Clinical trials: Liver Transplants
Blood Loss, Postoperative, Liver Transplant
Individualized Multimodal Hemostasis Evaluation Pyramid (IMHOTEP)
This study evaluates the hemostatic changes defined as hemostasis reserve capacity (HRC) in the first perioperative 48 hours of bloodless liver transplanted patients.
- Conditions
- Blood Loss, Postoperative, Liver Transplant, Hemostatic Disorder
- Trial name
- NCT03555383
- Testing
- Coagulation factor levels
- Where
- Hungary
- Volunteers
- 59 people
- Sponsor
- Semmelweis University
Hepatitis E
Prevalence of Hepatitis E During Follow-up Liver and Kidney Transplant Patients in Guadeloupe, French West Indies
Hepatitis E is well known to be a common cause of severe hepatitis on organ-transplanted people. However, several studies also show a risk of transition to a chronic state.
- Trial name
- KARU-HEP (NCT07729202)
- Testing
- Liver and Kidney transplanted patients
- Where
- Guadeloupe
- Volunteers
- 95 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Rheumatoid Arthritis, Psoriatic Arthritis
Vaccine Response to COVID-19 Vaccines in Patients Using Immunosuppressive Medication
The purpose of this study is to assess the strength and duration of the immunological response to COVID-19 vaccines in patients treated with immunosuppressive and/or immunomodulating medication for immune-mediated inflammatory…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Spondyloarthritis, Crohn Disease
- Trial name
- Nor-vaC (NCT04798625)
- Where
- 2 sites in Norway
- Volunteers
- 2,300 people
- Sponsor
- Diakonhjemmet Hospital
Drug-drug Interaction, Liver Transplantation
Pharmaco-proteomic Platform to Evaluate Drug Interactions in Liver Transplant Patients
The goal of this observational study is to enhance the ability to forecast kidney failure in liver transplant patients in the ICU under multidrug treatment by developing a computer platform that integrates mathematical models of…
- Trial name
- NCT06682325
- Testing
- Multi-drug interaction
- Where
- 3 sites in Chile
- Volunteers
- 48 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Liver Transplant Failure and Rejection, Children, Only
Histologic Evolution of Patients With Liver Transplantation
Certain pediatric liver transplant patients with immunosuppression levels in the therapeutic range and normal liver function tests present histological alterations (inflammation or fibrosis) in protocol biopsies.
- Trial name
- NCT06103097
- Testing
- No interventions done (obervational)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Vall d'Hebron
Liver Transplantation
Prospective Evaluation of Predictors for Organ Failure Following Liver Transplantation
Early organ failure occurs frequently and is difficult to predict. The study aims to define a predictive score for early transplant failure.
- Trial name
- NCT00408889
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University
Liver Transplant
Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function.
- Trial name
- ELIMINATE (NCT06280950)
- Testing
- Everolimus, Tacrolimus (continued reduction), Tacrolimus (maintain 50% reduction)
- Where
- 12 sites in United States
- Volunteers
- 340 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Cirrhosis, Severe Malnutrition
Granulocyte-Colony Stimulating Factor (G-CSF) as Optimizing Therapy for Pediatric Liver Transplantation
This study compares the effect of human recombinant Granulocyte-Colony Stimulating Factor (G-CSF) in pediatric patients with liver cirrhosis with a control group.
- Conditions
- Liver Cirrhosis, Severe Malnutrition, PELD, Undernutrition
- Trial name
- NCT04113317
- Testing
- G-CSF (Filgrastim)
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Liver Transplant Rejection, Immunosuppressant Adverse Reaction
Long-term Benefit of MPA in Liver Transplantation
MPA drugs are antiproliferative immunosuppressants and are widely used in solid organ transplantation. MPA drugs do not affect the recipient's kidney function and do not cause metabolic abnormalities and other problems.
- Trial name
- NCT05707520
- Testing
- enteric-coated mycophenolate (MPAs), None MPA
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Evidence of Liver Transplantation
Study to Establish Whether the Use of T-Tube in Bile Duct Anastomosis in Liver Transplantation Decreases Morbidity
The purpose of this study was to compare the incidence and severity of biliary complications due to liver transplantation after choledochocholedochostomy with or without a T-tube.
- Trial name
- NCT01546064
- Testing
- Choledocho-choledochostomy with T-tube, Choledocho-choledochostomy without T-tube
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario La Fe
Liver Transplantation
A New Prediction Mode for Predicting the Risk of Pressure Injury in Patients Undergoing Liver Transplantation
Pediatric population is at a high-risk of pressure injury (PI). Patients undergoing liver transplantation are more prone to PIs compared with other types of surgery.
- Trial name
- PMPRPIULT (NCT05588271)
- Testing
- Exposures
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Liver Transplantation, Postreperfusion Syndrome
Ascorbic Acid to Prevent Postreperfusion Syndrome in Liver Transplantation
The goal of this clinical trial is to test the efficacy of intravenous ascorbic acid in preventing the postreperfusion syndrome in liver transplantation.
- Conditions
- Liver Transplantation, Postreperfusion Syndrome, Ascorbic Acid
- Trial name
- VITACTOH (NCT05754242)
- Testing
- Ascorbic acid, 0.9% Saline solution
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Cytomegalovirus Infection
CMV Antiviral Prevention Strategies in D+R-Liver Transplants ("CAPSIL")
This is a trial of preemptive therapy vs. prophylaxis for prevention of Cytomegalovirus (CMV) disease in R-D+ liver transplant patients.
- Trial name
- NCT01552369
- Testing
- Valganciclovir
- Where
- 6 sites in United States
- Volunteers
- 205 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplant; Complications, Immunosuppression
Effect of Cognitive Therapy on Immunosuppressive Treatment Compliance and Motivation
The study aims to analyze the effects of Mindfulness-Based Cognitive Therapy (MBCT) on the motivation levels and compliance with immunosuppressive therapy of post-liver transplant recipients.
- Conditions
- Liver Transplant; Complications, Immunosuppression, Compliance, Treatment
- Trial name
- NCT06879106
- Testing
- Intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Bitlis Eren University
Cirrhosis
Evaluation of Patient Care Support for Cirrhosis and/or Liver Transplants
Cirrhosis is a major challenge in France, with a growing prevalence of 1,500 to 2,500 cases per million inhabitants, and the discovery of 150 to 200 new cases per million inhabitants each year.
- Trial name
- PACCHUPS (NCT06544863)
- Testing
- Data collection; biological samples
- Where
- 3 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplantation
De Novo Everolimus Versus Tacrolimus in Combination With Mofetil Mycophenolate and Low Dose Corticosteroids to Reduce Tacrolimus Induced Nephrotoxicity in Liver Transplantation: a Prospective, Multicentric, Randomised Study
Tacrolimus is a calcineurin inhibitor. This is the immunosuppression of reference for patients undergoing a first liver transplant.
- Trial name
- FOREVER (NCT02909335)
- Testing
- Tacrolimus, Everolimus, Mycophenolate mofetil
- Sponsor
- Rennes University Hospital
Liver Transplant
Liver Transplantation With Tregs at UCSF
This is a single-center, prospective, open-label, non-randomized clinical trial exploring cellular therapy to facilitate immunosuppression withdrawal in liver transplant recipients.
- Trial name
- LITTMUS-UCSF (NCT03654040)
- Testing
- arTreg, leukapheresis, cyclophosphamide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intestine Transplantation, Kidney Transplantation
Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf®
Parts A \& B: Conversion of stable pediatric allograft recipients from Prograf® immunosuppression to Advagraf® immunosuppression to compare exposure and one year follow-up for safety and efficacy.
- Conditions
- Intestine Transplantation, Kidney Transplantation, Lung Transplantation, Liver Transplantation
- Trial name
- NCT01294020
- Testing
- Tacrolimus, Tacrolimus prolonged release
- Where
- 16 sites in Belgium, Czechia and 5 more
- Volunteers
- 81 people
- Sponsor
- Astellas Pharma Europe Ltd.
Hepatitis C
Follow-up Study of Patients Who Experienced Thromboembolic Events in the ENABLE Studies
The objective of this observational study is to characterize long-term (5 years post event) clinical outcomes in patients who experienced a thromboembolic event (TEE) during participation in the GSK ENABLE clinical trials.
- Trial name
- NCT01715779
- Testing
- Eltrombopag
- Volunteers
- 22 people
- Sponsor
- Novartis
Liver Transplantation
Influence of Genetic Polymorphism of Donor on Tacrolimus Concentration in Liver Transplant
To study the influence of donor's ABCB1、CYP3A4、CYP3A5、POR genetic polymorphism on tacrolimus blood concentration in liver transplant recipients.
- Trial name
- NCT03140462
- Where
- 2 sites in Taiwan
- Volunteers
- 96 people
- Sponsor
- National Taiwan University Hospital
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