Clinical trials: Liver Transplants
Liver Transplantation, Carotid Intima-media Thickness
Effect of Preoperative CIMT on Hemodynamics During Liver Transplantation
Candidates for liver transplantation (CT) carry an increased risk of cardiovascular disease (CVD) due to underlying end-stage liver disease (ESHD) and immunosuppressive drugs used post-transplantation.
- Trial name
- CIMT-LIVER (NCT07660679)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Dicle University
Chronic Hepatitis C Infection
A Study to Evaluate Chronic Hepatitis C Infection in Adult Transplant Recipients
The purpose of this study is to evaluate the safety and efficacy of ABT-450/r/ABT-267 with or without ABT-333 and with or without ribavirin (RBV) in adult liver or renal transplant recipients with hepatitis C virus (HCV) genotype…
- Trial name
- CORAL-I (NCT01782495)
- Testing
- ombitasvir/paritaprevir/ritonavir and dasabuvir, ombitasvir/paritaprevir/ritonavir, ribavirin
- Volunteers
- 129 people
- Sponsor
- AbbVie
Hepatic Insufficiency, Liver Insufficiency
Liver Transplantation and Reticuloendothelial Clearance Capacity
Study summary: "Liver transplantation and the reticuloendothelial clearance capacity." The purpose of this study is to evaluate the effect of liver transplantation on the immune system.
- Trial name
- NCT00929032
- Testing
- Nanocoll®
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Edinburgh
Liver Transplant
Systemic Variables in the Saliva of Children Undergoing Liver Transplantation
Saliva is used nowadays as a significant diagnostic tool due to the latest technological developments. The research compares two experimental groups; children after liver transplantation and a control group.
- Trial name
- NCT01307163
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Living Donor Liver Transplantation
Delayed Infusion of DCreg in Living Donor Liver Transplantation
Phase I/II, single center, prospective, open-label, non-controlled, non-randomized, interventional, cohort study in which low risk living donor liver transplant (LDLT) recipients who are between 1 and 3 years after…
- Trial name
- NCT04208919
- Testing
- Donor-derived DCreg
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Angus W. Thomson PhD DSc
Liver Transplantation, Anxiety
Endogenous Melatonin Levels on Anxiety in Living Liver Donors
Interesting in living liver donor transplantation have greatly increased because of inadequacy of cadaveric organs and the inability to supply the growing need for cadaveric transplantation.
- Conditions
- Liver Transplantation, Anxiety, Melatonin
- Trial name
- NCT04230707
- Testing
- Endogenous Melatonin Levels
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Portal Vein Thrombosis
A Study of the Correlation Between Portal Vein Thrombosis and Prognosis of Liver Transplantation
The goal of this observational study is to investigate the correlation between portal vein thrombosis (PVT) and the prognosis of liver transplantation.
- Trial name
- NCT06513780
- Testing
- Observation
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Ru-zhou Cai
Fibrolamellar Hepatocellular Carcinoma, Hepatocellular Carcinoma (Fibrolamellar Variant)
Sequential, Related Donor Partial Liver Transplantation Followed by Bone Marrow Transplantation for Hepatocellular Carcinoma (HCC)
This trial is a phase II, single arm, open-label, single center study to assess a reduced-intensity conditioning regimen, bone marrow transplantation and high dose PTCy in recipients of a partial liver allograft from a Human…
- Conditions
- Fibrolamellar Hepatocellular Carcinoma, Hepatocellular Carcinoma (Fibrolamellar Variant), Hepatocellular Carcinoma
- Trial name
- NCT02702960
- Testing
- living related donor partial liver transplantation, Total body irradiation, Bone marrow transplant from same donor
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hepatocellular Carcinoma, Liver Transplantation
Research and Application for New Clinical Diagnosis and Treatment System for HBV Related HCC Liver Transplantation
The study evaluated the protein expression levels of FK506-binding protein 12 (FKBP12) in hepatocellular carcinoma (HCC) and paracancerous tissues using immunohistochemistry (IHC).
- Conditions
- Hepatocellular Carcinoma, Liver Transplantation, Prognosis
- Trial name
- NCT06409507
- Testing
- FKBP12 expression
- Volunteers
- 178 people
- Sponsor
- First People's Hospital of Hangzhou
Liver Transplantation, End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial.
- Trial name
- REFIL-1 (NCT05647733)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Optimized cardiac output liberal fluid management strategy, Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hemorrhage
Predictions of Bleeding During Liver Transplantation With Thromboelastometry
Patients with cirrhosis present complex coagulation defects. Conventional coagulation tests (INR, platelets count) can not predict bleeding or blood product requirements during liver transplantation.
- Trial name
- NCT02356068
- Testing
- ROTEM analysis
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Neurotoxicity, Liver Transplant; Complications
Envarsus Neurotoxicity Burden in Liver Transplant Patients
This study will compare neurologic side effects associated with two immunosuppressant medications used in liver transplant patients.
- Trial name
- NCT03823768
- Testing
- Envarsus, Tacrolimus Immediate release
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Liver Transplantation, Tranexamic Acid
Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial
We propose a multi-center randomized trial to test the primary hypothesis that tranexamic acid is superior to placebo on blood loss in adult orthotopic liver transplantation within the initial 24 hours and that tranexamic acid is…
- Conditions
- Liver Transplantation, Tranexamic Acid, End-stage Liver Disease (ESLD)
- Trial name
- ESTA (NCT07157631)
- Testing
- tranexamic acid, 0.9 % saline
- Where
- China
- Volunteers
- 1,546 people
- Sponsor
- RenJi Hospital
Pediatric Liver Transplantation
Thromboelastometry as a Predictor of Thrombotic Complications During Pediatric Recipient Liver Transplantation
The study aims to correlate the perioperative results of a device called thromboelastogram, which is used to detect coagulation abnormalities, with thrombotic complications during pediatric recipient liver transplantation.
- Trial name
- NCT03494595
- Testing
- Pediatric Liver transplantation
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Liver Transplantation, Child
Pharmacokinetic of Tacrolimus in Paediatric Liver Transplant Patients
Tacrolimus is the cornerstone immunosuppressant in children with liver transplantation, its use is complicated by its narrow therapeutic index and variable pharmacokinetics.
- Trial name
- TACTHEP (NCT02337036)
- Testing
- Pharmacokinetic, Pharmacogenetic, Tacrolimus
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
PHYSIOLOGICAL PHENOMENA
Importance of Liver Innervation for the Osmopressor Response in Humans
In patients with autonomic dysfunction water drinking elicits a pressor response mediated by sympathetic activation. If any, in healthy subjects there is only a slight increase in blood pressure.
- Trial name
- HEP-Reflex (NCT01237431)
- Testing
- 500ml water intake
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Hepatocellular Carcinoma
Resection And Partial LIver Transplantation With Delayed Hepatectomy for Hepatocellular Carcinoma
This is a national, non-randomized, multicentric trial evaluating the feasibility and the tolerance of the RAPID procedure in patients with HCC with preserved liver function requiring a liver transplantation.
- Trial name
- RAPID-HCC (NCT05971628)
- Testing
- RAPID procedure
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatocellular Carcinoma
Y-90 Alone or With Sorafenib for Pre-Transplant Hepatocellular Carcinoma
A research study to determine the safety, efficacy, and tolerability of Therasphere® (also known as Y-90, or Y-90 Therasphere) combined with or without sorafenib (Nexavar®), in patients with hepatocellular carcinoma (HCC, or…
- Trial name
- NCT00846131
- Testing
- Sorafenib, Yttrium-90 (Y-90)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Liver Transplantation
Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant
This two-arm study will assess the efficacy and safety of a long-term calcineurin inhibitor-free maintenance regimen with CellCept and sirolimus in recipients of an orthotropic liver transplant.
- Trial name
- NCT00118742
- Testing
- mycophenolate mofetil [CellCept], Tacrolimus, Cyclosporine
- Where
- 46 sites in United States, Canada
- Volunteers
- 293 people
- Sponsor
- Hoffmann-La Roche