Clinical trials: Liver Transplants
Chronic Hepatitis C, HCV
A Study to Evaluate the Safety and Efficacy of ABT-493/ABT-530 in Adult Post-Liver or Post-Renal Transplant Recipients With Chronic Hepatitis C Virus (MAGELLAN-2)
The purpose of this study is to assess the safety and efficacy of 12 weeks of treatment of ABT-493/ABT-530 (glecaprevir/pibrentasvir) in adults who are post primary orthotopic liver or renal transplant with chronic hepatitis C…
- Conditions
- Chronic Hepatitis C, HCV, Hepatitis C Virus
- Trial name
- NCT02692703
- Testing
- glecaprevir/pibrentasvir
- Volunteers
- 100 people
- Sponsor
- AbbVie
Liver Transplantation, Postoperative Renal Complication
Postoperative Complications After Liver Transplantation
Incidence and risk factors for renal, cardiovascular and pulmonary complications after liver transplantation are not well defined.
- Conditions
- Liver Transplantation, Postoperative Renal Complication, Postoperative Pulmonary Complication, Postoperative Cardiovascular Complication
- Trial name
- NCT02761109
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Liver Transplant; Complications
HEalth Advocate for Liver Transplantation: Improving Transition of Care for Adolescent Liver Transplant Recipients
The Health Advocate for Liver Transplant (HEAL-Tx) Transition of Care Pilot is a nonrandomized, open-label intervention pilot of a health advocate intervention aimed to assess feasibility and acceptability of integrating a Health…
- Trial name
- HEAL-Tx:ToC (NCT06386198)
- Testing
- Health Advocate
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Hepatitis C
Prevention of Graft Reinfection After Liver Transplantation With Anti HCV Monoclonal Antibodies Identified in Chronically Infected Patients or in Patients With Resolved Hepatitis C
End stage HCV-related cirrhosis has become a major indication for liver transplantation (LT). Unfortunately, recurrence of HCV infection on the liver graft occurs in almost all patients following transplantation and causes a…
- Trial name
- NCT00638144
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Liver Transplantation
A Study of CellCept (Mycophenolate Mofetil) Combined With Calcineurin Inhibitors in Liver Transplant Patients.
This 2 arm study will compare the efficacy and safety of switching to CellCept combined with different regimens of reduced calcineurin inhibitors (CNI) in patients with liver transplants.
- Trial name
- NCT00717314
- Testing
- Mycophenolate mofetil, CNI (50%), CNI (≥75%)
- Where
- 11 sites in China
- Volunteers
- 87 people
- Sponsor
- Hoffmann-La Roche
Liver Transplant
Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients
This is an observational study examining serum markers in patients who are undergoing either a cadaveric liver transplant or a living related liver transplant.
- Trial name
- NCT00698399
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Liver Transplant; Complications, Renal Injury
Association of Intraoperative Renal Regional Oxygen Saturation and Acute Kidney Injury
This study is a prospective observational study of a single cohort of the patients who will undergo a scheduled living donor liver transplantation.
- Trial name
- NCT03877133
- Testing
- Near-infrared spectroscopy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
End-stage Liver Disease
Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients
'ThRIL' aims to explore the feasibility, safety and efficacy of TR002, a regulatory cell therapy, as adjunct immunosuppressive treatment in the context of liver transplantation
- Trial name
- ThRIL (NCT02166177)
- Testing
- Autologous regulatory T cell product
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Liver Transplantation
Study to Assess the Effect of Intravenous Supplementation of Omega-3 Fatty Acids on Outcome of Recipients in Living Donor Liver Transplantation
In this study, the investigators aim to analyse the effect of Omega 3 fatty acid supplementation on recipients undergoing living donor liver transplantation.
- Trial name
- NCT04030065
- Testing
- Omega 3 fatty acid
- Where
- India
- Volunteers
- 124 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Anesthesia, Liver Transplant
Closed-loop Anaesthesia for Liver Transplantation: a Pilot Study
Automated titration of propofol and remifentanil guided by the bispectral index (BIS) has been used for numerous surgical procedures.
- Trial name
- THConcentr (NCT03357900)
- Testing
- Automated titration of propofol and remifentanil
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hopital Foch
Evidence of Liver Transplantation
Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant.
Impact of melatonin on organ donor pretreatment and liver transplant recipient: prospective, randomized, double-blind trial. OBJECTIVES.
- Trial name
- NCT01860716
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Aragon Institute of Health Sciences
Recipients of Liver Transplant
Envarsus XL Immunosuppression Following Liver Transplantation
The standard immunosuppressive regimen for liver transplantation includes twice daily tacrolimus (Prograf). In other transplantation models, there are potential benefits to extended release formulations as lower peak…
- Trial name
- NCT03828058
- Testing
- Envarsus XR, Prograf
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Methodist Healthcare - Memphis
Liver Failure, Kidney Failure
Mesenchymal Stem Cells After Renal or Liver Transplantation
The immune system of a patient can attack the liver or the kidney received from a donor (organ rejection). This can be prevented by treating these patients long-life with immunosuppressive drugs.
- Trial name
- NCT01429038
- Testing
- Mesenchymal Stem Cells
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University of Liege
Liver Transplant
Ischemia Time and Graft Survival
Study the effect of ischemia time on patient and graft survival.
- Trial name
- NCT02521584
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- AlRefaey Kandeel
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Dilated Cardiomyopathy, Tricuspid Atresia
Methacetin Breath Test in Patients With Liver Disease Secondary to Heart Disease
The aim of this project is assess a non-invasive functional liver tests in patients with the Fontan circulation that may be used for prognostic purposes.
- Trial name
- MBT+Fontan (NCT04176458)
- Testing
- Methacetin Breath Test (MBT)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Northwestern University
Liver Diseases, Hepatocellular Cancer
A2ALL-Patients Safety System Improvements in Living Donor Liver Transplantation
Living donor liver transplantation (LDLT), involves complex systems and processes of care that are particularly vulnerable to medical errors and preventable complications.
- Conditions
- Liver Diseases, Hepatocellular Cancer, Endstage Liver Disease, Liver Cirrhosis
- Trial name
- NCT02073435
- Testing
- Donor pain management
- Where
- 4 sites in United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Acute Kidney Injury, Liver Failure
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
Comparing the effects of MAP 60, 75 and 90 mmHg, respectively, on renal blood flow, glomerular filtration rate and renal oxygen demand in patients with terminal liver failure directly after liver transplantation.
- Trial name
- NCT02455115
- Testing
- Alternating mean arterial pressure, Norepinephrine, Chromium ethylenediaminetetraacetic acid
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Sahlgrenska University Hospital
Cirrhosis, Registered on Transplant List
Evaluation of Cirrhotic Cardiomyopathy by Cardiac MRI in Patients Waiting for Liver Transplant.
The aim of this multicenter prospective interventional pilot study is to describe the evolution of myocardial fibrosis in cirrhotic patients before and after liver transplantation (LT).
- Trial name
- CARDIOFIBROCIR (NCT06327308)
- Testing
- MRI, Blood sampling
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Liver Disease Chronic, Muscle Weakness
Inspiratory Muscle Training Post-Liver Transplant
Individuals with chronic liver disease develop significant muscle wasting that remains post-liver transplant. The transplant surgery additionally challenges respiratory mechanics.
- Conditions
- Liver Disease Chronic, Muscle Weakness, Respiratory Insufficiency
- Trial name
- NCT03130608
- Testing
- Inspiratory Muscle Training
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Miami
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