Clinical trials: Liver Transplants
Chronic Hepatitis C Virus (HCV) Infection
An Efficacy and Safety Study of Telaprevir in Patients With Genotype 1 Hepatitis C Infection After Liver Transplantation
The purpose of this study is to evaluate the effectiveness of telaprevir in combination with Peg-IFN-alfa-2a and ribavirin in stable liver transplant patients with chronic hepatitis C virus (HCV) genotype 1.
- Trial name
- REPLACE (NCT01571583)
- Testing
- Telaprevir, Pegylated interferon alfa-2a, Ribavirin
- Where
- 21 sites in Austria, Belgium and 4 more
- Volunteers
- 74 people
- Sponsor
- Janssen-Cilag International NV
Liver Transplantation, Resistance Training
Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant
Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.
- Conditions
- Liver Transplantation, Resistance Training, Activities of Daily Living
- Trial name
- NCT01216722
- Testing
- Resistance Strengthening Exercise Program
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Miami
Hepatocellular Injury, Liver Transplant
HOPE for Human Extended Criteria and Donation After Brain Death Donor (ECD-DBD) Liver Allografts
The purpose of this study is to test the effects of hypothermic oxygenated machine perfusion (HOPE) in a phase-II prospective multicenter randomized clinical trial (RCT) on extended criteria donor allografts (ECD) in donation…
- Trial name
- HOPE-ECD-DBD (NCT03124641)
- Testing
- Hypothermic oxygenated perfusion (HOPE), Conventional cold storage (CCS)
- Where
- 4 sites in Czechia, Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital, Aachen
Hepatocellular Carcinoma, Evidence of Liver Transplantation
Prospective Liver Tumor (ProLiT) Database
The investigators propose a prospective, web-based database (developed within the framework of Quickbase, Intuit) which will allow an evaluation of the data for patients with a liver tumour who receive a liver transplant.
- Trial name
- ProLit (NCT01607788)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Geneva, Switzerland
End Stage Liver Disease, Living Donor
Effect of Intermittent Hepatic Inflow Occlusion During Donor Hepatectomy In Living Donor Liver Transplantation
Intermittent hepatic inflow occlusion (IHIO), also called Pringle maneuver, is a safe and effective procedure for major hepatectomy in patients with liver disease.
- Trial name
- NCT01171742
- Testing
- Intermittent hepatic inflow occlusion (IHIO)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Liver Transplant Rejection, Kidney Transplant; Complications
VOCs in Kidney and Liver Transplants
Kidney and liver trasplants represent very challenging lifesaving and effective surgical procedures for patients with end-stage kidney and/or liver disease.
- Trial name
- NCT04514666
- Testing
- Breath analysis
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Uveal Malignant Melanoma
Liver Transplantation and Uveal Malignant Melanoma
Patients with uveal malignant melanoma with liver metastases have median survival of less than 12 months. There is no established treatment showing increased overall survival.
- Trial name
- NCT01311466
- Testing
- Liver transplantation
- Where
- Norway
- Volunteers
- 2 people
- Sponsor
- Oslo University Hospital
Alcoholic Hepatitis
Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis.
Alcoholic hepatitis (AH) is the most severe form of acute alcohol-related liver disease. Maddrey's discriminant function (mDF) >32 defines the severe form of AH, which is associated with a high mortality.
- Trial name
- AH2023 (NCT05883891)
- Testing
- prothrombin time
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Transplantation
Clinical Outcome of Liver Transplant Patients With Tacrolimus-based Immunosuppression
Genetic polymorphism and numerous clinical factors could influence tacrolimus pharmacokinetics, which led to large inter-and intra-individual variability.Since its narrow therapeutic range,predicting therapeutic outcome and…
- Trial name
- NCT03800576
- Where
- Taiwan
- Volunteers
- 113 people
- Sponsor
- National Taiwan University Hospital
Hepatitis B
Registry Study for Patients With Chronic HBV Receiving Nucleotide Therapy
This registry will remain open for approximately 5 years (4 years of enrollment + 1 year of follow up). Subjects will be followed until Orthotopic Liver Transplant (OLT), resolution of liver decompensation, death, or conclusion…
- Trial name
- NCT01590615
- Testing
- Anti-HBV nucleoside/nucleotide therapy
- Where
- 27 sites in United States, Canada
- Volunteers
- 54 people
- Sponsor
- Gilead Sciences
Hepatitis B Infection
A Phase 2 Study of GC1102 (Recombinant Hepatitis B Immunoglobulin) in HBV-related Liver Transplant Recipients
This is a proof-of-concept study for GC1102 to demonstrate preventing the recurrence of hepatitis B virus (HBV) infection following liver transplantation and a dose-finding study to determine its optional dose.
- Trial name
- NCT02304315
- Testing
- GC1102 50,000 IU, GC1102 80,000 IU
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Green Cross Corporation
Heart Transplantation, Liver Transplantation
Organ Transplantation Rehabilitation: Effect of Bedside Exercise Device and Activity Reinforcement
The aims of this 3-year randomized, single-blinded clinical trial are to compare the effect of high and low feedback about performance on the bedside exercise device in heart or liver transplantation recipients during the…
- Trial name
- NCT01705015
- Testing
- direct feedback about exercise
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- National Taiwan University Hospital
Liver Transplant
Outcomes and Risk Factors for Liver Transplantation Using Significant Fibrotic Grafts
This is a multi-center study to investigate the impact of fibrotic liver greafts in liver transplant recipient.
- Trial name
- NCT07101718
- Testing
- No intervention
- Where
- China
- Volunteers
- 25,419 people
- Sponsor
- Zhejiang University
Amyloidosis, Familial, Transthyretin Amyloidosis
Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver Transplant
The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of patisiran in participants with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) with disease progression after liver…
- Trial name
- NCT03862807
- Testing
- Patisiran
- Where
- 9 sites in France, Germany and 5 more
- Volunteers
- 24 people
- Sponsor
- Alnylam Pharmaceuticals
Liver Failure
Pharmacokinetics of LCP-Tacro in Stable Liver Transplant Patients
A three sequence, open-label, multi-center, prospective, study in stable liver transplant patients to assess and compare the pharmacokinetics (Cmax, C24, and AUC), and safety of LCP-Tacro (tacrolimus) tablets versus Prograf…
- Trial name
- NCT00608244
- Testing
- LCP Tacro, Prograf
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Veloxis Pharmaceuticals
Evidence of Liver Transplantation, Myocardial Injury
Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation
The purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation
- Trial name
- NCT03013634
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin First Central Hospital
Liver Transplantation (LT)
Intraoperative Glycemic Variability and Infectious Complications After Liver Transplantation
This study aims to evaluate whether intraoperative glycemic variability (GV) is independently associated with the risk of infectious complications within 30 days after elective liver transplantation.
- Trial name
- SUGAR-LT (NCT07786857)
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw
Liver Transplant Disorder
Perioperative Factors and Living Donor Liver Transplantation
Liver transplant surgery is one of the treatments provided to patients suffering from end-stage liver disease, and has a successful treatment prognosis.
- Trial name
- NCT06312098
- Testing
- remote ischemic preconditioning (RIPC)
- Volunteers
- 533 people
- Sponsor
- Min Suk Chae
Osteoporosis, Liver Transplantation
Use of Bisphosphonates in the Treatment of Osteopathy After Liver Transplantation
Patients with a terminal chronic liver disease have a disordered bone metabolism resulting in a higher risk of falling ill with osteoporosis.
- Trial name
- NCT00302484
- Testing
- Zoledronate
- Where
- Austria
- Volunteers
- 96 people
- Sponsor
- Medical University of Vienna
Liver Transplant; Complications, Renal Complication of Procedure
Renal Outcomes Among Post Liver Transplantation Patients
To evaluate Renal outcomes among patients, post liver transplantation at Assiut university.
- Trial name
- NCT06123260
- Testing
- renal function tests
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
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