able to cover the fate of HCC candidates from an ITT point of view; 2) to develop such an approach on…
- Conditions
- Liver Cancer, Dropout, Patient, Recurrence
- Trial name
- TRAIN-SCORE (NCT03595345)
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 3,100 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Hepatitis B Reactivation
HBV Vaccine in Anti-core Positive Donors After LT
Anti-HBc positive liver donors frequently have occult HBV infection, and several studies in HBsAg-negative subjects have shown that there is often the detection in the liver of covalently closed circular DNA (cccDNA).
- Trial name
- NCT04442841
- Testing
- Hepatitis B vaccine
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplantation, Ischemia/Reperfusion Injury
Effect of Nitric Oxide (NO) on Ischemic/Reperfusion Injury During Extended Donor Criteria (EDC) Liver Transplantation
In this study, the researchers propose to investigate the efficacy of inhaled nitric oxide to prevent ischemia-reperfusion (I/R) hepatocyte injury in patients who receive extended donor criteria(EDC)liver grafts based on changes…
- Conditions
- Liver Transplantation, Ischemia/Reperfusion Injury, Oxidative Injury
- Trial name
- NCT00948194
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Liver Transplant Disorder
Intraoperative Carotid Peak Systolic Velocity Variability in Liver Transplant Patients
The aim of this study was to evaluate carotid peak systolic velocity variability using intraoperative ultrasound and to determine whether this method is useful in the assessment of hemodynamic status and intravascular volume in…
- Trial name
- CPSV (NCT07442201)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Inonu University
End Stage Liver Disease, Liver Diseases
Normothermic Liver Preservation Trial
This trial is to assess the safety and efficacy of normothermic machine perfusion (NMP) as an organ preservation method prior to transplantation using the OrganOx metra™ device.
- Trial name
- NCT03089840
- Testing
- OrganOx metra
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Alberta
Liver Transplant, Kidney Transplant
Optimizing Immunosuppression Drug Dosing Via Phenotypic Precision Medicine
Clinical trial applying Phenotypic Precision Medicine (PPM) to tacrolimus dosing in liver and/or kidney transplant recipients to show improvement in maintaining drug trough levels within the target range.
- Trial name
- PPM - Pro (NCT03527238)
- Testing
- PPM-based Computation Assisted Drug Dosing, Tacrolimus
- Where
- 3 sites in United States, Singapore
- Volunteers
- 62 people
- Sponsor
- University of Florida
Liver Diseases, Liver Cirrhosis
Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)
The purpose of the study is to determine the role of new biomarkers in the diagnosis of sepsis in critically-ill patients with liver failure and to correlate the prognosis of these patients with parameters of endothelial function…
- Conditions
- Liver Diseases, Liver Cirrhosis, Sepsis, Critical Illness
- Trial name
- SELLIFA (NCT00488917)
- Where
- Belgium
- Volunteers
- 167 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Complication of Transplanted Liver, Hepatitis C, Chronic
Prediction of Hepatitis C Recurrence in Liver Transplant Recipients
The purpose of the study is to look at cells of the immune system to see if the cells are different among people with different risk factors that have received a liver transplant.
- Trial name
- NCT00867243
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Hepatocellular Carcinoma, Scirrhous, Recurrence Tumor
HepatoPredict Prognostic Tool for the Decision of Liver Transplant in Hepatocellular Carcinoma
Liver transplant is the most effective treatment for hepatocellular carcinoma (HCC) in cirrhosis. Due to organs shortage, the proper selection of patients is imperative.
- Trial name
- HepatoPredict (NCT04499833)
- Testing
- liver transplant
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Liver Transplantation, Thrombin
Thrombin Generation in Liver Transplant Surgery
This is a prospective observational study of 100 patients undergoing liver transplantation at a single centre. Thrombin generation and kinetics will be assessed using a novel point-of-care device, and compared to conventional…
- Conditions
- Liver Transplantation, Thrombin, Hemostasis, Surgical, Blood Coagulation Disorder Due to Liver Disease
- Trial name
- NCT04762550
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Liver Transplant
Long-term Mortality Post Liver Transplantation in the Era of Modern Immunosuppression.
Liver transplantation is the primary intervention for decompensated chronic liver diseases and some cases of hepatocellular carcinoma.
- Trial name
- NCT06636409
- Testing
- Collection of medical data
- Where
- France
- Volunteers
- 1,343 people
- Sponsor
- University Hospital, Montpellier
Alcoholic Liver Cirrhosis
Long-Term Follow-up of Patients With Alcoholic Liver Cirrhosis Treated With Cellgram-LC
The goal of this observational study is to learn about the long-term safety of Cellgram-LC in patients with alcoholic liver cirrhosis who previously received Cellgram-LC in the PMC-P-07 study.
- Trial name
- NCT05093881
- Where
- 14 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Pharmicell Co., Ltd.
Liver Transplantation
Pilot Study of Immunosuppression Drug Weaning in Liver Recipients Exhibiting Biomarkers of High Likelihood of Tolerance
Immunosuppressive drugs can be successfully withdrawn in a fraction of liver transplant patients. Specific peripheral blood gene expression markers can be employed to select patients with a high likelihood of being tolerant.
- Trial name
- NCT01445236
- Testing
- Immunosuppresion withdrawal
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Clinic of Barcelona
Living Donor Liver Transplantation, Reperfusion Injury
Magnesium Administration in Liver Transplantation and Reperfusion Injury
The purpose of this study is to evaluate the effect of intravenous magnesium infusion before reperfusion with employing some clinical parameters including blood lactate levels, because the intraoperative changes in the blood…
- Trial name
- NCT00994981
- Testing
- magnesium, normal saline
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- The Catholic University of Korea
Liver Disease, Liver Transplantation
Peripheral Immunologic Response of Solid Organ Transplant Recipients to Depletion Versus Non-depletion Protocols
Rejection and infection are primary causes of morbidity and mortality in solid organ transplant recipients. Current clinical practice relies on immunosuppressive drug levels measured in plasma to reflect the peripheral immune…
- Trial name
- NCT00839709
- Testing
- blood sampling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
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