Clinical trials: Liver Transplants
Liver Transplant
Intraoperative Glucose Control in Liver Transplant
The goal of the proposed study is to evaluate the effectiveness of intraoperative, strict glycemic control to improve survival and infection rates following liver transplantation in a randomized, prospective trial.Primary…
- Trial name
- NCT00780026
- Testing
- insulin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Infection
Anti-infection Therapy Based on mNGS Etiological Diagnosis and Infection After Liver Transplantation
Liver transplantation is the most efficacious treatment for end-stage liver disease; however, postoperative infection remains a major complication and leading cause of recipient mortality.
- Trial name
- NCT06212115
- Testing
- mNGS
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shenzhen Third People's Hospital
Cardiac Output, Low, Liver Transplant; Complications
Hemodynamic Monitoring in Liver Transplant With VEnaRt Cardiac Output Versus Swan-Ganz Catheter (VERO Study)
The Swan-Ganz catheter is the gold standard to measure cardiac output during liver transplantation surgery. This is an invasive hemodynamic monitoring system.
- Trial name
- VERO (NCT04825015)
- Testing
- VEnaRt Cardiac Output
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Liver Transplant Disorder
Viability Assessment Using FMN Measured in Perfusate and Bile During Normothermic Machine Perfusion
Discarded perfusate samples will be collected from donors after circulatory death (DCD) or donors after brain death (DBD) organs during the machine perfusion period prior to transplantation by the study team.
- Trial name
- NCT07315204
- Where
- United States
- Volunteers
- 850 people
- Sponsor
- The Cleveland Clinic
Asses Immunosuppression Modulation on Renal Recovery Post LT
Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant
This is a study to help understand how well new combinations of immunosuppressive medications (medications that weaken your immune system to prevent your body from rejecting the transplanted liver) work compared to standard…
- Trial name
- NCT04104438
- Testing
- Basiliximab 20 MG
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Fady M Kaldas, M.D., F.A.C.S.
Evidence of Liver Transplantation
Evaluate the Efficacy and Safety of the ADVAGRAF®
The primary objective of this study is to evaluate the efficacy of 6-month treatment with Advagraf® converted from 12-month treatment with tacrolimus in stable liver transplant recipients.
- Trial name
- STABLE (NCT04763096)
- Testing
- Advagraf
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Linical Korea
Liver Transplantation, Postoperative Pain
Effects of Virtual Reality After Liver Transplantation
This randomized controlled study aims to evaluate the effects of a virtual reality intervention on pain, fatigue and vital signs in patients during the early postoperative period after liver transplantation.
- Conditions
- Liver Transplantation, Postoperative Pain, Fatigue
- Trial name
- VR-LT (NCT07572305)
- Testing
- Virtual Reality Intervention, Standard Care
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Malatya Turgut Ozal University
Hepatocellular Carcinoma
TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients
This trial is designed to be the initial prospective pilot investigation of the effectiveness of combined SBRT and TACE as bridging therapy for HCC patients awaiting liver transplanation.
- Trial name
- NCT01918683
- Testing
- TACE transarterial chemoembolization, stereotatic body radiotherapy (SBRT)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Colorectal Cancer Metastatic, Liver Metastases
Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated, Irresectable Colorectal Liver Metastases
Nearly one third of patients with colorectal cancer develop liver metastases. It is well known that the achievement of a R0-situation is one of the most important factors for a positive long-term outcome.
- Trial name
- LIVERT(W)OHEAL (NCT03488953)
- Testing
- Living donor liver transplantation with two-staged hepatectomy.
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Renal Insufficiency
Safety Use of ATeGe in Liver Transplant Recipients With Pre-transplant Renal Dysfunction
Renal dysfunction in the context of liver transplantation is a major issue, with difficult patients' management and determining a worsened prognosis.
- Trial name
- ATG_HVH (NCT01453218)
- Testing
- ATeGe-Fresenius
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Vall d'Hebron
Liver Transplantation
Non-Invasive Assessment of Graft Fibrosis After Living Donor Liver Transplantation
The aim of this study is to compare prospectively the ability of MRE and Transient Elastography in detection and staging of allograft fibrosis in comparison to Liver biopsy in patients who underwent Living Donor Liver…
- Trial name
- NCT03176290
- Testing
- Fibro-α score = (1.35 (numeric constant) +AFP (IU ml-1) × 0.009584 + aspartate aminotransferase (AST)/alanine aminotransferase(ALT) × 0.243 - platelet count (×109 l-1) × 0.001624).
- Volunteers
- 31 people
- Sponsor
- Ain Shams University
Cirrhosis, Liver, Diabetes Mellitus Risk
Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant
The goal of this observational study is to establish risk factors for post-transplant in adult individuals with cirrhosis without diabetes undergoing liver transplant evaluation.
- Conditions
- Cirrhosis, Liver, Diabetes Mellitus Risk, Transplant; Failure, Liver, Transplant-Related Disorder
- Trial name
- NCT06950788
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
End Stage Liver Disease, Hepatitis C
DAA Treatment in Donor HCV-positive to Recipient HCV-negative Liver Transplant
This is a single center study for the donation of Hepatitis C Virus (HCV)-positive livers to HCV negative recipient patients, with preemptive, interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- NCT03208127
- Testing
- Treatment with Direct Acting Antiviral tablet
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Liver Transplant Disorder
Benefit of ESP Peri Operative Analgesia for Live Liver Donor Transplantation
Liver donors have a significant risk to develop persistent and chronic pain around 20 to 30% affecting social and professional life (17%) up to 1 year after the surgery.
- Trial name
- ESPLIVERDON (NCT04570969)
- Testing
- Erector spinae plane block
- Where
- Vietnam
- Volunteers
- 24 people
- Sponsor
- Vinmec Healthcare System
Liver Cirrhosis, Liver Failure
Associated Balance of Risk Score - Comprehensive Complication Index for the Prediction of Post-transplant Survival
In recent years, several scoring systems have been developed aimed at predicting early post-LT graft function. However, many of them showed poor efficacy when long-term survivals were tested.
- Conditions
- Liver Cirrhosis, Liver Failure, Liver Diseases, Transplant Failure
- Trial name
- NCT03723317
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 1,782 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Liver Cirrhosis, Hemophilia
Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease
The goal of this observational study is to learn about the changes in coagulation factor VIII and IX levels in patients undergoing liver transplantation to help guide future management of coagulation factor replacement in…
- Conditions
- Liver Cirrhosis, Hemophilia, Hemophilia A, Hemophilia B
- Trial name
- NCT06014320
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Liver Cirrhosis
Fatty Acids Lipidome and Oxidative Stress in Liver Transplantation
The purpose of this study is to determine lipid metabolism in chronic liver disease in the attempt to find a useful biomarker of liver function and of prognostic value of graft function in those patients who undergo liver…
- Trial name
- NCT01389115
- Where
- 3 sites in Italy
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Acute Renal Failure
Acute Renal Failure Post Liver Transplantation
Trial to test the effect of administering N-acetylcysteine on cytokines and markers of oxidant stress and the incidence of acute renal failure post liver tranplant
- Trial name
- NCT01907061
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Osteoporosis, Liver Transplantation
Osteoporosis in Children and Adults Following Liver Transplantation
This pilot project aims to 1) estimate the prevalence of osteoporosis in adults having undergone liver transplantation in childhood, and 2) identify risk factors for osteoporosis in this group. We aim to study 40 individuals.
- Trial name
- NCT00008788
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Center for Research Resources (NCRR)
Cytomegalovirus Infections, Heart Transplantation
Quantiferon CMV to Identify Treatment Need for Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT)
Context Cytomegalovirus (CMV) infection is a frequent and potentially severe event in solid organ transplant (SOT) recipients. Most of available treatment display adverse effects that limit their use.
- Conditions
- Cytomegalovirus Infections, Heart Transplantation, Kidney Transplantation, Lung Transplantation
- Trial name
- QUANTIFOT (NCT06341543)
- Testing
- Quantiferon CMV (assay that determine the presence of CMV-specific T lymphocytes)., Communication of the result of the QF-CMV to the clinician in charge
- Where
- France
- Volunteers
- 288 people
- Sponsor
- University Hospital, Grenoble
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