Clinical trials: Liver Transplants
Cirrhosis
Correlation of Hepatitis C, Alcoholic Liver Disease, and Renal Failure With Hyperfibrinolysis in Liver Failure
1. Further characterize the incidence of hyperfibrinolysis in cirrhotics 2. Correlate hyperfibrinolysis with 1. hepatitis C 2. alcoholic liver disease 3. the subset of a\&b with renal failure with and without dialysis 3.
- Trial name
- NCT02737345
- Testing
- Rotem
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Scott Allen
Liver Transplantation
Evaluation of Celsior® in Liver Transplant Preservation.
The aim of the study is to determine the efficacy and safety of a preservation solution in liver transplantation. Its efficacy will be compared to the efficacy of other currently used preservation solutions.
- Trial name
- NCT00151593
- Testing
- Celsior®
- Where
- 9 sites in France
- Volunteers
- 140 people
- Sponsor
- Rennes University Hospital
Liver Transplantation
Withdrawal of Immunosuppression in Long Term Stable Liver Transplant Recipients
Long-term immunosuppression carries potential adverse effects such as risk of infection, malignancy, renal insufficiency, diabetes and hypertension.
- Trial name
- tolerance (NCT01198314)
- Testing
- immunosuppression withdrawal, continue of taking immunosuppressant
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Liver Disease
Portal Blood Flushes in the Peri-Reperfusion Stage of Liver Transplantation
By showing that increased levels of acidotic metabolites and electrolytes in the systemic blood of patients who do not receive portal blood flush prior to reperfusion compared to patients who do receive portal blood flush, and…
- Trial name
- NCT03563404
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
The Recipients Undergoing Liver Transplantation
Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors.
- Trial name
- NCT03344380
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Yonsei University
Liver Transplant Disorder, Reperfusion Injury
Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation
Researchers are trying to improve the understanding of systolic function of the heart at the time of liver reperfusion in patients undergoing orthotopic liver transplantation.
- Trial name
- NCT04316468
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Liver Cirrhosis, Copeptin
Copeptin Serum Level in Liver Transplant Recipients
The study aim is to measure perioperative copeptin concentration in blood of liver transplant recipients and to assess whether there is a correlation between its level and hemodynamic derangement.
- Conditions
- Liver Cirrhosis, Copeptin, Liver Transplant
- Trial name
- NCT03587623
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- Medical University of Warsaw
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
Liver Transplantation
Investigation of the Effects of Motor Cognitive Dual Task Exercises on Cognitive Function, Balance and Functional Capacity in Patients Who Have Undergone Liver Transplantation.
Liver transplantation is a life-saving treatment of choice for patients with acute or chronic liver failure. Liver transplantation is performed with a graft taken from a living donor or cadaver in patients with end-stage liver…
- Trial name
- NCT05909371
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Cirrhosis, Liver, Liver Transplant Surgery
Online Prehabilitation for Patients Awaiting Liver Transplantation
Physical frailty is common in patients awaiting liver transplantation and has been associated with poor health outcomes. There is promising data from small studies showing that behavioural, nutrition, exercise therapy…
- Conditions
- Cirrhosis, Liver, Liver Transplant Surgery, Liver Disease
- Trial name
- OPAL (NCT05899231)
- Testing
- Prehabilitation Programming
- Where
- 6 sites in Canada
- Volunteers
- 177 people
- Sponsor
- University of Alberta
Ventral Hernia, Liver Transplantation
Ventral Hernia Prevention After Liver Transplantation
This study aims to evaluate if the risk of developing ventral hernia after liver transplantation can be reduced through the prophylactic implantation of a synthetic, fully resorbable mesh "Phasix" in the course of liver…
- Trial name
- NCT03222102
- Testing
- Phasix mesh
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Medical University of Graz
Hepatocellular Carcinoma
Radiotherapy Versus no Intervention in Adult Patients With Hepatocellular Carcinoma Not Eligible for Transarterial Chemoembolization or Ablation Prior to Liver Transplant (RADBRI)
Liver transplantation (LT) represents the best treatment for patients with selected, early stage hepatocellular carcinoma (HCC).
- Trial name
- RADBRI (NCT03172559)
- Testing
- Stereotactic body radiotherapy
- Sponsor
- University Health Network, Toronto
Liver Cirrhosis, Liver Dysfunction
Impact of Exercise Therapy on Functional Capacity in Patients Listed for Liver Transplantation
A UK prospective, single-centre feasibility study investigating the effects of exercise therapy on functional capacity in patients on the waiting list for liver transplantation.
- Trial name
- NCT02949505
- Testing
- Home prehabilitation program
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Matthew Armstrong
Evidence of Liver Transplantation
Changes of Macrophage Migration Inhibitory Factor During Orthotopic Liver Transplantation
Collecting blood, graft liver effluent and urine samples from patients undergoing orthotopic liver transplantation.
- Trial name
- NCT02695979
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Liver Transplantation, Thymoglobulin
rATG Induction and Tacrolimus Monotherapy in Pediatric Liver Transplantation
This open-label clinical trial will evaluate the pharmacodynamics, pharmacogenomics and early efficacy and safety of steroid-free Tacrolimus (TAC) monotherapy and its minimization after induction with rabbit, anti-human thymocyte…
- Conditions
- Liver Transplantation, Thymoglobulin, Rejection
- Trial name
- NCT01207141
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Pittsburgh
Kidney Disease, Liver Transplantation
Evaluation of Kidney Disease in Liver Transplant Recipients
A non-invasive urinary test that detects kidney injuries in liver transplant (LT) candidates would be useful for monitoring of kidney damage.
- Trial name
- NCT00585429
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Pediatric Patients Who Need Liver Transplantation
Transfusion Strategies for Pediatric Liver Transplantation
The patients assigned to the restrictive group will receive transfusion once the hemoglobin concentration falls below 6.0 g per deciliter, with a target hemoglobin range of 7.5 to 8.0 g per deciliter.
- Trial name
- NCT02951013
- Testing
- restrictive transfusion, liberal transfusion
- Where
- China
- Volunteers
- 488 people
- Sponsor
- RenJi Hospital
Liver Carcinoma
De Novo Sirolimus-based Immunosuppression After Liver Transplantation for Hepatocellular Carcinoma
This study investigates whether sirolimus could decrease the rate of hepatoma recurrence after liver transplantation in high risk hepatoma patients.
- Trial name
- NCT00328770
- Testing
- Sirolimus
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Liver Transplant Failure, Prognostic Biomarkers
Serum GLYcomics to Predict Graft Loss and Mortality After Liver Transplantation
The first 12 months after liver transplantation (LT) are decisive in posttransplant outcome, as almost half of deaths and two thirds of graft loss requiring retransplant occur in the first year after LT.
- Trial name
- GLYGALT (NCT05866796)
- Testing
- GlycoTransplantTest
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Ghent
Organ Preservation Solutions
Peri-operative rATG-perfusion of Solid Transplants
The increasing demand for organ transplantation and the shortage of available organs limit the success of organ transplantation programs.
- Trial name
- ATG-perfusion (NCT03377283)
- Testing
- organ perfusion with rabbit anti-thymocyte globulin (rATG), organ perfusion with saline
- Volunteers
- 80 people
- Sponsor
- Medical University Innsbruck
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