Clinical trials: Liver Transplants
Chronic Hepatitis B
Truvada Versus Truvada Plus Hepatitis B Immunoglobulin (HBIg) in Prevention of Chronic Hepatitis B Recurrence Post Liver Transplant
The objective of this 96-week study was to evaluate the safety and antiviral efficacy of emtricitabine/tenofovir disoproxil fumarate (FTC/TDF, coformulated; Truvada®) with or without hepatitis B immunoglobulin (HBIg) in…
- Trial name
- NCT00507689
- Testing
- FTC/TDF, Hepatitis B Immunoglobulin (HBIg)
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Gilead Sciences
Liver, Metastasis
Neo-adjuvant Peptide Receptor Mediated Radiotherapy With 177Lutetium in Front of Curative Intended Liver Transplantation in Patients With Hepatic Metastasis of Neuroendocrine Tumors (NEO-LEBE)
The purpose of this study is to show the tumor free long term survival of patients with isolated non-resectable liver metastases of neuroendocrine tumors after neo-adjuvant radio receptor treatment and following liver…
- Conditions
- Liver, Metastasis, Neuroendocrine Tumors
- Trial name
- NEO-LEBE (NCT01201096)
- Testing
- 177Lutetium, Liver transplantation
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- University of Jena
Liver Transplantation
Secretin in Ex-situ Liver Perfusion
The main objective is to assess whether the use of human synthetic secretin in a clinical (COR-)NMP procedure can restore physiological HCO3- content of the bile during ex-situ NMP.
- Trial name
- NCT07651748
- Testing
- Secretin administration during ex-situ liver machine perfusion
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Chronic HCV Infection
Ledipasvir/Sofosbuvir Fixed-Dose Combination Plus Ribavirin in Participants With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant
This study will evaluate ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) plus ribavirin (RBV) in participants with advanced liver disease or posttransplant and chronic genotype 1 or 4 hepatitis C virus (HCV)…
- Trial name
- NCT02010255
- Testing
- LDV/SOF, RBV
- Where
- 34 sites in Australia, Austria and 10 more
- Volunteers
- 334 people
- Sponsor
- Gilead Sciences
Cardiac Output, Low, Liver Transplant; Complications
Hemodynamic Monitoring in Liver Transplant With VEnaRt Cardiac Output Versus Swan-Ganz Catheter (VERO Study)
The Swan-Ganz catheter is the gold standard to measure cardiac output during liver transplantation surgery. This is an invasive hemodynamic monitoring system.
- Trial name
- VERO (NCT04825015)
- Testing
- VEnaRt Cardiac Output
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Indirect Calorimetry
Using Indirect Calorimetry for Liver Transplants Patients
Although predicted REE calculated using the Penn state 1988 method agreed (ICC 0.61, p=0.00014) with the measured REE, all three predictive equations had a fixed bias and appeared to be inaccurate for predicting REE for liver…
- Trial name
- NCT03622268
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Liver Transplantation
A Multicenter Study in Liver Transplant Patients Converted From Prograf® to Advagraf® During the First Post-transplantation Year
A study in which two groups of patients will be analysed; patients converted from Prograf to Advagraf within the first 3 months after transplantation and patients converted from Prograf to Advagraf between 3 months and 1 year…
- Trial name
- COBALT (NCT02143479)
- Testing
- Tacrolimus
- Where
- 18 sites in France
- Volunteers
- 398 people
- Sponsor
- Astellas Pharma S.A.S.
Hepatitis
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
The primary purpose of this study is to evaluate the safety and efficacy of larsucosterol, as determined by transplant-free survival through Day 90 in participants with severe alcohol-associated hepatitis (AH) with pre-treatment…
- Trial name
- NCT07428538
- Testing
- Larsucosterol
- Where
- 92 sites in United States
- Volunteers
- 350 people
- Sponsor
- Bausch Health Americas, Inc.
Liver Cirrhosis
Changes in Body Composition and Nutritional Status in Patients Undergoing Liver Transplantation
Liver transplant is the goal treatment for every patient with end-stage chronic liver disease. Quality of life improves after transplant because the main complications of end-stage liver disease disappear, but due to…
- Trial name
- NCT02023190
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Autoimmune Liver Disease, Liver Transplant Disorder
A Study of SIPLIZUMAB in AILD and LT Patients
There is a significant unmet need for safe and effective therapeutic approaches to prevent immune-mediated graft injury and its complications in liver transplant (LT) recipients with autoimmune liver disease (AILD) including…
- Conditions
- Autoimmune Liver Disease, Liver Transplant Disorder, Autoimmune Hepatitis, Primary Sclerosing Cholangitis
- Trial name
- SET-SAIL (NCT06455280)
- Testing
- Siplizumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Elizabeth C. Verna
Fungemia, Mycoses
Caspofungin as Prophylaxis in High Risk Liver Transplantation Recipients
The aim of the study is to determine viable use of caspofungin in post-OLTx patients, and to demonstrate in particular the effectiveness, understood as the ability to reduce the incidence of invasive fungal infections, and to…
- Trial name
- CPHRLTX (NCT01260974)
- Testing
- Caspofungin
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Azienda Ospedaliera di Padova
Liver Transplant Disorder
The Effect of Teleyoga in Liver Transplant Patients
Online yoga practices will be applied in liver transplant patients and the effects of online yoga on balance, frailty, cognition and quality of life of transplant patients will be examined.
- Trial name
- NCT06563570
- Testing
- yoga (online)
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Dokuz Eylul University
Hepatitis C Virus, Liver Transplantation
Assessment of Intrahepatic Hepatitis C Virus (HCV) RNA Levels at the Time of Liver Transplantation
The purpose of this study is to measure intrahepatic HCV RNA levels at the time of liver transplantation in patients receiving antiviral therapy while on the liver transplant waiting list.
- Trial name
- NCT01836718
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Schiano, Thomas D., MD
Liver Transplantation, Pain Management
Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors
Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes.
- Trial name
- NCT07123740
- Testing
- Intrathecal Morphine, Bi-level Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Hepatitis B, Liver Transplantation
Adefovir Plus Vaccination in Transplant Patients Without Hepatitis B That Receive a Core Antibody Positive Liver
The primary purpose of this study is to evaluate the efficacy of adefovir (ADV) in preventing de novo Hepatitis B in patients who receive Hepatitis B core antibody (HBcAb) positive grafts but who are not Hepatitis B Surface…
- Trial name
- NCT01146808
- Testing
- Adefovir dipivoxil and hepatitis B vaccination
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
End Stage Liver Disease, Physical Activity
The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital
The primary outcome of this study is to demonstrate the feasibility of a prehabilitation program at Barnes Jewish Hospital for liver transplant candidates.
- Trial name
- NCT02444273
- Testing
- Exercise
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Liver Transplantation and Antithrombin
Antithrombin III and Post-liver Transplantation Acute Kidney Injury
The reno-protective effect of Antithrombin III (ATIII) has been well-studied in various animal studies; however, little is known about the effect of ATIII on kidney function in patients undergoing liver transplantation (LT).
- Trial name
- NCT04912193
- Testing
- Antithrombin III
- Where
- South Korea
- Volunteers
- 2,395 people
- Sponsor
- Asan Medical Center
Liver Transplant; Complications, Diabete Mellitus
Effect of Oral Semaglutide on Liver Fat and Body Composition in Liver Transplant Recipients With Diabetes Mellitus
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions ranging from liver steatosis (NAFL), steatohepatitis (NASH), advanced liver fibrosis and ultimately leads to cirrhosis in a significant proportion of…
- Trial name
- Sema-Lit (NCT06060392)
- Testing
- Semaglutide Pill
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Medanta, The Medicity, India
Liver Transplant
Efficacy and Safety of Once-Daily Tacrolimus in Liver Transplant Recipients (SOUL)
The purpose of this study is to evaluate the efficacy and safety of conversion to TacroBell slow-release cap.(Once-daily Tacrolimus) in patients undergoing maintenance therapy with Twice-Daily Tacrolimus after liver…
- Trial name
- NCT04069065
- Testing
- Conversion to Once-daily Tacrolimus
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Liver Cirrhosis, Chronic Hepatitis B
Study on the Pharmacokinetic Characteristics of I.V. Hepabig Injection Used for Prevention of Hepatitis B Relapse After Liver Transplantation
An exploratory clinical trial to evaluate the pharmacokinetic characteristics of I.V. Hepabig injection used for prevention of hepatitis B relapse after liver transplantation.
- Trial name
- LT (NCT02125071)
- Testing
- Blood Sample Collection
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Dong-Gu Kim
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