Clinical trials: Liver Transplants
Liver Transplantation, Metabolic Syndrome X
Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients
Many metabolic complications can develop after liver transplant including: diabetes, high blood pressure, obesity, heart attacks and stroke.
- Conditions
- Liver Transplantation, Metabolic Syndrome X, Obesity
- Trial name
- NCT02174783
- Testing
- Control group, Mediterranean diet, Protein-Sparing Modified Fast (PSMF)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Varicella, Transplants
Response and Clearance of Viral DNA Following Administration of Live Attenuated Varicella Vaccine.
Varicella zoster virus (VZV) can lead to significant morbidity and mortality in transplant recipients. Current recommendations suggest a 4 week waiting period between vaccination and transplantation and consideration of booster…
- Trial name
- NCT02692066
- Testing
- varicella vaccine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Liver Transplant
Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates
This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (CMV-MVA) Triplex CMV vaccine…
- Trial name
- COLT (NCT06075745)
- Testing
- CMV-MVA Triplex
- Where
- 18 sites in United States
- Volunteers
- 416 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatocellular Carcinoma
SBRT as Bridging Therapy for Hepatocellular Carcinoma Patients on Transplant Waitlist
This is a single center, prospective study to assess the efficacy and safety of using stereotactic body radiation therapy (SBRT) as bridging treatment for hepatocellular carcinoma (HCC) patients on transplant waitlist.
- Trial name
- NCT03950102
- Testing
- SBRT
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Liver Transplant Rejection, Liver Transplant; Complications
Safety of DNP007 in Healthy Subjects
This clinical trial evaluated the safety, tolerability, pharmacokinetic properties, and immunogenicity of DNP007 when administered as a single dose.
- Conditions
- Liver Transplant Rejection, Liver Transplant; Complications, Steatohepatitis, Nonalcoholic
- Trial name
- NCT06400771
- Testing
- DNP007
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Living Donor Liver Transplantation
Impact of Splenic Artery Ligation in LDLT for Patients With Portal Hypertension
In this study, the investigators aim to prove that performing splenic artery ligation in living donor liver transplantation for patients with portal hypertension is beneficial for early graft function postoperatively.
- Trial name
- NCT04988100
- Testing
- splenic artery ligation, No intervention
- Volunteers
- 30 people
- Sponsor
- Assiut University
Liver Diseases, Liver Cirrhosis
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial.
- Conditions
- Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
- Trial name
- CHANCE (NCT04613921)
- Testing
- Observational Protocol
- Where
- 106 sites in United States, Argentina and 25 more
- Volunteers
- 3,000 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Primary Sclerosing Cholangitis, Post- Orthotopic Liver Transplantation
Vancomycin Treatment in Recurrent PSC in Liver Transplant Patients
The purpose of the study is to investigate the safety and efficacy of oral vancomycin in patients with recurrent Primary Sclerosing Cholangitis (PSC) after liver transplantation.
- Trial name
- NCT03046901
- Testing
- Vancomycin
- Where
- United States
- Sponsor
- Ochsner Health System
Hepatitis C, Hepatitis C Virus Infection, Response to Therapy of
Prevention of Transmission of Hepatitis C Virus (HCV) From HCV-Viremic Organ Donor
This trial will be done in participants who undergo transplantation of heart, kidney or lung at University of California, San Diego (UCSD) and receive a hepatitis C infected donor organ.
- Trial name
- NCT04596475
- Testing
- glecaprevir/pibrentasvir (GLE/PIB)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Diego
Hemophilia, Hemophilia B
Study Evaluating Liver Transplantation in Haemophilia Patients in Spain
This study will analyze survival and outcome of patients with severe haemophilia who undergo liver transplantation in Spain
- Trial name
- NCT00927992
- Testing
- Epidemiological Non interventional
- Volunteers
- 11 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Living Donor Liver Transplantation Recipients
Pressure Controlled Versus Volume Controlled Mechanical Ventilation During Anesthesia for Living Donor Liver Transplantation Recipients
pressure controlled ventilation will improve oxygenation indices , hemodynamics during anesthesia for living donor liver transplantation recipients ,improving postoperative graft function and decreasing postoperative pulmonary…
- Trial name
- NCT01865019
- Testing
- mechanical ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Incisional Hernia of Anterior Abdominal Wall
Study on the Efficacy of Prophylactic on Lay Mesh in Preventing Post-operative Hernia in Liver Transplant Patients
Study Design: Single-blinded, randomized, prospective clinical trial. Study Population: End-stage liver disease patients' candidates for liver transplantation.
- Trial name
- NCT04512469
- Testing
- Low molecular weight mesh
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Organ Failure, Multiple, LIVER TRANSPLANTATION
Electronic Archive of Internal Medicine for the Treatment of Severe Organ Failure and Liver Transplantation-MITIGO
ELECTRONIC ARCHIVE OF INTERNAL MEDICINE FOR THE TREATMENT OF SERIOUS ORGAN FAILURES AND LIVER TRANSPLANTATION
- Trial name
- NCT06781502
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Transplant
Safety and Immunogenicity of Human Papillomavirus (HPV) Vaccine in Solid Organ Transplant Recipients
Human papillomavirus (HPV) affects a significant number of transplant patients. In women, human papillomavirus (HPV) causes genital warts, pre-cancerous areas of the cervix, and cervical cancer.
- Trial name
- NCT00677677
- Testing
- Human papillomavirus quadrivalent vaccine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Living Donor Liver Transplantation
Population Pharmacokinetics of Fentanyl in Patients Undergoing Living Donor Liver Transplantation
The aim of this study was to characterize pharmacokinetics of fentanyl during and after Living Donor Liver Transplantation (LDLT), using population pharmacokinetic analysis with non linear mixed effects modeling.
- Trial name
- NCT01144312
- Testing
- Fentanyl
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Liver Disease, Immunosuppression
Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients
Varicella is a vaccine-preventable disease, which can be severe in immunosuppressed children. Currently, the (live) vaccine is not recommended in pediatric orthotopic liver transplant recipients.
- Conditions
- Liver Disease, Immunosuppression, Varicella
- Trial name
- VZVinOLTx (NCT00492739)
- Testing
- Vaccination with VZV vaccine
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Liver Transplantation, Erythrocyte Transfusion
Blood Salvage From Liver Donors: a Feasibility Pilot Study
Blood recovery is a common procedure that limits patient exposure to allogeneic blood products. Blood recovery is usually performed during different types of surgery, including cardiac and vascular surgery, or liver…
- Trial name
- BLEED (NCT05835882)
- Testing
- Red Blood Cell concentrates from organ donor
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Kidney Transplant Recipients, Liver Transplant Recipients
COVID Protection After Transplant-Immunosuppression Reduction
This study will enroll individuals who have: Completed primary series of mRNA COVID-19 vaccine, and An antibody response ≤ 2500 U/mL measured at least 30 days after the last dose of vaccine.
- Trial name
- CPAT-ISR (NCT05077254)
- Testing
- Pfizer-BioNTech COVID-19 Vaccine 2023-2024, Moderna COVID-19 Vaccine 2023-2024, SOC IS Regimen
- Where
- 15 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatocellular Carcinoma
A Study of TCR-Redirected T Cell Infusion to Prevent Hepatocellular Carcinoma Recurrence Post Liver Transplantation
Hepatocellular Carcinoma (HCC) recurrence rate is high among liver transplant patients, while treatment measures are limited. This study plans to recruit 39 subjects with Hepatitis B virus (HBV) related HCC after liver…
- Trial name
- NCT02686372
- Testing
- TCR-T, No intervention and TCR-T (at crossover)
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Lion TCR Pte. Ltd.
Liver Transplant; Complications
POCS in Liver Transplantation Patients
A prospective, multi-center, non-randomized, observational, consecutive case series, which will compare Endoscopic Retrograde Cholangiopancreatoscopy (ERCP) and cholangioscopy with Spy Glass Digital System (DS) procedure at 5-10…
- Trial name
- NCT03205072
- Testing
- Spy Glass DS
- Where
- 5 sites in United States, Brazil and 2 more
- Volunteers
- 42 people
- Sponsor
- Boston Scientific Corporation
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