Clinical trials: Liver Transplants
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
End Stage Liver Disease
Study of Peripheral Tissue Oxygenation in End-stage Liver Disease Patients During Liver Transplantation
End - stage liver disease can cause many problems to the patients including fatigue, weakness,jaundice, confusion, abdominal pain and distension. Another important problem is the cardiovascular system (heart and blood vessels).
- Trial name
- NCT01794637
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hepatocellular Carcinoma
Value of Negative 18FDG PET/CT in Milan Out, Up-to-seven in, HCC Transplant Candidates
Hepatocellular carcinoma (HCC) is a rising public health concern with few curative options but liver transplantion (LT) in highly selected cases.
- Trial name
- NCT05276037
- Testing
- Liver transplantation
- Where
- 6 sites in Belgium
- Volunteers
- 350 people
- Sponsor
- University of Liege
Mycoses, Fungemia
Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients
The purpose of this study is to compare the efficacy of anidulafungin versus fluconazole for the prevention of fungal diseases in liver transplant recipients
- Conditions
- Mycoses, Fungemia, Central Nervous System Fungal Infections, Lung Diseases, Fungal
- Trial name
- NCT00841971
- Testing
- Anidulafungin, Fluconazole
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Heart Transplantation, Kidney Transplantation
A Paediatric, Open, Follow up Study With Modigraf Examining Safety and Efficacy in de Novo Allograft Recipients
The purpose of this study, a follow up to study FG506-CL-0403, is to see how safe and effective Modigraf® is (Part A) and to see how safe and effective it is to change your child's medication from Modigraf® to Prograf® (Part B).
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation
- Trial name
- PROGRESSION (NCT01371344)
- Testing
- Tacrolimus granules, Tacrolimus capsules
- Where
- 12 sites in Belgium, France and 4 more
- Volunteers
- 47 people
- Sponsor
- Astellas Pharma Europe Ltd.
Liver Disease
Randomized Controlled Trial of ImmuKnow in Liver Transplantation
ImmuKnow detects cell-mediated immunity in solid-organ transplant recipients undergoing immunosuppressive therapy. Increasing ImmuKnow values indicate a decrease of immunosuppression and decreasing ImmuKnow values suggest an…
- Trial name
- NCT01764581
- Testing
- Tacrolimus regulation according to ImmuKnow values
- Volunteers
- 206 people
- Sponsor
- University of Bologna
Small-for-Size Syndrome
Octreotide vs. Splenic Artery Ligation for Portal Flow Modulation in Living Donor Liver Transplants (SCALOP Trial)
The goal of this clinical trial is to compare two treatments for regulating blood flow in small liver grafts during living donor liver transplantation (LDLT).
- Trial name
- SCALOP (NCT06974344)
- Testing
- Octreotide (drug), Splenic Artery Ligation (SAL)
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Liver Transplantation, Liver Transplant
Effect of Preoperative Oral Carbohydrate Loading on Postoperative Outcomes in Liver Transplant Patients
The aim of the study is to evaluate the effect of preoperative oral carbohydrate loading on postoperative outcomes in liver transplant recipients.
- Conditions
- Liver Transplantation, Liver Transplant, Liver Transplant Surgery, End Stage Liver Disease
- Trial name
- NCT07519057
- Testing
- Preoperative Oral Carbohydrate Loading
- Where
- Poland
- Volunteers
- 434 people
- Sponsor
- Medical University of Warsaw
Chronic HCV Infection
Ledipasvir/Sofosbuvir Fixed-Dose Combination + Ribavirin in Subjects With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant
This study will evaluate ledipasvir/sofosbuvir (LDV/SOF) fixed-dose combination (FDC) plus ribavirin (RBV) in participants with advanced liver disease or posttransplant and chronic genotype 1 or 4 hepatitis C virus (HCV)…
- Trial name
- NCT01938430
- Testing
- LDV/SOF, RBV
- Where
- 30 sites in United States
- Volunteers
- 339 people
- Sponsor
- Gilead Sciences
Cirrhosis
Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis
Liver transplantation has been universally recognized to improve survival of patients suffering from end-stage (Pugh C) alcoholic cirrhosis.
- Trial name
- TRANSCIAL (NCT00701792)
- Testing
- liver transplantation, standard care for liver disease
- Where
- 13 sites in France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Liver Failure
Randomized Trial of Hepaticojejunostomy Versus Duct-to-duct Anastomosis in Right Lobe Living Donor Liver Transplantation
The scarcity of deceased donor organ supply has driven the practice of living donor liver transplantation (LDLT). Right lobe LDLT (RLDLT) has developed over the last 10 years to extend the benefit of LDLT to adult patients.
- Trial name
- NCT04139473
- Testing
- Hepaticojejunostomy / Duct-to-duct anastomosis
- Where
- 2 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Prognostic Biomarker, Liver Transplantation
Serum Glycomics as Prognostic and Diagnostic Biomarkers of Disease Recurrence in Liver Transplant Recipients With Hepatocellular Carcinoma
Liver transplantation (LT) is the only curative option for a selection of patients with hepatocellular carcinoma (HCC) based on clinical selection criteria known as the Milan criteria.
- Conditions
- Prognostic Biomarker, Liver Transplantation, Diagnostic Biomarker, Hepatocellular Carcinoma
- Trial name
- GLITCA (NCT05866783)
- Testing
- HCCRecurrencePrognosticScore, HCCRecurrenceDiagnosticScore
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- University Hospital, Ghent
Massive Transfusion, Trauma
Australian and New Zealand Massive Transfusion Registry
Severe and un-stopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies.
- Conditions
- Massive Transfusion, Trauma, Cardiothoracic Surgery, Gastrointestinal Bleeding
- Trial name
- ANZ-MTR (NCT02863250)
- Where
- Australia
- Volunteers
- 50,000 people
- Sponsor
- Monash University
Liver Disease, Liver Transplant
Pediatric Liver Database
The purpose of this study is to collect data to examine and characterize the clinical outcomes of pediatric patients diagnosed with any liver disease at Children's Hospital of Wisconsin.
- Trial name
- NCT00677625
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- Medical College of Wisconsin
Kidney Failure
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function
Tacrolimus is the standard immunosuppressive drug used to prevent organ rejection post liver transplant. One side effect of Tacrolimus is nephrotoxicity. Everolimus does not have the nephrotoxicity side effects of Tacrolimus.
- Trial name
- NCT04258423
- Testing
- Tacrolimus, Everolimus
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Weight Gain
Impact of a LCD on Metabolic Inflexibility and Cardiovascular Risk in Liver Transplant Patients
This study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on the heart and blood vessel health.
- Trial name
- NCT04145427
- Testing
- Control, LCD
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Virginia Commonwealth University
Hepatectomy
The Use of Technical Vessel Sealing Devices for Recipient Hepatectomy in Liver Transplantation
The surgical technique used in liver transplantation has undergone constant Evolution in an effort towards towards a safe, highly standardized procedure.
- Trial name
- SEALIVE (NCT03323242)
- Testing
- LigaSure, Harmonic Ultrasonic dissector
- Volunteers
- 69 people
- Sponsor
- University Hospital Heidelberg
Liver Cancer
Contrast-Enhanced CT and MRI in Diagnosing and Staging Liver Cancer Using UNOS Policy
RATIONALE: Diagnostic procedures, such as contrast-enhanced CT scan and contrast-enhanced MRI, may help find liver cancer and find out how far the disease has spread.
- Trial name
- ACRIN6690 (NCT01082224)
- Testing
- iodinated contrast dye, motexafin gadolinium, Eovist-enhanced MRI
- Where
- 9 sites in United States
- Volunteers
- 440 people
- Sponsor
- American College of Radiology Imaging Network
Hepatitis B
PK Study of Tacrolimus and Cyclosporine When Co-Administered With Adefovir Dipivoxil in Post-Liver Transplant Patients
Open-label pharmacokinetic drug interaction study.
- Trial name
- NCT00644761
- Testing
- Adefovir Dipivoxil
- Where
- 11 sites in United States
- Volunteers
- 16 people
- Sponsor
- Gilead Sciences
Liver Transplantation, Biomarkers
Molecular Assessment and Profiling of Liver Transplant Recipients
The objective of this protocol is to conduct longitudinal and prospective studies of liver transplant recipients, using a multimodality approach, akin to that used in kidney transplantation.
- Trial name
- MAPLE (NCT04793360)
- Testing
- LiverCare
- Where
- 26 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- CareDx
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